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Erica Golemis, PhD

Erica Golemis, PhD


Deputy Chief Science Officer

Co-Leader, Molecular Therapeutics

Research Program

Mammary tumor formation analysis shows absence of NEDD9 decreases tumor incidence.
Figure 2
Figure 3.
Figure 4.


Education, Training & Credentials

Educational Background

  • Post-Doctoral Studies, (yeast biotechnology/development of a two-hybrid system) , Massachusetts General Hospital Department of Molecular Biology and Harvard Medical School Department of Genetics, 1993
  • PhD, Biology (focus: murine retroviruses and leukemogenesis), Massachusetts Institute of Technology, 1988
  • BA, Biology and English, Bryn Mawr College, 1983


    • Member, American Society for Cell Biology
    • Member, American Association for Cancer Research
    • Member, American Association for the Advancement of Science
    Research Profile

    Research Program

    Research Facility

    Research Interests

    Targeting signaling networks to improve therapy

    • The molecular basis for resistance to targeted anti-cancer agents
    • Interactions of the oncogenes NEDD9 and Aurora-A kinase in cancer and polycystic kidney disease.
    • Targeting HSP90 to improve therapy: new strategies.
    • Defining the underlying basis for cancer risk.

    Lab Overview

    In disease states such as cancer, tumors reprogram their signaling to support abnormal growth processes. Our laboratory is interested in defining the changes in cell signaling that occur as tumors initiate, progress, and develop resistance to drugs, with the ultimate goal of inhibiting these processes. We hope through these studies to better define the interactions of signaling pathways in malignant versus normal cells, allowing improvements in cancer diagnosis and treatment. In specific projects, our work divides between a body of translational studies focused on the optimal use of therapeutic drugs, and more basic investigations into fundamental cell signaling mechanisms.  

    In the area of translational studies, we have been exploring the use of HSP90-targeting inhibitors in two ways. Gaponova, Nikonova, Deneka, and Feng have been evaluating the use of novel HSP90-targeted cytotoxic agents for efficacy in small cell lung cancer, a disease with few therapeutic options. Beck and Korobeynikov have used high throughput RNA interference screening to identify genes that regulate response to the HSP90 inhibitor ganetespib. Nikonova has also been investigating the use of HSP90 inhibitors and other targeted cancer agents in autosomal dominant polycystic kidney disease (ADPKD), that conserves many features of cancer. Arora is investigating the hereditary basis for undiagnosed familial gastrointestinal and genitourinary tumors.  Members of the laboratory, led by Serebriiskii, actively collaborate with numerous clinical investigators at Fox Chase Cancer Center, on topics including definition of biomarkers for cancer risk and therapeutic response, and mechanisms of resistance to targeted inhibitors of EGFR, Aurora-A, Src, and other proteins relevant to the core interests of the laboratory.  

    Increasingly, these studies incorporate analysis of underlying genetic features of tumors, through use of next generation sequencing and bioinformatic interpretation. As basic research projects, Nikonova, Deneka, and Kopp studies the activity of a signaling scaffold, NEDD9, and interacting proteins such as the oncogenic kinase Aurora-A, to understand the requirement for their action in normal cells, lung cancer, and in ADPKD. With Korobeynikov, and as an area of emphasis, these investigators study regulation of the cell cilium, an organelle that coordinates receipt of extracellular signals related to fluid flow and the Hedgehog, Wnt, and other signaling systems, and which is regulated by NEDD9 and Aurora-A signaling.


    Ilya Serebriiskii, PhD

    Assistant Professor

    Room: W406

    Anna S. Nikovona, PhD

    Postdoctoral Associate

    Room: W406

    Anna Gaponova, MS

    Room: W406

    Alexander Deneka, MD

    Room: W406

    Sanjeevani Arora, PhD

    Room: W406

    Tim Beck, BS

    Graduate Student

    Room: W406

    Yayi Feng, BS

    Graduate Student

    Room: W406

    Meghan Kopp, BS

    Graduate Student

    Room: W406

    Vladislav Korobeynikov , MD

    Graduate Student

    Room: W406

    Additional Staff

    Student Assistants and Volunteers

    Rahmat Sykder, volunteer

    Laboratory Alumni/ae

    Margret B. Einarson, PhD - postdoc

    Sarah Fashena, PhD - postdoc

    Eugene Izumchenko, PhD - grad student

    Vladimir Khazak, PhD - postdoc

    Susan Law, PhD - postdoc

    Joy L. Little, PhD - postdoc

    Hanqing Liu, PhD - postdoc

    Rochelle Nasto, PhD - grad student

    Geraldine M. O'Neill, PhD - postdoc

    Olga V. Plotnikova, PhD - grad student

    Elena N. Pugacheva, PhD - postdoc

    Vladimir Ratushny, MD, PhD - grad student

    Tamina Seeger-Nukpezah, MD, PhD - postdoc

    Victoria Serzhanova - Graduate Student

    Natalya Skobeleva, MD, PhD - Research Associate

    Nadezhda (Nadya) Tikhmyanova, PhD - grad student

    Garabet Toby, PhD - grad student

    Yu-Zhu Zhang, Ph.D. - postdoc

    Rihua Chen, volunteer
    Adaeze Chikwem, volunteer
    Christiaan Honig, Volunteer, Germantown Academy, Fort Washington, PA
    Sammi Hurley, Volunteer, University of Michigan, Ann Arbor, MI
    Brook Neumann, volunteer
    Katherine Xu, volunteer

