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Camille Ragin, PhD, MPH

Camille Ragin, PhD, MPH
About

Associate Professor

Head and Neck Cancer TRDG Member

Research Program

HPV genomes integrated in chromosomes from head and neck and cervical tumors
Prostate cancer risk among African American men
Distribution of African-derived-single nucleotide polymorphisms (AD-SNPs) on genes involved in tobacco metabolism. The genes are shown on chromosome (outer circle). The distribution of AD-SNPs on chromosomes are shown by line graph and heatmap.
Map of participants enrolled in the CAP 3 study
Education and Training

Educational Background

  • MPH, Epidemiology, University of Pittsburgh, PA
  • PhD, Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA
  • BS, Medical Laboratory Sciences, Hunter College, New York, NY

Memberships

  • Member, External Advisory Committee, NCI P20 grant, Florida Minority Cancer Research & Training Center, University of Florida 2014-present
  • Member, African Organization for Research and Training in Cancer 2012 – Present
  • Member, Lung Cancer Working Group, Fox Chase Cancer Center 2012-present
  • Scientific Advisory Board Member - Hampton University Skin of Color Research Institute 2009 - 2011
  • Delta Omega Honorary Society in Public Health, Omicron Chapter 2008 – Present
  • Member, Women in Cancer Research (AACR) 2004 – Present
  • Member, Minorities in Cancer Research (AACR) 2004 – Present
  • Member, American Association for Cancer Research 2002 – Present

Honors & Awards

  • International Community Service Award, TJB - Philadelphia, PA 2015
  • My Sisters’ Health Watch Distinguished Stakeholder, Permanent Mission of Grenada to the United Nations 2015
  • Citation, City Council of Philadelphia, for the African Caribbean Cancer Consortium contribution and commitment to community engagement and uniting families in the Philadelphia African Diaspora 2015
  • Certificate of Appreciation, FunTimes Magazine, in recognition of invaluable contribution of cancer health communications focused on the African Diaspora, Philadelphia, PA 2013
  • Citation, City Council of Philadelphia, 2012 Echoes of Africa Community Service Award 2012
  • Honorary Citation, Commonwealth of Pennsylvania Legislative Black Caucus, for the International Conference of the African-Caribbean Cancer Consortium 2012
  • Third Annual Charles Gordon Henry Award, in appreciation of dedicated work in Cancer Research, Dec. 2012, Barbados Society of Pennsylvania, Inc. 2012
  • University of Pittsburgh & Jackson State University Research Career Development Institute in Minority Health and Health Disparities Scholar 2005
  • Keleti Prize for Excellence in Environmental Health (University of Pittsburgh, GSPH) 2005
  • Edward A. Smuckler Memorial Workshop Scholar: Pathobiology of Cancer (AACR), Aspen, CO. 2004
Research Profile

Research Program

Research Interests

 Molecular Epidemiology of Cancer in the African Diaspora

  •   Genomic basis for cancer risks and outcomes.
  •   Cancer Prevention Project of Philadelphia (CAP3) - multicultural community-based cohort of healthy participants.
  •   African Caribbean Cancer Consortium (AC3) - a global effort to access cancer burden in the African Diaspora.

Lab Overview

Racial disparities in head and neck squamous cell carcinoma

Squamous cell carcinoma of the head and neck refers to a variety of malignant tumors arising from the oral cavity and upper aerodigestive tract. The primary risk factors for head and neck cancer are tobacco and alcohol use, and more recently HPV has been defined as an independent risk factor for oropharyngeal tumors. Racial disparities among patients with head and neck squamous cell carcinoma (HNSCC) have remained unchanged for more than three decades. Persons of African ancestry have a higher incidence compared to persons of European ancestry. Notably, Black patients consistently have lower five-year survival rates as compared to White patients. Although studies of racial disparities in HNSCC have been conducted, many suggest that the observed differences may be related to barriers to care and screening; but we have shown that the differences may be independent of these factors. After matching on age and smoking-dose (pack-years) and adjusting for socioeconomic and insurance status, any tobacco and alcohol use, any family history of cancer, gender, and age, we observed that Black oral cavity cancer patients were more likely than Whites to be diagnosed with advanced-stage disease (AdjOR = 3.60, 0.97–13.41). Similarly, Black larynx cancer patients were more likely than Whites to be diagnosed with positive lymph nodes (AdjOR = 2.26, 0.92–5.61) and Black patients were more likely than White patients to develop second primaries, recurrences or metastasis (AdjHR = 1.47, 0.99-2.18). We believe that genetic and environmental risk factors and their interaction may contribute to the higher incidence of head and neck cancer in Black Americans. We are currently evaluating the interactions of tobacco/alcohol exposure and genetic variations in genes involved in these metabolic pathways in order to understand how these interactions contribute to the differences in cancer risk and outcome between Black and White populations.

