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Shannon Lynch, PhD, MPH
About
Assistant Professor
Research Program
Treatment Philosophy
I’m your “neighborhood researcher” in many ways. I grew up in the Fox Chase area, and my research focuses on understanding how biomarkers and social factors, including neighborhood circumstances, act together to affect cancer. Born and raised in Philadelphia, I feel privileged that I get the opportunity to help those in my community fight cancer as part of my every day. I am grateful to all of the patients and families who participate in research programs at Fox Chase. You are making a difference. Thank you for your commitment. It’s so nice to be home.
Education and Training
Educational Background
- PhD, Epidemiology, University of Pennsylvania, Philadelphia, PA, 2015
- MPH, Environ. Health, The George Washington University, Washington, DC, 2005
- Marymount University, Arlington, VA, 2003
Memberships
- American Association of Cancer Research (AACR)
Research Profile
Research Program
Research Interests
Multilevel studies of cancer focused on identifying factors at the macro-environmental, individual, and biologic levels that relate to cancer risk and prognosis.
- Integrating large-scale, multilevel social and biologic data
- Empirical methods development to study risk factors within/across multiple levels
- Improving cancer risk prediction models
Currently conducting parallel studies of biologic and social factors implicated in cancer, specifically:
- Reducing prostate cancer health disparities through the study of neighborhood circumstances, race/ethnicity, and biomarkers of dual relevance to social factors and cancer, for instance, telomere length.
- Identifying potential early detection and prognostic markers in pancreatic cancer using blood and tissue samples.
Publications
Selected Publications
Multilevel Studies
Lynch SM, Mitra N, Ravichandran K, Branas C, Spangler E, Zhou W, Peek MK, Gehlert S, Paskett ED, Riethman H, Rebbeck TR. Telomere Length and Neighborhood: Evaluating Biologic Response to Unfavorable Exposures. Cancer Epidemiology Biomarkers Prevention. 2017. PubMed
Lynch SM and Rebbeck TR. Bridging the Gap Between Biological, Individual, and Macro-Environmental Factors in Cancer: A Multilevel Approach. Cancer Epidemiology Biomarkers and Prevention. 2013. Apr; 22(4):485-495. PubMed
Lynch SM, Peek, MK, Mitra N, Ravichandran K, Branas C, Spangler E, Zhou W, Gehlert S, Paskett ED, Rebbeck TR, Riethman H. Race, Ethnicity, Psychosocial Factors and Telomere Length in a Multicenter Setting. 2015. PlosOne. In Press. PubMed
Lynch SM, Moore JM. A Call for Biological Data Mining Approaches in Epidemiology. BioData Mining. In Press. PubMed
Neighborhood-level studies :
Lynch SM, Mitra N, Ross M, Dailey K, Jackson TJ, Zeigler-Johnson CZ, Branas C, Riethman H, Rebbeck TR. A Neighborhood Wide-Association Study(NWAS): Identification of Neighborhood Signatures in Prostate Cancer Aggressiveness. PLOS One. 2017
Individual-level Studies
Sturgeon KM, Dean LT, Heroux M, Kane J, Bauer T, Palmer E, Long J, Lynch SM, et al. J Cancer Surviv (2016) 11: 246. doi:10.1007/s11764-016-0582-z. PMID: 27873046.
Lynch SM, Stricker CT, Filseth S, Brown JB, Berardi J, Branas A, Schmitz KH, Sarwer D. Evaluation of a Web-based Weight Loss Program in Young Cancer Survivors. Obesity Science & Practice. 2017.
