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Robert Uzzo, MD, MBA, FACS

Robert Uzzo, MD, FACS

Clinical Locations

Primary Location

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111

Secondary Location

Huntingdon Pike
8 Huntingdon Pike
Rockledge, PA


President & CEO, Fox Chase Cancer Center

G. Willing "Wing" Pepper Chair in Cancer Research

Professor, Department of Surgery

Professor of Surgery, Temple University Health System

Adjunct Professor of Bioengineering, Temple University College of Engineering

Treatment Focus

  • Robotic and laparoscopic urologic oncology
  • Organ preservation (kidney, bladder, testicular and adrenal)
  • Non-surgical management of low risk urinary tumors
  • Complex urological reconstruction

Research Program

Key Awards

Philadelphia Magazine Top Docs 2022

Treatment Philosophy

I believe in treating patients as I would my own family. I strive to communicate effectively with patients and family members at all levels. Through extensive discussions with my patients, I develop treatment plans that are both effective and acknowledge that quality of life issues are exceptionally important. I emphasize individually tailored treatments to help patients achieve success and limit treatment-related side effects which can affect quality of life.

I am sensitive to the particular issues regarding surgical treatment of genitourinary cancer, especially the physical and emotional effects on patients and their family. By fostering a doctor-patient relationship based on mutual respect and open dialogue, I encourage patients to become empowered managers of their care... Expand



As President & CEO, Fox Chase Cancer Center, Robert Uzzo is responsible for leading the overall clinical operations of Fox Chase. In his role as Chair of the Department of Surgery, he leads the surgery efforts and oversees research laboratory initiatives to study molecular mechanisms of genitourinary cancers.

In addition to these roles, Uzzo is the G. Willing “Wing” Pepper Chair in Cancer Research and also serves as the organization’s President of the Medical Group. He also serves as the founding Executive Director of the nation’s second largest urologic quality collaborative, the Pennsylvania Urologic Regional Collaborative... Expand

Education and Training

Educational Background

  • Fellow, Urologic Oncology, Cleveland Clinic Foundation
  • Fellow, Renal Transplantation and Renovascular Surgery, Cleveland Clinic Foundation
  • Chief Resident, Urology, New York Hospital-Cornell University Medical Center, New York, NY
  • Senior Resident, Urology, Memorial Sloan-Kettering Cancer Center, New York, NY
  • MD, Cornell Medical College, New York, NY, 1991
  • BS/BA, Union College, Schenectady, NY, 1987, Valedictorian


  • Diplomate, American Board of Urology


  • The American Urological Association
  • Member, American Association of Genitourinary Surgeons, AAGUS
  • Society of Urologic Oncology, Board of Directors
  • Society of Urologic Oncology, Clinical Trials Consortium, President 
  • Society of Urologic Oncology, Clinical Trials Consortium, Renal Program Chairman  
  • Board of Directors, SUO Clinical Trials Consortia, member-at-large  
  • Fox Chase Cancer Center Society of Scholars  
  • Kidney Cancer Association Medical Advisory Board  
  • Fellow American College of Surgeons (F.A.C.S.)  
  • Society of Urologic Oncology  
  • Pennsylvania Medical Society
  • Philadelphia County Medical Society  
  • The MidAtlantic Section of the American Urological Association
  • Eastern Cooperative Oncology Group  
  • Radiation Therapy Oncology Group
  • American College of Surgeons Oncology Group - Vice Chairman, GU Organ Committee   2002-2006 
  • American Society of Transplant Surgeons 
  • Urologic Society of Transplant and Vascular Surgeons
  • Society for Basic Urologic Research  
  • American Association for Cancer Research

Honors & Awards

  • Philadelphia Magazine Top Doctors, 2002-20
  • Best Doctors in America®, 2013-16, 2019-2020, Urology
  • America’s Top Doctors®, 2008-17
  • AUA Residents National Committee Teaching Award
  • Consumer’s Research Council of America –America’s Top Physicians 
Patient Stories

Darnell Washington

Kidney Cancer

Darnell Washington

Kidney Cancer

Darnell Washington had severe back pain in 2011 and ended up at a local hospital in Philadelphia. Tests conducted detected a renal hemorrhage caused by tumors around both of his kidneys. After X-rays and an MRI, an oncologist at the hospital said the tumors were cancerous and that his only option was to have both kidneys removed. Darnell was only 52 years old and would spend the rest of his life on dialysis. He decided to seek a second opinion with Dr. Robert Uzzo at Fox Chase Cancer Center. Dr. Uzzo said the imaging tests were poor and that he couldn’t make a firm diagnosis based on those tests, so he ordered an extensive round of testing that included outpatient biopsies of Darnell's kidney masses. When both tests came back benign, Darnell was beyond thrilled to know he did not have cancer after all.  With regular monitoring, Darnell can live a dialysis-free life. "If it weren’t for Dr. Uzzo and his knowledge of these things, I would not have the quality of life I have today," he said. "From the beginning, it was such a good experience for me at Fox Chase. Everyone was so nice and understanding. They made it as easy as possible on me."

