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Stephanie Greco, MD

Stephanie Greco, MD

Clinical Locations

Primary Location

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111

About

Assistant Professor, Department of Surgical Oncology

Treatment Focus

Gastrointestinal cancers (stomach, esophagus, small intestine, colorectal),
melanoma and skin/soft tissue tumors (sarcoma)

Treatment Philosophy

I am very excited to join the department of surgical oncology at Fox Chase Cancer Center. 

Growing up in the NY/NJ/PA area, I completed my general surgery training at NYU/Bellevue Hospital where I had exposure to a wide range of cancer pathology in a diverse and complex patient population.  I also completed a two-year research fellowship where I studied the immune mechanisms of pancreatic and liver carcinogenesis and developed an interest in translating basic science into clinical practice.

I then went on to complete my surgical oncology fellowship at Rutgers Cancer Institute of New Jersey, the state’s only NCI-designated cancer center. I have had extensive training in both open and minimally invasive techniques for a wide variety of gastrointestinal and hepatobiliary cancers, peritoneal surface malignancies, and skin/soft tissues tumors.  My clinical research focuses on understanding the biology of cancer metastasis and dormancy and the use of biomarkers for clinical trial development.

It is truly a privilege to take care of cancer patients. As a former competitive swimmer, I greatly enjoy and understand the importance of a multidisciplinary team approach to oncology treatment. I strive to develop personalized treatment plans for my patients and take pride in being a strong patient advocate, good listener, and effective communicator.  I am thrilled to be part of the Fox Chase team!

Education and Training

Educational Background

  • Fellow, Complex General Surgical Oncology, Rutgers Cancer Institute of New Jersey, Division of Surgical Oncology, New Brunswick, NJ, 2017-19
  • General Surgery Residency, New York University School of Medicine, Department of Surgery, New York Langone Medical Center, Bellevue Hospital, Manhattan VA Hospital, New York, NY, 2010-17 
  • Postdoctoral Research Fellow, S. Arthur Localio Laboratory, New York University School of Medicine, Department of Surgery, 2012-14
  • MD, Rutgers, Robert Wood Johnson Medical School (formerly UMDNJ), Piscataway, NJ, 2010
  • BA Classic-Latin, Harvard University, Cambridge, MA, 2005

Certifications

  • American Board of Surgery

Memberships

  • Association for Academic Surgery
  • Association of Women Surgeons
  • Society of Surgical Oncology
  • American College of Surgeons
  • Society for Surgery of the Alimentary Tract

Honors & Awards

  • NYU Resident Research Award, 2017
  • Americas Hepato-Pancreato-Biliary Association (AHPBA)- Research Award – ($30,000 grant for Physiology/Biology), 2013
  • Summer Research Fellowship, Robert Wood Johnson Medical School, 2006
  • Cum laude Classics Graduate, Harvard University, 2005
Publications

Selected Publications

Hasan OB, Greco SH, Kennedy T, Carpizo D, Kempf J, Nosher JL. Aberrant Arc Between the Common Hepatic Artery and a Replaced Right Hepatic Artery Resulting in Misperfusion in a Patient with a Hepatic Arterial Infusion Pump. Surgical and Radiologic Anatomy (accepted).

Greco SH, Torres-Hernandez A, Kalabin A, Whiteman C, Rokosh R, Ravirala S, Ochi A, Gutierrez J, Salyana MA, Mani VR, Nagaraj SV, Deutsch M, Seifert L, Daley D, Barilla R, Hundeyin M, Nikifrov Y, Tejada K, Gelb BE, Katz SC, Miller G. Mincle Signaling Promotes Con A Hepatitis. J Immunol. 2016 Oct 1;197(7):2816-2.

Seifert L, Werba G, Tiwari S, Giao Ly NN, Alothman S, Alqunaibit D, Avanzi A, Barilla R, Daley D, Greco SH, Torres-Hernandez A, Pergamo M, Ochi A, Zambirinis CP, Pansari M, Rendon M, Tippens D, Hundeyin M, Mani VR, Hajdu C, Engle D, Miller G. The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. Nature. 2016 Apr 14;532(7598):245-9.

