Efrat Dotan, MD

Efrat Dotan, MD

Clinical Locations

Primary Location

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111


Director, Hematology/Oncology Fellowship Training Program

Assistant Professor, Department of Hematology/Oncology

TRDG Member, Colorectal and SI CancerEsophagus, Pancreas, and Liver Cancer

NCCN, Cancer-Related Fatigue Panel Member

NCCN, Older Adult Oncology Panel Member

NCCN, Pancreatic Adenocarcinoma Panel Member

Treatment Focus

Gastrointestinal cancers; Geriatric Oncology

Research Program

Language(s) Other than English


Treatment Philosophy

I specialize in treatment of patients with gastrointestinal cancers with various chemotherapies. My goal is to provide each patient with cutting-age therapy for their cancer, and the supportive care necessary for tolerating treatment. I am specifically interested in caring for older adults with gastrointestinal cancers, while focusing on other factors that are not related to their cancer and complicate their care.

Follow on Twitter @efratdotan

Education, Training & Credentials

Educational Background

  • Fellow & Chief Fellow, Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA
  • Resident & Chief Resident, Internal Medicine, Lenox Hill Hospital, New York, NY, 2007
  • Resident, Internal Medicine, Lenox Hill Hospital, New York, NY, 2006
  • MD, Technion, Israel Institute of Technology, Israel, 2002


  • American Board of Internal Medicine
  • Board Certification in Hematology and Medical Oncology 


  • National Comprehensive Cancer Network (NCCN)
    • Cancer-Related Fatigue Panel
    • Occult Primary Panel
    • Older Adult Oncology Panel
  • American Society of Clinical Oncology (ASCO)
  • International Society of Geriatric Oncology (SIOG)
  • Cancer and Aging Research Group (CARG)
  • Eastern Cooperative Oncology Group (ECOG)
  • American Medical Association (AMA) 

Honors & Awards

  • AMGEN Fellowship Grant 2009;
  • American College of Physician (ACP): Associate Research Competition Award
Patient Stories

Robert Evans

Robert Evans

In August 2015, Robert Evans, 70, went to a local suburban, Philadelphia hospital to have surgery for a ruptured bowl after experiencing extreme pain in his abdomen. During the surgery, doctors decided it was best to remove his appendix because it was enflamed and interfering with the procedure. This was a fairly routine procedure and a cancer diagnoses was far from Robert’s mind.  

Darryl Hall

Colorectal Cancer

Darryl Hall

Colorectal Cancer

For a few months, Darryl Hall wasn’t feeling right. He was constipated and had difficulty with bowel movements. “I hadn’t been to a doctor in several years, so I decided that I should get this checked out,” recalls Darryl, 65. “My family doctor ordered both a CAT and an X-Ray and I was told a mass was detected.  I was referred to a surgeon at my local hospital. After two colposcopies and anexploratory surgery, I still didn’t have answers. I would go back to see several doctors at my community hospital and the doctors never seemed to communicate. I was getting frustrated and I knew I needed to get a second opinion.”

Frances Hatalovsky

GIST (Gastrointestinal Stromal Tumor)

Frances Hatalovsky

GIST (Gastrointestinal Stromal Tumor)

When Fran Hatalovsky turned 74 in 2006, she wasn’t even entertaining the idea of retirement. In fact, when she was told by her Fox Chase Cancer Center surgeon that carcinoid cancer had spread throughout her body, her main concern was whether she'd be able to return to work. Her surgeon assured her that he would do everything in his power to make it happen. Just two months after her surgeon performed a very complex procedure to remove the cancerous tissue that affected Fran's colon, small intestine, ovaries and liver, she was able to return to work and couldn't have been more pleased.

Research Profile

Research Program

Research Interests

  • Clinical trials of novel treatments for gastrointestinal cancers.
  • Drug Development
  • Clinical trial specific to older cancer patients

Selected Publications

Vijayvergia N, Dotan E, Devarajan K, et al. Patterns of care and outcomes of older versus younger patients with metastatic pancreatic cancer: A Fox Chase Cancer Center Experience. J Geriatr Oncol. 2015; S1879-4068. [Epub ahead of print]. PubMed

Dotan E, Li T, Hall M, Meropol N, Beck R, Wong YN. Oncologists’ Response to New Data Regarding the Use of Epidermal Growth Factor Receptor Inhibitors in Colorectal Cancer. JOP. September 2014 10(5): 308-14.  PubMed

McCleary N, Dotan E, Browner I. Refining Chemotherapy Approach for Older Patients with Colon Cancer. J Clin Oncol, August 2014; 32: 2570-2580. PubMed

Dotan E, Devarajan K, D’Silva JA, Beck A, Kloth D, Cohen J S, Denlinger C. Patterns of use and tolerance of anti-epidermal growth factor receptor antibodies among older adults with metastatic colorectal cancer. Clinical Colorectal Cancer. September 2014; 13(3):192-8. PubMed

Dotan E, Meropol N, Zhu F, Bove B, Cai K, Godwin A, Golemis A, Astsaturov I, Cohen S. Increased Aurora kinase A gene copy number is associated with improved prognosis and response to chemotherapy in patients with metastatic colorectal cancer. British Journal of Cancer. 2012 Feb 14;106(4):748-55   PubMed

Dotan E, Browner I, Hurria A, Denlinger C: Challenges in the management of elderly patients with colon cancer. JNCCN February 2012, 10(2):213-24  PubMed

Dotan E, Meropol J N, Burtness B, Denlinger C et al. A phase II study of capecitabine, oxaliplatin, and cetuximab with or without bevacizumab as front line therapy for metastatic colorectal cancer.  A Fox Chase Extramural Research Study. J Gastrointest Cancer, December 2012, 43(4), 562-569. PMCID: PMC340072  PubMed

Dotan E, Cohen S J. Challenges in the management of stage II colon cancer. Seminars in Oncology Aug 2011; 38(4): 511-20   PubMed

Dotan E, Cohen S J, Alpaugh K, Meropol N J. Circulating tumor cells: evolving evidence and future challenges. The oncologist, November 2009, 14(11): 1070-1082 PubMed

Additional Publications


This Fox Chase professor participates in the Undergraduate Summer Research Fellowship
Learn more about Research Volunteering.