Robert G. Uzzo, MD, MBA, FACS

Robert Uzzo, MD, FACS

Clinical Locations

Primary Location

Huntingdon Pike
8 Huntingdon Pike
Rockledge, PA

Secondary Location

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111


Chairman, Department of Surgery

G. Willing "Wing" Pepper Chair in Cancer Research

Professor, Department of Surgery

Professor of Surgery, Temple University Health System

Adjunct Professor of Bioengineering, Temple University College of Engineering

Treatment Focus

  • Robotic and laparoscopic urologic oncology
  • Organ preservation (kidney, bladder, testicular and adrenal)
  • Non-surgical management of low risk urinary tumors
  • Complex urological reconstruction

Research Program

Key Awards

Philadelphia Magazine Top Docs 2020      Urology

Treatment Philosophy

I believe in treating patients as I would my own family. I strive to communicate effectively with patients and family members at all levels. Through extensive discussions with my patients, I develop treatment plans that are both effective and acknowledge that quality of life issues are exceptionally important. I emphasize individually tailored treatments to help patients achieve success and limit treatment-related side effects which can affect quality of life.

I am sensitive to the particular issues regarding surgical treatment of genitourinary cancer, especially the physical and emotional effects on patients and their family. By fostering a doctor-patient relationship based on mutual respect and open dialogue, I encourage patients to become empowered managers of their care... Expand

Follow on Twitter: @FCUroOnc

Chairman, Department of Surgery

Nationally known as a leader in the field of urologic oncology, Dr. Uzzo has made important clinical, scientific and educational contributions to the Department of Surgery.

A fellow of the American College of Surgeons, Uzzo has consistently ranked among Castle Connolly’s and Philadelphia magazine's "Top Docs" in urology. He is a national principal investigator for a clinical trial by the Eastern Cooperative Oncology Group to evaluate new, targeted therapies for kidney cancers and immunotherapy.  He is the author of more than 350 chapters, articles, books and abstracts on urologic tumors and has presented hundreds of regional, national and international lectures.

In addition to his extensive clinical practice, he oversees research laboratory initiatives studying molecular mechanisms of genitourinary cancers. In 2003, he was promoted from Associate Professor to Professor with tenure in Fox Chase's division of medical science... Expand

Education and Training

Educational Background

  • Fellow, Urologic Oncology, Cleveland Clinic Foundation
  • Fellow, Renal Transplantation and Renovascular Surgery, Cleveland Clinic Foundation
  • Chief Resident, Urology, New York Hospital-Cornell University Medical Center, New York, NY
  • Senior Resident, Urology, Memorial Sloan-Kettering Cancer Center, New York, NY
  • MD, Cornell Medical College, New York, NY, 1991
  • BS/BA, Union College, Schenectady, NY, 1989, Valedictorian


  • Diplomate, American Board of Urology


  • The American Urological Association
  • Member, American Association of Genitourinary Surgeons, AAGUS
  • Society of Urologic Oncology, Board of Directors
  • Society of Urologic Oncology, Clinical Trials Consortium, President 
  • Society of Urologic Oncology, Clinical Trials Consortium, Renal Program Chairman  
  • Board of Directors, SUO Clinical Trials Consortia, member-at-large  
  • Fox Chase Cancer Center Society of Scholars  
  • Kidney Cancer Association Medical Advisory Board  
  • Fellow American College of Surgeons (F.A.C.S.)  
  • Society of Urologic Oncology  
  • Pennsylvania Medical Society
  • Philadelphia County Medical Society  
  • The MidAtlantic Section of the American Urological Association
  • Eastern Cooperative Oncology Group  
  • Radiation Therapy Oncology Group
  • American College of Surgeons Oncology Group - Vice Chairman, GU Organ Committee   2002-2006 
  • American Society of Transplant Surgeons 
  • Urologic Society of Transplant and Vascular Surgeons
  • Society for Basic Urologic Research  
  • American Association for Cancer Research

Honors & Awards

  • Philadelphia Magazine Top Doctors, 2002-20
  • Best Doctors in America®, 2013-16, 2019-2020, Urology
  • America’s Top Doctors®, 2008-17
  • AUA Residents National Committee Teaching Award
  • Consumer’s Research Council of America –America’s Top Physicians 
Patient Stories

