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This Fox Chase professor participates in the Undergraduate Summer Research Fellowship.
Learn more about Research Volunteering.
Chair, Department of Clinical Genetics
Professor, Department of Clinical Genetics
Director, Gastrointestinal Risk Assessment
Co-Leader, Cancer Prevention and Control Program
NCCN, Genetic Colorectal/Colorectal Cancer Screening Panel Member
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| Medical Oncology |
I am a GI oncologist and a clinical cancer geneticist, and I have found over the years that my strongest skills are in helping my patients and their families to understand the complicated risks of cancer screening, surgery and treatment, to weigh the different options for treatment, and finally to develop a plan that is both in line with cutting edge research but also with their personal needs and preferences for their health and their lives. In cancer medicine, there is no longer a one size fits all approach, and in my practice I strive to build on my patients’ unique strengths and to further bring the multi-faceted expertise of my colleagues at Fox Chase and my colleagues nationally to offer each of my patients the best care I possibly can.
Since 1991, the Risk Assessment Program has received strong support from its clinical and research participants and referring providers. Over 11,000 patients have joined RAP’s registry and donated epidemiologic data and a biospecimen (~8,000 blood donations). This valuable resource is available to FCCC investigators and the wider genetics community and has generated significant grant support, publications, and presentations at national/international venues. RAP, the research component of the Department of Clinical Genetics, is part of the FCCC Cancer Prevention and Control (CPC) program. RAP maintains close collaborations with clinical, behavioral, and laboratory scientists with research interests in genetic risk and cancer prevention. RAP administers studies of the biological, genetic and environmental factors that influence cancer risk. RAP has established a unique registry of family data, blood, and tissue samples that is used to study the genetic basis of cancer. Our work is supported by funding from governmental, foundation, industry, and philanthropic sources and has contributed significantly to the field.
My group’s research is in three areas related to GI genetic risk and risk assessment. My primary syndrome of expertise and study is Lynch syndrome, but I have also performed research among all high risk GI patients, patients with hereditary breast/ovarian cancer and BRCA1/2 mutations, hereditary pancreatic cancer, high risk renal cell cancers, and others:
Early in 2019, I started to experience an uncomfortable feeling whenever I sat down on a hard surface. Little things like riding my bike or just resting on a bench started to hurt a little. At first, it wasn’t that bad, so I just ignored it and hoped it would go away on its own.
[Treatment] is worthwhile because once you are on the other side, you have a promise of a future. That is impactful. You need to find a path through it if you can.
Being defeated is a matter of perspective and will. I feel that no matter how serious the illness is, I can overcome it with the right help and the right attitude.
Unfortunately, because of COVID-19 precautions, my kids couldn’t be with me when I rang the bell to celebrate my last treatment in May. However, I was able to finish treatment with all the same nurses and staff who were there from the very beginning. They became like family to me.
Hoadley A., Bass S.B., Chertock Y., Brajuha J., D'Avanzo P., Kelly P.J.,Hall M.J., The role of medical mistrust in concerns about tumor genomic profiling among black and African American cancer patients. Int J Environ Res Public Health. 19(5)2022. PMC8909390.https://www.ncbi.nlm.nih.gov/pubmed/35270290.
Hall MJ, Bernhisel R, Hughes E, Larson K, Rosenthal E, Singh NA, Lancaster JM, Kurian AW. Germline pathogenic variants in the Ataxia Telangiectasia Mutated (ATM) gene are associated with high and moderate risks for multiple cancers. Accepted for publication January 2021, Cancer Prevention Research
Hall MJ. Updates in Chemoprevention Research for Hereditary Gastrointestinal and Polyposis Syndromes. Current Treatment Options in Gastroenterology. CTOG-D-20-00028R1. 8.2020.
Tricarico R, Nicolas E, Hall MJ, Golemis EA. X- and Y-linked chromatin-modifying genes as regulators of sex-specific cancer incidence and prognosis. Clin Cancer Res, 2020.
Salem ME, Bodor JN, Puccini A, Xiu J, Goldberg RM, Grothey A, Korn WM, Shields AF, Worrilow WM, Kim ES, Lenz HJ, Marshall JL, Hall MJ. Relationship Between MLH, PMS2, MSH2, and MSH6 Gene Specific Alternations and Tumor Mutation Burden (TMB) in 1,057 Microsatellite Instability-high Solid Tumors. Int J Cancer. 2020 May 24. doi: 10.1002/ijc.33115. [Epub ahead of print]. PMID: 32449172.
