Penny R. Anderson, MD

Penny R. Anderson, MD

Clinical Locations

Primary Location

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111


Professor, Department of Radiation Oncology

Chief, Division of Breast and Gynecologic Radiation Oncology

Vice Chair for Quality Assurance and Process Improvement

TRDG Member: Breast Cancer; Ovarian and Gynecologic Cancer; Sarcoma and GIST Cancer

Treatment Focus


Key Awards

Philadelphia Magazine Top Docs 2019
Radiation Oncology

Treatment Philosophy

After completing my training at Fox Chase, I joined the radiation oncology department attending staff in 1999. I chose to stay at Fox Chase because I wanted to remain in a research setting at a hospital with the highest excellence in cancer care. In my practice, I specialize in treating patients with gynecological cancers, breast cancer and sarcoma.

As a female oncologist, I address the many unique treatment issues specific to women. My patients discuss their personal issues surrounding their cancer, as well as the side effects of treatment. It is gratifying to offer comfort, not only through radiation treatment, but afterwards in their follow-up care.

As director of breast and gynecologic radiation oncology, I believe it is important to spend time educating my patients. These women have many personal issues related to quality-of-life. We provide education and support from diagnosis throughout treatment and follow-up care.

A particular accomplishment of mine was changing the practice of gynecological high-dose-rate brachytherapy in 2001 from an inpatient to an outpatient procedure for patients. This procedure is now much easier for patients to tolerate, while maximizing our highest quality of care.

At Fox Chase, we use the most sophisticated technology for both external beam (IMRT) radiation therapy and brachytherapy. We have a CT and an MRI simulator for gynecological cancer treatment planning. We use CT/MR-based brachytherapy treatment planning for patients with gynecological cancers.

As a breast cancer specialist, I am part of the Breast Evaluation Center's multispecialty team at Fox Chase. My role is integral in developing the best course of treatment for our newly diagnosed breast cancer patients. At Fox Chase, we use IMRT to treat women with breast cancer.

In treating patients with sarcoma, I collaborate with the surgeons and medical oncologists to determine the best course of treatment. Before surgery, radiation therapy helps to reduce the tumor's size, making it easier to remove. Following surgery, radiation therapy can improve local control and chance for cure. In treating sarcomas, we use an MR simulator in the planning process, which helps improve accuracy of treatment.

Research is another interest of mine. I am a member of multiple national committees aimed at constantly improving and advancing the treatment and outcome of gynecologic and breast cancers. I am the principal investigator for several national trials evaluating novel, innovative approaches for breast and gynecologic cancer treatment. Each year, I am invited to present at many professional meetings, including the Gynecologic Oncology Group (GOG), ASTRO (American Society for Therapeutic Radiology and Oncology), and the Radiation Therapy Oncology Group (RTOG).


Education and Training

Educational Background

  • Fellow, Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA
  • Resident, Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA
  • MD, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 1994


  • American Board of Radiology, Therapeutic Radiology


  • American Society of Clinical Oncology
  • American Society for Therapeutic Radiology and Oncology
  • Radiation Therapy Oncology Group
  • Gynecologic Oncology Group
  • Eastern Cooperative Oncology Group
  • American Brachytherapy Society

Honors & Awards

  • Philadelphia Magazine Top Doctors, 2017-19
  • America's Top Doctors®, 2016-17
Patient Stories

Judy Tomarchio


Judy Tomarchio


Judy Tomarchio didn't spend her honeymoon lying on a beach or cruising the Mediterranean. Instead, the South Philadelphia native found herself on the operating table at Fox Chase. In 2007, Judy, who was 54, was being treated for leiomyosarcoma, a rare kind of cancer of the soft tissue that can arise from smooth muscle cells anywhere in the body. "We moved the wedding up so we'd be married before the surgery," recalls Judy. "My Dave was with me from day one - he was my rock."

Amy Owen

Breast Cancer

Amy Owen

Breast Cancer

During a self-breast exam in December 2001, 33-year-old mother of two, Amy Owen, noticed something unusual. “It felt like a frozen pea,” she shares. It was one week before Christmas and Amy considered ignoring the sign. Instead, she followed her instinct and called her OB/GYN to schedule an appointment. That doctor referred Amy for a mammogram and told her not to worry. At her community hospital, following the mammogram, the on-site radiologist noticed something suspicious and ordered a breast ultrasound. After review, Amy was referred to an oncologist for further determination.

Charlette Gray

Breast Cancer

Charlette Gray

Breast Cancer

I was on a business trip the summer of 2011 when I noticed a lump in my breast, so I made an appointment with my internist when I returned home. An ultrasound detected the lump, and within just a few days a biopsy confirmed lobular breast cancer. I quickly arranged a consultation with a surgeon in my hometown that same week, who advised me of my options.

Barbara Pennypacker


Barbara Pennypacker


I was diagnosed with a retroperitoneal liposarcoma located in the fat around my kidney in January 2011. When the scans detected a mass near my liver, the doctor referred me to Dr. Margaret von Mehren, an oncologist at Fox Chase Cancer Center who directs the sarcoma program.


  • 1
  • 2
  • 3
  • of
  • 3
Research Profile

Research Interests

Breast Cancer; Gynecologic Cancers; Brachytherapy



Our Patient Satisfaction Rating is an average of all responses to care provider related questions from our nationally-recognized Press Ganey Patient Satisfaction Survey. Learn more.


4.9 / 5.0


  • 4.9
  • 4.9
  • 4.9
  • 4.9
  • 4.9


  • 5.0
    April 10, 2019
    Everything was good. Dr. Anderson is the BEST!
  • 5.0
    February 18, 2019
    I feel so confident with Dr. Anderson.
  • 5.0
    February 04, 2019
    Loved Dr. Anderson & her staff!!
  • 5.0
    January 21, 2019
    Dr. Anderson is wonderful! Could not ask for a better physician.
  • 5.0
    January 06, 2019
    Dr. Anderson is at a top notch caregiver & doctor whom I trust immensely.
  • 5.0
    October 31, 2018
    At this visit I had some concerns about left breast pain I was having & Dr. Anderson was very caring & helpful in talking through options with me. [...]
  • 5.0
    September 11, 2018
    Dr. Anderson was thorough, patient, understanding & knowledgeable & I liked her very much. I came for a second opinion on my illness, diagnosis & treatment & the feedback from Dr. Anderson was superb. Thank you.
  • 5.0
    August 21, 2018
    Good experience. Any questions I had she answered.

Connect with Fox Chase