Shuanzeng Wei, MD, PhD

Shuanzeng (Sam) Wei, MD, PhD
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Associate Professor, Department of Pathology

Medical Director, Clinical Genomics Laboratory


  • Anatomic Pathology
  • Clinical and Laboratory Pathology

Areas of Expertise

Kidney Cancer, Thyroid Cancer, Head & Neck Cancer, Sarcoma, Bladder Cancer, Prostate Cancer


Clinical Locations

  • Fox Chase Cancer Center
    333 Cottman Avenue
    Philadelphia, PA 19111
    Phone: 888-369-2427

Educational Background

  • Fellow, Cytopathology and Surgical pathology, Hospital of the University of Pennsylvania, Philadelphia, PA
  • Resident/Chief resident (AP),  Anatomic Pathology and Clinical Pathology, Hospital of the University of Pennsylvania, Philadelphia, PA
  • Research Fellow, The Johns Hopkins Hospital, Baltimore, MD
  • PhD, Peking Union Medical College, Beijing, China
  • MD, North China University of Science and Technology, Tangshan, China


  • American Board of Pathology - Anatomic Pathology
  • American Board of Pathology - Cytopathology


  • College of American Pathologists 
  • American Society of Clinical Pathology 
  • American Society of Cytopathology
  • United States and Canadian Academy of Pathology

Honors & Awards

  • Philadelphia Magazine Top Doctors, 2024

Research Interests

Translational Research on Genitourinary Pathology, Sarcoma, Head/Neck Pathology and Cytopathology

Travis Ferguson

Travis Ferguson

  • Kidney Cancer

I wasn’t expecting the doctors to tell me I had cancer. It all started in December of 2020 when I had back surgery. Afterward, I started to feel a numbness in my legs. I’d go horseback riding and couldn’t tell if my feet were secure in the stirrups or dangling uselessly in the open air. Horseback riding is a big part of my life, so I had to figure out what was wrong.


Selected Publications

Wei S, Krause HB, Geynisman DM, Elliott A, Kutikov A, Uzzo RG, Pei J, Barata P, Carneiro B, Heath E, Ryan C, Farrell A, Nabhan C, Ali-Fehmi R, Naqash AR, Argani P, McKay RR. Molecular Characterization of TFE3-rearranged Renal Cell Carcinoma, A Comparative Study with Papillary and Clear Cell Renal Cell Carcinomas. Mod Pathol. 2023 Dec 15:100404. doi: 10.1016/j.modpat.2023.100404.

Wei S, Talarchek JN, Huang M, Gong Y, Du F, Ehya H, Flieder DB, Patchefsky AS, Wasik MA, Pei J. Cell Block-Based RNA Next Generation Sequencing for Detection of Gene Fusions in Lung Adenocarcinoma: An Institutional Experience. Cytopathology. 2023;34(1):28-34.

Wei S, Testa JR, Argani P. A review of neoplasms with MITF/MiT family translocations. Histol Histopathol. 2022;37(4):311-321

Wei S, Kutikov A, Patchefsky A, Flieder D, Talarchek J, Al-Saleem T, Dulaimi E, Uzzo R, Testa J, Pei J. Papillary Renal Neoplasm with Reverse Polarity is Often Cystic: Report of Seven Cases and Review of 93 Cases in the Literature. Am J Surg Pathol. 2022;46(3):336-343

Wei S, Pei J, von Mehren M, Abraham JA, Patchefsky AS, Cooper HS. SMARCA2-NR4A3 is a novel fusion gene of extraskeletal myxoid chondrosarcoma identified by RNA next-generation sequencing. Genes, Chromosomes and Cancer. 2021;60(10):709-712.

Pei J, Liu JC, Ehya H, Wei S. BOC-PLAG1, a new fusion gene of pleomorphic adenoma: Identified in a fine needle aspirate by RNA next-generation sequencing. Diagnostic Cytopathology. 2021;49(6):790-2.

Pei J, Flieder DB, Talarchek JN, Cooper HS, Patchefsky AS, Wei S. Clinical Application of Chromosome Microarray Analysis in the Diagnosis of Lipomatous Tumors. Appl Immunohistochem Mol Morphol. 2021;29(8):592-598

Pei J, Al-Saleem T, Uzzo R, Dulaimi E, Testa J, Wei S. Application of Chromosome Microarray Analysis for the Differential Diagnosis of Low grade renal cell carcinoma with clear cell and papillary features. Appl Immunohistochem Mol Morphol. 2020; 28(2):123-129.

Wei S, Veloski C, Sharda P, Ehya H. Performance of Afirma GSC versus GEC: An Institutional Experience. Cancer Cytopathol. 2019; 127(11):720-724.

Pei J, Zhao X, Patchefsky A, Flieder D, Talarchek J, Testa J, Wei S. Clinical Application of RNA Sequencing in Sarcoma Diagnosis: An Institutional Experience. Medicine (Baltimore). 2019; 98(25):e16031. doi: 10.1097/MD.0000000000016031.

Pei J, Flieder D, Patchefsky A, Talarchek J, Cooper H, Testa J, Wei S. Detecting MYB and MYBL1 Fusion Genes in Tracheobronchial Adenoid Cystic Carcinoma by Targeted RNA-Sequencing. Mod Pathol. 2019;32(10):1416-1420.

