Igor Astsaturov, MD, PhD

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Clinical Locations

  • Fox Chase Cancer Center
    333 Cottman Avenue
    Philadelphia, PA 19111
    Phone: 888-369-2427

Associate Professor, Department of Hematology/Oncology

Co-Director, Marvin & Concetta Greenberg Pancreatic Cancer Institute

Inaugural Holder of Paul F. Engstrom Professorship in Oncology


  • Gastrointestinal Medical Oncology

Areas of Expertise

Esophageal Cancer, Pancreatic Cancer, Colorectal Cancer, Neuroendocrine Tumors, Liver, Gall Bladder & Bile Duct Cancer, Stomach (Gastric) Cancer

Treatment Focus

Gastrointestinal cancers, Neuroendocrine carcinomas


Language(s) Other than English

  • Russian

Treatment Philosophy

I chose to stay at Fox Chase as an attending physician for the love of the institutional environment and the great patients I am so privileged to treat. I love my work for the great team spirit cultivated among my colleagues, physicians and nurses. I am extremely grateful to the fact that patients are at the center of everybody’s attention. It is easy for me to do my job in such an atmosphere of concern and indefatigable compassion.

Fox Chase also offers me an opportunity to work both in the clinic and in the lab, where I am studying cancer biology with the goal to design better treatment options for the patients. In my field of gastrointestinal malignancies, I am convinced that the treatment choices for each individual cancer patient will soon be defined by the molecular makeup of their cancer cells. This knowledge can help us match the treatment strategies with the biology of individual patient’s tumors. I am interested to translate the knowledge about cancer available in the lab to the clinic by conducting hypothesis-driven clinical trials.

I am deeply convinced that the best way to help our patients is to push the boundaries by doing clinical and basic research.

Lab Overview

My lab opened in 2009 endowed with the challenge to define the critical regulators of tumor cell response to drugs targeting EGFR (Astsaturov, Science Signaling, 2010). From this initial task which ultimately led to 2 clinical trials in patients with head and neck and lung cancers, 3 NIH grants and 6 papers, we define a previously overlooked step of C4-demethylation in the enzymatic cascade of cholesterol biosynthesis. Inactivation of SC4MOL or NSDHL involved in the oxidative demethylation at C4 leads to dramatic alteration in the vesicular trafficking of the endocytosed EGFR and sensitizes cancer cells to EGFR inhibitors (Sukhanova et al., Cancer Discovery, 2013).

Following this initial lead, Linara Gabitova took on the challenge to pinpoint the mechanism executing such a dramatic effect of accumulating C4-methylated sterols. She found that LXR alpha was the critical effector triggered by these sterol species, so that activation of LXR can be used to deregulate cholesterol turnover in cancer synergistically with EGFR antagonists in in the KRAS-driven tumors (Cell Reports, 2015).

Dr. Gabitova-Cornell next developed a mouse model of pancreatic cancer to study the role of mevalonate pathway in pancreatic carcinogenesis (Cancer Cell, 2020). She discovered a mechanism by which cholesterol metabolism controls the development and differentiation of pancreatic ductal adenocarcinoma (PDAC). In her novel mouse model, disruption of distal cholesterol biosynthesis by conditional inactivation of the rate limiting enzyme Nsdhl, or treatment with cholesterol-lowering statins switches glandular pancreatic carcinomas to a basal (mesenchymal) phenotype in mouse models driven by KrasG12D expression and homozygous Trp53 loss. Consistently, PDACs in patients receiving statins show enhanced mesenchymal features. Mechanistically, statins and NSDHL loss induce SREBP1 activation, which promotes the expression of Tgfb1 enabling epithelial-mesenchymal transition. Evidence from patient samples in this study suggests activation of TGFβ signaling and epithelial-mesenchymal transition by cholesterol-lowering statins may promote basal type of PDAC conferring poor outcomes in patients.

