Robert Uzzo, MD, MBA, FACS

Robert Uzzo, MD, FACS
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Clinical Locations

President and CEO, Fox Chase Cancer Center

Executive Vice President for Cancer Services – Temple University Health System

Senior Associate Dean, Clinical Cancer Research – Lewis Katz School of Medicine at Temple University

G. Willing "Wing" Pepper Chair in Cancer Research

Treatment Focus

  • Robotic and laparoscopic urologic oncology
  • Organ preservation (kidney, bladder, testicular and adrenal)
  • Non-surgical management of low risk urinary tumors
  • Complex urological reconstruction

Research Program

Key Awards

2023 top doctors
Urology

Treatment Philosophy

I believe in treating patients as I would my own family. I strive to communicate effectively with patients and family members at all levels. Through extensive discussions with my patients, I develop treatment plans that are both effective and acknowledge that quality of life issues are exceptionally important. I emphasize individually tailored treatments to help patients achieve success and limit treatment-related side effects which can affect quality of life.

I am sensitive to the particular issues regarding surgical treatment of genitourinary cancer, especially the physical and emotional effects on patients and their family. By fostering a doctor-patient relationship based on mutual respect and open dialogue, I encourage patients to become empowered managers of their care... Expand

Bio

As President & CEO, Fox Chase Cancer Center, Robert Uzzo is responsible for leading the overall clinical operations of Fox Chase.

In addition to these roles, Uzzo is the G. Willing “Wing” Pepper Chair in Cancer Research and also serves as the organization’s President of the Medical Group. He also serves as the founding Executive Director of the nation’s second largest urologic quality collaborative, the Pennsylvania Urologic Regional Collaborative... Expand

Educational Background

  • Fellow, Urologic Oncology, Cleveland Clinic Foundation
  • Fellow, Renal Transplantation and Renovascular Surgery, Cleveland Clinic Foundation
  • Chief Resident, Urology, New York Hospital-Cornell University Medical Center, New York, NY
  • Senior Resident, Urology, Memorial Sloan-Kettering Cancer Center, New York, NY
  • MD, Cornell Medical College, New York, NY, 1991
  • BS/BA, Union College, Schenectady, NY, 1987, Valedictorian

Certifications

  • Diplomate, American Board of Urology

Memberships

  • The American Urological Association
  • Member, American Association of Genitourinary Surgeons, AAGUS
  • Society of Urologic Oncology, Board of Directors
  • Society of Urologic Oncology, Clinical Trials Consortium, President 
  • Society of Urologic Oncology, Clinical Trials Consortium, Renal Program Chairman  
  • Board of Directors, SUO Clinical Trials Consortia, member-at-large  
  • Fox Chase Cancer Center Society of Scholars  
  • Kidney Cancer Association Medical Advisory Board  
  • Fellow American College of Surgeons (F.A.C.S.)  
  • Society of Urologic Oncology  
  • Pennsylvania Medical Society
  • Philadelphia County Medical Society  
  • The MidAtlantic Section of the American Urological Association
  • Eastern Cooperative Oncology Group  
  • Radiation Therapy Oncology Group
  • American College of Surgeons Oncology Group - Vice Chairman, GU Organ Committee   2002-2006 
  • American Society of Transplant Surgeons 
  • Urologic Society of Transplant and Vascular Surgeons
  • Society for Basic Urologic Research  
  • American Association for Cancer Research

Honors & Awards

  • Philadelphia Magazine Top Doctors, 2002-20
  • Best Doctors in America®, 2013-16, 2019-2020, Urology
  • America’s Top Doctors®, 2008-17
  • AUA Residents National Committee Teaching Award
  • Consumer’s Research Council of America –America’s Top Physicians 

David Juall

  • Kidney Cancer

In 2006, at age 51, David Juall was a healthy, active attorney, and a pilot, who enjoyed traveling and outdoor fun.  During a court proceeding in Bucks County, he had a medical emergency and was taken to a local community hospital.

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James Tetzlaff

  • Kidney Cancer

When he thinks back on October 28, 2013, Jim Tetzlaff realizes it would have been easy to ignore what happened and not give it another thought. “I’m a man – we have a tendency to ignore things that have to do with our health,” says Jim, who was 75 at the time. On that day, after one of his grandson’s football games, Jim went to the bathroom and saw blood in his urine. “It was upsetting, but I didn’t have any other symptoms so I thought it had to be a fluke,” recalls the former medical equipment salesman.