Michaud DS, Vrieling A, Jiao L, Mendelsohn J, Steplowski E, Lynch SM, Wactawski-Wende J, Stolzenberg-Solomon RZ, and other PanScan coauthors. Alcohol Intake and Pancreatic Cancer: A Pooled Analysis from the Pancreatic Cancer Cohort Consortium (PanScan). Cancer Causes Control. 2010. PubMed
Jacobs EJ, Chanock SJ, Fuchs CS, LaCroix A, McWilliams RR, Steplowski E, Stolzenberg-Solomon RZ, Arslan AA , Bueno-de-Mesquita H.B., Gross M, Helzlsouer K, Petersen G, Zheng W, Agalliu I, Allen NE, Amundadottir L, Boutron-Ruault MC, Buring JE, Canzian F, Clipp S, Dorronsoro M, Gaziano JM, Giovannucci EL, Hankinson SE, Hartge P, Hoover RN, Hunter DJ, Jacobs K, Jenab M, Kraft P, Kooperberg C, Lynch SM, et al. Family History of Cancer and Risk of Pancreatic Cancer: A Pooled Analysis from the Pancreatic Cancer Cohort Consortium (PanScan). International Journal of Cancer. Jan. 4. 2010. PubMed
Arslan AA, Helzlsouer KJ, Kooperberg C, Patel AV, Shu X, Steplowski E, Tobias GS, Lynch SM, et al. Anthropometry, Body Mass Index and Pancreatic Cancer: a Pooled Analysis from the Pancreatic Cancer Cohort Consortium (PanScan). Archives of Internal Medicine Arch Intern Med. 2010 May 10;170(9):791-802. PubMed
Lynch SM, Vrieling A, Lubin JH, Kraft P, Mendelsohn J, Hartge P, Canzian F, Steplowski E, Bueno-de-Mesquita HB, Stolzenberg-Solomon RZ, and the PANSCAN consortium. Cigarette Smoking and Pancreatic Cancer: A Pooled Analysis from the Pancreatic Cancer Cohort Consortium (PanScan). Am J Epidemiol. 2009. Aug 15;170(4):403-13. Epub 2009 Jun 26. PubMed
Lynch SM, Mahajan R, Blair A, Alavanja M. Cancer Incidence Among Pesticide Applicators Exposed to Butylate in the Agricultural Health Study. Environmental Research. 2009. Jul 15. [Epub ahead of print]. PubMed
Lynch SM, Rusiecki JA, Blair A, Dosemeci M, Lubin J, Sandler D, Hoppin JA, Lynch CF, and Alavanja M. 2006. Cancer Incidence among Pesticide Applicators Exposed to Cyanazine in the Agricultural Health Study. Environ Health Perspect. 2006. PubMed
Biologic Level Studies
Hofmann JN, Hutchinson AA, Cawthon R, Liu CS, Lynch SM, Lan Q, Rothman N, Stolzenberg-Solomon R, Purdue MP. Telomere Length Varies by DNA Extraction Method: Implications for Epidemiologic Research-letter. Cancer Epidemiol Biomarkers Prev. 2014 Jun; 23(6):1129-30. PubMed
Lynch SM, Weinstein S, Lan Q, Rothman N, Albanes D, Stolzenberg-Solomon RZ. Telomere Length and Risk of Pancreatic Cancer in the Alpha-Tocopherol Beta-Carotene (ATBC) Trial and the Prostate, Lung, Colorectal and Ovarian screening trial. Int J of Cancer. 2013 May 15. PubMed
Lynch SM, Weinstein S, Lan Q, Rothman N, Albanes D, Stolzenberg-Solomon RZ. Mitochondrial DNA Copy Number and Risk of Pancreatic Cancer in the Alpha-Tocopherol Beta-Carotene (ATBC) Trial. Cancer Prevention Research. Sept. 2011 [epub ahead of print]. PubMed
Wolpin BM, Kraft P, Gross M, Helzlsouer K, Bueno-de-Mesquita HB, Steplowski E, Stolzenberg-Solomon RZ, Arslan AA, Jacobs EJ, Lacroix A, Petersen G, Zheng W, Albanes D, Allen NE, Amundadottir L, Anderson G, Boutron-Ruault MC, Buring JE, Canzian F, Chanock SJ, Clipp S, Gaziano JM, Giovannucci EL, Hallmans G, Hankinson SE, Hoover RN, Hunter DJ, Hutchinson A, Jacobs K, Kooperberg C, Lynch SM, et al. Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium. Cancer Res. 2010 Feb 1;70(3):1015-23. Epub 2010 Jan 26. PubMed
