Fox Chase Cancer Center News

Jose Russo, MD
April 6, 2011

Fox Chase Researchers Find that Fish Oil Boosts Responses to Breast Cancer Drug Tamoxifen

ORLANDO, FL (April 6, 2011) – Breast cancer is the second most common cancer among women, with more than 200,000 women diagnosed each year. Being exposed to estrogen over a long period of time is one factor that can increase a woman's risk of developing the disease.  One way a woman can combat this risk factor is by taking the breast cancer drug tamoxifen, which interferes with the activity of estrogen.  Now, researchers at Fox Chase Cancer Center have found that omega-3 fatty acids—abundant in fish—could be a safe and beneficial booster for tamoxifen therapy.

April 6, 2011

Fox Chase Researchers Report that Naproxen Reduces Tumors in a Mouse Model of Colon Cancer

ORLANDO, FL (April 6, 2011) – Numerous studies show that non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of colon cancer. However, animal studies testing the NSAID naproxen or its derivative, NO-naproxen, have focused primarily on chemically-induced tumor formation. Now, researchers at Fox Chase Cancer Center find that naproxen and NO-naproxen reduce tumor formation in a strain of mutant mice that spontaneously develop colon tumors. The data also suggest that naproxen blocks a gatekeeper step that initiates tumor formation.

April 5, 2011

Fox Chase Scientists Report Interplay Between Cancer and Aging in Mice

ORLANDO, FL (April 5, 2011) – Cancer risk increases with age, and scientists have long perceived a possible evolutionary tradeoff between longer lifespan and greater risk of cancer. Now, researchers at Fox Chase Cancer Center find direct evidence for that tradeoff in new data showing that expression of a key tumor suppressor protein induces premature aging in mice.

Greg H. Enders, MD, PhD, associate professor in the Epigenetics and Progenitor Cell Program at Fox Chase, will present the results at the AACR 102nd Annual Meeting 2011 on Tuesday, April 5.

Dr. Russo
April 5, 2011

Fox Chase Researchers Identify Gene Expression Pattern in Breast Tissue that Differs Between Post-Menopausal Women Who Had Children and Those Who Did Not

ORLANDO, FL (April 5, 2011) – Women who have children, particularly early in life, have a lower lifetime risk of breast cancer compared with women who do not. Now, Fox Chase Cancer Center researchers have identified a gene expression pattern in breast tissue that differs between post-menopausal women who had children and post-menopausal women who did not. The results will help scientists understand why pregnancy reduces breast cancer risk and may help them develop chemopreventive strategies that can provide similar protection for women who did not have children.

April 5, 2011

Fox Chase Researchers Develop a Screen for Identifying New Anticancer Drug Targets

ORLANDO, FL (April 5, 2011) –Tumor suppressor genes normally control the growth of cells, but cancer can spring up when these genes are silenced by certain chemical reactions that modify chromosomes. Among the most common culprits responsible for inactivating these genes are histone deacetylases, a class of enzymes that remove acetyl groups from DNA-scaffolding proteins, and DNA methyltransferases, a family of enzymes that add methyl groups to DNA.

April 5, 2011

Fox Chase Researchers Show Vitamin A Derivative Can Inhibit Early Forms of Breast Cancer

ORLANDO, FL (April 5, 2011) – A nutrient found in carrots and sweet potatoes may prove key to fighting breast cancer at early stages, according to a new study by researchers at Fox Chase Cancer Center. Sandra Fernandez, PhD, an assistant research professor at Fox Chase, will present the findings at the AACR 102nd Annual Meeting 2011 on Tuesday, April 5.

April 4, 2011

MicroRNA Variations Found to be Associated with Earlier Time to Prostate Cancer Diagnosis in African American Men Undergoing Screening

ORLANDO, FL (April 4, 2011) – Prostate cancer is the second leading cause of cancer-related death among American men. Yet population-wide screening programs have not reduced the number of deaths from the disease. By focusing screening programs on the men who are at greatest risk for aggressive disease or diagnosis at a young age, researchers think they could improve mortality rates and personalize the screening approach. For that reason, scientists have been looking for genetic markers to help them identify exactly which men are at high risk and require regular screening.

April 4, 2011

Fox Chase Researchers Link Common Variant of p53 Tumor Suppressor Gene to Increased Inflammatory Responses

ORLANDO, FL (April 4, 2011) – New findings by Fox Chase Cancer Center researchers link a common variant of the powerful anticancer gene p53 to increased inflammatory responses following DNA damage. The results may help explain why African Americans, who more frequently possess this variant, tend to be more susceptible to certain kinds of inflammation-related diseases and cancers, such as type II diabetes and colorectal cancer.


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