    Jennifer Cracchiolo, Temple University School of Medicine
    Nicolas G. Day, Student Assistant, St. John's College, Annapolis, MD
    Sanat Deshpande, Wissahickon Senior High School

    Louisa Eckman, Haverford College
    Rachel Georgopoulos, Temple University School of Medicine
    Timothy Kistner, Student Assistant
    Rabuil Ryan, Student Assistant
    David Sarcu, Temple University School of Medicine
    Manali Shah, Student Assistant
    Shelly Singh, University of Pittsburgh
    Zachary Smithline, Volunteer, Council Rock High School, Council Rock, PA
    Zachary Wells, Student Assistant, Liberty College, Lynchburg, VA
    Cecilia Zemanek, Student Assistant
    Extramural Affiliations
    • Adjunct, Cell and Molecular Biology group, University of Pennsylvania
    • Adjunct, Department of Biochemistry, Drexel University School of Medicine
    • Adjunct, Department of Biochemistry, Lewis Katz School of Medicine, Temple University

    Selected Publications

    Gabitova, L., Restifo, D., Gorin, A., Manocha, K., Handorf, E., Yang, D.H, Cai, K.Q., Klein-Szanto, A.J., Cunningham, D., Kratz, L.D., Herman, G.E., Golemis, E.A., and Astsaturov, I. Endogenous sterol metabolites regulate growth of EGFR/KRAS-dependent tumors via LXR. Cell Reports Epub Sep 4, 2015. PubMed

    Arora, S., Yan, H., Cho, I., Fan, H.-Y., Luo, B., Gai, X., Zhou, Y., Handorf, E., Andrake, M., Nicolas, E., Serebriiskii, I., Yen, T.J., Hall, M.J., Golemis, E., and Enders, G.H. Constitutional predisposition to DNA double strand breaks defines a new molecular class of familial colon cancer. Gastroenterology, Epub Sep 4 2015. 

    Nicolas, E., Arora, S., Zhou, Y., Serebriiskii, I.G., Andrake, M.D., Handorf, E.D., Dunbrack, R.L., Giri, V.N., Ross, E.A., Golemis, E.A., Hall, M.J., and Daly, M.B. Information-driven approaches to predicting familial risk for prostate cancer. Oncotarget, in press.

    Plimack, E., R., Dunbrack, R.L., Brennan, T., Andrake, M, Zhou, Y., Serebriiskii, I.G., Wei, Q., Slifker, M., Alpaugh, K., Dulaimi, E., Palma, N., Hoffman-Censits, J., Wong, Y.-N., Bilusic, M., Kutikov, A., Viterbo, R., Greenberg, R.E., Chen, D., Lallas, C.D., Trabulsi, E.J., Yelensky, R., McConkey, D., Miller, V.A., Golemis, E.A., and Ross, E.G. Alterations in ATM, Rb1 or FANCC predict response to neoadjuvant cisplatin based chemotherapy in muscle invasive bladder cancer. Europ Urol, Epub July 31 2015. PubMed

    Zhang, Y.-W., Nasto, R.E., Varghese, R., Jablonski, S.A., Serebriiskii, I.G., Surana, R., Calvert, V.S., Bebu, I., Murray, Kolcun, G., J., Jin, L., Johnson, M., Riggins, R., Ressom, H., Petricoin III, E., Clarke, R., Golemis, E.A., and Weiner, L.M. Acquisition of Estrogen Independence Induces TOB1-Related Mechanisms Supporting Breast Cancer Cell Proliferation and Survival. Oncogene Epub July 13 2015.  PubMed

    Ramirez, U.D., Nikonova, A.S., Liu, H., Pecherskaya, A., Lawrence, S.H., Serebriiskii, I.G., Zhou, Y., Einarson, M.B., Golemis, E.A., and Jaffe, E.K. Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization. BMC Cancer, 15:436, 2015. PubMed

    Boquoi A, Arora S, Chen T, Litwin S, Koh J, Enders GH. Top of Form Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16Ink4a.2015 Aging Cell. Feb;14(1):139-47 

    Beck, T.N., Kaczmar, J., Handorf, E., Nikonova, A., Dubyk, C., Peri, S., Lango, M., Ridge, J.A., Serebriiskii, I.G., Burtness, B.A., Golemis, E.A., and Mehra, R. Phospho-T356RB1 predicts survival in HPV-Negative Squamous Cell Carcinoma of the Head and Neck.  Oncotarget, 6:18863-18874, 2015. PubMed


    Additional Publications

    My NCBI

    This Fox Chase professor participates in the Undergraduate Summer Research Fellowship
    Or learn more about Research Volunteering.