Reza Nejati, MD

Reza Nejati MD

Associate Professor, Department of Pathology

Medical Director of Clinical Laboratory Services

Director, Flow Cytometry Lab

Specialties

  • Clinical and Laboratory Pathology

Areas of Expertise

Lymphoma, Leukemia, Myeloma

Treatment Focus

Acute and Chronic Leukemias, Lymphomas, Blastic plasmacytoid dendritic cell neoplasm, Myelodysplasia, Flow Cytometry

Distinctions

Treatment Philosophy

I joined the pathology department at Fox Chase Cancer Center because it is a pioneer in cancer research and one of the most reputable cancer centers in the country. I am a board-certified anatomic and clinical pathologist, with sub-specialty trainings in hematopathology and oncologic surgical pathology. In hematopathology, we work very closely with a multi-disciplinary team of outstanding and dedicated clinicians and pathologists to provide the optimal patient care by continuously making precise diagnosis of cancers that affect the blood and the lymphoid systems.

Early on in my medical career, I became fascinated by cancer biology. I yearned to explore challenging fields, which had the potential for improving lives; a yearning that continues to fascinate me about pathology today. It is inspiring to see how the advancements in diagnosis, research, and treatment in this discipline are rapidly improving healthcare and patient outcomes. These prospects are exciting and as a hematopathologist, my aim is to arm clinicians with the most comprehensive diagnosis by utilizing cutting-edge technologies to provide for the most effective and up to date treatment options for patients.

Clinical Locations

  • Fox Chase Cancer Center
    333 Cottman Avenue
    Philadelphia, PA 19111
    Phone: 888-369-2427

Educational Background

  • Fellow, Hematopathology, University of Pennsylvania Perelman School of Medicine
  • Fellow, Oncologic Surgical Pathology, MD Anderson Cancer Center
  • Resident, Anatomic and Clinical Pathology, University of Tennessee Health Science Center
  • MD, Tehran University of Medical Sciences, Iran, 1995

Certifications

  • American Board of Pathology - Anatomic Pathology
  • American Board of Pathology - Hematopathology

Memberships

  • American Board of Pathology, Anatomic and Clinical Pathology American Society of Hematology (ASH)
  • American Society for Clinical Pathology (ASCP)                                           
  • College of American Pathologists (CAP)                                                       
  • United States and Canadian Academy of Pathology (USCAP)

Honors & Awards

  • Philadelphia Magazine Top Doctors, 2023-2024

Selected Publications

Umeshkumar Vekariya, Monika Maria Toma, Margaret Nieborowska-Skorska, Bac Viet Le, Marie-Christine Caron, Anna-Mariya Kukuyan, Katherine Sullivan-Reed, Paulina Podszywalow-Bartnicka, Kumaraswamy Naidu Chitrala, Jessica Atkins, Malgorzata Drzewiecka, Wanjuan Feng, Joe Chan, Srinivas Chatla, Konstantin Golovine, Jaroslav Jelinek, Tomasz Sliwinski, Jayashri Ghosh, Ksenia Matlawska-Wasowska, Gurushankar Chandramouly, Reza Nejati, Mariusz A Wasik, Stephen Sykes, Katarzyna Piwocka, Emir Hadzijusufovic, Peter Valent, Richard T Pomerantz, George Morton, Wayne Childers, Huaqing Zhao, Elisabeth Paietta, Ross L Levine, Martin S Tallman, Hugo Fernandez, Mark R Litzow, Gaorav Gupta, Jean-Yves Masson, Tomasz Skorski. DNA polymerase theta protects leukemia cells from metabolic-induced DNA damage.  Blood. 2022 Dec 29; blood.

Wenjun Wu, Pin Lu, Priyal Patel, Ji Ma, Kathy Qi Cai, Vinay S Mallikarjuna, Sahar Poureghbali, Shazia R Nakhoda, Reza Nejati, Y Lynn Wang. SHP1 loss augments DLBCL cellular response to ibrutinib: a candidate predictive biomarker. Oncogene. 2022 Dec 8.doi: 10.1038/s41388-022-02565-7. Online ahead of print.


