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Marc C. Smaldone, MD, MSHP, FACS

Marc Smaldone, MD, MSHP

Clinical Locations

Primary Location

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111

Secondary Location

Fox Chase Cancer Center Huntingdon Pike
8 Huntingdon Pike
Rockledge, PA 19046


Associate Professor, Department of Surgical Oncology

NCCN, Prostate Cancer Early Detection Panel Member

Treatment Focus

  • Robotic and laparoscopic minimally invasive surgery
  • Continent urinary diversion
  • Salvage and reconstructive Surgery

Research Program

Treatment Philosophy

I am a urologic oncologist specializing in the surgical management of tumors of the kidney, bladder, prostate, adrenal, testis and other genitourinary organs. As part of the multi-disciplinary Genitourinary Cancer Patient Care Team, I work closely with my colleagues in Medical and Radiation Oncology to develop a comprehensive treatment plan that offers the best chance for cure for each patient.

The mission at the Fox Chase Cancer Center is to deliver world class oncologic care in the most compassionate and respectful way possible. A cancer diagnosis brings fear and uncertainty for patients and their families, and my personal philosophy is to treat patients how I would wish for my family members to be treated. Patient education is essential, and I consider it of utmost importance to take the time necessary for patients to understand and feel comfortable with all possible treatment options to inspire confident decision making.

I have expertise in open, laparoscopic, and robotic surgical techniques, which allows me to tailor a specific treatment plan based on individual patient need and preferences. I have particular expertise in minimally invasive organ preserving and reconstructive techniques to preserve function and quality of life, including nerve-sparing prostatectomy for patients with prostate cancer and partial nephrectomy for patients with kidney cancer. I have experience performing both robotic and open cystectomy for patients with bladder cancer, and prefer to construct continent urinary diversions whenever possible. I have a clinical interest in the surgical management of patients with high risk and advanced disease, and have experience performing retroperitoneal lymph node dissection following chemotherapy in patients with testicular cancer, cytoreductive nephrectomy and thrombectomy for patients with metastatic kidney cancer or tumors extending into the vena cava, and salvage surgery following radiation for patients with bladder or prostate cancer.


Follow on Twitter: @FCUroOnc

Education and Training

Educational Background

  • Fellowship: Urologic Oncology, Fox Chase Cancer Center, Philadelphia, PA
  • Residency: Urologic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • MS, Health Policy Research, University of Pennsylvania, Philadelphia, PA
  • MD, State University of New York at Stony Brook School of Medicine, Stony Brook, NY


  • American Board of Urology


  • National Comprehensive Cancer Network (NCCN)
    • Prostate Cancer Early Detection Panel
  • American Urological Association
  • Society of Urologic Oncology

Honors & Awards

  • Main Line Today Top Doctors, 2018-2019
Patient Stories

Brian Kredo

Bladder Cancer

Brian Kredo

Bladder Cancer

My name is Brian Kredo and I am 53 years old. I work as a lawyer and live in Bucks County, which is in suburban Philadelphia, with my wife Jodi and my two teenage children.

A few years ago, I noticed some drops of blood at the end of my urine stream. When I went to see my urologist, he ran some tests, and the results came back atypical. He said we’d need to do a biopsy, but he was going on vacation for two weeks, so he wanted to do it when he got back. That felt like too long to wait.

Bill Doyle

Bladder Cancer

Bill Doyle

Bladder Cancer

Bill Doyle always knew he wanted to be on the radio. As one half of the Deminski & Doyle talk radio show on New Jersey 101.5, life was good for Bill until he was diagnosed with bladder cancer at 52. After surgery and several rounds of chemotherapy, Bill is back on the airwaves, thanks in part to the support of his family and the countless 101.5 listeners who have offered words of support during his cancer journey.

John Mullarkey, Jr.

Prostate Cancer

John Mullarkey, Jr.

Prostate Cancer

I have always been proactive about my health and started having annual prostate exams when I turned 50 in 2007. My first report was great and showed that my PSA level was undetectable.

Sister Marcille McEntee

Melanoma;  Ureteral Cancer

Sister Marcille McEntee

Melanoma;  Ureteral Cancer

Her gastroenterologist performed a PET scan which revealed a rare kind of cancer, a mucosal melanoma. “At that point, my urologist admitted 'this is beyond me. You need to go somewhere else',” she recalled.

Chuck Leonard

Kidney Cancer

Chuck Leonard

Kidney Cancer

In August 2012, at the age of 61, Chuck Leonard was diagnosed with stage four kidney cancer that had metastasized to his lungs. After seeing one doctor, Chuck decided to seek a second opinion from a specialist at Fox Chase Cancer Center, where he planned to take part in a clinical trial. However, additional testing revealed he was a candidate for surgery. Chuck also underwent radiation using Cyberknife technology at Fox Chase Buckingham after an MRI revealed the kidney cancer had spread to his brain. “In 2016, I can mark three years since I have had detectable cancer,” he said. “I’m so thankful for all the outstanding care, both medical and other, provided by Fox Chase and the caring doctors and nurses. Hopefully, my tests will continue to have good outcomes, and, if not, I know I’m getting the best care possible from Fox Chase Cancer Center.”


Research Profile

Research Program

Research Interests

  • Quality of care
  • Comparative effectiveness
  • Risk assessment
  • Access disparities
  • Surgical outcomes
  • Health services research

Selected Publications

Masic S.,Smaldone M.C., Robotic renal surgery for renal cell carcinoma with inferior vena cava thrombus. Transl Androl Urol. 10(5): 2195-2198, 2021. PMC8185684. https://www.ncbi.nlm.nih.gov/pubmed/34159102.