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Darnell Washington

  • Kidney Cancer

Darnell Washington had severe back pain in 2011 and ended up at a local hospital in Philadelphia. Tests conducted detected a renal hemorrhage caused by tumors around both of his kidneys. After X-rays and an MRI, an oncologist at the hospital said the tumors were cancerous and that his only option was to have both kidneys removed. Darnell was only 52 years old and would spend the rest of his life on dialysis. He decided to seek a second opinion with Dr. Robert Uzzo at Fox Chase Cancer Center. Dr. Uzzo said the imaging tests were poor and that he couldn’t make a firm diagnosis based on those tests, so he ordered an extensive round of testing that included outpatient biopsies of Darnell's kidney masses. When both tests came back benign, Darnell was beyond thrilled to know he did not have cancer after all.  With regular monitoring, Darnell can live a dialysis-free life. "If it weren’t for Dr. Uzzo and his knowledge of these things, I would not have the quality of life I have today," he said. "From the beginning, it was such a good experience for me at Fox Chase. Everyone was so nice and understanding. They made it as easy as possible on me."

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Research Interests

  • Clinical and translational questions involving renal cell carcinoma including decision making models in the management of renal cancers and processes/quality of care in urologic malignancies
  • Analyses of outcomes involving excision, ablation, and active surveillance for localized kidney cancer and techniques/outcomes of surgery in locally advanced and metastatic RCC
  • Actively develop and accrue to multiple industry sponsored national and international urological oncology trials as well as investigator initiated trials.
  • Translational interests include biomarker development in kidney cancer and the role of zinc dyshomeostasis in prostate cancer

Selected Publications

Chapters and Publications from over 400:

Correa A.F., Jegede O.A., Haas N.B., Flaherty K.T., Pins M.R., Adeniran A., Messing E.M., Manola J., Wood C.G., Kane C.J., Jewett M.A.S., Dutcher J.P., DiPaola R.S., Carducci M.A., Uzzo R.G., Predicting disease recurrence, early progression, and overall survival following surgical resection for high-risk localized and locally advanced renal cell carcinoma. Eur Urol. 80(1): 20-31, 2021. PMC8627688. https://www.ncbi.nlm.nih.gov/pubmed/33707112.

Smith S.M., Wachter K., Burris H.A., 3rd, Schilsky R.L., George D.J., Peterson D.E., Johnson M.L., Markham M.J., Mileham K.F., Beg M.S., Bendell J.C., Dreicer R., Keedy V.L., Kimple R.J., Knoll M.A., LoConte N., MacKay H., Meisel J.L., Moynihan T.J., Mulrooney D.A., Mulvey T.M., Odenike O., Pennell N.A., Reeder-Hayes K., Smith C., Sullivan R.J., Uzzo R., Clinical cancer advances 2021: Asco's report on progress against cancer. J Clin Oncol. 39(10): 1165-1184, 2021. https://www.ncbi.nlm.nih.gov/pubmed/33527845.

Campbell S.C., Novick A.C., Belldegrun A., Blute M.L., Chow G.K., Derweesh I.H., Faraday M.M., Kaouk J.H., Leveillee R.J., Matin S.F., Russo P., Uzzo R.G., Guideline for Management of the Clinical T1 Renal Mass, 2009, Journal of Urology, 182, 4 SUPPL., 1271, 1279 PubMed

Goel N, Manstein SM, Ward WH, DeMora L, Smaldone MC, Farma JM, Uzzo RG, Esnaola NF. Does the Surgical Apgar Score predict serious complications after elective major cancer surgery? Journal of Surgical Research, 231:242-7, 2018. 

Uzzo R.G., Novick A.C., Nephron sparing surgery for renal tumors: Indications, techniques and outcomes, 2001, Journal of Urology, 166, 1, 6, 18 PubMed

Kutikov A, Uzzo RG. The RENAL Nephrometry Score: A comprehensive standardized system for quantitating renal tumor size, location and depth. J Urol, 182(3):844-53, 2009. (cited 401 times) PubMed

Chawla S.N., Crispen P.L., Hanlon A.L., Greenberg R.E., Chen D.Y.T., Uzzo R.G., The natural history of observed enhancing renal masses: Meta-analysis and review of the world literature, 2006, Journal of Urology, 175, 2, 425, 431 PubMed

Kunkle D.A., Egleston B.L., Uzzo R.G., Excise, Ablate or Observe: The Small Renal Mass Dilemma-A Meta-Analysis and Review, 2008, Journal of Urology, 179, 4, 1227, 1234 PubMed

Kunkle D.A., Uzzo R.G., Cryoablation or radiofrequency ablation of the small renal mass: A meta-analysis, 2008, Cancer, 113, 10, 2671, 2680 PubMed

Uzzo R.G., Wei J.T., Waldbaum R.S., Perlmutter A.P., Byrne J.C., Vaughan Jr. D., The influence of prostate size on cancer detection, 1995, Urology, 46, 6, 831, 836 PubMed... Expand

Additional Publications

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