Huang M, Wei S. Overview of Molecular Testing of Cytology Specimens. Acta Cytol. 2019; 1-11.

Pei S, Cooper H, Flieder D, Talarchek J, Al-Saleem T, Uzzo R, Dulaimi E, Patchefsky A, Testa J, Wei S. NEAT1-TFE3 and KAT6A-TFE3 Renal Cell Carcinomas, New Members of MiT Family Translocation Renal Cell Carcinoma. Mod Pathol. 2019;32(5):710-716

Wei S, Ehya H. Degenerated Keratinized Tumor Cells in Oropharyngeal Human Papilloma Virus-Associated Squamous Cell Carcinoma: A Pitfall in p16 Immunostaining of Fine-Needle Aspiration Specimens. Acta Cytol. 2018; 2:1-7.

Handra-Luca A, Wei S. Intrathyroid cystic thyroglossal duct remnant and ectopic thymus: a fortuitous or development-related association? Surg Today (official journal of the Japan Surgical Society). 2018;48(8):815-818

Wei S, Al-Saleem T. The Pathology and Molecular Genetics of Sarcomatoid Renal Cell Carcinoma: A Mini-Review. J Kidney Cancer VHL. 2017; 22;4(2):19-23.

Wei S, Layfield LJ, LiVolsi VA, Montone KT, Baloch ZW. Reporting of Fine Needle Aspiration (FNA) Specimens of Salivary Gland Lesions: A Comprehensive Review. Diagn Cytopathol. 2017;45(9):820-827.

Wei S, LiVolsi VA, Montone KT, Morrissette JJ, Baloch ZW. Detection of Molecular Alterations in Medullary Thyroid Carcinoma Using Next-Generation Sequencing: an Institutional Experience. Endocr Pathol. 2016;27(4):359-362.

Wei S, Lieberman D, Morrissette JJ, Baloch ZW, Roth DB, McGrath C. Using "residual" FNA rinse and body fluid specimens for next-generation sequencing: An institutional experience. Cancer Cytopathol. 2016;124(5):324-9

Wei S, LiVolsi VA, Montone KT, Morrissette JJ, Baloch ZW. PTEN and TP53 Mutations in Oncocytic Follicular Carcinoma. Endocr Pathol. 2015; 26(4):365-9.

Wei S, LiVolsi VA, Brose MS, Montone KT, Morrissette JJ, Baloch ZW. Somatic STK11 Mutation Identified in Thyroid Carcinoma. Endocr Pathol. 2016; 27(1):65-9.

Wei S, Dumas A, Zhang PD, Cooper K. Palisading and Verocay body-prominent dermatofibrosarcoma protuberans: a case report. Pathol Res Pract. 2016; 212(2):145-7.

Wei S, Baloch ZW, LiVolsi VA. Pathology of Struma Ovarii: a report of 96 cases. Endocr Pathol. 2015;26(4):342-8.

Wei S, Bing Z, Yao Y, Master S, Gupta P. Higher expression of miR-182 in cytology specimen of high grade urothelial carcinoma, a potential diagnostic marker. Acta Cytol. 2015; 59(1):109-12.

Wei S, LiVolsi VA, Baloch ZW. Parathyroid adenoma with frozen section artifact mimics thyroid papillary carcinoma. Endocr Pathol. 2015; 26(2):185-186.

Wei S, LiVolsi VA, Baloch ZW. Pathology of Thyroglossal Duct: an Institutional Experience. Endocr Pathol. 2015;26(1):75-9.

Wei S, Baloch ZW, LiVolsi VA. Parathyroid Adenoma in Patients with Graves' Disease: a Report of 21 Cases. Endocr Pathol. 2015; 26 (1): 71-4.

Wei S, Baloch ZW, LiVolsi VA. Thyroid Carcinoma in Patients with Graves' Disease: an Institutional Experience. Endocr Pathol. 2015; 26 (1): 48-53.

Lee JV, Carrer A, Shah S, Snyder NW, Wei S, Venneti S, Worth AJ, Yuan ZF, Lim HW, Liu S, Jackson E, Aiello NM, Haas NB, Rebbeck TR, Judkins A, Won KJ, Chodosh LA, Garcia BA, Stanger BZ, Feldman MD, Blair IA, Wellen KE. Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation. Cell Metab. 2014; 20(2):306-19.

Hu R, Dunn TA, Wei S, Isharwal S, Veltri RW, Humphreys E, Han M, Partin AW, Vessella RL, Isaacs WB, Bova GS, Luo J. Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Research 2009; 69(1): 16-22.

Wei S, Dunn TA, Isaacs WB, De Marzo AM, Luo J. GOLPH2 and MYO6: Putative Prostate Cancer Markers Localized in the Golgi Apparatus. The Prostate 2008; 68(13): 1387-1395.

Shafee N, Smith CR, Wei S, Kim Y, Mills GB, Hortobagyi GN, Stanbridge EJ, Lee EY. Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors. Cancer Research 2008; 68(9): 3243-3250.

Furuta S, Wang JM, Wei S, Jeng YM, Jiang X, Gu B, Chen PL, Lee EY, Lee WH. Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature. Cancer Cell 2006; 10(1): 13-24.

Additional Publications

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