Jeffrey Chang-Jen Liu, MD, FACS

Jeffrey Chang-Jen Liu, MD

Clinical Locations

Primary Location

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111


Attending Surgeon

Associate Professor, Department of Surgical Oncology

Medical Director, Speech Pathology

Associate Professor, Department of Otolaryngology

Treatment Focus

Head and neck cancer, including cancers of the tongue, throat, voice box. Thyroid cancer, skin cancer.

Research Program

Key Awards

Philadelphia Magazine Top Docs 2021

Treatment Philosophy

I am committed to developing a coordinated, personalized plan appropriate for the treatment of your head and neck cancer. This will often be done in coordination with other physicians and staff from other specialties, including radiation therapists, medical oncologists, dentists and prosthodontists, plastic and reconstructive surgeons, pathologists, neuroradiologists, oncology social workers, oncology nutritionists and speech/swallow specialists.

Our Head and Neck Multidisciplinary Tumor Board at Fox Chase Cancer Center offers an opportunity to coordinate all facets of your care to execute a unique treatment plan tailored to give you the best chance of curing your cancer while maintaining function.


Follow on Twitter: @FCCCSurgOnc

Education and Training

Educational Background

  • Fellow, Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 2010
  • Resident, Otolaryngology, New York Presbyterian Hospital, Columbia and Cornell Campuses, New York, NY, 2008
  • MD, with Honors in Research, Weill Medical College, Cornell University, New York, NY, 2003


  • American Board of Otolaryngology/Head and Neck Surgery


  • American College of Surgeons
  • American Head and Neck Society
  • American Academy of Otolaryngology

Honors & Awards

  • Philadelphia Magazine Top Doctors, 2018-20
  • Resident Leadership Grant Recipient, American Academy of Otolaryngology, 2007-11
  • National Institute of Health T32 Training Grant Recipient (CA09685), Memorial Sloan Kettering Cancer Center, 2008
  • 1st Place, 6th Annual Resident Research Competition, Columbia/Cornell Otolaryngology, 2006
Research Profile

Research Program

Research Interests

  • Translational research evaluating genetics and molecular profiles in head and neck cancer outcomes
  • Racial disparities in head and neck cancer incidence and treatment

Selected Publications

Brickman CE, Propert KJ, Merlin JS, Liu JC, Eady S, Mcghee-Jez A, Ragin C, Grover S, Cohen RB, Gross R. Treatment and Outcomes of Oropharyngeal Cancer in People with Human Immunodeficiency Virus. AIDS Res Hum Retroviruses. 2019 Aug 29;. doi: 10.1089/AID.2019.0009. [Epub ahead of print] PubMed PMID: 31347379.

Jones EA, Shuman AG, Egleston BL, Liu JC. Common Pitfalls of Head and Neck Research Using Cancer Registries. Otolaryngol Head Neck Surg. 2019 Aug;161(2):245-250. doi: 10.1177/0194599819838823. Epub 2019 Apr 2. PubMed PMID: 30939098.

Avkshtol V, Handorf EA, Ridge JA, Leachman BK, Liu JC, Bauman J, Galloway TJ. Examining adjuvant radiation dose in head and neck squamous cell carcinoma. Head Neck. 2019 Jul;41(7):2133-2142. doi: 10.1002/hed.25680. Epub 2019 Feb 9. PubMed PMID: 30737968.

Liu JC, Kaplon A, Blackman E, Miyamoto C, Savior D, Ragin C. The impact of the multidisciplinary tumor board on head and neck cancer outcomes. Laryngoscope. 2019 May 16;. doi: 10.1002/lary.28066. [Epub ahead of print] PubMed PMID: 31095740.

Liu JC, Bhayani M, Kuchta K, Galloway T, Fundakowski C. Patterns of distant metastasis in head and neck cancer at presentation: Implications for initial evaluation. Oral Oncol. 2019 Jan;88:131-136. doi: 10.1016/j.oraloncology.2018.11.023. Epub 2018 Nov 27. PubMed PMID: 30616783.

Lee Z, Waldorf BT, Cho EY, Liu JC, Metro MJ, Eun DD. Robotic Ureteroplasty with Buccal Mucosa Graft for the Management of Complex Ureteral Strictures. The Journal of urology. 2017; 198(6):1430-1435.

Wang LS, Handorf EA, Wu H, Liu JC, Perlis CS, Galloway TJ. Surgery and Adjuvant Radiation for High-risk Skin Adnexal Carcinoma of the Head and Neck. American journal of clinical oncology. 2017; 40(4):429-432. NIHMSID: NIHMS648261

Ramakodi MP, Devarajan K, Blackman E, Gibbs D, Luce D, Deloumeaux J, Duflo S, Liu JC, Mehra R, Kulathinal RJ, Ragin CC. Integrative genomic analysis identifies ancestry-related expression quantitative trait loci on DNA polymerase β and supports the association of genetic ancestry with survival disparities in head and neck squamous cell carcinoma. Cancer. 2017; 123(5):849-860. NIHMSID: NIHMS827555

 Liederbach E, Kyrillos A, Wang CH, Liu JC, Sturgis EM, Bhayani MK. The national landscape of human papillomavirus-associated oropharynx squamous cell carcinoma. International journal of cancer. 2017; 140(3):504-512.