In an ongoing productive collaboration with a partnering laboratory of Dr. Edna Cukierman, we have begun in-depth analyses of the role cancer-associated fibroblasts (CAFs) in pancreatic cancer. We are currently investigating the role of CAFs in providing tumor cells with essential lipids such as cholesterol and other membrane lipid particles. This project led by a postdoctoral fellow, Dr. Charline Ogier, is aimed to develop new strategies to disrupt CAF-cancer cell interactions. We are looking for metabolic vulnerabilities in the cholesterol pathway as well as developing innovative drug delivery tools to improve lives of the patient with this devastating and thus far recalcitrant cancer.


  • Link to /sites/default/files/styles/slider_desktop/public/images/slide/1L_2.gif?itok=valZgMlT

    Mechanisms of resistance to anti-EGFR agents


    Educational Background

    • Fellow, Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA, 2005-2008
    • Intern and Resident, Internal Medicine, Good Samaritan Hospital, Baltimore, MD, 2002-2005
    • Postdoctoral Research Fellow, Immunology, University of Toronto, Ontario, Canada, 1998-2002
    • Resident, Internal Medicine/Hematology, Russian Hematological Research Center, Moscow, Russia, 1992-1994
    • MD, I.M. Sechenov Moscow Medical Academy, Moscow, 1992
    • PhD, Russian Academy Research Center for Hematology, Moscow, 1997


    • Member, Laboratory Science Committee, Eastern Cooperative Oncology Group
    • American Association for Cancer Research
    • American Society of Clinical Oncology
    • Ad hoc Junior Faculty member, NCI Esophago-Gastric Cancer Taskforce

    Honors & Awards

    • Philadelphia Magazine Top Doctors, 2023-24
    • Training Award (ICRETT), International Union Against Cancer, Geneva, Switzerland
    • Scholar-in-Training Award, AACR-OSI
    • Sol Sherry Research Award, Temple University, Philadelphia, PA
    • Fox Chase-Genentech Scholar, Fox Chase Cancer Center
    Steven Zatoris and his wife.

    Steven Zatoris

    • Sarcoma
    • Colorectal Cancer
    • Lung Cancer

    In 2021, I started having pain in my left leg. I visited my family doctor, and at first we thought it might be a deep vein thrombosis. When we ruled that out, I saw a vascular doctor in case it might be varicose veins. That doctor had me get an MRI, and after those results came back, I had to get a biopsy. That’s when the doctors confirmed that I had a stage IV tumor in my leg.

    Link to /sites/default/files/styles/patient_story/public/images/patient-stories/Nick%20and%20wife%20Jen%20at%20Philadelphia%20PurpleStride_PANCAN%205K%20event%202018%20in%20remission.jpg?h=119e92fa&itok=PPA28HPe

    Nick Pifani

    • Pancreatic Cancer

    I’m 45 and live in Delran, New Jersey, with my wife and two kids. I work as a vice president of business development for MasterCard, and in my spare time I love to run.

    I’ve run marathons and completed an Ironman 70.3 (also known as a Half Ironman), which consists of a 1.2-mile swim, a 56-mile bike ride, and a 13.1-mile run. So, I’m no stranger to pain and discomfort.

    Link to /sites/default/files/styles/patient_story/public/images/patient-stories/DreBurkePancreaticCancerSurvivor.JPG?h=c2f3fb04&itok=VAjMOx8S

    Andre Burke

    • Pancreatic Cancer

    I often share my story and always encourage people who feel something is wrong to go to the doctor to get checked out. If you wait too long, it may be too late. I am thankful that I took that advice.



    Research Interests

    Cancer Metabolism and signaling

    • The central role for sterol metabolism in regulation of cell growth and signaling
    • Pancreatic cancer biology and "smart drugs" for treatment of pancreatic cancer
    • Translating therapeutic concepts to the clinic using the platform of patient-derived avatar models and genetically engineered pancreatic cancer models


    Former Staff

    Linara Gabitova-Cortnell, PhD

    Andrei Gorin, PhD

    Anna Sukhanova, PhD

    Eugenia Banina, MD

    The following ratings and reviews are based on verified feedback collected from independently administered patient experience surveys. The ratings and comments submitted by patients reflect their own views and opinions. Patient identities are withheld to ensure confidentiality and privacy. Learn more about our Patient Experience Ratings.

