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Paul F. Engstrom, MD

Paul Engstrom, MD

Clinical Locations

Primary Location

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111

About

Chair, Hematology/Oncology 
Samuel M.V. Hamilton Chair in Cancer Prevention
Professor of Medicine, Lewis Katz School of Medicine, Temple University

Treatment Focus

As a medical oncologist with over 45 years of continuous experience in a cancer hospital, I have developed expertise in the diagnosis, staging and treatment of patients with localized or advanced malignant tumors of the GI tract with special emphasis on neuroendocrine tumor management. I employ chemotherapy and treatments that are recommended in the National Comprehensive Cancer Network, (NCCN) Guidelines. I administer chemotherapy regimens that are listed in the NCCN Compendium. Patients who are appropriate and eligible for Phase II or Phase I cancer treatment trials are encouraged to receive investigational therapy.

Research Program

Key Awards

  • America’s Top Doctors® 2016
  • ACCC Annual Clinical Care Achievement Award, 2013
  • Philadelphia magazine Top Doc, 2010, 2011
  • Distinguished Achievement Award, American Society of Preventive Oncology, 2010
  • Distinguished Service Award, American Cancer Society, 2009
  • Cancer Control Award, American Cancer Society, Philadelphia Division, 1989

Treatment Philosophy

In my leadership role at Fox Chase, I am involved in cancer research, specifically prevention and survivorship issues. In my practice, I specialize in gastrointestinal malignancies, especially neuroendocrine tumors and colon-rectum cancer management. I offer a second opinion service at several of our Fox Chase Cancer Center Partner hospitals for patients with breast cancer and other diagnoses.

I am the chair of the National Comprehensive Cancer Network (NCCN) Colorectal-Anal Cancer Guidelines Panel and am a member of the NCCN Neuroendocrine Malignancy Panel and Senior Adult Oncology Task Force.

Chair, Department of Hematology/Oncology

Dr. Paul F. Engstrom, who joined Fox Chase in 1970, has devoted his professional and academic career to improving cancer prevention and early detection research and service.

He established the first Cancer Prevention and Control Program in an NCI-designated cancer center at Fox Chase in 1979. Twelve years later, he established a highly successful and ongoing training and career development program that has groomed national leaders in cancer prevention and control research.

He has been the principal investigator for numerous cancer prevention and screening research programs, including the Early Detection Research Network focused on breast and ovarian cancer screening and diagnosis (2005-2015).

Dr. Engstrom has served as an advisor on some of the most influential cancer prevention and screening boards including the American Cancer Society, Philadelphia Division; the National American Cancer Society; the American Association of Cancer Institutes; the American Society of Clinical Oncology; and the National Cancer Institute.

Dr. Engstrom has over 200 peer-reviewed scientific articles devoted to cancer prevention and screening research. He has served on the Editorial Board for Cancer Epidemiology, Biomarkers and Prevention; Journal of Cancer Prevention; Journal of Clinical Oncology; Primary Care and Cancer; Clinical Cancer Research; and currently is Senior Editor for Cancer Prevention Research.

He has been an advocate for cancer prevention and screening programs in research throughout the U.S. and around the globe. He is the founding member for the American Russian Cancer Alliance, which was instrumental in leading the Russian Duma and the Blokhin Russian National Cancer Center to pass legislation controlling cigarette sales, smoking restrictions, and smoking cessation programs in Russia.

He is a founding member of the National Comprehensive Cancer Network Patient Guideline Committee.  He is a worldwide spokesperson for the national guidelines to screen, diagnose, manage, and support cancer patients.

In 2009, Dr. Engstrom received the Distinguished Service Award from the American Cancer Society for his myriad contributions to cancer control and prevention. He was recognized for Distinguished Achievement by the American Society of Preventive Oncology in 2010. He is consistently cited as a “Top Doc” by Philadelphia Magazine.

He was appointed the Samuel M.V. Hamilton Chair in Cancer Prevention in 2012.

Education, Training & Credentials

Educational Background

  • Public Health Service Trainee in Medical Oncology (Grant CA5158), University of Minnesota Hospitals, Minneapolis, MN, 1967
  • Resident, University of Minnesota Hospitals, Minneapolis, MN, 1965
  • Intern in Medicine, University of Minnesota Hospitals, Minneapolis, MN, 1963
  • Medical Student Trainee, Epidemiology Research, 1959
  • Training Program, California Department of Public Health, 1959
  • BA, St. Olaf College, Northfield, MN, 1954
  • MD, University of Minnesota Medical School, Minneapolis, MN 1962