Smaldone M.C., Tomaszewski J.J., Current controversies in minimally invasive urologic oncology. Transl Androl Urol. 10(5): 2149-2150, 2021.PMC8185655 (available at http://dx.doi.org/10.21037/tau-21-258). https://www.ncbi.nlm.nih.gov/pubmed/34159096.

Correa AF, Handorf E, Joshi SS, Geynisman DM, Kutikov A, Chen DY, Uzzo RG, Viterbo R, Greenberg RE, Smaldone MC. Differences in Survival Associated with Performance of Lymph Node Dissection in Patients with Invasive Penile Cancer: Results from the National Cancer Database. J Urol, 199(5):1238-44, 2018. PubMed

Goel N, Manstein SM, Ward WH, DeMora L, Smaldone MC, Farma JM, Uzzo RG, Esnaola NF. Does the Surgical Apgar Score predict serious complications after elective major cancer surgery? Journal of Surgical Research, 231:242-7, 2018. 

Smaldone, M.C., Corcoran, A.T., Hayn M.H., Konety, B.R., Hrebinko Jr., R.L., Davies, B.J. (2009). Estimation of mortality and morbidity risk in patients undergoing radical cystectomy with continent diversion using the POSSUM and Portsmouth POSSUM predictor equations. J Urol,182(6): 2619-24. PubMed

Smaldone, M.C., Cowan, J., Carroll, P.R., Davies, B.J. (2010). Comparison of eligibility for active surveillance and pathologic outcomes in men undergoing radical prostatectomy in a large community-based cohort. J Urol,183(1):138-43. PubMed

Kutikov, A., Smaldone, M.C., Egleston, B.L., Manley, B.J., Simhan, J., Boorjian, S.A., Viterbo, R., Chen, D.Y., Greenberg, R.E., Uzzo, R.G. (2011). Anatomic features of enhancing renal masses predict malignant and high-grade pathology: a preoperative nomogram using the RENAL Nephromety Score. Eur Urol, 60(2): 241-8. PubMed

Smaldone, M.C., Kutikov, A., Egleston, B., Simhan, J., Canter, D.J., Teper, E., Viterbo, R., Chen, D.Y., Greenberg, R.E., Uzzo, R.G. (2012). Assessing performance trends in laparoscopic nephrectomy and nephron sparing surgery for localized renal tumors. Urology, 80(2): 286-92. PubMed

Smaldone, M.C., Kutikov, A., Egleston, B.L., Canter, D.J., Viterbo, R., Chen, D.Y., Jewett, M.A., Greenberg, R.E., Uzzo, R.G. (2012). Small renal masses progressing to metastases under active surveillance: a systematic review and pooled analysis. Cancer, 118(4):997-1006. PubMed

Smaldone, M.C., Egleston, B.L., Uzzo, R.G., Kutikov, A. (2012). Does partial nephrectomy result in a durable overall survival benefit in the Medicare population? J Urol 188(6): 2089-94. PubMed... Expand

Additional Publications




Our Patient Satisfaction Rating is an average of all responses to care provider related questions from our nationally-recognized Press Ganey Patient Satisfaction Survey. Learn more.


4.9 / 5.0


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  • 4.9
  • 4.9
  • 4.9
  • 4.9


  • No Star Ratings Available June 23, 2022
    Dr Smaldone is amazing and I would highly recommend him
  • 5.0
    June 23, 2022
    Excellent care, very responsive and clear answers.
  • 5.0
    June 15, 2022
    An excellent doctor and team
  • 5.0
    June 14, 2022
    Only GOOD.
  • 5.0
    June 11, 2022
    I have never met such an amazing Doctor and staff. Everyone I dealt with was exceptional. I am so happy that I ended up with all these professionals.
  • 5.0
    June 08, 2022
    Everyone was considerate and helpful during my office visit
  • 5.0
    June 06, 2022
    Dr. Smaldone and his staff are the best!!!
  • No Star Ratings Available June 06, 2022
  • 5.0
    June 05, 2022
    I believe that Fox Chase is the best Cancer treatment facility that I am aware of
  • 5.0
    May 31, 2022
    Dr. Smaldone and his staff made a unpleasant situation bearable. They were very professional and considered to the privacy of the patient.
  • No Star Ratings Available May 29, 2022
    Dr. Smaldone is very attentive and always willing to listen to your concerns and questions. He provides answers and offers several paths that could lead to a comforting and relaxing peace of mind.
  • 5.0
    May 24, 2022
    Great experience
  • 5.0
    May 24, 2022
    My cancer diagnosis has been life-changing.Grateful to be cared for by Marc Smaldone and his team.
  • 5.0
    May 23, 2022
    The very best care I could ask for.
  • 5.0
    May 15, 2022
    The date and time for my appointment with Dr. Smaldone was on [...]. Dr. Smaldone is a wonderful doctor and I always receive the best treatment. He advises me on my progress in an understanding manner. He is always very considerate when answering any questions I have. Makes my feel 100% better when I leave. I know I'm in very good hands whenever I see him. Thank you Dr. Smaldone for all the great service that has been provided to me, so far - both in and out of the hospital. Thank you all..
  • No Star Ratings Available May 14, 2022
    I have full confidence in Dr Smaldone and he is easy to talk to.
  • 5.0
    May 13, 2022
    Very good experience.
  • 5.0
    May 09, 2022
    Very pleased with care I am receiving from fox chase and Dr Smaldones staff.
  • 5.0
    May 05, 2022
    Dr. Smaldone is an excellent doctor and a caring person. The staff at Fox Chase always is helpful, friendly and respectful.
  • 5.0
    May 04, 2022
    Dr. Smaldone the best

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