Efrat Dotan, MD

Efrat Dotan, MD

Clinical Locations

Primary Location

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111


Chief, Division of Gastrointestinal Medical Oncology

Associate Professor, Department of Hematology/Oncology

Associate Director, Hematology/Oncology Fellowship Training Program

NCCN, Chair of the Older Adult Oncology Panel

NCCN, Pancreatic Adenocarcinoma Panel Member

Treatment Focus

Gastrointestinal cancers; Geriatric Oncology

Research Program

Language(s) Other than English


Treatment Philosophy

I specialize in treatment of patients with gastrointestinal cancers with various chemotherapies. My goal is to provide each patient with cutting-age therapy for their cancer, and the supportive care necessary for tolerating treatment. I am specifically interested in caring for older adults with gastrointestinal cancers, while focusing on other factors that are not related to their cancer and complicate their care.


Follow on Twitter @efratdotan

Education and Training

Educational Background

  • Fellow & Chief Fellow, Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA
  • Resident & Chief Resident, Internal Medicine, Lenox Hill Hospital, New York, NY, 2007
  • Resident, Internal Medicine, Lenox Hill Hospital, New York, NY, 2006
  • MD, Technion, Israel Institute of Technology, Israel, 2002


  • American Board of Internal Medicine
  • Board Certification in Hematology and Medical Oncology 


  • National Comprehensive Cancer Network (NCCN)
    • Cancer-Related Fatigue Panel
    • Occult Primary Panel
    • Older Adult Oncology Panel
  • American Society of Clinical Oncology (ASCO)
  • International Society of Geriatric Oncology (SIOG)
  • Cancer and Aging Research Group (CARG)
  • Eastern Cooperative Oncology Group (ECOG)
  • American Medical Association (AMA) 

Honors & Awards

  • AMGEN Fellowship Grant 2009;
  • American College of Physician (ACP): Associate Research Competition Award
Patient Stories

Shelby Hurley

Breast Cancer

Shelby Hurley

Breast Cancer

I remember lying on the operating table before surgery, worrying about what was going to happen next. My breast was trying to kill me but it had still been difficult to make the decision to undergo a mastectomy.

Robert Evans

Robert Evans

In August 2015, Robert Evans, 70, went to a local suburban Philadelphia hospital to have surgery for a ruptured bowl after experiencing extreme pain in his abdomen. During the surgery, doctors decided it was best to remove his appendix because it was enflamed and interfering with the procedure. This was a fairly routine procedure, and a cancer diagnosis was far from Robert’s mind. When Robert learned he had cancer of the appendix, he sought a second opinion at Fox Chase Cancer Center, where he later underwent surgery. "I was, and remain today, very impressed by Fox Chase," Robert said. "My stay there was unlike any other hospital stay I have had. The quietness was absolutely incredible, and it was a very calming environment. From the person cleaning my room to the top-level nurses and physicians, everyone was spectacular."

Darryl Hall

Colorectal Cancer

Darryl Hall

Colorectal Cancer

When Darryl Hall was diagnosed with colon cancer, he was referred to a surgeon at a local hospital. After two colonoscopies and exploratory surgery, Darryl still felt he had no solid answers regarding his condition. He decided to seek a second opinion from a specialist at Fox Chase Cancer Center. Darryl had a completely different experience at Fox Chase, where he underwent surgery and chemotherapy. "I encourage other people like me to get a second opinion if they are not happy with their current treatment plan," he said. "Both my wife and I received the best of care at Fox Chase. We are grateful to our doctors, and we recommend Fox Chase to anyone needing cancer care. Today we are both doing well and can enjoy the time we spend together and with our five grandchildren."

Frances Hatalovsky

GIST (Gastrointestinal Stromal Tumor)

Frances Hatalovsky

GIST (Gastrointestinal Stromal Tumor)

When Frances Hatalovsky was diagnosed with metastatic carcinoid cancer at age 74, she sought treatment at Fox Chase Cancer Center. In January 2006, she had surgery to remove the cancerous tissue from her colon, small intestine, ovaries, and liver. The surgery was successful, and Frances returned to work two months later. "I will never forget how patient, kind, compassionate, and attentive the Fox Chase staff was when they first met with me and my husband, John," she said. "They reviewed my records and test results, showed us my X-rays, and pointed out exactly where the cancer was located and how far it had spread. They asked me how I wanted to proceed given the diagnosis, and they gave me the confidence I needed to know I could beat the cancer."

