Senior Vice President
Deputy Director
Chief Scientific Officer
Stanley P. Reimann Chair in Oncology Research
Co-Leader, Cancer Biology
TRDG Member,
As Chief Scientific Officer, Dr. Chernoff coordinates and charts the future course of research at Fox Chase.
Chernoff joined the staff in 1991 as an associate member and was promoted to member with tenure in 1996. In 2002 he was promoted to be a senior member in Fox Chase Cancer Center's Basic Science division, the equivalent of a full professor in a university.
A molecular oncologist as well as a board-certified medical oncologist, Chernoff has a special interest in factors that control cell growth and movement, including oncogenes and anticancer or tumor-suppressor genes, and has made fundamental contributions in this research.
Chernoff earned his MD and his PhD in biochemistry in 1984 at Mount Sinai School of Medicine in New York City. He completed his residency in internal medicine at the University Health Center of Pittsburgh and a clinical fellowship in medical oncology at Johns Hopkins Oncology Center. He then held a postdoctoral fellowship in cellular and developmental biology at Harvard University before coming to Fox Chase.
In recognition of his national reputation in molecular oncology and biochemistry, Chernoff also holds the Stanley P. Reimann Chair in Oncology.
The process of neoplastic transformation can be conceptually divided into two components. The first of these, proliferative transformation, refers to the ability of transformed cells to bypass growth suppression signals, suriviving and dividing when normal cells would not. The second, morphologic transformation, refers to loss of normal cytoskeletal architecture, often accompanied by decreased adhesion and acquisition of the ability to invade surrounding tissues. These two fundamental properties are intimately linked to one another, although experimentally they can be dissected apart through the use of gain-of-function and loss-of-function manupulation of signaling molecules. The overall focus this research is in uncovering the roles of protein phosphorylation in governing these two fundamental aspects of cancer biology.
Jonathan.Chernoff@fccc.edu
Office Phone: 215-728-5319
Lab Phone: 215-728-5320
Fax: 215-728-3616
Office: W455
Lab: W422, W450-451
Jonathan.Chernoff@fccc.edu
Office Phone: 215-728-5319
Lab Phone: 215-728-5320
Fax: 215-728-3616
Office: W455
Lab: W422, W450-451
Senior Vice President
Deputy Director
Chief Scientific Officer
Stanley P. Reimann Chair in Oncology Research
Co-Leader, Cancer Biology
TRDG Member,
As Chief Scientific Officer, Dr. Chernoff coordinates and charts the future course of research at Fox Chase.
Chernoff joined the staff in 1991 as an associate member and was promoted to member with tenure in 1996. In 2002 he was promoted to be a senior member in Fox Chase Cancer Center's Basic Science division, the equivalent of a full professor in a university.
A molecular oncologist as well as a board-certified medical oncologist, Chernoff has a special interest in factors that control cell growth and movement, including oncogenes and anticancer or tumor-suppressor genes, and has made fundamental contributions in this research.
Chernoff earned his MD and his PhD in biochemistry in 1984 at Mount Sinai School of Medicine in New York City. He completed his residency in internal medicine at the University Health Center of Pittsburgh and a clinical fellowship in medical oncology at Johns Hopkins Oncology Center. He then held a postdoctoral fellowship in cellular and developmental biology at Harvard University before coming to Fox Chase.
In recognition of his national reputation in molecular oncology and biochemistry, Chernoff also holds the Stanley P. Reimann Chair in Oncology.
The process of neoplastic transformation can be conceptually divided into two components. The first of these, proliferative transformation, refers to the ability of transformed cells to bypass growth suppression signals, suriviving and dividing when normal cells would not. The second, morphologic transformation, refers to loss of normal cytoskeletal architecture, often accompanied by decreased adhesion and acquisition of the ability to invade surrounding tissues. These two fundamental properties are intimately linked to one another, although experimentally they can be dissected apart through the use of gain-of-function and loss-of-function manupulation of signaling molecules. The overall focus this research is in uncovering the roles of protein phosphorylation in governing these two fundamental aspects of cancer biology.
This Fox Chase professor participates in the Undergraduate Summer Research Fellowship.
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