Certifications

  • Diplomate, American Board of Internal Medicine, 1969
  • Diplomate, American Board of Internal Medicine, Medical Oncology, 1973
  • Basic Science Certification for Minnesota
  • Minnesota State Board of Medicine
  • Pennsylvania State Board of Medical Education & Licensure
  • New Jersey State Board of Medical Education & Licensure

Memberships

  • National Comprehensive Cancer Network (NCCN)
    • NCCN Board of Directors
    • Colon/Rectal/Anal Cancers Panel
    • Distress Management Panel
    • Guidelines Steering Committee
    • Neuroendocrine Tumors Panel
    • YIA Review Committee
  • American Association for Cancer Education
  • American Medical Association
  • American Society of Clinical Oncology
  • American Federation for Clinical Research
  • American College of Physicians, Fellow
  • Member, Cancer Control Committee, Philadelphia County Medical Society
  • Philadelphia College of Physicians
  • Chairman, Breast Cancer Task Force, Philadelphia Division, American Cancer Society

Honors & Awards

  • America’s Top Doctors® 2016 
  • ACCC Annual Clinical Care Achievement Award, 2013
  • Samuel M.V. Hamilton Chair in Cancer Prevention, 2012
  • Philadelphia magazine Top Doc, 2010, 2011
  • Distinguished Achievement Award, American Society of Preventive Oncology, 2010
  • Distinguished Service Award, American Cancer Society, 2009
  • Cancer Control Award, American Cancer Society, Philadelphia Division, 1989
Patient Stories

Lynn Tucker

Neuroendocrine Tumors

Lynn Tucker

Neuroendocrine Tumors

Lynn Tucker remembers back to the severe stomach pain she experienced for five years: pain that left her sometimes lying down for hours and often homebound for days. For years she went from doctor to doctor and was misdiagnosed again and again. “I was told I had a hernia, Crohn’s Disease and several other conditions. Finally, I just accepted the pain as something I would have to live with. I didn’t think I would ever feel well,” Lynn remembers.

Alan Stachura

Colorectal Cancer

Alan Stachura

Colorectal Cancer

Not many people can say they "grew up at Fox Chase," but Alan Stachura can. When he was only six years old, his mother was diagnosed with invasive breast cancer. When she arrived at Fox Chase Cancer Center to meet with medical oncologist Paul F. Engstrom, MD, she learned that the disease had already spread to her bones.

Todd Jackman

Colorectal Cancer

Todd Jackman

Colorectal Cancer

Maintaining an active lifestyle was always a priority for Todd Jackman, a professor of biology at Villanova University. He enjoyed running and was training for a half-marathon with his son. In the spring of 2014, he started experiencing bleeding which he attributed to hemorrhoids. Six months had passed with this ongoing symptom, and his wife urged him to go to the doctor.“I went to see my family doctor, who performed a physical,” recalls Todd.

Angela Fedele

Breast Cancer;  Kidney Cancer;  Pancreatic Cancer

Angela Fedele

Breast Cancer;  Kidney Cancer;  Pancreatic Cancer

In 1983, Angela Fedele was diagnosed with breast cancer at the same time she was going through a divorce. This 42-year-old mother of 4 felt that her whole life was crumbling apart. "I felt totally alone and full of despair," shared Angela, who put her health in the hands of her surgeon. After the mastectomy to remove the cancer, Angela tried to pick up the pieces of her life and move on. Little did she know this was just the beginning of a long journey with cancer that would span more than 2 decades.

Research Profile

Research Program

Research Interests

  • Cancer prevention research
  • Identification and development of biomarkers directed to cancer etiology, prognosis and response to therapy
  • Phase II and Phase I cancer chemotherapy investigations.  
Publications

Selected Publications

Benson AB, Venook AP, Bekaii-Saab T, Chan E, Chen YJ, Cooper HS, Engstrom PF, Enzinger PC, Fenton MJ, Fuchs CS, Grem JL, Grothey A, Hochster HS, Hunt S, Kamel A, Kirilcuk N, Leong LA, Lin E, Messersmith WA, Mulcahy MF, Murphy JD, Nurkin S, Rohren E, Ryan DP, Saltz L, Sharma S, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Gregory KM, Freedman-Cass D. Rectal cancer, version 2.2015: Featured updates to the NCCN guidelines. JNCCN Journal of the National Comprehensive Cancer Network. 2015;13(6):719-28.    PubMed

 Kulke MH, Shah MH, Benson AB, Bergsland E, Berlin JD, Blaszkowsky LS, Emerson L, Engstrom PF, Fanta P, Giordano T, Goldner WS, Halfdanarson TR, Heslin MJ, Kandeel F, Kunz PL, Kuvshinoff BV, Lieu C, Moley JF, Munene G, Pillarisetty VG, Saltz L, Sosa JA, Strosberg JR, Vauthey JN, Wolfgang C, Yao JC, Burns J, Freedman-Cass D. Neuroendocrine Tumors, Version 1.2015. Journal of the National Comprehensive Cancer Network, 13(1):78-108, 2015. PubMed