Petersen GM, Amundadottir L, Fuchs CS, Kraft P, Stolzenberg-Solomon RZ, Jacobs KB, Arslan AA, Bueno-de-Mesquita HB, Gallinger S, Gross M, Helzlsouer K, Holly EA, Jacobs EJ, Klein AP, Lacroix A, Li D, Mandelson MT, Olson SH, Risch HA, Zheng W, Albanes D, Bamlet WR, Berg CD, Boutron-Ruault MC, Buring JE, Bracci PM, Canzian F, Clipp S, Cotterchio M, de Andrade M, Duell EJ, Gaziano JM, Giovannucci EL, Goggins M, Hallmans G, Hankinson SE, Hassan M, Howard B, Hunter DJ, Hutchinson A, Jenab M, Kaaks R, Kooperberg C, Krogh V, Kurtz RC, Lynch SM, et al. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet. 2010 Jan 24. [Epub ahead of print] PubMed
Amundadottir L, Kraft P, Stolzenberg-Solomon R, Fuchs C, Petersen G, Arslan A, Bueno-de-Mesquita B, Gross M, Helzlsouer K, Jacobs E, LaCroix A, Zheng W, Albanes D, Buring J, Canzian F, Colditz G, Gaziano M, Hankinson S, Hayes R, van Houwelingen HC, Jacobs K, Kooperberg C, Lynch SM, Mendelsohn J, Prentice R, Riboli E, et al. Genome-Wide Association Study Identifies ABO Blood Group Susceptibility Variants for Pancreatic Cancer. Nature Genetics. 2009. Sep;41(9):986-90. Epub 2009 Aug 2. PubMed
Contact Information
Shannon.Lynch@fccc.edu
Office Phone 215-728-5377
Office: P4159
Assistant Professor
Research Program
Treatment Philosophy
I’m your “neighborhood researcher” in many ways. I grew up in the Fox Chase area, and my research focuses on understanding how biomarkers and social factors, including neighborhood circumstances, act together to affect cancer. Born and raised in Philadelphia, I feel privileged that I get the opportunity to help those in my community fight cancer as part of my every day. I am grateful to all of the patients and families who participate in research programs at Fox Chase. You are making a difference. Thank you for your commitment. It’s so nice to be home.
Education
Educational Background
- PhD, Epidemiology, University of Pennsylvania, Philadelphia, PA, 2015
- MPH, Environ. Health, The George Washington University, Washington, DC, 2005
- Marymount University, Arlington, VA, 2003
Memberships
- American Association of Cancer Research (AACR)
Research Profile
Research Interests
Multilevel studies of cancer focused on identifying factors at the macro-environmental, individual, and biologic levels that relate to cancer risk and prognosis.
- Integrating large-scale, multilevel social and biologic data
- Empirical methods development to study risk factors within/across multiple levels
- Improving cancer risk prediction models
Currently conducting parallel studies of biologic and social factors implicated in cancer, specifically:
- Reducing prostate cancer health disparities through the study of neighborhood circumstances, race/ethnicity, and biomarkers of dual relevance to social factors and cancer, for instance, telomere length.
- Identifying potential early detection and prognostic markers in pancreatic cancer using blood and tissue samples.