Jim Roberts

Prostate Cancer

Jim Roberts

Prostate Cancer

Jim Roberts believes he could have had a less stressful experience when faced with a cancer diagnosis if he would have started his treatment at Fox Chase Cancer Center. At the age of 61, in 2001, Jim’s PSA levels (prostate-specific antigen) were elevated, which raised concern. PSA levels may indicate a man’s risk of having or developing prostate cancer. A biopsy proved negative so Jim’s doctors continued to monitor his health. Later that year, his PSA levels more than tripled, which required further testing and another biopsy.

Alvin Rollin

Bladder Cancer

Alvin Rollin

Bladder Cancer

"Learning you have cancer is a very sobering moment. It was exactly that for me. I felt like my life was over," said Alvin Rollin when he recounted the doctor visit when he heard he had bladder cancer.

Al's next step was to call his doctor, who recommended three cancer specialists. "By the time I was able to see the first doctor, my mind had been through many scenarios, most of them bad," Al recalled. 

Jay Hyman

Kidney Cancer

Jay Hyman

Kidney Cancer

When Jay Hyman was diagnosed with kidney cancer, he sought treatment at Fox Chase Cancer Center. He got an appointment the next day with Dr. Robert Uzzo, and two days later was in surgery. Jay later enrolled in a clinical trial since he was not a candidate for lung surgery due to the small size of the nodules on his lungs. The treatment was effective, and Jay returned to work. Today, he is feeling good and is taking a new immunotherapy drug to help prevent a recurrence. "I recommend that anyone with a diagnosis of cancer go to Fox Chase," he said. "They will do everything they can to make you feel whole again."

Raymond Bebak

Kidney Cancer

Raymond Bebak

Kidney Cancer

I am a mechanical engineer and have worked at Boeing for more than 20 years. As an engineer, I embrace new technology, and so I wanted my cancer treatment to be conducted by experienced surgeons who would use the latest technology and most sophisticated tools.


Research Profile

Research Program

Research Interests

  • Clinical and translational questions involving renal cell carcinoma including decision making models in the management of renal cancers and processes/quality of care in urologic malignancies
  • Analyses of outcomes involving excision, ablation, and active surveillance for localized kidney cancer and techniques/outcomes of surgery in locally advanced and metastatic RCC
  • Actively develop and accrue to multiple industry sponsored national and international urological oncology trials as well as investigator initiated trials.
  • Translational interests include biomarker development in kidney cancer and the role of zinc dyshomeostasis in prostate cancer

Selected Publications

Chapters and Publications from over 400:

Correa A.F., Jegede O.A., Haas N.B., Flaherty K.T., Pins M.R., Adeniran A., Messing E.M., Manola J., Wood C.G., Kane C.J., Jewett M.A.S., Dutcher J.P., DiPaola R.S., Carducci M.A., Uzzo R.G., Predicting disease recurrence, early progression, and overall survival following surgical resection for high-risk localized and locally advanced renal cell carcinoma. Eur Urol. 80(1): 20-31, 2021. PMC8627688. https://www.ncbi.nlm.nih.gov/pubmed/33707112.

Smith S.M., Wachter K., Burris H.A., 3rd, Schilsky R.L., George D.J., Peterson D.E., Johnson M.L., Markham M.J., Mileham K.F., Beg M.S., Bendell J.C., Dreicer R., Keedy V.L., Kimple R.J., Knoll M.A., LoConte N., MacKay H., Meisel J.L., Moynihan T.J., Mulrooney D.A., Mulvey T.M., Odenike O., Pennell N.A., Reeder-Hayes K., Smith C., Sullivan R.J., Uzzo R., Clinical cancer advances 2021: Asco's report on progress against cancer. J Clin Oncol. 39(10): 1165-1184, 2021. https://www.ncbi.nlm.nih.gov/pubmed/33527845.

