Mary B. Daly, MD, PhD, FACP

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Clinical Locations

  • Fox Chase Cancer Center
    333 Cottman Avenue
    Philadelphia, PA 19111
    Phone: 888-369-2427

Professor, Department of Clinical Genetics

Former Chair, Department of Clinical Genetics

Director, Risk Assessment Program

Timothy R. Talbot Jr. Chair in Cancer Research

NCCN, Breast Cancer Risk Reduction Panel Member

NCCN, Breast Cancer Screening and Diagnosis Panel Member

NCCN, Genetic/Familial High-Risk Assessment: Breast and Ovarian Panel Member


  • Clinical Genetics
  • Medical Oncology

Areas of Expertise

Breast Cancer, Ovarian & Primary Peritoneal Cancer, Endometrial (Uterine) Cancer

Treatment Focus

Clinical Genetics; breast cancer; Risk Assessment; chemoprevention research; family risk assessment and genetic testing; epidemiology; gynecologic cancers

Treatment Philosophy

I consider it an honor and a privilege to have the opportunity to accompany my patients on their cancer journey. I am allowed to witness their strength and courage, to be exposed to the devotion of their families and friends, and to become part of their lives in a very special way.

By extending this care to family members through the risk assessment program, we can work together towards the reduction of risk and prevention of cancer. I like to approach every patient encounter as a mutual learning experience. It is an opportunity for me to share with each patient the latest information about their cancer and treatment or their cancer risk, and give them the tools they need to make informed decisions.

It is also an opportunity for them to teach me something about themselves, about their lives and families, and how they cope with illness and promote their own health. I always feel both drained and enriched after a day in clinic.

Director, Risk Assessment Program

Dr. Daly is a national leader in the field of clinical cancer genetics, and is the founder and director of one of the first cancer risk assessment and counseling programs in the country, established in 1991.

Dr. Daly is the founder and director of Fox Chase Cancer Center’s Risk Assessment Program, which is heavily grounded in research. The program has contributed to early observations regarding risk perception and risk-reducing behavior among women with a family history of breast and/or ovarian cancer, and has been instrumental in the development of state-of-the-art cancer risk counseling interventions... Expand

Educational Background

  • Fellow, Oncology, University of Texas Health Center, Austin, TX
  • Resident, Internal Medicine, University of Texas Health Center, Austin, TX
  • MD, University of North Carolina at Chapel Hill, Chapel Hill, NC, 1978
  • PhD, Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 1973
  • MSPH, Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 1971
  • BA, Biology, College of New Rochelle, New Rochelle, NY, 1965


  • American Board of Internal Medicine - Internal Medicine
  • American Board of Internal Medicine - Medical Oncology


  • National Comprehensive Cancer Network (NCCN)
    • Breast Cancer Risk Reducation Panel
    • Breast Cancer Screening and Diagnosis Panel
    • Genetic/Familial High-Risk Assessment: Breast and Ovarian Panel
    • JNCCN Editorial Board
  • International Gynecologic Cancer Society
  • American Society of Clinical Oncology
  • American Association for Cancer Research
  • American Society for Preventive Oncology
  • American Public Health Association

Honors & Awards

  • Inaugural Impact Award From Basser Center for BRCA
  • Philadelphia Magazine Top Doctors, 2009-19
  • America’s Top Doctors®, 2015-2017
  • Susan G. Komen Light of Life Award, 2014
  • Women of Distinction Award, Philadelphia Business Journal, 2011
  • Cancer Control Award, American Cancer Society, 1996, 2004
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Angela Shammo

  • Breast Cancer

I was a first grade teacher for six years before becoming a reading specialist for kids with learning disabilities. After having four children of my own, I decided to be a stay-at-home mom and teach my children, along with my nieces and nephews.

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Karin McAnlis

  • Pancreatic Cyst

I am BRCA1 and BRCA2 positive, meaning I have mutations in those two genes that make me more susceptible to cancer. When I was 67 years old, I was diagnosed with premalignant pancreatic cysts and anal cancer in the same year.

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Linda Snow

  • Breast Cancer

Linda Snow was active, maintained a healthy diet, and underwent genetic testing, followed by two double mastectomies and a hysterectomy. So she was shocked that even with all of these precautionary procedures that she still got breast cancer. Linda sought treatment at Fox Chase Cancer Center, where she met with her treatment team. After a long road, she is now cancer free and credits her survival to Fox Chase. "Where you start your cancer treatment really does make a difference," said Linda. "You have got to act with a sense of urgency because it can mean the difference between life and death. I unequivocally believe that I am alive today because I chose Fox Chase."



  • Michael Hall, MD
    Michael Hall, MD, MS
    Chair, Department of Clinical Genetics
  • Link to
    Catherine Neumann, MS, LCGC
    Cancer Genetic Counselor
  • Michelle McSweeny, LCGC
    Michelle McSweeny, MS, LCGC
    Cancer Genetic Counselor
  • Link to
    Hannah Campbell, ScM, LCGC
    Cancer Genetic Counselor
  • chau-nguyen
    Chau Q. Nguyen, MS, LCGC
  • Wineland, Dylane
    Dylane Wineland MS, LCGC
  • Zrada, Corinne
    Corinne M. Zrada, MS, LCGC
  • Yana Chertock, MA
    Project Manager
  • Deborah Grace, BcS
    Research Assistant

Research Interests

  • Risk Assessment Program Registry
  • Philadelphia Breast Cancer Family Registry
  • Improving the Estimation and Communication of Ovarian Cancer Risk among BRCA1/2 and Lynch Syndrome Carriers to Optimize Decision Making
  • Translation of Genomics into Improvements in Cancer Prevention and Treatment
  • COGENT (Communicating Genetic Test Results by Telephone)
  • LEGACY (A cohort of youth in families from the Breast Cancer Family Registry)
  • Return of Genetic Research: Ethical Issues


The Risk Assessment Program at Fox Chase looks at your personal and possible inherited genetic factors that may put you at higher possibility for getting cancer. We comprehensively examine your profile for all cancer types, including — but not limited to — breast cancer, ovarian cancer, gastrointestinal cancers, prostate cancer, and melanoma. Knowing your risk helps you learn what you can do to lower your chances of getting cancer.