Hampel H, Chruch J, Dudley BR, Hall MJ, Stoffel E, Yurgelun MB, Kupfer S, Singh A, You YN, Mork ME, Stoll JLK. Collaborative Group of the Americas on Inherited Gastrointestinal Cancer Position Statement on Multigene Panel Testing for Patients with Colorectal Cancer and/or Polyposis. Fam Cancer. 2020 Jul;19(3):223-239. doi: 10.1007/s10689-020-00170-9.PMID: 32172433
Biller L, Ukaegbu C, Dhingra T, Burke C, Chertock Y, Chittenden A, Church J, Koeppe E, Leach B, Levinson E, Lim R, Lutz M, Salo-Mullen E, Sheikh R, Idos G, Kastrinos F, Stoffel E, Weiss J, Hall MJ, Kalady M, Stadler Z, Syngal S, Yurgelun M. A Multi-Institutional Cohort of Therapy-associated Polyposis in Childhood and Young Adulthood Cancer Survivors. Canc Prev Res. 2020 Feb 12. Doi: 10.1158/1940-6207. CAPR-19-0416R1. PMID: 32051178.
Golan T et al, Hall MJ. Geographic and Ethnic Heterogeneity of Germline BRCA1 or BRCA2 Mutation Prevalence with Metastatic Pancreatic Cancer Screened for Entry into the POLO Trial. Clin Oncol. 2020 Feb 19: JCO1901890. doi: 10.1200/JCO.19.01890. PMID: 32073954.
Jain R, Handorf E, Khare V, Blau M, Chertock Y, Hall MJ. Impact of Baseline Nutrition and Exercise Status on Toxicity and Outcomes in Phase I and II Oncology Clinical Trial Participants. Oncologist. 2020 Feb; 25 (2): 161-169. doi: 10.1634/theoncologist.2019-0289.Epub 2019 Nov 20. PMID: 32043776.
Nicolas E, Tricarico R, Savage M, Golemis EA, Hall MJ. Disease-Associated Genetic Variation in Human Mitochondrial Protein Import. American Journal of Human Genetics, 2019. PubMed
Golan T, Hammel P, Reni M, Van Cutsem E, Hall MJ, et all. Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer. N Engl J Med. 2019 Jul 25;381(4):317-327. doi: 10.1056/NEJMoa1903387. Epub 2019 Jun 2. PMID: 31157963; PMCID: PMC6810605.
Hall MJ et al. The COGENT study group. Use and patient reported outcomes of clinical multi-gene panel testing for cancer susceptibility in the multi-center Communication of Genetic Test Results by Telephone Study. JCO Precision Oncology.Dec.2018.00199.
Gray PN, Tsai P, Chen D, Wu S, Hoo J, Hall MJ, et al. TumorNext-Lynch-MMR: A Comprehensive Next Generation Sequencing Assay for the Detection of Germline and Somatic Mutations in Genes Associated with Mismatch Repair Deficiency and Lynch Syndrome. Oncotarget. 2018 Apr 17;9(29):20304-20322. PMID: 29755653; PMCID: PMC5945525.
Shaikh T, Handorf EA, Meyer JE, Hall MJ, Esnaola NF. Mismatch Repair Deficiency Testing in Patients with Colorectal Cancer and Nonadherence to Testing Guidelines in Young Adults. JAMA Oncol. 2018 Feb 8;4(2):e173580. PMID: 29121143; PMCID: PMC5838708.
Kurian AW, Hughes E, Handorf EA, Gutin, A, Allen B, Hartman AR, Hall, MJ. Breast and Ovarian Cancer Penetrance Estimates Derived from Germline Multiple –Gene Sequencing Results in Women. JCO Precision Oncology 2017. June 27.10.1200.00066.
Meyer JE, Cohen SJ, Ruth KJ, Sigurdson ER, Hall MJ. Young Age Increases Risk of Lymph Node Positivity in Early-Stage Rectal Cancer. J Natl Cancer Inst. 2016 Jan;108(1) PubMed PMID: 26719881; PubMed Central PMCID: PMC4715232
Arora S, Yan H, Cho I, Fan HY, Luo B, Gai X, Hall M, et al. Genetic Variants That Predispose to DNA Double-Strand Breaks in Lymphocytes from a Subset of Patients With Familial Colorectal Carcinomas. Gastroenterology. 2015 Dec;149(7):1872-1883.e9. doi: 10.1053/j.gastro.2015.08.052. Epub 2015 Sep 5. PMID: 26344056; PMCID: PMC4663158.