Cancer Prevention Project of Philadelphia (CAP3 Study)

Through our community engagement efforts we have developed a successful model for population-based health disparities research studies. We provide the community not only with information about the importance of incorporating cancer prevention practice and screening into their lifestyle but we also provide community members with a better understanding of the importance of cancer disparities research and the value of participating in research studies. This approach over the years has led to an overwhelming acceptance, thus providing us with the ability to successfully recruit study participants of African Ancestry. This model involving community engagement and research recruitment has been successfully adapted in the Caribbean, the “Tobago Cervical and Oral Cancer Research Study”, as well as the US Philadelphia metropolitan area, the “Cancer Prevention Project of Philadelphia (CAP3)”. The CAP3 study is research registry of cancer-free participants and serves as a pipeline project for our population-based molecular epidemiology research studies. To date there are more than 750 participants of African Ancestry enrolled and recruitment is ongoing. To learn more please call Dr. Camille Ragin at 215-728-1148.

African Caribbean Cancer Consortium (AC3)

The AC3 is a multi-institutional collaborative network that focuses on studies of cancer risk and outcomes among populations of African ancestry (African-American, African and Caribbean). AC3 is a broad-based resource for education, training and research on etiology, screening, prevention, treatment and survivorship related to cancer in populations of African Descent. Our overarching goals are: a) To build knowledge, capacity and infrastructure b) To advance the science of cancer prevention and control in populations of African ancestry. Recognizing the public health significance of cancer in populations of African origin, and socio-cultural factors that influence disparities in health outcomes, we have provided a platform in the AC3 to report country-level findings and we have also fostered collaborative research to examine genetic and environmental contributions in carcinogenesis among populations of African origin. Our working groups focus on investigating gene x environment interactions. Since 2009, AC3 members have conducted studies of biomarkers of susceptibility to and outcomes from prostate cancer among men of African ancestry; cervical human papillomavirus (HPV) infections in Black women from the US, Jamaica, Tobago, Barbados, Guadeloupe and the Bahamas and assessments of knowledge, perception and attitudes of HPV and the HPV vaccine in the US, and Bahamas and many others. AC3 has conducted community education and research information sessions to the community since its conception in 2006. In addition, research skills training sessions during our AC3 meetings has contributed to developing and strengthening of population-based cancer research and cancer registration in the Caribbean to facilitate stronger collaborative research studies. We also provide research training opportunities in our CORE laboratory here at Fox Chase Cancer Center to undergraduate and graduate students where they learn molecular biology techniques, epidemiology study designs and applications. Additional information can be found at www.ac3online.org

Gene x environment interactions and prostate cancer risk in Black men

It is well documented that there is a disproportionate burden of prostate cancer among not only African-American men but also Black men from other parts of the world. Furthermore, the prostate cancer death rate among African-American males is higher than US males of European descent, and higher death rates have been reported in other populations of African descent in the Caribbean islands and Africa. Our recent study of GSTM1 polymorphisms and prostate cancer risk offers a classic example of gene x environment interactions. Studies in populations of European descent have demonstrated that a genetic variation in the GSTM1 gene resulting in a deletion is associated with an increased risk of prostate cancer among smokers and this risk increases with smoking dose. Therefore, we conducted a multi-national analysis of prostate cancer risk to evaluate the association of GSTM1 deletion among Black men and found that GSTM1 genotype modifies the effect of tobacco exposure on prostate cancer risk for African-American men but not for Black Caribbean men. Our findings suggest that other environmental factors unique to Caribbean men may contribute to prostate cancer risk. We are currently developing additional studies to further investigate gene-environment interactions and prostate cancer risk among Black men.igate gene-environment interactions and prostate cancer risk among Black men.
Lab Staff