Kulke MH, Shah MH, Benson AB, Bergsland E, Berlin JD, Blaszkowsky LS, Emerson L, Engstrom PF, Fanta P, Giordano T, Goldner WS, Halfdanarson TR, Heslin MJ, Kandeel F, Kunz PL, Kuvshinoff BV, Lieu C, Moley JF, Munene G, Pillarisetty VG, Saltz L, Sosa JA, Strosberg JR, Vauthey JN, Wolfgang C, Yao JC, Burns J, Freedman-Cass D. Neuroendocrine Tumors, Version 1.2015. Journal of the National Comprehensive Cancer Network, 13(1):78-108, 2015. PubMed

Marks JR, Anderson KS, Engstrom P, Godwin AK, Esserman LJ, Longton G, Iversen ES, Mathew A, Patriotis C, Pepe MS. Construction and Analysis of the NCI-EDRN Breast Cancer Reference Set for Circulating Markers of Disease. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 24(2):435-41, 2015. PubMed

Perkins J, Boland P, Cohen S, Olszanski A, Zhou Y, Engstrom P, Astsaturov I.  Successful Imatinib therapy of neuroendocrine carcinoma with activating KIT mutation:  a case study.  JNCCN 2014 June;12:847-852. PMID: 24925195  Benson AB, Venook AP, Bekaii-Saab T, Chan E, Chen YJ, Cooper HS, Engstrom PF, Enzinger PC, Fenton MJ, Fuchs CS, Grem JL, Hunt S, Kamel A, Leong LA, Lin E, Messersmith W, Mulcahy MF, Murphy JD, Nurkin S, Rohren E, Ryan DP, Saltz L, Sharma S, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Gregory KM, Freedman-Cass CA.  Colon Cancer, Version 3.2014.  JNCCN 2014;12(7):1028-59.  PubMed

A phase II trial of the proteasome inhibitor bortezomib in patients with advanced biliary tract cancers.  Clin Colorectal Cancer 2014 Jan 4.  [epub ahead of print]  PubMed

Engstrom, Paul F.  Physician Burnout.  JNCCN 2013 April; 11(4): 1-3  PubMed

Khrizman P, Niland JC, ter Veer A, Milne D, Bullard Dunn K, Carson WE 3rd, Engstrom PF, et al.  Postoperative adjuvant chemotherapy use in patients with stage II/III rectal cancer treated with neoadjuvant therapy; a national comprehensive network analysis.  J Clin Oncol. 2013 Jan 1;31(1):30-8  PubMed

Gordiev M, Engstrom PF, Khasanov R, et al.  Genetic Analysis of Polymorphisms in Dopamine Receptor and Transporter Genes for Association with Smoking among Cancer Patients.  Eur Addict Res. 2012 Nov 2:19(2)105-111. PubMed

Engstrom PF.  Commentary:  Ten Years of Progress in Colon Cancer Therapy.  JNCCN 2012 May; 10(5); 574-575. PubMed

Schnoll RA, Subramanian S, Martinez E, Engstrom PF. Correlates of continued tobacco use and intention to quit smoking among Russian cancer patients. International Journal of Behavioral Medicine. 2011 Jan;18(4):325-32. PubMed

O'Grady MA, Slater E, Sigurdson ER, Meropol NJ, Weinstein A, Lusch CJ, Sein E, Keeley P, Miller B, Engstrom PF, Cohen SJ. Assessing Compliance with National Comprehensive Cancer Network Guidelines for Elderly Patients with Stage III Colon Cancer: The Fox Chase Cancer Center Partners' Initiative. Clinical Colorectal Cancer. 2011 Jun;10(2):113-6.  PubMed

Engstrom PF Cohen SJ Emerging Therapies for Advanced Gastroenteropancreatic Neuroendocrine Tumors   PubMed

Denlinger CS, Engstrom PF.  Colorectal cancer survivorship:  Movement matters.  Cancer Prev. Res; 4(4);502-11, 2011. PubMed

Morris GJ, Greco FA, Hainsworth JD, Engstrom PF, et al.  Cancer of unknown primary site.  Seminars in Oncology 37(2):71-79, 2010. PubMed

Braithwaite D, Wernli KJ, Anton-Culver H, Engstrom P, Greenberg R, Meyskens F.  Opportunities for cancer epidemiology and control in low-and middle-income PubMed

Additional Publications

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