Publications
Selected Publications
Multilevel Studies
Lynch SM, Mitra N, Ravichandran K, Branas C, Spangler E, Zhou W, Peek MK, Gehlert S, Paskett ED, Riethman H, Rebbeck TR. Telomere Length and Neighborhood: Evaluating Biologic Response to Unfavorable Exposures. Cancer Epidemiology Biomarkers Prevention. 2017. PubMed
Lynch SM and Rebbeck TR. Bridging the Gap Between Biological, Individual, and Macro-Environmental Factors in Cancer: A Multilevel Approach. Cancer Epidemiology Biomarkers and Prevention. 2013. Apr; 22(4):485-495. PubMed
Lynch SM, Peek, MK, Mitra N, Ravichandran K, Branas C, Spangler E, Zhou W, Gehlert S, Paskett ED, Rebbeck TR, Riethman H. Race, Ethnicity, Psychosocial Factors and Telomere Length in a Multicenter Setting. 2015. PlosOne. In Press. PubMed
Lynch SM, Moore JM. A Call for Biological Data Mining Approaches in Epidemiology. BioData Mining. In Press. PubMed
Neighborhood-level studies :
Lynch SM, Mitra N, Ross M, Dailey K, Jackson TJ, Zeigler-Johnson CZ, Branas C, Riethman H, Rebbeck TR. A Neighborhood Wide-Association Study(NWAS): Identification of Neighborhood Signatures in Prostate Cancer Aggressiveness. PLOS One. 2017
Individual-level Studies
Sturgeon KM, Dean LT, Heroux M, Kane J, Bauer T, Palmer E, Long J, Lynch SM, et al. J Cancer Surviv (2016) 11: 246. doi:10.1007/s11764-016-0582-z. PMID: 27873046.
Lynch SM, Stricker CT, Filseth S, Brown JB, Berardi J, Branas A, Schmitz KH, Sarwer D. Evaluation of a Web-based Weight Loss Program in Young Cancer Survivors. Obesity Science & Practice. 2017.
Michaud DS, Vrieling A, Jiao L, Mendelsohn J, Steplowski E, Lynch SM, Wactawski-Wende J, Stolzenberg-Solomon RZ, and other PanScan coauthors. Alcohol Intake and Pancreatic Cancer: A Pooled Analysis from the Pancreatic Cancer Cohort Consortium (PanScan). Cancer Causes Control. 2010. PubMed
Jacobs EJ, Chanock SJ, Fuchs CS, LaCroix A, McWilliams RR, Steplowski E, Stolzenberg-Solomon RZ, Arslan AA , Bueno-de-Mesquita H.B., Gross M, Helzlsouer K, Petersen G, Zheng W, Agalliu I, Allen NE, Amundadottir L, Boutron-Ruault MC, Buring JE, Canzian F, Clipp S, Dorronsoro M, Gaziano JM, Giovannucci EL, Hankinson SE, Hartge P, Hoover RN, Hunter DJ, Jacobs K, Jenab M, Kraft P, Kooperberg C, Lynch SM, et al. Family History of Cancer and Risk of Pancreatic Cancer: A Pooled Analysis from the Pancreatic Cancer Cohort Consortium (PanScan). International Journal of Cancer. Jan. 4. 2010. PubMed
Arslan AA, Helzlsouer KJ, Kooperberg C, Patel AV, Shu X, Steplowski E, Tobias GS, Lynch SM, et al. Anthropometry, Body Mass Index and Pancreatic Cancer: a Pooled Analysis from the Pancreatic Cancer Cohort Consortium (PanScan). Archives of Internal Medicine Arch Intern Med. 2010 May 10;170(9):791-802. PubMed
Lynch SM, Vrieling A, Lubin JH, Kraft P, Mendelsohn J, Hartge P, Canzian F, Steplowski E, Bueno-de-Mesquita HB, Stolzenberg-Solomon RZ, and the PANSCAN consortium. Cigarette Smoking and Pancreatic Cancer: A Pooled Analysis from the Pancreatic Cancer Cohort Consortium (PanScan). Am J Epidemiol. 2009. Aug 15;170(4):403-13. Epub 2009 Jun 26. PubMed