Greco SH, Mahmood SK, Vahle AK, Ochi A, Batel J, Deutsch M, Barilla R, Seifert L, Pachter HL, Daley D, Torres-Hernandez A, Hundeyin M, Mani VR, Miller G. Mincle suppresses Toll-like receptor 4 activation. J Leukoc Biol. 2016 Jul;100(1):185-94.

Siefert L, Deutsch M, Alothman S, Alqunaibit D, Werba G, Pansari M, Pergamo M, Ochi A, Torres-Hernandez A, Levie E, Tippens D, Greco SH, Tiwari S, Giao Ly NN, Eisenthal A, Van Heerden E, Avanzi A, Barilla R, Zambirinis CP, Rendon M, Daley D, Pachter HL, Hajdu C, Miller G. Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways. Cell Reports. 2015 Dec 1;13(9):1909-21.

Zambirinis CP, Levie E, Nguy S, Avanzi A, Barilla R, Xu Y, Siefert L, Daley D, Greco SH, Deutsch M, Jonnadula S, Torres-Hernandez A, Tippens D, Pushalkar S, Eisenthal A, Saxena D, Ahn J, Hajdu C, Engle DD, Tuveson D, Miller G. TLR9 Ligation in Pancreatic Stellate Cells Promotes Tumorigenesis. Journal of Experimental Medicine. 2015 Nov 16;212(12):2077-94.

Greco SH*, Tomkötter L*, Vahle A-K*, et al: TGF-β Blockade Reduces Mortality and Metabolic Changes in a Validated Murine Model of Pancreatic Cancer Cachexia. PLoS ONE. 2015 Jul 14;10(7):e0132786.

Deutsch M, Graffeo CS, Rokosh R, Pansari M, Ochi A, Levie EM, Van Heerden E, Tippens DM, Greco S, Barilla R, Tomkötter L, Zambirinis CP, Avanzi N, Gulati R, Pachter HL, Torres-Hernandez A, Eisenthal A, Daley D, Miller G. Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury. Cell death and disease 015 May 7;6:e1759.

Rao R, Graffeo CS, Gulati R, Jamal M, Narayan S, Zambirinis CP, Barilla R, Deutsch M, Greco SH, Ochi A, Tomkötter L, Blobstein R, Avanzi A, Tippens DM, Gelbstein Y, Van Heerden E, Miller G. Interleukin 17-Producing gammadelta T Cells Promote Hepatic Regeneration in Mice. Gastroenterology. 2014 Aug;147(2):473-84.

Rehman A, Hemmert KC, Ochi A, Jamal M, Henning JR, Barilla R, Quesada JP, Zambirinis CP, Tang K, Ego-Osuala M, Rao RS, Greco S, Deutsch M, Narayan S, Pachter HL, Graffeo CS, Acehan D, Miller G. Greco S, Ego-Osuala M, Bin-Saeed U, Rao RS, Badar S, Quesada JP, Acehan D, Miller G.  Role of Fatty-acid Synthesis in Dendritic Cell Generation and Function. J Immunol. 2013 May 1;190(9):4640-9.

Henning JR, Graffeo CS, Rehman A, Fallon NC, Zambirinis CP, Ochi A, Barilla R, Jamal M, Deutsch M, Greco S, Ego-Osuala M, Bin-Saeed U, Rao RS, Badar S, Quesada JP, Acehan D, Miller G. Dendritic cells limit fibro-inflammatory injury in NASH. Hepatology. 2013 Aug;58(2):589-602.

Zambirinis P, Ochi A, Barilla R, Greco S, Deutsch M, Miller G. Induction of TRIF- or MYD88-dependent pathways perturbs cell cycle regulation in pancreatic cancer. Cell Cycle. 2013 Apr 15;12(8):1153-4.

Ochi A, Graffeo CS, Zambirinis CP, Rehman A, Hackman M, Fallon N, Barilla RM, Henning JR, Jamal M, Rao R, Greco S, Deutsch M, Medina-Zea MV, Bin Saeed U, Ego-Osuala MO, Hajdu C, Miller G. Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans. J Clin Invest 2012 Nov;122(11):4118-29.

Greco SH, Nellans K, Levine WN: Lateral epicondylitis – Open vs arthroscopic. Op Tech Orthop 2009 Oct; 19(4): 228–234.

Additional Publications

Stephanie Heaton Greco on PubMed

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