Elizabeth Plimack, MD, MS, FASCO

Elizabeth Plimack MD, MS Professor, Department of Hematology/Oncology

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Clinical Locations

  • Fox Chase Cancer Center
    333 Cottman Avenue
    Philadelphia, PA 19111
    Phone: 888-369-2427

Deputy Director, Fox Chase Cancer Center

Professor, Department of Hematology/Oncology

Specialties

  • Medical Oncology

Areas of Expertise

Kidney Cancer, Urethral Cancer, Bladder Cancer, Ureteral Cancer, Prostate Cancer

Research Program

Distinctions

Treatment Philosophy

With a diagnosis of cancer comes uncertainty and fear for many patients. As a medical oncologist, my first job is to help each patient understand his or her diagnosis. With that understanding, together we can design the best plan of action. At Fox Chase, each patient has the benefit of an interdisciplinary team working together to ensure the highest quality care. This interdisciplinary approach is crucial in determining and implementing the best treatment plan.

I specialize in the treatment of kidney, bladder, prostate and testicular cancer, and my clinical practice is focused on these diseases. By concentrating exclusively on genitourinary malignancies I am able to offer expert knowledge as well as access to both standard treatments and emerging therapies in the form of clinical trials. The pace of scientific discovery has accelerated in recent decades, and fortunately we have seen these discoveries translate into meaningful improvements in cancer treatments.

As part of the genitourinary group here at Fox Chase, I am proud to be a part of a team of distinguished researchers who have pioneered many of these new treatments. My particular research efforts focus on the development of new therapies for bladder and kidney cancer.

Educational Background

  • Chief Fellow, Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX
  • Intern and Resident, Internal Medicine, New York University Medical Center / Bellevue Hospital, NY
  • MS, Patient-Based Biologic Research, University of Texas Graduate School of Biomedical Sciences, 2008
  • MD with Honors in Pathology, New York University School of Medicine, 2002

Certifications

  • American Board of Internal Medicine - Medical Oncology

Memberships

  • National Comprehensive Cancer Network (NCCN)
    • Bladder/Penile Cancers Panel
    • Kidney/Testicular Cancers Panel
    • Prostate Cancer Panel
  • American Society of Clinical Oncology (ASCO)
    • 2015-2018 — ASCO Scientific Committee, Genitourinary (non-prostate)
    • 2016-2017 — Track Chair, ASCO Scientific Committee, Genitourinary (non-prostate)
    • 2020-2024 — Elected Member, ASCO Board of Directors
  • Bladder Cancer Advocacy Network (BCAN)
    • 2013-2019 — BCAN Think Tank Steering Committee
    • 2016-2017 — Co-Chair, 2017 BCAN Think Tank
    • 2017-2018 — Chair, 2018 BCAN Think Tank
    • 2014 — Bladder Cancer Advocacy Network Young Investigator Award Study Section
    • 2015-2018 — Chair, Bladder Cancer Advocacy Network Young Investigator Award Study Section
    • 2018-Present — Bladder Cancer Research Network (BCRN) Management Committee
    • 2020-2023 — Chair, BCAN Scientific Advisory Board
  • Department of Defense (DOD) Congressionally Directed Medical Research Programs (CDMRP) Study Section
    • 2015, 2016, 2017 — Reviewer, Peer Reviewed Cancer Research Program (PRCRP), Kidney Cancer
    • 2020 — Chair, Peer Reviewed Cancer Research Program (PRCRP), Kidney Cancer
    • 2021 — Programmatic Panel Member. Congressionally Directed Medical Research Programs: Kidney Cancer

Honors & Awards

  • Philadelphia Magazine Top Doctors, 2017-2024
  • Best Doctors in America® , 2019-2020, Medical Oncology and Hematology
  • America's Top Doctors®, 2017
  • Leadership Forum Excellence Award, Fox Chase Cancer Center, 2012
  • Humanitas Award, Division of Cancer Medicine Hematology/Oncology Fellowship, MD Anderson Cancer Center, 2008
  • Award for Achievement in Clinical Investigation, Division of Cancer Medicine, MD Anderson Cancer Center, 2008
  • Research Forum, MD Anderson Cancer Center, 2008
  • Honorable Mention, First Annual Hematology/Oncology Fellowship Program, 2008
  • ASCO Foundation Merit Award, ASCO Genitourinary Cancers Symposium, 2008

Research Interests

  • Biomarkers predictive of response to neoadjuvant cisplatin based chemotherapy in bladder cancer
  • Refining neoadjuvant chemotherapy regimens for bladder cancer
  • Developmental Therapeutics – early stage clinical trials of novel agents
  • Immunotherapy in GU Malignancies

Selected Publications

Bilusic M., Girardi D., Zhou Y., Jung K., Pei J., Slifker M., Chen Q., Meerzaman D., Alpaugh K., Young D., Flieder D., Gray P., Plimack E., Molecular profiling of exceptional responders to cancer therapy. Oncologist. 26(3): 186-195, 2021. PMC7930427. https://www.ncbi.nlm.nih.gov/pubmed/33210795.