Campbell S.C., Novick A.C., Belldegrun A., Blute M.L., Chow G.K., Derweesh I.H., Faraday M.M., Kaouk J.H., Leveillee R.J., Matin S.F., Russo P., Uzzo R.G., Guideline for Management of the Clinical T1 Renal Mass, 2009, Journal of Urology, 182, 4 SUPPL., 1271, 1279 PubMed

Goel N, Manstein SM, Ward WH, DeMora L, Smaldone MC, Farma JM, Uzzo RG, Esnaola NF. Does the Surgical Apgar Score predict serious complications after elective major cancer surgery? Journal of Surgical Research, 231:242-7, 2018. 

Uzzo R.G., Novick A.C., Nephron sparing surgery for renal tumors: Indications, techniques and outcomes, 2001, Journal of Urology, 166, 1, 6, 18 PubMed

Kutikov A, Uzzo RG. The RENAL Nephrometry Score: A comprehensive standardized system for quantitating renal tumor size, location and depth. J Urol, 182(3):844-53, 2009. (cited 401 times) PubMed

Chawla S.N., Crispen P.L., Hanlon A.L., Greenberg R.E., Chen D.Y.T., Uzzo R.G., The natural history of observed enhancing renal masses: Meta-analysis and review of the world literature, 2006, Journal of Urology, 175, 2, 425, 431 PubMed

Kunkle D.A., Egleston B.L., Uzzo R.G., Excise, Ablate or Observe: The Small Renal Mass Dilemma-A Meta-Analysis and Review, 2008, Journal of Urology, 179, 4, 1227, 1234 PubMed

Kunkle D.A., Uzzo R.G., Cryoablation or radiofrequency ablation of the small renal mass: A meta-analysis, 2008, Cancer, 113, 10, 2671, 2680 PubMed

Uzzo R.G., Wei J.T., Waldbaum R.S., Perlmutter A.P., Byrne J.C., Vaughan Jr. D., The influence of prostate size on cancer detection, 1995, Urology, 46, 6, 831, 836 PubMed... Expand

Additional Publications




Our Patient Satisfaction Rating is an average of all responses to care provider related questions from our nationally-recognized Press Ganey Patient Satisfaction Survey. Learn more.


5.0 / 5.0


  • 4.9
  • 4.9
  • 5.0
  • 5.0
  • 5.0


  • 5.0
    June 24, 2022
    *Dr. Uzzo is the best!!
  • 5.0
    June 19, 2022
    Dr.Uzzo and staff and the entire unit are the ultimate in quality healthcare provision.
  • 5.0
    June 16, 2022
    Efficient, compassionate, competent care.
  • 5.0
    June 14, 2022
    Very impressed with the care given by Dr. Uzzo & his team.
  • 5.0
    June 13, 2022
    Dr. Uzzo and Fox Chase and staff excellent!
  • 5.0
    May 31, 2022
    All aspects of my experience was exceptional!
  • 5.0
    May 02, 2022
    Excellent experience.
  • 5.0
    May 02, 2022
    I consider myself extremely lucky to be treated by someone as knowledgeable as Dr. Uzzo and his staff.
  • 5.0
    April 28, 2022
    Dr Uzzo is great
  • 5.0
    April 27, 2022
    Dr uzzo and his office and team and [...] are aces in my book
  • 5.0
    April 23, 2022
    Great Experience !! Second Opinion From Dr Uzzo, Went Exceptionally well ; Dr.Uzzo ,In A Matter of Minutes Was Able To Help Me To Calm My Mind ! Am Now Ready To Deal With My Condition !! Thank You Dr.Uzzo !!
  • 5.0
    April 22, 2022
    Dr.Uzzo is a first class highly skilled physician. I like the way he thinks about personalizing my care and treatments for the best results keeping me healthy for the long term.
  • 5.0
    April 22, 2022
    Dr Uzzo and staff were phenomenal.
  • No Star Ratings Available April 18, 2022
    I received useful feedback regarding my self care.
  • 5.0
    March 28, 2022
    Dr.Uzzo and his team are some of the best that I have ever met. They are concerned about all my medical difficulties. I truly trust him and his team to get me thru these difficult times. They took there time during my appointment and explained everything so I could understand what needs to be done.
  • 5.0
    March 27, 2022
    Great experience
  • 5.0
    March 22, 2022
    I am so grateful for this wonderful care. Superior.
  • 5.0
    March 21, 2022
    I felt very comfortable when I first arrived and left feeling very confident that I came to the right place.
  • 5.0
    March 21, 2022
    Every visit w/a Fox Chase dr. or dept. has been a 1st class experience (scans, blood work etc.).
  • 5.0
    March 18, 2022
    Very good first experience. (New patient).

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