Fox Chase Cancer Center News

Vladimir Kolenko Receives Grant from the Department of Defense to Study PARP-1 inhibitors in Renal Cell Carcinoma

PHILADELPHIA (October 29, 2018) – Vladimir Kolenko, MD, PhD, has received a grant from the Department of Defense to study histone-dependent PARP-1 inhibitors in the treatment of renal cell carcinoma. The objective of the proposal is to validate the therapeutic potential of novel PARP (poly ADP ribose polymerase)-1 inhibitors using clinically relevant cell and animal models of human clear cell renal cell carcinoma and investigate the mechanisms underlying their anti-tumor activity.

VIEW STORY