Guindalini RS, Win AK, Gulden C, Lindor NM, Hall MH, et all. Mutation spectrum and risk of colorectal cancer in African American families with Lynch syndrome. Gastroenterology. 2015 Nov;149(6):1446-53. doi: 10.1053/j.gastro.2015.07.052. Epub 2015 Aug 3. PMID: 26248088; PMCID: PMC4648287.
Nicolas E, Arora S, Zhou Y, Serebriiskii IG, Hall, MJ. Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer. Oncotarget. 2015 Nov 24;6(37):39614-33. doi: 10.18632/oncotarget.5554. PMID: 26485759; PMCID: PMC4741850.
Boland PM, Ruth K, Matro JM, Rainey KL, Fang CY, Wong YN, Daly MB, Hall MJ. Genetic counselors' (GC) knowledge, awareness, understanding of clinical next-generation sequencing (NGS) genomic testing. Clin Genet. 2015 Dec;88(6):565-72. doi: 10.1111/cge.12555. Epub 2015 Jan 22. PMID: 25523111; PMCID: PMC4474774.
Hall MJ, Innocent J, Rybak CM, Veloski C, Scott WJ, et all. Case Report: Bilateral granulosa cell carcinoma: A novel malignant manifestation of MEN1 syndrome associated with a rare intronic deletion. Appl Clin Gen 2014. PubMed
Hall MJ, Forman AD, Montgomery SV, Rainey KL, Daly MB. Understanding patient and provider perceptions and expectations of genomic medicine. J Surg Oncol. 2015 Jan;111(1):9-17. doi: 10.1002/jso.23712. Epub 2014 Jul 3. PMID: 24992205; PMCID: PMC4286413.
Bradbury AR, Patrick-Miller L, Long J, Stopfer J, Hall MJ et all. Development of a tiered and binned counseling model for informed consent in the era of multiplex testing for cancer susceptibility Genet Med. 2014 Oct 9. PubMed
Hall MJ, Forman AD, Pilarski R, Wiesner G, Giri VN. Gene panel testing for inherited cancer risk. J Natl Compr Canc Netw. 2014 Sep;12(9):1339-1346. PubMed
Hall MJ. Conflicted Confidence: Academic Oncologists' Views on Multiplex Pharmacogenomic Testing. J Clin Oncol. 2014 Mar 24. PubMed
Hall MJ, Herda MM, Handorf EA, Rybak CC, Keleher CA, Siemon M, Daly MB. Direct access to universal mismatch repair (MMR) screening results for Lynch syndrome (LS) via electronic personal health record (ePHR):A feasibility study. Genet Med. 2014 May 1.
Matro JM, Ruth KJ, Wong YN, McCully KC, Rybak CM, Meropol NJ, Hall MJ. Cost-sharing and hereditary cancer risk: predictors of willingness-to-pay for genetic testing. J Genet Couns. 2014 May 6.
Hall MJ, Manne SL, Myers RE, Keenan EM, Balshem AM, Weinberg DS. Association of knowledge and race to gene environment risk assessment (GERA) testing for colorectal cancer Genome Med 2012;4(11):92 [epub ahead of print] PMID: 23194586.
Hall MJ, Ruth K, Giri VN. Predictors of compliance with age-appropriate colorectal cancer screening in men enrolled in a prostate cancer screening program. Cancer 2012 Jan 15;118(2):478-84.
This Fox Chase professor participates in the Undergraduate Summer Research Fellowship.
Learn more about Research Volunteering.
Dr. Michael Hall is an excellent doctor and I feel blessed to be cared by him and his team for my cancer treatment at Fox Chase Cancer center.
Dr. Michael Hall was exceptional. He explained everything so I could understand. A great doctor and a very good asset to [...]. I'm glad you have him.
Dr. Hall is extremely kind and caring. He gives you his time.
Dr. Hall is knowledgeable, caring and kind dr.
Every experiences were excellent.
I am always surprised at how well they know me. They read all my records they have access to, even the ones that are not from Fox Chase. This makes me feel like they care about my progress.
Dr Hall is the best and I wouldn't go to anyone else.
Was very Helpful.
Excellent care
Dr. Hall and his team are the best.
Dr Hall and staff are very caring and compassionate in their care
Dr. Hall is an excellent caring doctor.
Always treat me with consideration and professionalism.
I have had extremely positive interactions with Dr Hall and everyone his office. I am grateful for their care and kindness.
dr. Hall is a compassionate, kind and informative man.
Dr. Hall & his staff are superb.
Dr. Hall is always good to work with, and very helpful in presenting valuable options for managing my health.