Gina M. Mantia-Smaldone, MD

Gina Mantia-Smaldone, MD

Clinical Locations

Primary Location

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111

Secondary Location

Fox Chase Cancer Center East Norriton-Hospital Outpatient Center
2701 Dekalb Pike
East Norriton, PA 19401


Assistant Professor, Department of Surgical Oncology

Ovarian and Gynecologic Cancer TRDG Member

Treatment Focus

Minimally invasive surgery (laparoscopy and robotic surgery); endometrial cancer and hyperplasia; cervical cancer and dysplasia; vulvar cancer and dysplasia; vaginal cancer and dysplasia; gestational trophoblastic disease; surgical management of pelvic masses

Research Program

Treatment Philosophy

I am excited to be a part of the gynecologic cancer patient care team at Fox Chase Cancer Center. I chose to work at Fox Chase to provide comprehensive, cutting-edge oncologic care by translating advances in research directly into my clinical practice.

As a gynecologic oncologist, I specialize in the surgical and medical management of tumors of the uterus, cervix, ovary, fallopian tube, vulva and vagina. I have extensive experience with complex open, laparoscopic and robotic surgery, which allows me to tailor a surgical plan based upon a patient’s needs and preferences. I also have expertise in administering intravenous and intraperitoneal chemotherapy for gynecologic malignancies. As a member of the multidisciplinary gynecologic cancer patient care team, I work closely with my colleagues in medical and radiation oncology to develop a comprehensive treatment plan that offers the best chance of cure for each patient.

I appreciate the challenges and commitment necessary to care for cancer patients. I understand that a cancer diagnosis can be overwhelming for patients and their families, and I always treat patients how I would want my family members to be treated: with honesty and compassion. I devote the time necessary to educate my patients on their options so they are best able to make an informed decision about their treatment.

Professionally, my research interests focus on endometriosis-associated ovarian cancer and hereditary ovarian cancer, including those resulting from BRCA1 or 2 mutations. The abundant resources available at Fox Chase, as well as my research experiences during my postdoctoral fellowship at the Magee-Womens Research Institute and as a clinical fellow at the University of Pennsylvania allow for me to participate in translational research and investigate innovative therapies to improve the quality of life for women with gynecologic malignancies.

Education and Training

Educational Background

  • Clinical Fellow, Gynecologic Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, 2010-2013
  • Fellow, Ovarian Cancer Immunology, Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, 2008-2010
  • Resident, Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, 2004-2008
  • MD, State University of New York at Stony Brook School of Medicine, Stony Brook, NY, 2004
  • BA, Biochemistry and Molecular Biology, Boston University, Boston, MA, 2000


  • American Board of Obstetrics and Gynecology – Obstetrics & Gynecology; Gynecologic Oncology


  • American Association for Cancer Research
  • American College of Obstetrics and Gynecology
  • NRG Oncology – Ovarian Cancer Core Committee; New Investigator Committee
  • Society of Gynecologic Oncology, Registry Taskforce Committee
  • Teal Tea Foundation, Advisory Board Member
  • Alpha Omega Alpha

Honors & Awards

  • Main Line Today Top Doctors, 2018-2019
Patient Stories

Diane Smith

Colorectal Cancer

Diane Smith

Colorectal Cancer

Diane Smith was 55 years old when she was diagnosed with colon cancer. After a local gastroenterologist initially diagnosed her with hemorrhoids, she sought a second opinion from a specialist at Fox Chase Cancer Center. Diane underwent a laparoscopic procedure that resulted in no scarring and allowed her to heal faster. After a week in the hospital, she returned home to finish her recovery. "I am now enjoying my time with friends, reading, walking in Pennypack Park, living a healthy lifestyle, and attending church regularly," she said. "I came back from cancer, and I thank God every day for directing me to Fox Chase."

Patti Rose

Breast Cancer

Patti Rose

Breast Cancer

At 36, Patti Rose, a wife and mother to seven children, was shocked to learn she had a rare form of breast cancer. Because her husband works in construction and had done several projects for Fox Chase Cancer Center, they knew right away Fox Chase was the right place for Patti's treatment. At Fox Chase, Patti underwent chemotherapy and radiation therapy, followed by a lumpectomy and additional surgery. The experience was extremely difficult, but Patti credits the staff at Fox Chase for giving her a positive outlook and helping her get through it. Today, she is cancer free and could not be more pleased with the treatment she received. "Fox Chase helped me to be positive. If I didn’t have that connection with doctors and nurses and even the security guard that I would talk to every time I was there, I think I would have felt more afraid," she said. "Knowing all those people were praying for me, thinking of me, and trying to get me through it made me feel like I could overcome it."

Jennifer Gilbert

Cervical Cancer

Jennifer Gilbert

Cervical Cancer

Jennifer Gilbert was 35 years old when she was diagnosed with cervical cancer. She was referred to Fox Chase Cancer Center for treatment, and she soon underwent surgery, and chemotherapy and radiation treatment. An exercise enthusiast, Jennifer started to experience severe swelling in my legs and was diagnosed with lymphedema, and rec eived therapy and underwent plastic and reconstructive surgery at Fox Chase. The surgeries worked, and today she is married with two adopted children. 