James Tetzlaff

Kidney Cancer

James Tetzlaff

Kidney Cancer

When he thinks back on October 28, 2013, Jim Tetzlaff realizes it would have been easy to ignore what happened and not give it another thought. “I’m a man – we have a tendency to ignore things that have to do with our health,” says Jim, who was 75 at the time. On that day, after one of his grandson’s football games, Jim went to the bathroom and saw blood in his urine. “It was upsetting, but I didn’t have any other symptoms so I thought it had to be a fluke,” recalls the former medical equipment salesman.

Darnell Washington

Kidney Cancer

Darnell Washington

Kidney Cancer

Darnell Washington had severe back pain in 2011 and ended up at a local hospital in Philadelphia. Tests conducted detected a renal hemorrhage caused by tumors around both of his kidneys. After X-rays and an MRI, an oncologist at the hospital said the tumors were cancerous and that his only option was to have both kidneys removed. Darnell was only 52 years old and would spend the rest of his life on dialysis. He decided to seek a second opinion with Dr. Robert Uzzo at Fox Chase Cancer Center. Dr. Uzzo said the imaging tests were poor and that he couldn’t make a firm diagnosis based on those tests, so he ordered an extensive round of testing that included outpatient biopsies of Darnell's kidney masses. When both tests came back benign, Darnell was beyond thrilled to know he did not have cancer after all.  With regular monitoring, Darnell can live a dialysis-free life. "If it weren’t for Dr. Uzzo and his knowledge of these things, I would not have the quality of life I have today," he said. "From the beginning, it was such a good experience for me at Fox Chase. Everyone was so nice and understanding. They made it as easy as possible on me."

Jim Roberts

Prostate Cancer

Jim Roberts

Prostate Cancer

Jim Roberts believes he could have had a less stressful experience when faced with a cancer diagnosis if he would have started his treatment at Fox Chase Cancer Center. At the age of 61, in 2001, Jim’s PSA levels (prostate-specific antigen) were elevated, which raised concern. PSA levels may indicate a man’s risk of having or developing prostate cancer. A biopsy proved negative so Jim’s doctors continued to monitor his health. Later that year, his PSA levels more than tripled, which required further testing and another biopsy.

Alvin Rollin

Bladder Cancer

Alvin Rollin

Bladder Cancer

"Learning you have cancer is a very sobering moment. It was exactly that for me. I felt like my life was over," said Alvin Rollin when he recounted the doctor visit when he heard he had bladder cancer.

Al's next step was to call his doctor, who recommended three cancer specialists. "By the time I was able to see the first doctor, my mind had been through many scenarios, most of them bad," Al recalled. 

Jay Hyman

Kidney Cancer

Jay Hyman

Kidney Cancer

When Jay Hyman was diagnosed with kidney cancer, he sought treatment at Fox Chase Cancer Center. He got an appointment the next day with Dr. Robert Uzzo, and two days later was in surgery. Jay later enrolled in a clinical trial since he was not a candidate for lung surgery due to the small size of the nodules on his lungs. The treatment was effective, and Jay returned to work. Today, he is feeling good and is taking a new immunotherapy drug to help prevent a recurrence. "I recommend that anyone with a diagnosis of cancer go to Fox Chase," he said. "They will do everything they can to make you feel whole again."


Research Profile

Research Program

Research Interests

  • Clinical and translational questions involving renal cell carcinoma including decision making models in the management of renal cancers and processes/quality of care in urologic malignancies
  • Analyses of outcomes involving excision, ablation, and active surveillance for localized kidney cancer and techniques/outcomes of surgery in locally advanced and metastatic RCC
  • Actively develop and accrue to multiple industry sponsored national and international urological oncology trials as well as investigator initiated trials.
  • Translational interests include biomarker development in kidney cancer and the role of zinc dyshomeostasis in prostate cancer

Selected Publications

Chapters and Publications from over 400:

Campbell S.C., Novick A.C., Belldegrun A., Blute M.L., Chow G.K., Derweesh I.H., Faraday M.M., Kaouk J.H., Leveillee R.J., Matin S.F., Russo P., Uzzo R.G., Guideline for Management of the Clinical T1 Renal Mass, 2009, Journal of Urology, 182, 4 SUPPL., 1271, 1279 PubMed

Goel N, Manstein SM, Ward WH, DeMora L, Smaldone MC, Farma JM, Uzzo RG, Esnaola NF. Does the Surgical Apgar Score predict serious complications after elective major cancer surgery? Journal of Surgical Research, 231:242-7, 2018. 