The Department of Clinical Genetics is built on the success of Fox Chase's Margaret Dyson Family Risk Assessment Program (now Risk Assessment Program), which Dr. Mary Daly began in 1991. A high-risk screening clinic was developed for individuals with a family history of breast or ovarian cancer. In addition to the clinic, genetic counseling was provided for both high risk and breast and ovarian cancer patients. As the clinic developed, it became clear that it was important to provide consultations for biopsy findings that put women at increased risk. Since then, Fox Chase has expanded risk assessment services to those at high risk for all cancers.

The following ratings and reviews are based on verified feedback collected from independently administered patient experience surveys. The ratings and comments submitted by patients reflect their own views and opinions. Patient identities are withheld to ensure confidentiality and privacy. Learn more about our Patient Experience Ratings.

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Selected Publications

Pal T, Agnese D, Daly M, La Spada A, Litton J, Wick M, Klugman S, Esplin ED, Jarvik GP, Professional Practice G. Points to consider: is there evidence to support BRCA1/2 and other inherited breast cancer genetic testing for all breast cancer patients? A statement of the American College of Medical Genetics and Genomics (ACMG). Genetics in Medicine, 22(4):681-5, 2020.

Houghton LC, Knight JA, Wei Y, Romeo RD, Goldberg M, Andrulis IL, Bradbury AR, Buys SS, Daly MB, John EM, Chung WK, Santella RM, Stanczyk FZ, Terry MB. “Association of Prepubertal and Adolescent Androgen Concentrations With Timing of Breast Development and Family History of Breast Cancer”. JAMA Netw Open. 2019 Feb 1;2(2):e190083. doi:10.1001/jamanetworkopen.2019.0083. PMID: 30794303

Terry MB, Daly MB, Phillips KA, Ma X, Zeinomar N, Leoce N, Dite GS, MacInnis RJ, Chung WK, Knight JA, Southey MC, Milne RL, Goldgar D, Giles GG, Weideman PC, Glendon G; kConFab Investigators, Buchsbaum R, Andrulis IL, John EM, Buys SS, Hopper JL. “Risk-Reducing Oophorectomy and Breast Cancer Risk Across the Spectrum of Familial Risk”.J Natl Cancer Inst. 2018 Nov 28. doi: 10.1093/jnci/djy182. [Epub ahead of print] PMID:30496449

Nicolas E, Demidova EV, Iqbal W, Serebriiskii IG, Vlasenkova R, Ghatalia P, Zhou Y, Rainey K, Forman AF, Dunbrack RL Jr, Golemis EA, Hall MJ, Daly MB, Arora S. Interaction of germline variants in a family with a history of early-onset clear cell renal cell carcinoma. Mol Genet Genomic Med. 2019 Mar;7(3):e556. doi: 10.1002/mgg3.556. Epub 2019 Jan 24. PMID: 30680959; PMCID: PMC6418363.

Frost CJ, Andrulis IL, Buys SS, Hopper JL, John EM, Terry MB, Bradbury A, Chung WK, Colbath K, Quintana N, Gamarra E, Egleston B, Galpern N, Bealin L, Glendon G, Patrick Miller L, Daly MB. “Assessing Patient Readiness for Personalized Genomic Medicine”. Journal of Community Genetics, 10 (1), 109-120. Received: 26 June 2017 /Accepted: 18 April 2018 EPUB ahead of print 5.29.18

Wolf SM, Scholtes E, Koenig BA, Petersen GM, Berry SA, Beskow LM, Daly MB, Fernandez CV, Green RC, LeRoy BS, Lindor NM, O'Rourke PP, Breitkopf CR, Rothstein MA, Van Ness B, Wilfond BS. “Pragmatic Tools for Sharing Genomic Research Results with the Relatives of Living and Deceased Research Participants”. J Law Med Ethics. 2018 Mar;46(1):87-109. doi: 10.1177/1073110518766024. Epub 2018 Mar 27. No abstract available.

Buys, S.S., Sandbach, J.F., Gammon, A., Patel, G., Kidd, J., Brown, K.L., Sharma, L., Saam, J., Lancaster, J., Daly, M.B. “A Study of Over 35,000 Women with Breast Cancer Tested with a 25-gene Panel of Hereditary Cancer Genes,” Cancer 2017 May 15; 123(10): 1721-1730. doi: 10l1002/cncr.30498.

Daly, M.B., Montgomery, S., Bingler, R., Ruth, K. “Communicating Genetic Test Results within the Family: Is it Lost in Translation: A Survey of Relatives in the Randomized Six-Step Study,” Familial Cancer 2016;15(4):697-706. (PMCID: PMC5010833).

Additional Publications

This Fox Chase professor participates in the Undergraduate Summer Research Fellowship
Learn more about Research Volunteering.