Jeffrey Chang-Jen Liu, MD, FACS

Jeffrey Chang-Jen Liu, MD

Clinical Locations

Primary Location

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111


Attending Surgeon

Associate Professor, Department of Surgical Oncology

Medical Director, Speech Pathology

Associate Professor, Department of Otolaryngology

Head and Neck Cancer TRDG Member

Thyroid and Endocrine Cancer TRDG Member

Treatment Focus

Head and neck cancer, including cancers of the tongue, throat, voice box. Thyroid cancer, skin cancer.

Treatment Philosophy

I am committed to developing a coordinated, personalized plan appropriate for the treatment of your head and neck cancer. This will often be done in coordination with other physicians and staff from other specialties, including radiation therapists, medical oncologists, dentists and prosthodontists, plastic and reconstructive surgeons, pathologists, neuroradiologists, oncology social workers, oncology nutritionists and speech/swallow specialists.

Our Head and Neck Multidisciplinary Tumor Board at Fox Chase Cancer Center offers an opportunity to coordinate all facets of your care to execute a unique treatment plan tailored to give you the best chance of curing your cancer while maintaining function.

Follow on Twitter: @FCCCSurgOnc

Education, Training & Credentials

Educational Background

  • Fellow, Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 2010
  • Resident, Otolaryngology, New York Presbyterian Hospital, Columbia and Cornell Campuses, New York, NY, 2008
  • MD, with Honors in Research, Weill Medical College, Cornell University, New York, NY, 2003


  • American Board of Otolaryngology/Head and Neck Surgery


  • American College of Surgeons
  • American Head and Neck Society
  • American Academy of Otolaryngology

Honors & Awards

  • Resident Leadership Grant Recipient, American Academy of Otolaryngology, 2007, 2008, 2009, 2010, 2011
  • National Institute of Health T32 Training Grant Recipient (CA09685), Memorial Sloan Kettering Cancer Center, 2008
  • 1st Place, 6th Annual Resident Research Competition, Columbia/Cornell Otolaryngology, 2006
Research Profile

Research Interests

  • Translational research evaluating genetics and molecular profiles in head and neck cancer outcomes
  • Racial disparities in head and neck cancer incidence and treatment

Selected Publications

Liu JC, Parajuli S, Blackman E, Gibbs D, Ellis A, Hull A, Beck JR, Giri V, Iherjirka P, Khurana JS, Ragin CR. High Prevalence of Discordant HPV and p16 Oropharynx Squamous Cell Carcinomas in an African American Cohort. Head Neck. 2015 May 12.

Liu JC, Ridge JA, Brizel DM, O'Sullivan B, Cohen EW, Mann BS, Adelstein DJ. Current status of clinical trials in head and neck cancer 2014. Otolaryngol Head Neck Surg. 2015 Mar;152(3):410-7.

Lango MN, Egleston B, Fang C, Burtness B, Galloway T, Liu JC, Mehra R, Ebersole B, Moran K, Ridge JA. “Baseline health perceptions, dysphagia, and survival in patients with head and neck cancer.” Cancer. 2014 Mar 15;120(6):840-7. Sopka DM1,

Koskareva Y, Liu JC, Lango M, Galloway T, Gaughn JP, Ridge JA. “Cervical Metastasis in Squamous Cell Carcinoma of the Hard Palate and maxillary alveolus.” ENT Journal. 2013 (Accepted)

Li T, Lango MN, Mehra R, Liu JC, Burtness B, Flieder DB, Ridge JA, Galloway TJ. “Dysplasia at the margin? Investigating the case for subsequent therapy in 'low-risk' squamous cell carcinoma of the oral tongue.” Oral Oncol. 2013 Nov;49(11):1083-7.

Givi B, Liu JC, Bilsky MH, Shah JP, Mehrara BJ, Disa JJ, Pusic AL, Cordiero PG, Kraus DH. “Outcome of surgical management of skull base tumors with infratemporal fossa involvement.” Head Neck. 2013 Nov;35(11):1567- 72

Rosenberg TL, Kelley K, Dowdall JR, Replogle WH, Liu JC, Raol NP, Zafereo ME. “Section for residents and fellows-in-training survey results.” Otolaryngology Head and Neck Surgery. Apr 14, 2013.

Givi B, Liu J, Bilsky M, Mehrara B, Disa J, Pusic A, Cordeiro P, Shah JP, Kraus DH. “Outcome of resection of infratemporal fossa tumors.” Head and Neck. Jan 16, 2013.

Mehra S, Liu JC, Sheinfeld J, Gupta A, Kraus DH. “Testicular Cancer for the Head and Neck Surgeon:Evaluation, Management, Complications, and Outcomes.” Laryngoscope, Feb;122(2):286-90, , 2012.

Lok B, Khan S, Mutter R, Liu J, Fields R, Pulitzer M, Kraus D, Busam K, Brownell I, Coit D, Lee N. “Selective radiotherapy for the treatment of head and neck Merkel cell carcinoma.” Cancer. Dec 16, 2011.

Liu JC, Givi B; Wolden S, Kleinerman R, Dunkel IJ, Lee N, Ambramson DH, Shah JP, Kraus DH. “Skull Base Surgery for Radiation Associated Tumors in Retinoblastoma Patients.” Skull Base. Mar;21(2):103-8, 2011.

Kim A, Liu JC, Ganly I, Kraus DH. “Minimally Invasive Video Assisted Thyroidectomy: Expanded Indications” Head and Neck, 2010 Dec 28.

Liu JC and Shah JP. “Surgical Technique Refinements in Head and Neck Oncologic Sugery” J Surg Oncol. 2010 Jun 15;101(8):661-8

Liu JC and Stewart, MG. “Teaching Evidence-Based Medicine in Otolaryngology.” Otolaryngol Clin North Am. 2007 Dec;40(6):1261-74.

Pusic AL, Liu JC, Chen C, Cano S, Davridge K, Klassen A, Patel S, Kraus D, Cordeiro PG. “A Systematic Review of Patient-reported outcome Measures in Head and Neck Cancer Surgery.” Otolaryngol Head Neck Surg. 2007 Apr;136(4):525-35

Liu JC, Singh B, Tallini G, Carlson DL, Katabi N, Shaha A, Tuttle M, Ghossein RA. “Follicular Variant of Papillary Thyroid Cancer: A Clinicopathologic Study of a Problematic Entity.” Cancer. Sep 15;107(6):1255-64

Selesnick SH, Liu JC, Jen A, Newman J. “The incidence of cerebrospinal fluid leak after vestibular schwannoma surgery.” Otol Neurotol. 2004 May;25(3):387-93.

Selesnick SH, Liu JC, Jen A, Carew JF. “Management options for cerebrospinal fluid leak after vestibular schwannoma surgery and introduction of an innovative treatment.” Otol Neurotol. 2004 Jul;25(4):580-6