Uzzo R.G., Novick A.C., Nephron sparing surgery for renal tumors: Indications, techniques and outcomes, 2001, Journal of Urology, 166, 1, 6, 18 PubMed

Kutikov A, Uzzo RG. The RENAL Nephrometry Score: A comprehensive standardized system for quantitating renal tumor size, location and depth. J Urol, 182(3):844-53, 2009. (cited 401 times) PubMed

Chawla S.N., Crispen P.L., Hanlon A.L., Greenberg R.E., Chen D.Y.T., Uzzo R.G., The natural history of observed enhancing renal masses: Meta-analysis and review of the world literature, 2006, Journal of Urology, 175, 2, 425, 431 PubMed

Kunkle D.A., Egleston B.L., Uzzo R.G., Excise, Ablate or Observe: The Small Renal Mass Dilemma-A Meta-Analysis and Review, 2008, Journal of Urology, 179, 4, 1227, 1234 PubMed

Kunkle D.A., Uzzo R.G., Cryoablation or radiofrequency ablation of the small renal mass: A meta-analysis, 2008, Cancer, 113, 10, 2671, 2680 PubMed

Uzzo R.G., Wei J.T., Waldbaum R.S., Perlmutter A.P., Byrne J.C., Vaughan Jr. D., The influence of prostate size on cancer detection, 1995, Urology, 46, 6, 831, 836 PubMed

Pollack A., Hanlon A.L., Horwitz E.M., Feigenberg S.J., Konski A.A., Movsas B., Greenberg R.E., Uzzo R.G., Ma C.-M.C., McNeeley S.W., Buyyounouski M.K., Price Jr. R.A., Dosimetry and preliminary acute toxicity in the first 100 men treated for prostate cancer on a randomized hypofractionation dose escalation trial, 2006, International Journal of Radiation Oncology Biology Physics, 64, 2, 518, 526 PubMed

Qiao J., Uzzo R., Obara-Ishihara T., Degenstein L., Fuchs E., Herzlinger D., FGF-7 modulates ureteric bud growth and nephron number in the developing kidney, 1999, Development, 126, 3, 547, 554

Lane B.R., Russo P., Uzzo R.G., Hernandez A.V., Boorjian S.A., Thompson R.H., Fergany A.F., Love T.E., Campbell S.C., Comparison of cold and warm ischemia during partial nephrectomy in 660 solitary kidneys reveals predominant role of nonmodifiable factors in determining ultimate renal function, 2011, Journal of Urology, 185, 2, 421, 427 PubMed

Mann S.J., Pickering T.G., Sos T.A., Uzzo R.G., Sarkar S., Friend K., Rackson M.E., Laragh J.H., Captopril renography in the diagnosis of renal artery stenosis: accuracy and limitations, 1991, The American Journal of Medicine, 90, 1, 30, 40 PubMed

Dulaimi E., Uzzo R.G., Greenberg R.E., Al-Saleem T., Cairns P., Detection of Bladder Cancer in Urine by a Tumor Suppressor Gene Hypermethylation Panel, 2004, Clinical Cancer Research, 10, 6, 1887, 1893 PubMed

Kunkle D.A., Crispen P.L., Chen D.Y.T., Greenberg R.E., Uzzo R.G., Enhancing Renal Masses With Zero Net Growth During Active Surveillance, 2007, Journal of Urology, 177, 3, 849, 854 PubMed

Touijer K., Jacqmin D., Kavoussi L.R., Montorsi F., Patard J.J., Rogers C.G., Russo P., Uzzo R.G., Van Poppel H., The Expanding Role of Partial Nephrectomy: A Critical Analysis of Indications, Results, and Complications, 2010, European Urology, 57, 2, 214, 222 PubMed

Additional Publications




Our Patient Satisfaction Rating is an average of all responses to care provider related questions from our nationally-recognized Press Ganey Patient Satisfaction Survey. Learn more.