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    Selected Publications

    Skripova V., Vlasenkova R., Zhou Y., Astsaturov I., Kiyamova R., Identification of new regulators of pancreatic cancer cell sensitivity to oxaliplatin and cisplatin. Molecules. 27(4)2022. PMC8875979 https://www.ncbi.nlm.nih.gov/pubmed/35209078.

    Surumbayeva A., Kotliar M., Gabitova-Cornell L., Kartashov A., Peri S., Salomonis N., Barski A., Astsaturov I. Preparation of mouse pancreatic tumor for single-cell rna sequencing and analysis of the data. STAR Protoc. 2(4): 100989, 2021.PMC8649395. https://www.ncbi.nlm.nih.gov/pubmed/34927097.

    Gabitova-Cornell, L., Surumbayeva, A., Peri, S, Franco-Barraza, J, Restifo, D, Weitz, N, Ogier, C, Goldman, AR, Hartman, TR, Francescone, R, Tan, YF, Nicolas, E, Shah, N, Handorf, EA, Cai, QK, O’Reilly, AM, Sloma, I, Chiaverelli, R, Moffitt, RA, Khazak, V, Fang, CY, Golemis, EA, Cukierman, E, Astsaturov, I. Cholesterol pathway inhibition induces TGFβ signaling to promote basal differentiation in pancreatic cancer. Cancer Cell. 2020,38(4):p.567-583e11.PMID: 32976774; PMCID: PMC7572882; doi.org/10.1016/j.ccell.2020.08.015. –cover feature article, Editorial Preview; highlighted-Science Signaling, 10 Nov 2020: Vol. 13, Issue 657, DOI: 10.1126/scisignal.abf5642

    Francescone, R., Barbosa Vendramini-Costa, D., Franco-Barraza, J., Wagner, J., Muir, A., Lau, A. N., Gabitova, L., Pazina, T., Gupta, S., Luong, T., Rollins, D., Malik, R., Thapa, R. J., Restifo, D., Zhou, Y., Cai, K. Q., Hensley, H. H., Tan, Y., Kruger, W. D., Devarajan, K., Balachandran, S., Klein-Szanto, A. J., Wang, H., El-Deiry, W. S., Vander Heiden, M. G., Peri, S., Campbell, K. S., Astsaturov, I.,Cukierman, E. Cancer Discovery 2020. PubMed PMID: 33127842; PubMed Central PMCID: pending. DOI: 10.1158/2159-8290.CD-20-0775

    Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers RS, Puré E, Ramirez DC, Scherz-Shouval R, Sherman MH, Stewart S, Tlsty TD, Tuveson DA, Watt FM, Weaver V, Weeraratna AT, Werb Z. A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer. 2020 Jan 24;PubMed PMID: 31980749.

    Gabitova L, Restifo D, Gorin A, Manocha K, Handorf E, Yang DH, Cai KQ, Klein-Szanto AJ, Cunningham D, Kratz LE, Herman GE, Golemis EA, Astsaturov I. Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR. Cell Rep. 2015 Sep 22;12(11):1927-38. doi: 10.1016/j.celrep.2015.08.023. Epub 2015 Sep 3. PubMed; PubMed Central 

    Sukhanova A, Gorin A, Serebriiskii IG, Gabitova L, Zheng H, Restifo D, Egleston BL, Cunningham D, Bagnyukova T, Liu H, Nikonova A, Adams GP, Zhou Y, Yang DH, Mehra R, Burtness B, Cai KQ, Klein-Szanto A, Kratz LE, Kelley RI, Weiner LM, Herman GE, Golemis EA, Astsaturov I. Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation. Cancer Discov. 2013 Jan;3(1):96-111. doi: 10.1158/2159-8290.CD-12-0031. Epub 2012 Nov 2. PubMed; PubMed Central.

    Additional Publications

    This Fox Chase professor participates in the Undergraduate Summer Research Fellowship
    Learn more about Research Volunteering.