Research Profile

Research Program

Research Interests

  • Clinical trials of novel treatments for gastrointestinal cancers.
  • Drug Development
  • Clinical trial specific to older cancer patients

Selected Publications

Vijayvergia N, Dotan E, Devarajan K, et al. Patterns of care and outcomes of older versus younger patients with metastatic pancreatic cancer: A Fox Chase Cancer Center Experience. J Geriatr Oncol. 2015; S1879-4068. [Epub ahead of print]. PubMed

Dotan E, Li T, Hall M, Meropol N, Beck R, Wong YN. Oncologists’ Response to New Data Regarding the Use of Epidermal Growth Factor Receptor Inhibitors in Colorectal Cancer. JOP. September 2014 10(5): 308-14.  PubMed

McCleary N, Dotan E, Browner I. Refining Chemotherapy Approach for Older Patients with Colon Cancer. J Clin Oncol, August 2014; 32: 2570-2580. PubMed

Dotan E, Devarajan K, D’Silva JA, Beck A, Kloth D, Cohen J S, Denlinger C. Patterns of use and tolerance of anti-epidermal growth factor receptor antibodies among older adults with metastatic colorectal cancer. Clinical Colorectal Cancer. September 2014; 13(3):192-8. PubMed

Dotan E, Meropol N, Zhu F, Bove B, Cai K, Godwin A, Golemis A, Astsaturov I, Cohen S. Increased Aurora kinase A gene copy number is associated with improved prognosis and response to chemotherapy in patients with metastatic colorectal cancer. British Journal of Cancer. 2012 Feb 14;106(4):748-55   PubMed

Dotan E, Browner I, Hurria A, Denlinger C: Challenges in the management of elderly patients with colon cancer. JNCCN February 2012, 10(2):213-24  PubMed

Dotan E, Meropol J N, Burtness B, Denlinger C et al. A phase II study of capecitabine, oxaliplatin, and cetuximab with or without bevacizumab as front line therapy for metastatic colorectal cancer.  A Fox Chase Extramural Research Study. J Gastrointest Cancer, December 2012, 43(4), 562-569. PMCID: PMC340072  PubMed

Dotan E, Cohen S J. Challenges in the management of stage II colon cancer. Seminars in Oncology Aug 2011; 38(4): 511-20   PubMed

Dotan E, Cohen S J, Alpaugh K, Meropol N J. Circulating tumor cells: evolving evidence and future challenges. The oncologist, November 2009, 14(11): 1070-1082 PubMed

Additional Publications




Our Patient Satisfaction Rating is an average of all responses to care provider related questions from our nationally-recognized Press Ganey Patient Satisfaction Survey. Learn more.


4.9 / 5.0


  • 4.9
  • 4.9
  • 4.9
  • 5.0
  • 4.9


  • 5.0
    July 27, 2021
    Having been diagnosed with cancer I was very scared and thought I would die. Dr Dotan treatments saved my life. I would recomend her to everyone.
  • 5.0
    June 24, 2021
    Absolutely best care!!!
  • 5.0
    June 21, 2021
    Nothing but exceptional - Very good experience.
  • 5.0
    February 19, 2021
    service is always excellent
  • 5.0
    February 03, 2021
    My experiences have been very good. Everyone is most kind & helpful.
  • No Star Ratings Available January 13, 2021
    she was very patient and allowed me to ask questions and take notes
  • 5.0
    January 11, 2021
    Very good.
  • 5.0
    October 06, 2020
    Very good care - Excellent care & service always.
  • 3.0
    September 28, 2020
    Dr. Dotan and her team are very professional and very qualified individuals. Whenever I have a question or a concerned they seem to respond in a positive way. I have been in precarious situations regarding my health condition and her team displayed and applied positive outcomes each and every time. I am very Thankful for Dr. Dotan and her team.
  • 5.0
    July 10, 2020
    I am very pleased with the competence of Dr. Dotan and Dr. [...]
  • 5.0
    June 14, 2020
    Very good.
  • 5.0
    April 27, 2020
    Dr. Dotan is the greatest doctor. I'm very satisfied.

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