Joan Font-Burgada, PhD

Joan Font-Burgada, PhD

Assistant Professor

Research Program

Education and Training

Educational Background

  • PhD in Genetics, University of Barcelona, Barcelona, 2010 
  • MS in Genetics, University of Barcelona, Barcelona, 2004 
  • BS in Biology, University of Barcelona, Barcelona, 2000

Honors & Awards

  • 2001 Predoctoral fellowship from Spanish Ministry of Education
  • 2005 Predoctoral fellowship. Scientific Parc of Barcelona (PCB)
  • 2010 Summa cum laude distinction of Doctoral Thesis
  • 2012 California Institute for Regenerative Medicine Postdoctoral Training Grant
  • 2015 K99/R00 NIH Pathway to Independence award
  • 2015 Hertzberg-Schechter Prize for Stem Cell Research
Lab Staff

Nicola de Prisco, PhD

Postdoctoral Associate

Charlie Hewitt

Technical Staff

Ellie Stout



Selected Publications

Marty R, de Prisco N, Carter H, Font-Burgada J. MHC-I genotype drives early immune selection of oncogenic mutations. Molecular and Cellular Oncology, 5(2), 2018. PubMed

Marty R, Kaabinejadian S, Rossell D, Slifker M, van der Haar J, Engin HB, de Prisco N, Ideker T, Hildebrand WH, Font-Burgada J#,*, Carter H*. “ MHC-I genotype restricts the oncogenic mutational landscape”.
Cell. 2017 Nov 30;171(6):1272-1283.e15. doi: 10.1016/j.cell.2017.09.050. (#corresponding author, *equally contributed). PMID: 29107334  Highlighted in Nature Reviews Immunology (2017; 17, 729), Nature Reviews Clinical Oncology (2018; 15, 5) and Cell (2017; 171(6):1252–1253). PubMed

Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M. “p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells”.
Cancer Cell. 2016 May 19; doi: 10.1016/j.ccell.2016.04.006. [Epub ahead of print]. PubMed

Font-Burgada J, Sun B, Karin M. “Obesity and cancer: The oil that feeds the flame”.
Cell Metabolism. 2016 Jan 12; 23(1):48–62. doi: 10.1016/j.cmet.2015.12.015. PubMed 

Font-Burgada J#, Shalapour S, Ramaswamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M#. “Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer”.
Cell. 2015. Aug 13;162(4):766-79. doi: 10.1016/j.cell.2015.07.026. PMID: 26276631. (# co-corresponding authors). Highlighted in Cell Stem Cell (2015 Oct 1;17(4):377-8) and Nature Reviews Gastroenterology and Hepatology (2015 Oct;12(10):549) PubMed

Shalapour S, Font-Burgada J, Di Caro G, Zhong Z, Sanchez-Lopez E, Dhar D, Willimsky G, Ammirante M, Strasner A, Hansel DE, Jamieson C, Kane CJ, Klatte T, Birner P, Kenner L, Karin M. “Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy”.
Nature. 2015 May 7;521(7550):94-8. doi: 10.1038/nature14395. PMID: 25924065. PubMed

Wree A, Johnson CD, Font-Burgada J, Eguchi A, Povero D, Karin M, Feldstein AE. “Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation”.
Cell Death Differ. 2015 Dec;22(12):1985-94. doi: 10.1038/cdd.2015.46. PMID: 25909884. PubMed

Kessler R, Tisserand J, Font-Burgada J, Reina O, Coch L, Attolini CS, Garcia-Bassets I, Azorín F. “dDsk2 regulates H2Bub1 and RNA polymerase II pausing at dHP1c complex target genes”.
Nat Commun. 2015 Apr 28;6:7049. doi: 10.1038/ncomms8049.PMID: 25916810. PubMed

Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle N, Wu LW, Yang J, Dowdy SF, Reya T, Karin M. “Ubc13 Controls Breast Cancer Metastasis through a TAK1-p38 MAP Kinase Cascade”.
Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13870-5. doi: 10.1073/pnas.1414358111. PMID: 25189770. PubMed

Nakagawa H*, Umemura A*, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M (2014). “ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development.”
Cancer Cell. 2014 Sep 8;26(3):331-43. doi: 10.1016/j.ccr.2014.07.001. PMCID: PMC4165611 (*co-first authors). PubMed

Nakagawa H*, Hikiba Y*, Hirata Y, Font-Burgada J, Sakamoto K, Hayakawa Y, Taniguchi K, Umemura A, Kinoshita H, Sakitani K, Nishikawa Y, Hirano K, Ikenoue T, Ijichi H, Dhar D, Shibata W, Akanuma M, Koike K, Karin M, Maeda S. (2014) “Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis.”
Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1090-5. doi: 10.1073/pnas.1322731111 PMCID:PMC3903249 (*co-first authors). PubMed

Font-Burgada J*#., Reina O*, Rossell D#, Azorin F# (2014). “chroGPS, a global chromatin positioning system for the functional analysis and visualization of the epigenome.”
Nucleic Acids Res. 2014 Feb;42(4):2126-37 doi: 10.1093/nar/gkt1186 PMCID: PMC3936722 (*co-first authors. #co-corresponding authors.) Selected as cover article. PubMed

He G*, Dhar D*, Nakagawa H*, Font-Burgada J*, Ogata H*, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K and Karin M (2013). “Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling”.
Cell. 2013 Oct 10;155(2):384-96. doi: 10.1016/j.cell.2013.09.031 PMID:24120137 (*co-first authors). Highlighted in: Nature Medicine 2013 19(11):1376. PubMed

Font-Burgada J., Seki, E., Karin, M. (2012). “CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction”.
Cancer Cell. 2012 Jun 12;21(6):711-2. doi: 10.1016/j.ccr.2012.05.034.PMID:22698394. PubMed

Font-Burgada J, Rossell D, Auer H, Azorin F (2008). “Drosophila HP1c isoform interacts with the zinc-finger proteins WOC and Relative-of-WOC to regulate gene expression”.
Genes & Dev. 22(21): 3007-3023. doi: 10.1101/gad.481408 PMCID: PMC2577788. PubMed

Additional Publications

Dr. Font-Burgada on PubMed

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