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Yibin Yang, PhD

Yibin Yang, PhD
About

Research Program

The Genomic Assault on Cancer
The Genomic Assault on Cancer
Functional and Structural Cancer Genomics
Functional and Structural Cancer Genomics
Positions Available

Positions are available for postdoctoral fellows and rotation students. For postdoctoral fellows, please forward a cover letter and updated CV to Dr. Yibin Yang (yibin.yang@fccc.edu). For rotation students , please contact Dr. Yibin Yang (yibin.yang@fccc.edu) for additional details. 

Education and Training

Educational Background

  • Postdoctoral Training,  National Cancer Institute, National Institutes of Health, Bethesda, MD
  • PhD, Cancer Biology,  University of Massachusetts Medical School, Worcester, MA, 2010
  • BS, Biological Science, Wuhan University, Wuhan, China, 2001

Memberships

  • American Association for Cancer Research
  • American Society of Hematology

Honors & Awards

  • The W. W. SMITH Charitable Trust, 2018
  • American Cancer Society- IRG, 2017
  • NCI K22 Transition Career Development Award, 2016-2019
  • NIH Fellows Award for Research Excellence, 2015
Research Profile

Research Program

Research Interests

Immune Signaling and Regulatory Pathways in Lymphoid Malignancies

  • Identifying previously unrecognized molecular effectors that drives tumor immune escape, in order to provide novel opportunities to improve immunotherapeutic intervention strategies in lymphoma.
  • Identifying novel immune signaling molecular — “addictions” — of cancer cells that could be exploited therapeutically, and defining the molecular mechanism by which these immune pathways contribute to tumor initiation and maintenance.
  • Investigating the mechanism and the effectiveness of novel anti-cancer drugs, to develop innovative therapeutic strategies to overcome drug resistance in lymphoma that are both effective and safe. 

Lab Overview

A deep knowledge of cellular immunology has accelerated our understanding of the molecular circuitry that drives human lymphoid malignancies, including common mechanisms of signaling, transcriptional regulation, and survival. Functional cancer genomics using high-throughput library screens have provided the foundation for molecular, cellular and genetic approaches to investigate the role and function of specific genes and pathways in cancer biology, which is essential not only to understand the molecular basis of cancer but also to develop the means to target these pathways therapeutically. 

Our laboratory mainly focused on the immune regulatory pathways in human lymphoid malignancies.  We are interested in the immune signaling pathways, particularly key transcriptional factors and ubiquitin-mediated signaling, required for lymphoma pathogenesis and immunotherapy.  We have established an unbiased high-throughput CRISPR library screening technology to rapidly and accurately identify key pathways that are suitable for targeted therapy and immunotherapy.

As such, our lab focuses on following interdisciplinary directions based on the high-throughput CRISPR library screening technologies:

#1: The success of PD1/PD-L1 based immunotherapy highlights the critical role played by PD-L1 in cancer progression, and reveals an urgent need to develop new approaches to attenuate PD-L1 function by gaining insight into how its level is controlled.  Using high-throughput CRISPR library screen technologies, we are pursuing a comprehensive understanding of the molecular effectors required for PD-L1 regulation in lymphoma, especially the novel transcriptional factors and ubiquitination enzymes. The findings will provide new strategies to improve immunotherapy efficacy. 

#2: Although the significance of tumor microenvironment in the pathogenesis of lymphoid malignancies is indisputable, our understanding of the connection between the signaling input from the tumor microenvironment and genetic alternations in malignant cells is still at an elementary stage. We have developed an analytic pipeline in HL and ALCL Lymphoma, using high-throughput CRISPR library screen and next-generation sequencing (NGS), to discover deep oncogenic mechanisms for how immune regulatory and protein ubiquitination pathway regulate the micro-environmental signaling to support tumor cell survival.

#3: We have also established a drug sensitization screen platform using the high-throughput CRISPR library screen technologies, and we have started to investigate the therapeutic potential and resistance mechanism of some of the most promising anti-lymphoma drugs based on the insights into lymphoma pathogenesis that have emerged from our laboratory. These translational research works provide the mechanistic understanding of how new drugs act in lymphoma, leading to the rational design of new clinical trials for lymphoma patients.

Positions are available for postdoctoral fellows and rotation students. For postdoctoral fellows, please forward a cover letter and updated CV to Dr. Yibin Yang (yibin.yang@fccc.edu). For rotation and summer students, please contact Dr. Yibin Yang (yibin.yang@fccc.edu) for additional details. 

