Erica Golemis, PhD


This Fox Chase professor participates in the Undergraduate Summer Research Fellowship
Learn more about Research Volunteering.

Educational Background

  • Post-Doctoral Studies, (yeast biotechnology/development of a two-hybrid system) , Massachusetts General Hospital Department of Molecular Biology and Harvard Medical School Department of Genetics, 1993
  • PhD, Biology (retroviruses and leukemogenesis), Massachusetts Institute of Technology, 1988
  • BA, Biology and English, Bryn Mawr College, 1983


    • Member, American Society for Cell Biology (ASCB)
    • Member, American Association for Cancer Research (AACR)
    • Member, American Association for the Advancement of Science (AAAS)

    Honors & Awards

    • American Cancer Society, Southeast Pennsylvania: Award for Scientific Accomplishment
    • Michael J. Brody Lecturer, University of Iowa College of Medicine
    • Session Chair, Keystone Meeting on Cilia, Tahoe City, CA
    • International Keynote Speaker, Hunter Meeting, Sydney, Australia
    • Award for Translational Science, Temple University School of Medicine
    • William Wikoff Smith Foundation, Endowed Chair in Cancer Research
    • Fellow, American Association for the Advancement of Science
    • Editor in Chief, Cancer & Metastasis Reviews


    Additional Staff

    Laboratory Alumni/ae

    Anna S. Nikonova, PhD - research associate

    Sanjeevani Arora, PhD - postdoc

    Tim Beck – MD/PhD, graduate student

    Margret B. Einarson, PhD - postdoc

    Sarah Fashena, PhD - postdoc

    Yayi Feng,  MS, grad student

    Anna Gaponova, PhD - grad student

    Eugene Izumchenko, PhD - grad student

    Leonid Kharin, MD, Visiting Scientist

    Vladimir Khazak, PhD - postdoc

    Meghan Kopp, MS grad student

    Anna Kiseleva, PhD, grad student

    Vlad Korobeynikov, MS, grad student

    Susan Law, PhD - postdoc

    Joy L. Little, PhD - postdoc

    Hanqing Liu, PhD - postdoc

    Rochelle Nasto, PhD - grad student

    Geraldine M. O'Neill, PhD - postdoc

    Olga V. Plotnikova, PhD - grad student

    Elena N. Pugacheva, PhD - postdoc

    Vladimir Ratushny, MD, PhD - grad student

    Tamina Seeger-Nukpezah, MD, PhD - postdoc

    Victoria Serzhanova - MS grad student

    Natalya Skobeleva, MD, PhD - Research Associate

    Danlin Sun, MS grad student

    Nadezhda (Nadya) Tikhmyanova, PhD - grad student

    Rossella Tricarico, PhD – Visiting Scientist

    Garabet Toby, PhD - grad student

    Peishan Zhang, MS – grad student

    Yu-Zhu Zhang, PhD - postdoc

    Alexander Deneka, MD, PhD-  Research Associate

    Mitchell Parker- MD. PhD Student, Drexel University College of Medicine

    Shabnam Pirestani, MS


    Former Lab Staff

    Joanne Estojak, scientific technician

    Wahiba Gherraby, scientific technician


    Former Student Volunteers

    Rihua Chen, volunteer

    Adaeze Chikwem, MD, volunteer

    Christiaan Honig, Volunteer, Germantown Academy, Fort Washington, PA

    Sammi Hurley, Volunteer, University of Michigan, Ann Arbor, MI

    Brook Neumann, volunteer

    Ian E. Ochs, Volunteer, Germantown Academy

    Katherine Xu, volunteer

    Jennifer Cracchiolo, MD, Temple University School of Medicine

    Nicolas G. Day, Student Assistant, St. John's College, Annapolis, MD

    Sanat Deshpande, Wissahickon Senior High School

    Louisa Eckman, Haverford College

    Rachel Georgopoulos, Temple University School of Medicine

    Timothy Kistner, Student Assistant

    Rabuil Ryan, Student Assistant

    David Sarcu, Temple University School of Medicine

    Manali Shah, Student Assistant

    Shelly Singh, University of Pittsburgh

    Rahmat Sykder, volunteer

    Zachary Smithline, Volunteer, Council Rock High School, Council Rock, PA

    Zachary Wells, Student Assistant, Liberty College, Lynchburg, VA

    Cecilia Zemanek, Student Assistant

    Research Facility

    Research Interests

    • Targeting signaling networks to improve therapy
    • The molecular basis for resistance to targeted anti-cancer agents
    • Interactions and activity of Aurora-A kinase

    Lab Overview

    The Golemis laboratory focuses on understanding factors contributing to the basis for aggressive tumor growth, and on evaluation of protein-targeted drugs, frequently collaborating with medical and radiation oncologists. To address these topics, the group uses bioinformatic analysis of very large genomic datasets to identify specific genetic features associated with specific patterns of therapeutic response in head and neck, lung, pancreatic and colorectal cancers. We integrate this work with use of animal models and cell-based strategies to elucidate the activity of signaling proteins and targeted therapies. We are particularly interested in investigating the Aurora-A kinase signaling axis in cancer and other pathological conditions.