Powles T., Plimack E.R., Soulières D., Waddell T., Stus V., Gafanov R., Nosov D., Pouliot F., Melichar B., Vynnychenko I., Azevedo S.J., Borchiellini D., McDermott R.S., Bedke J., Tamada S., Yin L., Chen M., Molife L.R., Atkins M.B.,Rini B.I., Pembrolizumab plus axitinib versus sunitinib monotherapy as first-line treatment of advanced renal cell carcinoma (keynote-426): Extended follow-up from a randomised, open-label, phase 3 trial. Lancet Oncol. 21(12): 1563-1573, 2020. https://www.ncbi.nlm.nih.gov/pubmed/33284113.

Vuky J., Balar A.V., Castellano D., O'Donnell P.H., Grivas P., Bellmunt J., Powles T., Bajorin D., Hahn N.M., Savage M.J., Fang X., Godwin J.L., Frenkl T.L., Homet Moreno B., de Wit R., Plimack E.R., Long-term outcomes in keynote-052: Phase ii study investigating first-line pembrolizumab in cisplatin-ineligible patients with locally advanced or metastatic urothelial cancer. J Clin Oncol. 38(23): 2658-2666, 2020. PMC5568632. https://www.ncbi.nlm.nih.gov/pubmed/32552471

Bamias A, Tzannis K, Bamia C, Harshman LC, Crabb S, Plimack ER, Pal S, De Giorgi U, Ladoire S, Theodore C, Agarwal N, Yu EY, Niegisch G, Sternberg CN, Srinivas S, Vaishampayan U, Necchi A, Liontos M, Rosenberg JE, Powles T, Bellmunt J, Galsky MD. The Impact of Cisplatin- or Non-Cisplatin-Containing Chemotherapy on Long-Term and Conditional Survival of Patients with Advanced Urinary Tract Cancer. The oncologist, 2019.

Changa NM, Xie WL, Bilen MA, Dzimitrowicz H, Burkart J, Geynisman DM, Balakrishnan A, Bowman IA, Jain R, Stadler W, Zakharia Y, Narayan V, Beuselinck B, McKay RR, Tripathi A, Pachynski R, Hahn AW, Hsu J, Shah SA, Lam ET, Rose TL, Mega AE, Vogelzang N, Harrison MR, Mortazavi A, Plimack ER, Vaishampayan U, Hammers H, George S, Haas N, Agarwal N, Pal SK, Srinivas S, Carneiro BA, Heng DYC, Bosse D, Choueiri TK, Harshman LC. Cabozantinib in advanced non-clear-cell renal cell carcinoma: a multicentre, retrospective, cohort study. Lancet Oncology, 20(4):581-90, 2019.

Rouvinov K, Plimack ER, Zibelman M, Ghatalia P, Geynisman DM. Update on perioperative systemic therapy for urothelial carcinoma. Clinical advances in hematology & oncology : H&O, 17(3):176-83, 2019.

Voss MH, Bhatt RS, Vogelzang NJ, Fishman M, Alter RS, Rini BI, Beck JT, Joshi M, Hauke R, Atkins MB, Burgess E, Logan TF, Shaffer D, Parikh R, Moazzam N, Zhang X, Glasser C, Sherman ML, Plimack ER. A phase 2, randomized trial evaluating the combination of dalantercept plus axitinib in patients with advanced clear cell renal cell carcinoma. Cancer, 2019.

Amin A, Plimack ER, Ernstoff MS, Lewis LD, Bauer TM, McDermott DF, Carducci M, Kollmannsberger C, Rini BI, Heng DYC, Knox J, Voss MH, Spratlin J, Berghorn E, Yang L, Hammers HJ. Correction to: Safety and efficacy of nivolumab in combination with sunitinib or pazopanib in advanced or metastatic renal cell carcinoma: the CheckMate 016 study. Journal for immunotherapy of cancer, 7(1):73, 2019. PMC6416882

He AR, Cohen RB, Denlinger CS, Sama A, Birnbaum A, Hwang J, Sato T, Lewis N, Mynderse M, Niland M, Giles J, Wallin J, Moser B, Zhang W, Walgren R, Plimack ER. First-in-Human Phase I Study of Merestinib, an Oral Multikinase Inhibitor, in Patients with Advanced Cancer. The oncologist, 2019.

Martinez Chanza N, Xie W, Asim Bilen M, Dzimitrowicz H, Burkart J, Geynisman DM, Balakrishnan A, Bowman IA, Jain R, Stadler W, Zakharia Y, Narayan V, Beuselinck B, McKay RR, Tripathi A, Pachynski R, Hahn AW, Hsu J, Shah SA, Lam ET, Rose TL, Mega AE, Vogelzang N, Harrison MR, Mortazavi A, Plimack ER, Vaishampayan U, Hammers H, George S, Haas N, Agarwal N, Pal SK, Srinivas S, Carneiro BA, Heng DYC, Bosse D, Choueiri TK, Harshman LC. Cabozantinib in advanced non-clear-cell renal cell carcinoma: a multicentre, retrospective, cohort study. The Lancet Oncology, 2019.

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