Lab Staff

Zhuhui Song

Postdoctoral Associate

Room: R390

Wei Wei

Postdoctoral Associate

Room: R390

Joseph Fabrizio

Summer Student

Room: R390

Ashish Abraham

Summer Student

Room: R390
Publications

Selected Publications

Zhang JP, Song ZH, Wang H, Lang L, Yang YZ, Xiao W, Webster DE, Wei W, Barta S, Kadin ME, Staudt LM, Nakagawa M and Yang Y   A novel model of controlling PD-L1 expression in ALK+ Anaplastic Large Cell Lymphoma revealed by CRISPR screening.   Blood. 2019 May 31. pii: blood.2019001043 .   https://www.ncbi.nlm.nih.gov/pubmed/31151983

Nakagawa M, Shaffer AL 3rd, Ceribelli M, Zhang M, Wright G, Huang DW, Xiao W, Powell J, Petrus MN, Yang Y, Phelan JD, Kohlhammer H, Dubois SP, Yoo HM, Bachy E, Webster DE, Yang Y, Xu W, Yu X, Zhao H, Bryant BR, Shimono J, Ishio T, Maeda M, Green PL, Waldmann TA, Staudt LM.  Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma. Cancer Cell. 2018 Aug 13;34(2):286-297.e10. doi: 10.1016/j.ccell.2018.06.014.  PMID: 30057145.   https://www.ncbi.nlm.nih.gov/pubmed/30057145

Barta SK, Zain J, MacFarlane AW 4th, Smith SM, Ruan J, Fung HC, Tan CR, Yang Y, Alpaugh RK, Dulaimi E, Ross EA, Campbell KS, Khan N, Siddharta R, Fowler NH, Fisher R and Oki Y.   Phase II Study of the PD-1 Inhibitor Pembrolizumab for the Treatment of Relapsed or Refractory Mature T-cell Lymphoma.   Clin Lymphoma Myeloma Leuk. 2019 Apr 3. pii: S2152-2650(18)31750-6.   https://www.ncbi.nlm.nih.gov/pubmed/31029646

Somech R, Lev A, Lee YN, Simon AJ, Barel O, Schiby G, Avivi C, Barshack I, Rhodes M, Yin J, Wang M, Yang Y, Rhodes J, Marcus N, Garty BZ, Stein J, Amariglio N, Rechavi G, Wiest DL, Zhang Y.  Disruption of Thrombocyte and T Lymphocyte Development by a Mutation in ARPC1B.  J Immunol. 2017 Dec 15;199(12):4036-4045.    https://www.ncbi.nlm.nih.gov/pubmed/29127144

Yang Y, Kelly P, Shaffer AL 3rd, Schmitz R, Yoo HM, Liu X, Huang da W, Webster D, Young RM, Nakagawa M, Ceribelli M, Wright GW, Yang Y, Zhao H, Yu X, Xu W, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza L, Staudt LM.  Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma.  Cancer cell. 2016; 29(4):494-507. PubMed

Yang Y, Staudt LM.  Protein ubiquitination in lymphoid malignancies. Immunol Rev. 2015 Jan;263(1):240-56. doi: 10.1111/imr.12247. PubMed

Yang Y, Schmitz R, Mitala J, Whiting A, Xiao W, Ceribelli M, Wright G, Zhao H, Yang Y, Xu W, Rosenwald A, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Wiestner A, Kruhlak MJ, Iwai K, Bernal F, and Staudt LM Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms. Cancer Discovery. 2014 Apr;4(4):480-93. PubMed

Kelly PN, Romero DL, Yang Y, Shaffer AL 3rd, Chaudhary D, Robinson S, Miao W, Rui L, Weslin WF, Kapeller R, Staudt LM.  Selective interleukin-1 receptor-associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy. J Exp Med. 2015 Nov 30. pii: jem.20151074. PubMed

Yang Y, Shaffer AL, Emre N.C, Ceribelli M, Zhang M, Wright G, Xiao W, Powell J, Platig J, Kohlhammer H, Young RM, Zhao H, Yang Y, Xu W, Buggy JJ, Balasubramanian S, Mathews LA, Shinn P, Guha R, Ferrer M, Thomas C, Waldmann TA, and Staudt LM   Exploiting Synthetic Lethality for the Therapy of ABC Diffuse Large B Cell Lymphoma. Cancer Cell. 2012 Jun 12;21(6):723-37. PubMed

Ceribelli M, Kelly PN, Shaffer AL, Wright GW, Xiao W, Yang Y, Mathews Griner LA, Guha R, Shinn P, Keller JM, Liu D, Patel PR, Ferrer M, Joshi S, Nerle S, Sandy P, Normant E, Thomas CJ, Staudt LM. Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors. PNAS. 2014 Jul 21. pii: 201411701 PubMed

Lim KH, Yang Y, Staudt LM Pathogenetic importance and therapeutic implications of NF-kB in lymphoid malignancies. Immunol Rev. 2012 Mar;246(1):359-78. PubMed

Yang Y, Xia F, Hermance N, Mabb A, Simonson S, Morrissey S, Gandhi P, Munson M, Miyamoto S, Kelliher MA. A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage. Mol Cell Biol. 2011 Jul;31(14):2774-86. PubMed PMID: 21606198; PubMed Central PMCID: PMC3133388.

Additional Publications

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