Sanjay S. Reddy, MD, FACS

Dr. Sanjay Reddy
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Clinical Locations

  • Fox Chase Cancer Center
    333 Cottman Avenue
    Philadelphia, PA 19111
    Phone: 888-369-2427

Associate Professor, Department of Surgical Oncology

Attending Surgeon

Marvin S. Greenberg, MD, Chair in Pancreatic Cancer Surgery

Associate Program Director, Complex General Surgical Oncology Fellowship

Co-Director, Marvin & Concetta Greenberg Pancreatic Cancer Institute

Collaborating Member, Molecular Therapeutics

NCCN, Hepatobiliary Cancers Panel Member


  • Surgical Oncology

Areas of Expertise

Appendix Cancer, Liver, Gall Bladder & Bile Duct Cancer, Neuroendocrine Tumors, Sarcoma, GIST (Gastrointestinal Stromal Tumor), Mesothelioma, Pancreatic Cyst, Stomach (Gastric) Cancer, Colorectal Cancer, Melanoma, Pancreatic Cancer, Skin Cancer

Treatment Focus

Hyperthermic intraperitoneal chemotherapy (HIPEC), gastric cancer, hepatobiliary cancer, general and minimally invasive surgery


Treatment Philosophy

I decided to join the Fox Chase Cancer Center team in conquering cancer because I saw first-hand the dramatic difference we can make here. I decided to continue my training in Philadelphia after completing my general surgery residency in New York City, under the tutelage of my father, also a surgeon who spent many years treating cancer. I completed a two-year fellowship in complex surgical oncology at Fox Chase, working closely with various multidisciplinary teams in caring for patients with colorectal, liver, pancreatic and stomach cancers, in addition to melanoma and sarcomas. Being trained by leaders in the field, I had the unique opportunity to hone my skills and expertise, and apply them to my own clinical practice.

I have extensive training in traditional open surgery, as well as laparoscopic and robotic techniques, allowing me to offer individualized care to patients. I have particular interests in the management of sarcomas and colorectal, melanoma and pancreatic cancers. The implementation of minimally-invasive surgical techniques to the management of colorectal cancer is routinely offered at Fox Chase, and similar techniques are used to address pancreatic diseases. I also have a keen interest in the use of hyperthermic intraperitoneal chemotherapy (HIPEC), following cytoreductive surgery for cancer of the peritoneum, including appendix cancer, peritoneal mesothelioma and pseudomyxoma peritonei. In addition to this, there is a necessity to understand the benefit of, and perform further research, incorporating HIPEC in patients with colorectal and gastric cancers, which our team will explore further.

The benefit of an NCI-designated cancer center is that we are able to offer many innovative strategies in treating all types of cancers. Whether through a national clinical trial or particular surgical technique, we optimize patient care to the individual. I believe the physician-patient relationship is one of the foundations to building a plan to treat cancer, and I offer guidance through each stage of treatment. Medicine has always been a family-oriented field for me; with my father being a surgeon, and mother an anesthesiologist, I take great pride in offering compassion and honesty in formulating individualized treatment plans for every patient and his or her family.

Follow on Twitter: @FCCCSurgOnc

Educational Background

  • Fellowship, Surgical Oncology Fellow, Fox Chase Cancer Center, Temple University Hospital, Philadelphia, PA
  • Residency, General Surgery, Beth Israel Medical Center, New York, NY


  • American Board of Surgery - Surgery
  • American Board of Surgery - Complex General Surgical Oncology


  • American College of Surgeons
  • Clinical Robotics Surgical Association
  • Association for Academic Surgery
  • American Society of Clinical Oncology
  • Society of Surgical Oncology
  • Society for Surgery of the Alimentary Tract
  • Pancreas Club
  • American Cancer Society- Metropolitan Philadelphia Chapter

Honors & Awards

  • Philadelphia Magazine Top Doctors, 2023-2024
  • Top Physicians Under 40 2020, Pennsylvania Medical Society
  • The John (Drew) Ridge Fellowship Award in Surgical Oncology, 2014
  • Resident Teaching Award, Beth Israel Medical Center, Albert Einstein College of Medicine,2011
  • Resident Teaching Award, St. Vincent's Medical Center, New York Medical College, 2010
  • Harriet Gold Foundation, Scholar in Humanism Award, New York Medical College, 2010
  • Academic Achievement in Molecular Cell Biology, St. Vincent's Medical Center, New York, NY, 2009
  • Pi Kappa Alpha, Honors Society, 2002-2003
  • University of Connecticut Dean's List, 2002-2003
Larry Holman

Larry Holman

  • GIST (Gastrointestinal Stromal Tumor)

I’m an 83-year-old U.S. Navy veteran. I smoked for twenty-odd years until I was 35 years old, which left me with some lingering COPD. Ten years ago I had a heart attack and had a stent put in. So when I received my cancer diagnosis, it crossed my mind that it might be time to go into hospice. But my wife Debbie was already battling breast cancer, and if she could fight, I felt like I could too.