Dmitry Zhigarev, Asya Varshavsky, Alexander W MacFarlane, Prathiba Jayaguru, Laura Barreyro, Marina Khoreva, Essel Dulaimi, Reza Nejati, Christina Drenberg, Kerry S Campbell. Lymphocyte Exhaustion in AML Patients and Impacts of HMA/Venetoclax or Intensive Chemotherapy on Their Biology. Cancers (Basel). 2022 Jul 10;14(14):3352.


Shazia Nakhoda, Farsha Rizwan, Aldana Vistarop, Reza Nejati. Updates in the Role of Checkpoint Inhibitor Immunotherapy in Classical Hodgkin's Lymphoma. Cancers (Basel). 2022 Jun 14;14(12):2936.

Joseph D Khoury, Eric Solary, Oussama Abla, Yassmine Akkari, Rita Alaggio , Jane F Apperley, Rafael Bejar, Emilio Berti, Lambert Busque, John K C Chan, Weina Chen, Xueyan Chen, Wee-Joo Chng, John K Choi, Isabel Colmenero, Sarah E Coupland, Nicholas C P Cross, Daphne De Jong, M Tarek Elghetany, Emiko Takahashi, Jean-Francois Emile, Judith Ferry, Linda Fogelstrand, Michaela Fontenay, Ulrich Germing, Sumeet Gujral, Torsten Haferlach, Claire Harrison, Jennelle C Hodge, Shimin Hu, Joop H Jansen, Rashmi Kanagal-Shamanna, Hagop M Kantarjian, Christian P Kratz, Xiao-Qiu Li, Megan S Lim, Keith Loeb, Sanam Loghavi, Andrea Marcogliese, Soheil Meshinchi, Phillip Michaels, Kikkeri N Naresh, Yasodha Natkunam, Reza Nejati, German Ott, Eric Padron, Keyur P Patel, Nikhil Patkar, Jennifer Picarsic, Uwe Platzbecker, Irene Roberts, Anna Schuh, William Sewell, Reiner Siebert, Prashant Tembhare, Jeffrey Tyner, Srdan Verstovsek, Wei Wang, Brent Wood, Wenbin Xiao, Cecilia Yeung, Andreas Hochhaus. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms. Leukemia. 2022 Jul;36(7):1703-1719.

Qian Zhang, Hong Y. Wang, Selene Nunez-­Cruz, Anindita Nayak, Artur Slupianek, John, Bassappa, Xiaobin Liu, Jing-­Song Fan, Seble Chekol, Reza Nejati, Agata M. Bogusz, Suzanne D. Turner, Kunchithapadam Swaminathan, and Mariusz A. Wasik. Induction of HES-1 and repression of TXNIP expression are essential components of oncogenic program imposed on target cells by chimeric kinase NPM/ALK. Am J Pathol. 2022 Aug;192(8):1186-1198.

Nils Kroeger, Cédric Lebacle, Justine Hein, P N Rao, Reza Nejati, Shuanzeng Wei, Martin Burchardt, Alexandra Drakaki, Marshall Strother, Alexander Kutikov, Robert Uzzo, Allan J Pantuck. Pathological and genetic markers improve recurrence prognostication with the University of California Los Angeles Integrated Staging System for patients with clear cell renal cell carcinoma. Eur J Cancer. 2022 Jun;168:68-76.

Gregory Hemenway, Marni B Tierno , Reza Nejati, Romina Sosa, Matthew Zibelman. Clinical Utility of Liquid Biopsy to Identify Genomic Heterogeneity and Secondary Cancer Diagnoses: A Case Report. Case Rep Oncol. 2022 Feb 7;15(1):78-85.