Lynch SM, Mahajan R, Blair A, Alavanja M. Cancer Incidence Among Pesticide Applicators Exposed to Butylate in the Agricultural Health Study. Environmental Research. 2009. Jul 15. [Epub ahead of print]. PubMed
Lynch SM, Rusiecki JA, Blair A, Dosemeci M, Lubin J, Sandler D, Hoppin JA, Lynch CF, and Alavanja M. 2006. Cancer Incidence among Pesticide Applicators Exposed to Cyanazine in the Agricultural Health Study. Environ Health Perspect. 2006. PubMed
Biologic Level Studies
Hofmann JN, Hutchinson AA, Cawthon R, Liu CS, Lynch SM, Lan Q, Rothman N, Stolzenberg-Solomon R, Purdue MP. Telomere Length Varies by DNA Extraction Method: Implications for Epidemiologic Research-letter. Cancer Epidemiol Biomarkers Prev. 2014 Jun; 23(6):1129-30. PubMed
Lynch SM, Weinstein S, Lan Q, Rothman N, Albanes D, Stolzenberg-Solomon RZ. Telomere Length and Risk of Pancreatic Cancer in the Alpha-Tocopherol Beta-Carotene (ATBC) Trial and the Prostate, Lung, Colorectal and Ovarian screening trial. Int J of Cancer. 2013 May 15. PubMed
Lynch SM, Weinstein S, Lan Q, Rothman N, Albanes D, Stolzenberg-Solomon RZ. Mitochondrial DNA Copy Number and Risk of Pancreatic Cancer in the Alpha-Tocopherol Beta-Carotene (ATBC) Trial. Cancer Prevention Research. Sept. 2011 [epub ahead of print]. PubMed
Wolpin BM, Kraft P, Gross M, Helzlsouer K, Bueno-de-Mesquita HB, Steplowski E, Stolzenberg-Solomon RZ, Arslan AA, Jacobs EJ, Lacroix A, Petersen G, Zheng W, Albanes D, Allen NE, Amundadottir L, Anderson G, Boutron-Ruault MC, Buring JE, Canzian F, Chanock SJ, Clipp S, Gaziano JM, Giovannucci EL, Hallmans G, Hankinson SE, Hoover RN, Hunter DJ, Hutchinson A, Jacobs K, Kooperberg C, Lynch SM, et al. Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium. Cancer Res. 2010 Feb 1;70(3):1015-23. Epub 2010 Jan 26. PubMed
Petersen GM, Amundadottir L, Fuchs CS, Kraft P, Stolzenberg-Solomon RZ, Jacobs KB, Arslan AA, Bueno-de-Mesquita HB, Gallinger S, Gross M, Helzlsouer K, Holly EA, Jacobs EJ, Klein AP, Lacroix A, Li D, Mandelson MT, Olson SH, Risch HA, Zheng W, Albanes D, Bamlet WR, Berg CD, Boutron-Ruault MC, Buring JE, Bracci PM, Canzian F, Clipp S, Cotterchio M, de Andrade M, Duell EJ, Gaziano JM, Giovannucci EL, Goggins M, Hallmans G, Hankinson SE, Hassan M, Howard B, Hunter DJ, Hutchinson A, Jenab M, Kaaks R, Kooperberg C, Krogh V, Kurtz RC, Lynch SM, et al. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet. 2010 Jan 24. [Epub ahead of print] PubMed
Amundadottir L, Kraft P, Stolzenberg-Solomon R, Fuchs C, Petersen G, Arslan A, Bueno-de-Mesquita B, Gross M, Helzlsouer K, Jacobs E, LaCroix A, Zheng W, Albanes D, Buring J, Canzian F, Colditz G, Gaziano M, Hankinson S, Hayes R, van Houwelingen HC, Jacobs K, Kooperberg C, Lynch SM, Mendelsohn J, Prentice R, Riboli E, et al. Genome-Wide Association Study Identifies ABO Blood Group Susceptibility Variants for Pancreatic Cancer. Nature Genetics. 2009. Sep;41(9):986-90. Epub 2009 Aug 2. PubMed
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