    Extramural Affiliations
    • Adjunct, Cell and Molecular Biology group, University of Pennsylvania
    • Adjunct, Department of Biochemistry, Drexel University School of Medicine
    • Adjunct, Department of Biochemistry, Lewis Katz School of Medicine, Temple University

    Selected Publications

    Deneka A.Y., Baca Y., Serebriiskii I.G., Nicolas E., Parker M.I., Nguyen T.T., Xiu J., Korn W.M., Demeure M.J., Wise-Draper T., Sukari A., Burtness B.,Golemis E.A., Association of tp53 and cdkn2a mutation profile with tumor mutation burden in head and neck cancer. Clin Cancer Res. 28(9): 1925-1937, 2022.

    Serebriiskii I.G., Pavlov V., Tricarico R., Andrianov G., Nicolas E., Parker M.I., Newberg J., Frampton G., Meyer J.E.,Golemis E.A., Comprehensive characterization of pten mutational profile in a series of 34,129 colorectal cancers. Nat Commun. 13(1): 1618, 2022.PMC8956741.

    Deneka A.Y., Kopp M.C., Nikonova A.S., Gaponova A.V., Kiseleva A.A., Hensley H.H., Flieder D.B., Serebriiskii I.G.,Golemis E.A., Nedd9 restrains autophagy to limit growth of early stage non-small cell lung cancer. Cancer Res. 81(13): 3717-3726, 2021.PMC8277748.

    Gabitova-Cornell L, Surumbayeva A, Peri S, Franco-Barraza J, Restifo D, Weitz N, Ogier C, Goldman AR, Hartman TR, Francescone R, Tan Y, Nicolas E, Shah N, Handorf EA, Cai KQ, O'Reilly AM, Sloma I, Chiaverelli R, Moffitt RA, Khazak V, Fang CY, Golemis EA, Cukierman E, Astsaturov I. Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer. Cancer Cell. 2020 Oct 12;38(4):567-583.e11, PMID: 32976774, PMCID: PMC7572882.

    Deneka, A.Y., Einarson, M.B., Bennett, J., Nikonova, A.S., Elmekawy, M., Zhou, Y., Lee, J.W., Burtness, B.A., and Golemis E.A. Synthetic lethal targeting of mitotic checkpoints in HPV-negative head and neck cancer.  Cancers (Basel). 2020 Jan 28;12(2). pii: E306. doi: 10.3390/cancers12020306. PMID: 32012873, PMCID: PMC7072436

    Tricarico, R., Nicolas, E., Hall, M.J., and Golemis, E.A. X- and Y-linked chromatin-modifying genes as regulators of sex-specific cancer incidence and prognosis.  Clin Cancer Res, 2020 Nov 1;26(21):5567-5578, PMID: 32732223, PMCID: PMC7642178

    Serebriiskii, I.G., Connelly, C., Frampton, G., Newberg, J., Cooke, M., Miller, V., Ali, S., Ross, J., Handorf, E., Arora, S., Lieu, C., Golemis, E.A., and Meyer, J.E. RAS mutational profile differs between colon and rectal cancers, and in old versus young patients. Nat Commun, 2019 Aug 19;10(1):3722. doi: 10.1038/s41467-019-11530-0. PMID: 31427573, PMCID: PMC6700103.

    Kiseleva, A.A., Korobeynikov, V.A., Deneka, A.Y., Nikonova, A.S., Zhang, P., Makhov, P., Einarson, M.B., Kolenko, V., Serebriiskii, I.G., Liu, H., Peterson, J.R., and Golemis, E.A. Unexpected activities in regulating ciliation contribute to off-target effects of targeted drugs. Clin Cancer Res, 2019 Mar 13. pii: clincanres.3535.2018. doi: 10.1158/1078-0432.CCR-18-3535. [Epub ahead of print] PMID: 30867219, PMCID: PMC6606352.

    Lieu, C., Golemis, E., Serebriiskii, I., Newberg, J., Hemmerich, A., Connelly, C., Messersmith, W., Eng, C., Eckhardt, S.G., Frampton, G., Cooke, M., and Meyer, J. Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer, Clinical Cancer Research, Oct 1;25(19):5852-5858., PMID: 31243121, PMCID: PMC6774873.

    Lee, J.W., Parameswaran, J., Sandoval-Schaefer, T., Eoh, K.J., Yang, D., Zhu, F., Mehra, R., Sharma, R., Gaffney, S.G., Perry, E.B., Townsend, J.P., Serebriiskii, I.G., Golemis E.A., Issaeva, N., Yarbrough, W.G., Koo, J.S., and Burtness, B. Combined Aurora kinase A (AURKA) and WEE1 inhibition demonstrates synergistic antitumor effect in squamous cell carcinoma of the head and neck. Clin Cancer 2019 Jun 1;25(11):3430-3442. doi: 10.1158/1078-0432. PMID:30755439, PMCID: PMC6548643... Expand

    Additional Publications

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    This Fox Chase professor participates in the Undergraduate Summer Research Fellowship
    Learn more about Research Volunteering.