5.0 / 5.0


  • 5.0
  • 4.9
  • 5.0
  • 5.0
  • 5.0
  • 5.0
  • 5.0
  • 5.0
  • 5.0
  • 4.9


  • 5.0
    May 27, 2020
    Dr. Uzzo and team where outstanding and I feel very lucky to have them helping me.
  • 5.0
    May 20, 2020
    I had an excellent experience. Dr. Uzzo is a great doctor.
  • 5.0
    May 17, 2020
    All good, The best provider ever
  • 5.0
    April 25, 2020
    Top notch. An attention to detail that I appreciate
  • 5.0
    April 19, 2020
    I really appreciate how thorough Dr. Uzzo is & explains well.
  • 5.0
    April 16, 2020
    Dr Uzzo and his assistants have always treated the best and he saved my life Great Doctor and hospital
  • 5.0
    April 04, 2020
    only good
  • 5.0
    March 30, 2020
    Would not change a thing. The best doctor & staff around.
  • 5.0
    March 26, 2020
    I can not say enough about how Dr. Uzzo and [...] is PA take care of me. They make sure I get testing when needed and address ANY concerns I have immediately. I can. ot say enough about how well I feel I am taken care of by Dr. Uzzo...He is the best doctor I have ever had...
  • 5.0
    March 26, 2020
    From my very firs contact with the nurse navigator through the whole process, D Uzzo and all of the people at Fox chase were excellent. I really mean that. It far exceeded my expectations. What a great organization you have. Dr Uzzo himself was excellent. He took his time and was very understanding. I felt very comfortable and so did my wife [...].Great guy. I highhly recommend Dr Uzzo.
  • 5.0
    March 20, 2020
    wonderful staff. people coming to Fox Chase have a serious condition. your staff treats patients with kindness caring and even some humor. glad I was referred to Fox Chase and Dr Uzzo.
  • 5.0
    March 13, 2020
    Great Dr who cares about you and your condition. His staff is caring and helpful.
  • 5.0
    March 12, 2020
    Dr Uzzo is the best Dr at Fox Chase, bar none! His office runs like clockwork! Totally professional! Wonderful teacher and surgeon.... He is great! Made me feel good with cancer, that I am with the right institution....
  • 5.0
    March 06, 2020
    The resident came in first and checked the incisions and explained Dr. Uzzo would also be coming in. This was my first time back since the surgery and I have done extremely well. I told the resident he is learning from the BEST. Dr. Uzzo and his staff are amazing and take the time to discuss whatever questions you may have as I did the first time I went and he explained EVERYTHING. [...] Thank you so much for having such an AMAZING Doctor and staff there.
  • 5.0
    March 06, 2020
    dr Uzzo is one of very best. I'm confident that he got all the cancer and that I will now live forever thanks to him !
  • 5.0
    February 29, 2020
    I travel an hour and half each way to be treated by Dr. Uzzo. Dr. Uzzo and his team have been treating my recurring bladder cancer for more than 6 years. I have the utmost confidence in them and am very grateful for their efforts on my behalf. I wouldn't even think of going anywhere else for treatment and when the opportunity arises I never hesitate to recommend others to Fox Chase Cancer Center.
  • 5.0
    February 28, 2020
    Very good experience
  • 5.0
    February 25, 2020
    Great job by Dr. Uzzo and his staff.
  • 5.0
    February 25, 2020
    I have been Dr Uzzo's patient for 19 years. He and his nurse , [...] are the best. I travel 70 miles to see him. He has to be the top Urology Oncologist in our country. I was diagnosed with Bladder Cancer 25 years ago. Dr Uzzo gives me the confidence that this disease will never be worse than in situ [...].
  • 5.0
    February 21, 2020
    Dr Uzzo and his team are the BEST!!

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