Efrat Dotan, MD

Efrat Dotan
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This Fox Chase professor participates in the Undergraduate Summer Research Fellowship
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Clinical Locations

  • Fox Chase Cancer Center
    333 Cottman Avenue
    Philadelphia, PA 19111
    Phone: 888-369-2427

Chief, Division of Gastrointestinal Medical Oncology

Associate Professor, Department of Hematology/Oncology

Associate Director, Hematology/Oncology Fellowship Training Program

NCCN, Chair of the Older Adult Oncology Panel

NCCN, Pancreatic Adenocarcinoma Panel Member


  • Gastrointestinal Medical Oncology

Areas of Expertise

Esophageal Cancer, Pancreatic Cancer, Colorectal Cancer, Neuroendocrine Tumors, Appendix Cancer, Liver, Gall Bladder & Bile Duct Cancer, Stomach (Gastric) Cancer

Treatment Focus

Gastrointestinal cancers; Geriatric Oncology


Language(s) Other than English

  • Hebrew

Treatment Philosophy

I specialize in treatment of patients with gastrointestinal cancers with various chemotherapies. My goal is to provide each patient with cutting-age therapy for their cancer, and the supportive care necessary for tolerating treatment. I am specifically interested in caring for older adults with gastrointestinal cancers, while focusing on other factors that are not related to their cancer and complicate their care.

Follow on Twitter @efratdotan

Educational Background

  • Fellow & Chief Fellow, Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA
  • Resident & Chief Resident, Internal Medicine, Lenox Hill Hospital, New York, NY, 2007
  • Resident, Internal Medicine, Lenox Hill Hospital, New York, NY, 2006
  • MD, Technion, Israel Institute of Technology, Israel, 2002


  • American Board of Internal Medicine - Medical Oncology


  • National Comprehensive Cancer Network (NCCN)
    • Cancer-Related Fatigue Panel
    • Occult Primary Panel
    • Older Adult Oncology Panel
  • American Society of Clinical Oncology (ASCO)
  • International Society of Geriatric Oncology (SIOG)
  • Cancer and Aging Research Group (CARG)
  • Eastern Cooperative Oncology Group (ECOG)
  • American Medical Association (AMA) 

Honors & Awards

  • Philadelphia Magazine Top Doctors, 2023-24
  • AMGEN Fellowship Grant 2009;
  • American College of Physician (ACP): Associate Research Competition Award
Rob Brown

Rob Brown

  • Colorectal Cancer
  • Lung Cancer

My cancer journey began in late 2021 when I began experiencing feelings of sickness, most often after eating. One night in February 2022, however, it became clear food was not the issue.

I’m the kind of guy who can sleep anytime, anywhere, so when the pain in my abdomen got so bad that I couldn’t sleep, I finally told my wife I needed to go to the ER. The doctors there did some testing and scans, but all they found was an infection, so they gave me an IV and antibiotics. After a few days, when I felt better, they sent me home.

Larry Holman

Larry Holman

  • GIST (Gastrointestinal Stromal Tumor)

I’m an 83-year-old U.S. Navy veteran. I smoked for twenty-odd years until I was 35 years old, which left me with some lingering COPD. Ten years ago I had a heart attack and had a stent put in. So when I received my cancer diagnosis, it crossed my mind that it might be time to go into hospice. But my wife Debbie was already battling breast cancer, and if she could fight, I felt like I could too.

Link to /sites/default/files/styles/patient_story/public/images/patient-stories/AC1A4264.jpg?h=7e339407&itok=eSsOhvcU

Shelby Hurley

  • Breast Cancer

I remember lying on the operating table before surgery, worrying about what was going to happen next. My breast was trying to kill me but it had still been difficult to make the decision to undergo a mastectomy.


Research Interests

  • Clinical trials of novel treatments for gastrointestinal cancers.
  • Drug Development
  • Clinical trial specific to older cancer patients

Selected Publications

Seedor R.S., Meeker C.R., Lewis B., Handorf E.A., Filchner K.A., Varadarajan R., Hensold J., Padmanabhan A., Negin B., Blankstein K., Chawla N.R., Song W., Epstein J., Winn J., Goldstein L.J., Dotan E., Prospective comparison of geriatric assessment and provider's assessment of older adults with metastatic breast cancer in the community. Oncologist. 27(2): E133-E141, 2022. <Go to ISI>://WOS:000764264500011.

Winer A., Handorf E.,Dotan E., Dosing schedules of gemcitabine and nab-paclitaxel for older adults with metastatic pancreatic cancer. Jnci Cancer Spectrum. 5(5): pkab074, 2021.PMC8438244. https://www.ncbi.nlm.nih.gov/pubmed/34532641.

Dotan E. The Future of Geriatric Oncology Research: Moving Toward Interventions and Objective Biomarkers of Aging. JNCCN September 2021, 19(9):1111-1113. DOI

Vijayvergia N, Dotan E, Devarajan K, et al. Patterns of care and outcomes of older versus younger patients with metastatic pancreatic cancer: A Fox Chase Cancer Center Experience. J Geriatr Oncol. 2015; S1879-4068. [Epub ahead of print]. PubMed

Dotan E, Li T, Hall M, Meropol N, Beck R, Wong YN. Oncologists’ Response to New Data Regarding the Use of Epidermal Growth Factor Receptor Inhibitors in Colorectal Cancer. JOP. September 2014 10(5): 308-14.  PubMed

McCleary N, Dotan E, Browner I. Refining Chemotherapy Approach for Older Patients with Colon Cancer. J Clin Oncol, August 2014; 32: 2570-2580. PubMed

Dotan E, Devarajan K, D’Silva JA, Beck A, Kloth D, Cohen J S, Denlinger C. Patterns of use and tolerance of anti-epidermal growth factor receptor antibodies among older adults with metastatic colorectal cancer. Clinical Colorectal Cancer. September 2014; 13(3):192-8. PubMed

Dotan E, Meropol N, Zhu F, Bove B, Cai K, Godwin A, Golemis A, Astsaturov I, Cohen S. Increased Aurora kinase A gene copy number is associated with improved prognosis and response to chemotherapy in patients with metastatic colorectal cancer. British Journal of Cancer. 2012 Feb 14;106(4):748-55   PubMed

Dotan E, Browner I, Hurria A, Denlinger C: Challenges in the management of elderly patients with colon cancer. JNCCN February 2012, 10(2):213-24  PubMed

Dotan E, Meropol J N, Burtness B, Denlinger C et al. A phase II study of capecitabine, oxaliplatin, and cetuximab with or without bevacizumab as front line therapy for metastatic colorectal cancer.  A Fox Chase Extramural Research Study. J Gastrointest Cancer, December 2012, 43(4), 562-569. PMCID: PMC340072  PubMed... Expand

Additional Publications

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This Fox Chase professor participates in the Undergraduate Summer Research Fellowship
Learn more about Research Volunteering.