Meganathan P. Ramakodi, PhD

Postdoctoral Associate

Room: Young Pavilion, P3046
215-728-2175

Elizabeth Blackman, MPH

Research Specialist

Room: Young Pavilion, P2039
215-214-1417

Denise Yvette Gibbs, BS

Biology, Scientific Technician II

Room: Young Pavilion, P2123,
215-728-7410

Additional Staff

Bhawna Dubey, PhD, Research Associate Volunteer, Bhawna.Dubey@fccc.edu

Christopher Nyenpan, Student Volunteer Intern, tud31569@temple.edu

 

Former Staff Member
 

Helina Tadesse, BSc

Publications

Selected Publications

Oliver JS, Allen RS, Eichorst MK, Mieskowski L, Ewell PJ, Payne-Foster P, Ragin C. A pilot study of prostate cancer knowledge among African American men and their health care advocates: implications for screening decisions. Cancer causes & control : CCC, 29(7):699-706, 2018. PubMed

CC Ragin, S Langevin, S Rubin, E Taioli: Review of studies on metabolic genes and cancer in populations of African descent.  Genet Med. 2010 Jan; 12(1):12-8.  PubMed

CC Ragin, SM Langevin, M Marzouk, J Grandis, E Taioli: Determinants of head and neck cancer survival by race. Head Neck 2011 Aug; 33(8):1092-8.  PubMed

E Taioli, RE Flores-Obando, I Agalliu, P Blanchet, CH Bunker, RE Ferrell, M Jackson, LC Kidd, S Kolb, NA Lavender, N McFarlane-Anderson, SS Morrison, L Multigner, L. Ostrande, JY Park, AL Patrick, TR Rebbeck, M Romana, JL Stanford, F Ukoli, TT Vancleave, CM Zeigler-Johnson, B. Mutetwa, C Ragin: Multi-institutional prostate cancer study of genetic susceptibility in populations of African descent.  Carcinogenesis 2011 Sept; 32(9):1361-5.  PubMed

CCR Ragin, JC Liu:  Epidemiology of HPV in head and neck cancer: variant strains, discrete protein function.  In Molecular Determinants in Head and Neck Cancer.  B. Burtness, E. Golemis (eds.), Springer: New York, p. 23, 2013.   PubMed

C Ragin, M Obikoya-Malomo, S Kim, Z Chen, R Flores-Obando, D Gibbs, C Koriyama, F Aguayo, J Koshiol, NE Caporaso, GE Carpagnano, M Ciotti, H Dosaka-Akita, M Fukayama, A Goto, DA Spandidos, V Gorgoulis, DAM Heideman, RAA van Boerdonk, K Hiroshima, R Iwakawa, NG Kastrinakis, I Kinoshita, S Akiba, MT Landi, HE Liu, J-L Wang, R Mehra, FR Khuri, W-T Lim, TK Owonikoko, S Ramalingam, E Sarchianaki, K Syrjanen, M-S Tsao, J Sykes, SW Hee, J Yokota, A Zaravinos, E Taioli: HPV-associated lung cancers: an international pooled analysis.  Carcinogenesis 2014 February; 35:1267-1275.   PubMed

E Blackman, J Campbell, C Bowen, E Delmoor, G Jean-Louis, R Noumbissi, Y O’Garro, O Richards-Waritay, S Straughter, V Tolbert, B Wilson, C Ragin: The 4th Annual International African-Caribbean Cancer Consortium Conference: Building Capacity to Address Cancer Health Disparities in Populations of African Descent.  Infect Agent Cancer 2014; 9:35    PubMed

JC Liu, S Parajuli, E Blackman, D Gibbs, A Ellis, A Hull, JR Beck, V Giri, P Ihejirika, J Khurana, C Ragin.  High Prevalence of Discordant HPV and p16 Oropharynx Squamous Cell Carcinomas in an African American Cohort. Head and Neck 2015 May 12 (epub ahead of print).   PubMed

Additional Publications

My NCBI

This Fox Chase professor participates in the Undergraduate Summer Research Fellowship
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