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American Society of Clinical Oncology Names Molecular Profiling Top Advance of the Year

April 22, 2021

Dr. Robert Uzzo, chair of the Department of Surgical Oncology, was one of the leading authors on the reportDr. Robert Uzzo, chair of the Department of Surgical Oncology, was one of the leading authors on the report

PHILADELPHIA (April 22, 2021)—The use of molecular profiling to identify the molecular and genetic signatures of cancer and deliver highly specific treatments was named the top advance of the year in the treatment of cancer, according to a recent collaborative report from the American Society of Clinical Oncology (ASCO).

The authors also identified achieving equity in cancer research as one of the top priorities for the future. Robert G. Uzzo, MD, MBA, FACS, chair of the Department of Surgical Oncology at Fox Chase Cancer Center, was one of the leading authors on the report.

“When helping to prepare this report, I looked for game-changing treatments at the highest level, even those beyond my area of expertise in the field of urologic tumors. You have to look for broad and important themes that transcend tumor types,” said Uzzo.

One key theme was that molecular profiling is rapidly changing diagnosis and clinical decision making for patients.

“There are many of implications for molecular profiling in cancer. We now have a much broader ability to sequence a tumor’s genome and use complex computer algorithms to recategorize tumors based on their mutational profiles. In the past we would classify a cancer by where it began, for example in the lungs.  Increasingly, we discuss tumor types by what mutations drive them, regardless of where it began, allowing us to make better treatment decisions and choices,” said Uzzo.

Equity in cancer research was named another key theme and a future priority. According to the report, not all levels of society benefit equally from progress in early detection and treatment of cancer. The authors noted the importance of a collective effort to develop approaches to address these differences.

“There are a lot of barriers to achieving equity in cancer care. Some of them are access, others may be structural, and some reflect different perceptions on cancer research and clinical trials due to a patient’s socioeconomics, education, experience, or trust of the healthcare system,” said Uzzo. “So the goal is to understand these barriers and try to improve participation in novel programs and clinical trials.”

Among some of the other top research priorities listed in the report were developing and integrating artificial intelligence and deep learning in cancer research; identifying strategies that predict response and resistance to immunotherapies; optimizing multimodality treatment for solid tumors; and optimizing care for older adults with cancer.

“Cancer death rates peaked in 1991. Since then there has been almost a 30% decline in overall cancer death rates. In the U.S. alone, we’ve averted almost 3 million people dying of cancer, and there have been about 150 new cancer drugs or indications approved by the Food and Drug Administration in the last 15 years,” said Uzzo. “So the message I have is one of great hope, that this rapid progress is going to mean longer lives, better quality of life on therapy, and greater comfort to cancer patients and those who love them.”

The report, “Clinical Cancer Advances 2021: ASCO’s Report on Progress Against Cancer,” was published in The Journal of Clinical Oncology.

The Hospital of Fox Chase Cancer Center and its affiliates (collectively “Fox Chase Cancer Center”), a member of the Temple University Health System, is one of the leading cancer research and treatment centers in the United States. Founded in 1904 in Philadelphia as one of the nation’s first cancer hospitals, Fox Chase was also among the first institutions to be designated a National Cancer Institute Comprehensive Cancer Center in 1974. Fox Chase researchers have won the highest awards in their fields, including two Nobel Prizes. Fox Chase physicians are also routinely recognized in national rankings, and the Center’s nursing program has received the Magnet recognition for excellence five consecutive times. Today, Fox Chase conducts a broad array of nationally competitive basic, translational, and clinical research, with special programs in cancer prevention, detection, survivorship and community outreach. It is the policy of Fox Chase Cancer Center that there shall be no exclusion from, or participation in, and no one denied the benefits of, the delivery of quality medical care on the basis of race, ethnicity, religion, sexual orientation, gender, gender identity/expression, disability, age, ancestry, color, national origin, physical ability, level of education, or source of payment.

 

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