Ragin C, Liu JC, Jones G, Shoyele O, Sowunmi B, Kennett R, Groen HJ, Gibbs D, Blackman E, Esan M, Brandwein MS, Devarajan K, Bussu F, Chernock R, Chien CY, Cohen MA, Samir EM, Mikio S, D'Souza G, Funchain P, Eng C, Gollin SM, Hong A, Jung YS, Krüger M, Lewis J Jr, Morbini P, Landolfo S, Rittà M, Straetmans J, Szarka K, Tachezy R, Worden FP, Nelson D, Gathere S, Taioli E. Prevalence of HPV Infection in Racial-Ethnic Subgroups of Head and Neck Cancer Patients. Carcinogenesis. 2016;

Koshkareva Y, Liu JC, Lango M, Galloway T, Gaughan JP, Ridge JA. Cervical metastasis in squamous cell carcinoma of the hard palate and maxillary alveolus. Ear, nose, & throat journal. 2016; 95(10-11):E6-E11.

Lango MN, Galloway TJ, Mehra R, Ebersole B, Liu JC, Moran K, Ridge JA. Impact of baseline patient reported dysphagia on acute gastrostomy placement in patients with head and neck squamous cell carcinoma undergoing definitive radiation. Head & neck. 2016; 38 Suppl 1:E1318-24.

Liu JC, Parajuli S, Blackman E, Gibbs D, Ellis A, Hull A, Beck JR, Giri V, Iherjirka P, Khurana JS, Ragin CR. High prevalence of discordant human papillomavirus and p16 oropharyngeal squamous cell carcinomas in an African American cohort. Head & neck. 2016; 38 Suppl 1:E867-72. NIHMSID: NIHMS724207

Fu W, Sun J, Huang G, Liu JC, Kaufman A, Ryan RJ, Ramanathan SY, Venkatesh T, Singh B. Squamous Cell Carcinoma-related Oncogene (SCCRO) Family Members Regulate Cell Growth and Proliferation through Their Cooperative and Antagonistic Effects on Cullin Neddylation. The Journal of biological chemistry. 2016; 291(12):6200-17.

Ramakodi MP, Kulathinal RJ, Chung Y, Serebriiskii I, Liu JC, Ragin CC. Ancestral-derived effects on the mutational landscape of laryngeal cancer. Genomics. 2016; 107(2-3):76-82. NIHMSID: NIHMS750683

Additional Publications




Our Patient Satisfaction Rating is an average of all responses to care provider related questions from our nationally-recognized Press Ganey Patient Satisfaction Survey. Learn more.


4.9 / 5.0


  • 4.8
  • 4.9
  • 4.9
  • 4.9
  • 4.8


  • 5.0
    January 29, 2022
    The best doctor ever !
  • 5.0
    January 24, 2022
    Appointment on time. Dr and staff very nice and professional. Listened to me and my concerns.
  • 5.0
    December 22, 2021
    Dr. Liu is great. Fox Case is best.
  • 5.0
    December 22, 2021
    The doctor, staff and nurses are always professional, friendly and attentive.
  • 5.0
    December 15, 2021
    Dr. Liu is a professional as well as warm and reassuring, always focused on my concerns when I am meeting with him.
  • 5.0
    November 13, 2021
    Dr Liu and his staff provided the best possible care.
  • 5.0
    November 02, 2021
    Dr. Liu is always thorough, knowledgeable and kind. I would highly recommend him to anyone.
  • 5.0
    October 25, 2021
    The nurse and Dr, Lui both made me feel more relieved. I was glad I came In with my Issues and left with a positive outcome.
  • 5.0
    October 20, 2021
    Dr.Liu, his team, and every staff member I met at Fox Chase made me feel cared for, seen, and valued. I was very nervous and I appreciate the time and attention I was given. I had a lot of questions I needed answers to and I did not feel at all rushed out of the office. I know I'm in good hands.
  • 5.0
    October 14, 2021
    All good.
  • 5.0
    October 05, 2021
    Great experience, I feel lucky to have Dr. Liu as my surgeon.
  • 5.0
    September 25, 2021
    It was our first time there. I was really impressed with the way everything was done. They took very good care of my sister. Answered all our questions.
  • 5.0
    September 16, 2021
    I have always been very satisfied with the care and attention I receive. Thank you.
  • 5.0
    August 29, 2021
    Dr. Lui is so courteous and always has time for my questions and concerns.
  • 5.0
    August 29, 2021
    In every interaction, Dr Liu and his staff have treated my father (the patient), my mother (his wife), and me with care and respect. We'd recommend him and Fox Chase to anyone
  • 5.0
    August 11, 2021
    Very good experience
  • 5.0
    August 06, 2021
    Always enjoy my visit with Dr. Lui.
  • 5.0
    August 06, 2021
    Dr. Liu is a wonderful doctor. I can't ask any better one. He cared about my concerns and dealt with them very well. He performed a biopsy during my visit, and he did so wonderful that I was able to walk out of his office without any dis-comfortable. When the result of my biopsy came out, Dr. Liu called me and explain it to me very clearly. He is amazing!
  • 5.0
    August 01, 2021
    I am very satisfied, and I am grateful Dr. Jeffrey Liu and his staff for their attitude to me. Thank You. [...]
  • 5.0
    July 25, 2021
    Dr Liu himself called me on a Sunday to reschedule my appointment due to a death in his family. This is going above and beyond what I expected. He makes me feel like a person not a number.

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