Research Profile

Research Program

Research Interests

  • Fertility and gynecologic cancers
  • Endometriosis-related ovarian cancer
  • Hereditary ovarian cancer
  • Immunotherapy and ovarian cancer

Selected Publications

Cripe JC, Handorf E, Brown JL, Woodman S, Rubin SC, Jain A and Mantia-Smaldone GM. National Cancer Database Report of Lymphadenectomy Trends in Endometrial Cancer. Accepted for publication to International Journal of Gynecological Cancer, 3/10/17.

Andersen C, Sikora M, Boisen M, Ma T, Christie A, Tseng G, Park YS, Luthra S, Chandran U, Haluska P, Mantia-Smaldone GM, Odunsi K, McLean K, Lee A, Elishaev E, Edwards RP, and Oesterreich S. Active estrogen receptor-alpha signaling in ovarian cancer models and clinical specimens. Clin Cancer Res. 2017 Jan 10. pii: clincanres.1501.2016. doi: 10.1158/1078-0432.CCR-16-1501. [Epub ahead of print]

 Mirza MR, Monk BJ, Herrstedt J, Oza AM, Mahner S, Redondo A, Fabbro M, Ledermann JA, Lorusso D, Vergote I, Ben-Baruch NE, Marth C, Mądry R, Christensen RD, Berek JS, Dørum A, Tinker AV, du Bois A, González-Martín A, Follana P, Benigno B, Rosenberg P, Gilbert L, Rimel BJ, Buscema J, Balser JP, Agarwal S, Matulonis UA; ENGOT-OV16/NOVA Investigators.Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer. N Engl J Med. 2016 Dec 1;375(22):2154-2164.

  Meyer LA, Cronin AM, Sun CC, Bixel K, Bookman MA, Cristea MC, Griggs JJ, Levenback CF, Burger RA, Mantia-Smaldone G, Matulonis UA, Niland JC, O'Malley DM, Wright AA. Use and Effectiveness of Neoadjuvant Chemotherapy for Treatment of Ovarian Cancer. J Clin Oncol. 2016 Sep 6. pii: JCO681239. [Epub ahead of print]

Esselen KM, Cronin A, Bixel K, Bookman M, Burger RA, Cohn D, Cristea M, Griggs J, Levenback CF, Mantia-Smaldone G, Meyer LA, Matulonis U, Niland J, Sun C, O’Malley DM, Wright A. Use of CA-125 Tests and CT Scans for Surveillance in Ovarian Cancer: Value-based Cancer Care? JAMA Oncol. 2016 Nov 1;2(11):1427-1433. doi: 10.1001/jamaoncol.2016.1842.

Shaikh T, Churilla TM, Mantia-Smaldone GM, Chu C, Rubin SC, Anderson PR.  The role of adjuvant radiation in lymph node positive endometrial adenocarcinoma. Gynecol Oncol. 2016 Jun;141(3):434-9. doi: 10.1016/j.ygyno.2016.04.010.

Churilla T, Egleston B, Dong Y, Shaikh T, Murphy C, Mantia-Smaldone G, Chu C, Rubin S, Anderson P. Disparities in the management and outcome of cervical cancer in the United States according to health insurance status. Gynecol Oncol. 2016 Jun;141(3):516-23. doi: 10.1016/j.ygyno.2016.03.025.

Hall MJ, Obeid EI, Schwartz SC, Mantia-Smaldone G, Forman AD, Daly MB.  Genetic testing for hereditary cancer predisposition: BRCA1/2, Lynch syndrome and beyond. Gynecol Oncol. 2016 Mar;140(3):565-74. doi: 10.1016/j.ygyno.2016.01.019

Wright AA, Cronin A, Milne DE, Bookman MA, Burger RA, Cohn DE, Cristea MC, Griggs JJ, Keating NL, Levenback CF, Mantia-Smaldone G, Matulonis UA, Meyer LA, Niland JC, Weeks JC, O'Malley DM.  Use and Effectiveness of Intraperitoneal Chemotherapy for Treatment of Ovarian Cancer. J Clin Oncol. 2015 Sep 10;33(26):2841-7. doi: 10.1200/JCO.2015.61.4776. Epub 2015 Aug 3.

Higuchi T, Flies DB, Marjon NA, Mantia-Smaldone G, Ronner L, Gimotty PA, Adams SF. CTLA-4 Blockade Synergizes with PARP inhibition in BRCA1-deficient Ovarian cancer. Cancer Immunol Res. 2015 Jul 2. [Epub ahead of print]

Suryawanshi S, Budiu R, Elishaev E, Zhang L, Kim S, Tseng G, Mantia-Smaldone G, Ma T, Donnellan N, Lee T, Mansuria S, Edwards RP, Huang X and Vlad AM. Complement pathway is frequently altered in endometriosis and endometriosis-associated ovarian cancer. Clin Cancer Res. 2014 Dec 1;20(23):6163-74. doi: 10.1158/1078-0432.CCR-14-1338. Epub 2014 Oct 7.