Shakiba Hassanzadeh, Nicholas Mackrides, Shima Rastegar, Reza Nejati. Diffuse Large B-Cell Lymphoma with a Background of Extensive Granulomatous Inflammation: A Potential Pitfall for Misdiagnosis. Cureus. 2021 Jul 5;13(7): e1619 Cureus. 2021 Jul 5;13(7): e16198.

Pin Lu, Shengchun Wang, Carrie A. Franzen, Girish Venkatarama, Rebecca McClure, Wenjun Wu, Nifang Niu, Lei Li, Jianming Pei, Reza M. Nejati, Donald Baldwin, Mariusz A. Wasik, Madina Sukhanova, Juehua Gao, Yihua Chen, Yifan Tu, Shuo Ma, Richard A. Larson, Nadia Khan.and Y. Lynn Wang. Ibrutinib and venetoclax target distinct subpopulations of CLL cells: Implication for residual disease eradication. Blood Cancer J. 2021 Feb 18;11(2):39.

Daniel A Pollyea, Dale Bixby, Alexander Perl, Vijaya Raj Bhatt, Jessica K Altman, Frederick R Appelbaum, Marcos de Lima, Amir T Fathi, James M Foran, Ivana Gojo, Aric C Hall, Meagan Jacoby, Jeffrey Lancet, Gabriel Mannis, Guido Marcucci, Michael G Martin , Alice Mims, Jadee Neff, Reza Nejati, Rebecca Olin, Mary-Elizabeth Percival, Thomas Prebet, Amanda Przespolewski, Dinesh Rao, Farhad Ravandi-Kashani, Paul J Shami, Richard M Stone, Stephen A Strickland, Kendra Sweet, Pankit Vachhani, Matthew Wieduwilt, Kristina M Gregory, Ndiya Ogba, Martin S Tallman. NCCN Guidelines Insights: Acute Myeloid Leukemia, Version 2.2021. J Natl Compr Canc Netw. 2021 Jan 6;19(1):16-27.

Zhihui Song, Wei Wei, Wenming Xiao, Essel D. Al-Saleem, Reza Nejati, Liqi Chen, Jiejing Yin, Joseph Fabrizio, Michael N. Petrus, Thomas A. Waldmann, and Yibin Yang. Essential role of the linear ubiquitin chain assembly complex and TAK1 kinase in A20 mutant Hodgkin lymphoma. Proc Natl Acad Sci USA. 2020 Nov 2;202014470.

Bac Viet Le, Paulina Podszywalow-Bartnicka, Silvia Maifrede1, Katherine Sullivan-Reed1, Margaret Nieborowska-Skorska1, Konstantin Golovine1, Juo-Chin Yao, Reza Nejati, Kathy Q. Cai, Julian Swatler, Michal Dabrowski, Zhaorui Lian, Peter Valent, Elisabeth M. Paietta,Ross L. Levine, Hugo F. Fernandez, Martin S. Tallman, Mark R. Litzow, Jian Huang, Grant A. Challen, Daniel Link, Mariusz A. Wasik, Katarzyna Piwocka, Tomasz Skorski. TGFβR–SMAD3 signaling induces resistance to PARP inhibitors in leukemia cells in the bone marrow microenvironment. Cell Rep. 2020 Oct 6;33(1):108221.

Jie Wang MD, Katarzyna Urbanska PhD, Prannda Sharma MS, Reza M. Nejati MD, Lauren Shaw, Megan S. Lim MD PhD, Stephen J. Schuster MD, Daniel Powell PhD. A novel approach for the treatment of T cell malignancies: targeting T cell receptor Vβ families. Vaccines (Basel) 2020 Oct 31;8(4): E631.

Qian Zhang, Elena J. Orlando, Hong Y. Wang, Agata M. Bogusz, Xiaobin Liu, Simon F. Lacey, Honore T. Strauser 1, Selene Nunez-Cruz, Reza Nejati, Paul Zhang, Sarah Brooks, Christopher Watt, J. Joseph Melenhorst, Carl H. June, Stephen J. Schuster, and Mariusz A. Wasik. Transdifferentiation of lymphoma into sarcoma associated with profound reprogramming of epigenome. Blood 2020 Jun 9; blood.2020005123.