Louise Buttaro

Louise Buttaro

  • Pancreatic Cancer

I’m 75 years old, which is pretty amazing when it comes to surviving pancreatic cancer, especially since I was diagnosed when I was 53.

Initially, when I went in with abdominal pain and trouble eating, my doctor treated me for an ulcer because I didn’t fit the profile for someone with cancer — there was no history of cancer in my family, and I was in good physical shape.

Janice Hudnell

Janice Hudnell-Davis

  • Pancreatic Cancer

In January 2022, I listened to my body, and it may have saved my life. I initially went to the doctor because I had hemorrhoids that had been acting up for about a week. Not only was an over-the-counter medication not working, but I had also noticed a change in the color of my stool. Together, these were red flags that something wasn’t right.


Research Interests

My research interest for colorectal malignancies focuses on the use of national cancer databases to assess the accuracy of clinical staging, to see if this has improved over time, and to observe reporting standards between academic institutions versus other centers. As treatment of colorectal cancers involve multimodality planning, accurate clinical staging proves to be the foundation on how best to deliver care.

I also have a strong research interest in the vascular resectability staging of pancreatic cancer. Currently under review is our preoperative venous and arterial staging for borderline resectable pancreatic cancers and whether we are able to predict from preoperative imaging the likelihood of clear margin achievement and prognosis. As treatment of borderline resectable pancreatic cancer continues to evolve, accurate preoperative vascular resectability staging is imperative to assess and guide multimodality therapy.

Selected Publications

Barrak D., Villano A.M., Villafane-Ferriol N., Stockton L.G., Hill M.V., Deng M., Handorf E.A., Reddy S.S., Total neoadjuvant therapy for pancreatic adenocarcinoma increases probability for a complete pathologic response. Eur J Surg Oncol, 2022.

Meyer J.E., Reddy S., ASO author reflections: Neoadjuvant chemoradiation impacts the prognostic effect of surgical margin status in pancreatic adenocarcinoma. Ann Surg Oncol. 29(1): 364-365, 2022. PMC9036528.

Moslim M.A., Lefton M.D., Ross E.A., Mackrides N.,Reddy S.S., Clinical and histological basis of adenosquamous carcinoma of the pancreas: A 30-year experience. J Surg Res. 259: 350-356, 2021. PMC8902409.

O'Halloran E.A., Board T., Lefton M., Devarajan K., Dotan E., Meyer J., Reddy S.S., Predicting positive peritoneal cytology in pancreatic cancer. J Cancer Res Clin Oncol. 147(6): 1825-1832, 2021.

Villano A.M., O'Halloran E., Goel N., Ruth K., Barrak D., Lefton M., Reddy S.S., Total neoadjuvant therapy is associated with improved overall survival and pathologic response in pancreatic adenocarcinoma. J Surg Oncol, 2022.

Tharmalingam S, Reddy S, Sharda P, Koch CA. Severe Hypocalcemia and transient hypoparathyroidism after hyperthermic intraperitoneal chemotherapy. Thieme Connect 2020;Aug 7

Moten AS, Movva S, von Mehren M, Wu H, Esnaola NF, Reddy SS, Farma JM. Granular cell tumor experience at a comprehensive cancer center. J Surg Res, 226:1-7, 2018. PubMed

Barnica VH, Reddy SS, Wu H, Fang Z, Olszanski A, Farma JM. High Mitotic Rates in Patients with Cutaneous Melanoma. (Manuscript pending publication).

Reddy SS, Cooper HS, Ruth K, Chun YS, Watson JC, Hoffman JP. The Role of Adjuvant Chemoradiotherapy in Pancreatobiliary versus Intestinal Subtypes of Ampullary Cancers. Gastroenterology. Volume 144(5). 1107-1108. (Manuscript pending publication).

Reddy SS, Boukovalas S, Barnica V, Fang Z, Wu H, Farma JM. The Presence of Tumor Infiltrating Lymphocytes and their Role as a Prognostic Indicator for Melanoma. (Manuscript pending publication)... Expand

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