Mantia-Smaldone G, Ronner L, Blair A, Gamerman V, Morse C, Orsulic S, Rubin S, Gimotty P and Adams SF.  The immunomodulatory effects of pegylated liposomal doxorubicin are amplified in BRCA1-deficienct ovarian tumors and can be exploited to improve treatment response in a mouse model.  Gynecol Oncol.  2014 Jun;133(3):584-90. doi: 10.1016/j.ygyno.2014.03.565. Epub 2014 Mar 27.

Mantia-Smaldone G, Bagley LJ, Kasner SE and Chu CS. Vertebral artery dissection and cerebral infarction in a patient with recurrent ovarian cancer receiving bevacizumab. Gynecologic Oncology Case Reports.  Volume 5, August 2013, 37-39.

Chiang CL, Kandalaft L, Tanyi J, Hagemann A, Motz G, Svoronos N, Smith L, Montone K, Mantia-Smaldone G, Nisenbaum H, Torigian D, Levine B, Mick R, Kalos M, Czerniecki B, Powell D, and Coukos G.  A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside.  Clin Cancer Res. 2013 Jul 15 [Epub ahead of print]

Mantia-Smaldone GM and Chu CS.  A Review of Dendritic Cell Therapy for Cancer: Progress and Challenges.  BioDrugs. 2013 Oct;27(5):453-68. doi: 10.1007/s40259-013-0030-9.

Additional Publications




Our Patient Satisfaction Rating is an average of all responses to care provider related questions from our nationally-recognized Press Ganey Patient Satisfaction Survey. Learn more.


4.9 / 5.0


  • 4.8
  • 4.9
  • 5.0
  • 5.0
  • 4.9


  • 5.0
    October 24, 2019
    Dr. Gina Mantia-Smaldone is THE BEST doctor in the world! She's very knowledgeable, supportive, caring, smart, intelligent, a good listener, and gentle when performing internal exams. I thank God or leading me to Fox Chase for my treatment. The ENTIRE staff/team is EXCELLENT and I will always recommend Fox Chase to anyone battling Cancer. From the bottom of my heart I appreciate Dr. Mantia-Smaldone. Thank you!
  • 5.0
    October 17, 2019
    Dr Gina is a savior. Takes time to listen and explain everything. Always professional and pleasant. Very caring.
  • 4.5
    October 13, 2019
    Good very good experience [...]!
  • 5.0
    October 11, 2019
    Outstanding care. Dr. Gina Mantia-Smaldone is young, smart and very compassionate .
  • 5.0
    October 02, 2019
    Wonderful - I'm a nurse, so I had a list of questions. After exam, review & discussion of tests and options there was only one (personal) question I had. Extremely thorough patient and kind. Rate 100%! Wonderful.
  • 5.0
    October 01, 2019
    this doctor listened with care and was very professional and knowledgeable I felt I could trust her
  • 5.0
    August 17, 2019
    I am extremely confident in Dr. Smaldone and her staff. I reside in Florida for most of the year, but Dr. Smaldone is my go-to-doctor for my GYN issues. There is nothing more calming than to have the privilege to see a doctor who has your utmost confidence. Thank you, Dr. Smaldone!
  • 5.0
    August 15, 2019
    love, love Dr Smalldone!! she saved me and care about my whole wellbeing and health! love Fox Chase! [...] I recommend Fox Chase to friends [...] I was lost and scared before I received help here!! couldn't be happier!
  • 4.5
    August 15, 2019
  • 5.0
    August 11, 2019
    Dr. Gina Smaldone is a wonderful and caring provider. I not only feel comfortable with her but also safe.
  • 5.0
    July 24, 2019
    Great service all around !
  • 5.0
    July 23, 2019
    Can't say enough good things about Dr. Smaldone - she's great makes dealing with cancer so much easier.
  • 4.5
    July 19, 2019
    My doctor was kind courteous and took time to listen to my questions. [...]
  • 5.0
    July 19, 2019
    Dr Mantia-Smaldone is excellent!!!
  • 5.0
    July 18, 2019
    Dr. Smaldone and her staff are the very best !
  • 4.0
    July 18, 2019
    Dr. Gina Mantia Smaldone is an excellent Physician. She has made me feel confident about my health issue and I would not go to anyone but Dr. Gina Mantia Smaldone. I would recommend her to friends and family. I would also like to extend my thanks to Fox Chase Cancer for being a top notch institution. I trust them completely.
  • 4.5
    July 18, 2019
    Dr. Mantia-Smaldone always makes me feel special.
  • 5.0
    June 30, 2019
    Always an excellent experience with this provider... kind, genuine, knowledgeable and caring
  • 5.0
    June 25, 2019
    dr mantia smaldone is a wonderful, compassionate and highly skilled doctor
  • 5.0
    June 25, 2019

Connect with Fox Chase