Jakub Svoboda, Daniel J. Landsburg, Sunita Dwivedy Nasta, Steven M. Bair, Sarah J. Nagle, Stefan K. Barta, Nadia Khan, Henry C. Fung, Joanne Filicko-O'Hara, Sameh Gaballa, Lauren Strelec, Elise Chong, Sheryl Mitnick,, Terease Waite, Cara King, Hatcher Ballard, Matthew Youngman, Agata M. Bogusz, Megan Lim, Christian Steidl, Hisae Nakamura, Stacy Hung, Olga Kutovaya, Reza Nejati, James Gerson, Marco Ruella and Stephen J. Schuster. Brentuximab Vedotin with R-CHP Chemotherapy as Frontline Treatment for Patients with CD30+ PMBCL, DLBCL, and GZL. Haematologica. 2020 May 15.

Yahy Hafiz, Stefan Barta, Nadia Khan, Reza Nejati. A rare association: autoimmune hemolytic anemia with indolent T-cell prolymphocytic leukemia. Cureus 12(5): e7994. doi:10.7759/cureus.7994. 

Reza Nejati, Shuanzeng Wei, Robert G. Uzzo, Sahar Poureghbali, Jianming Pei, Jacqueline N. Talarchek, Karen Ruth4, Essel Dulaimi, Alexander Kutikov, Joseph R. Testa, and Tahseen Al-Saleem. Monosomy of Chromosome 9 is Associated with Higher Grade, Advanced Stage and Adverse Outcome in Clear Cell Renal Cell Carcinoma. Clin Genitourin Cancer. 2020 Feb;18(1):56-61.

Phyu Aung, Narittee Sukswai, M. Reza Nejati, Sanam Loghavi, Weina Chen, Carlos Torres-Cabala, C. Cameron Yin, Marina Konopleva, Xiaofeng Zheng, Jing Wang, Zhenya Tang, L. Jeffrey Medeiros, Victor Prieto, Naveen Pemmaraju, Joseph Khoury. PD1/PD-L1 Expression in Blastic Plasmacytoid Dendritic Cell Neoplasm. Cancers (Basel). 2019 May 19;11(5).

Nejati R, Halperin DM, Goldstein JB, Wang H, Rashid A, Katz MH, Lee JE, Fleming JB, Canales JR, Blando J, Wistuba I, Maitra A, Wolff RA, Varadhachary GR and Wang H. The prognostic significance of infiltrating lymphocytes in patients with pancreatic ductal adenocarcinoma treated with neoadjuvant therapy. Pancreas. 2017 October;46(9):1180-1187.

Maifrede S, Martin K, Podszywalow-Bartnicka P, Sullivan K, Langer SK, Nejati R, Dasgupta Y, Gritsyuk D, Nieborowska-Skorska M, Lupey L, Piwocka K, Wasik MA, Tempera I, and Skorski T. (in press).  IGH/MYC translocation is associated with BRCA2 deficiency and predisposed to synthetic lethality by PARP1 inhibitors. Molecular Cancer Research. 2017 Aug;15(8):967-972.

Majors J, Stoikes NF, Nejati R, and Deneve JL. Resection and Abdominal Wall Reconstruction of a Desmoid Tumor with Endometrioma Features. Case Reports in Surgery Volume 2016, Article ID 9453450.

Skobowiat C, Nejati R, Lu Lu, Williams RW, and Slominski A. Genetic variation of the cutaneous HPA axis: An analysis of UVB-induced differential responses. Gene (Journal). 2013 November; 530 (1):1-7 

Nejati R, Skobowiat C, Slominski A. Commentary on the practical guide for the study of human and murine sebaceous glands. Experimental Dermatology 2013 October; 22(10) :629-30

Nejati R, Diane K, Slominski A. Neuro-immuno-endocrine functions of the skin. Expert Review of Dermatology 2013;8(6):581-583