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Phillip Abbosh, MD, PhD

Phillip Abbosh, MD, PhD
About
Education and Training

Educational Background

  • Urologic Oncology Fellowship, Fox Chase Cancer Center, Philadelphia, PA, 2015
  • Urology Residency, Barnes-Jewish Hospital/Washington University School of Medicine in St. Louis, MO. 2013
  • MD, Indiana University School of Medicine, 2008
  • PhD, Cellular and Integrative Physiology: Indiana University Medical Sciences Program, Bloomington, IN, 2005
  • BS, Biochemistry, Indiana University, Bloomington, IN, 1999

Certifications

  • Pennsylvania Medical License MD449537
  • DEA: FA4049537

Memberships

  • American Association for Cancer Research
  • American Society of Clinical Oncology
  • American Urological Association
  • Society for Urologic Oncology
Research Profile

Research Program

Research Interests

  • Role of PBRM1 loss in clear cell renal carcinoma
  • Molecular correlates to complete response to neoadjuvant chemotherapy in bladder cancer
  • Animal models of bladder cancer using multiplex genome editing

Lab Overview

PBRM1 is the second most commonly mutated gene in clear cell renal cell carcinoma (the most common type of kidney cancer) and was first identified in 2011.  Despite this, little is known about what the role of PBRM1 loss is in kidney cancer.  We are currently exploring changes in chromatin modification that occur after it is lost and identifying potential avenues for personalized treatment strategies in advance cases of kidney cancer.

When patients have muscle-invasive bladder cancer, the standard of care is to be treated with cisplatin-based chemotherapy before surgery to remove the entire bladder. At the time of bladder removal, about 30-40% of patients will not have residual cancer left in their bladder.  Patients and doctors alike wonder if bladder removal is necessary if there is no tumor left.  The answer at this point in time is “yes” because we do not have a way to reliably identify patients who will respond to chemotherapy (prospectively), or patients who actually did respond to chemotherapy (retrospectively).  We are currently using next generation sequencing to prospectively and retrospectively identify responders, with the aim to safely avoid bladder removal in responders in the future.

Lastly, bladder cancer sequencing efforts have revealed a large number of potentially therapeutically tractable targets, but how to target them is still unknown.  These genetic alterations can be modeled in mice using the exciting new genome editing tool CRISPR.  Using this technology, we are making many new bladder cancer models by introducing combinations of mutations into the mouse bladder to try to model the human disease more accurately in mice. This will hopefully allow us to marry individual mutations to therapeutic strategies in anticipation of personalized medicine algorithms in humans.

Lab Staff

Jeremiah Buttram

Scientific Technician

Room: P2119

Rashida Ginwala, PhD

Post Doc

Uttam Satyal

Post Doc

Publications

Selected Publications

Stromyer ML, Southerland MR, Satyal U, Sikder RK, Weader DJ, Baughman JA, Youngs WJ, Abbosh PH, Synthesis, characterization, and biological activity of a triphenylphosphonium-containing imidazolium salt against select bladder cancer cell lines, Eur J Med Chem. 2020 Jan 1;185:111832. doi: 10.1016/j.ejmech.2019.111832. Epub 2019 Oct 31. PubMed

Li Q, Damish AW, Frazier Z, Liu D, Reznichenko E, Kamburov A, Bell A, Zhao H, Jordan EJ, Gao SP, Ma J, Abbosh PH, Bellmunt J, Plimack ER, Lazaro JB, Solit DB, Bajorin D, Rosenberg JE, D'Andrea AD, Riaz N, Van Allen EM, Iyer G, Mouw KW, ERCC2 Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019; 25(3):977-988. NIHMSID: NIHMS1016538 PubMed [journal] PMID: 29980530, PMCID: PMC6434536

Abbosh PH, Plimack ER. Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer. Bladder cancer (Amsterdam, Netherlands). 2018; 4(1):9-18. PubMed [journal] PMID: 29430503, PMCID: PMC5798524

Liu D, Abbosh P, Keliher D, Reardon B, Miao D, Mouw K, Weiner-Taylor A, Wankowicz S, Han G, Teo MY, Cipolla C, Kim J, Iyer G, Al-Ahmadie H, Dulaimi E, Chen DYT, Alpaugh RK, Hoffman-Censits J, Garraway LA, Getz G, Carter SL, Bellmunt J, Plimack ER, Rosenberg JE, Van Allen EM. Mutational patterns in chemotherapy< resistant muscle-invasive bladder cancer. Nature communications. 2017; 8(1):2193. PubMed [journal] PMID: 29259186, PMCID: PMC5736752

Additional Publications

MyNCBI

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