David S. Weinberg, MD, MSc

David Weinberg, MD, MSc

Clinical Locations

Primary Location

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111


Chair, Department of Medicine

Chief, Section of Gastroenterology

Audrey Weg Schaus and Geoffrey Alan Weg Chair in Medical Science

TRDG Member, Colorectal and SI CancerEsophagus, Pancreas, and Liver Cancer

Treatment Focus

Molecular Epidemiology of Gastrointestinal Disease; Risk Assessment

Research Program

Key Awards

Philadelphia Magazine Top Docs 2020

Treatment Philosophy

I joined the staff at Fox Chase Cancer Center in 2001 as director of gastroenterology. While my gastroenterology colleagues and I see many patients with cancers of all types, we are very happy to care for the gastrointestinal needs of patients without cancer as well.

I have a special interest in cancer prevention, especially for patients who are at average risk for gastrointestinal cancers. The current methods of gastrointestinal cancer prevention tools, like colonoscopy, are very effective. However, it is very likely that the next generation of screening techniques will be substantially better. Finding new ways to increase participation in screening programs and to use molecular or genetic markers to provide more accurate estimates of risk are particular interests of mine. Hopefully, finding such markers will allow for better targeting of screening and other risk reduction strategies now and in the future.

Colorectal cancer (CRC) is the second leading cause of cancer death in the U.S. Periodic screening can reduce the incidence and mortality from this disease. Unfortunately, screening is underutilized. Less than 50% of the U.S. population has been appropriately screened according to standard guidelines. The poor acceptance rate is particularly disappointing since no other common human malignancy represents such an appropriate target for cancer prevention. Effective strategies to increase screening rates, targeted towards patients or providers, have proven elusive. The major goals of our research program are the development of novel CRC risk stratification tools in average risk populations to facilitate more appropriate use of screening tests as well as investigating new methods to increase screening utilization. Several ongoing, large multi-center trials are underway that investigate new clinical platforms for CRC screening, the impact of gene-environment interaction on CRC risk stratification and the utility of patient specific information tailoring to increase CRC screening use.

Chair, Department of Medicine

David S. Weinberg, MD, MSc, has served as the Chair of the Department of Medicine and the Director of Gastroenterology since his appointment in 2008.

Dr. Weinberg’s research centers on the prevention and control of gastrointestinal malignancies with a particular interest in biomarkers, chemoprevention, the cost effectiveness of clinical care and in novel methods to promote cancer screening utilization. He currently holds research support from the National Institutes of Health, the pharmaceutical industry, and philanthropic organizations. He is the author of more than 150 peer reviewed manuscripts and sits on the editorial boards of several biomedical journals including Gastroenterology.

In addition to research, Dr Weinberg continues an active clinical practice in Gastroenterology, winning multiple “top doctor” awards. In addition, he serves as the Chief Medical Officer of the Temple University Health System’s Office of International Health. Beyond activities at Fox Chase he has been appointed to leadership roles on national committees for a range of groups including the American Board of Internal Medicine, the National Cancer Institute, the American College of Physicians (ACP) and the American Gastroenterological Association (AGA).

Dr. Weinberg received his undergraduate degree magna cum laude from Yale University and his MD from Cornell University Medical College, where he earned the Research Thesis Award and was a member of the Alpha Omega Alpha honorary society. He served his internship and residency in internal medicine at Beth Israel Hospital in Boston and then his Gastroenterology fellowship training at the University of Pennsylvania. Concurrently, he was a National Research Service Award fellow in cancer epidemiology earning a masters’ degree in epidemiology from the University of Pennsylvania.

Education and Training

Educational Background

  • Fellow, Gastroenterology, University of Pennsylvania, Philadelphia, PA
  • Fellow, Clinical Epidemiology, University of Pennsylvania, Philadelphia, PA
  • Resident, Internal Medicine, Beth Israel Hospital, Boston, MA 
  • MSc, Cancer Epidemiology, University of Pennsylvania, Philadelphia, PA
  • MD, Cornell University Medical College, New York, NY
  • BA, Yale University, New Haven, CT


  • Gastroenterology, American Board of Internal Medicine


  • National Comprehensive Cancer Network (NCCN)
    • Genetic: Colorectal/Colorectal Cancer Screening Panel
  • American Association for Cancer Research
  • American College of Gastroenterology
  • American Gastroenterological Association, Fellow
  • National Institutes of Health

Honors & Awards

  • Philadelphia Magazine Top Doctors, 2009-20
  • Best Doctors in America® , 2019-2020, Gastroenterology
  • America’s Top Doctors®, 2015-17
Patient Stories

Alison Kovalchik

Breast Cancer

Alison Kovalchik

Breast Cancer

In 2013, Alison Kovalchik learned she carried the BRCA1 mutation that increases the risk for developing breast cancer. Because she already had a number of other health issues, she was very worried about her options for preventive treatment. Upon the recommendation of her doctor, Alison sought answers from a specialist at Fox Chase Cancer Center, where she later had preventive surgery. She was assigned to a team of physicians from several different departments who all worked together to form an individualized treatment plan to ensure the best outcome. "Even though Fox Chase is a cancer center, its staff considers the patient as a whole person, which is something I hadn’t encountered elsewhere, and, to me, it is a true miracle," Alison said. "Fox Chase Cancer Center’s doctors worked as a team to treat me...I trust my team at Fox Chase. My doctors gave me my life back—in all ways, not only with the BRCA mutation risk. I know I’m in the best hands for my care."

James Slade

Colorectal Cancer;  Prostate Cancer

James Slade

Colorectal Cancer;  Prostate Cancer

I was in my early 60s when my first PSA blood test detected slightly elevated levels, and I was advised to be retested 8 months later. When the levels increased 50% on the second test, my doctor in New Jersey performed a biopsy. The diagnosis was prostate cancer.

Albert Anderson

Colorectal Cancer

Albert Anderson

Colorectal Cancer

"Although the gastroenterologist recommended that I wait 6 months for a follow-up test, my wife and I decided that I should get a second opinion at Fox Chase Cancer Center, where I had been successfully treated for prostate cancer 3 years prior. "

Research Profile

Research Program

Research Interests

  • Gastrointestinal cancer prevention and control 
  • Cancer chemoprevention
  • Cost and clinical effectiveness studies

Selected Publications

Siedler MR, Allen JI, Falck-Ytter YT, Weinberg DS.  AGA Clinical Practice Guidelines: Robust, Evidence-Based Tools for Guiding Clinical Care Decisions. Gastroenterology. 2015 Aug;149(2):493-5   PubMed

Moayyedi P, Weinberg DS, Schünemann H, Chak A. Management of pancreatic cysts in an evidence-based world. Gastroenterology. 2015 Apr;148(4):692-5 PubMed

Rex DK, Schoenfeld PS, Cohen J, Pike IM, Adler DG, Fennerty MB, Lieb JG, Park WG, Rizk MK, Sawhney MS, Shaheen NJ, Wani S, Weinberg DS. Quality Indicators for Colonoscopy.  Am J Gastroenterol. 2015 Jan;110(1):72-90   PubMed

Weinberg DS, Myers RE, Keenan E, Ziring B, Sifri R, Ruth K , Ross E and Manne S:  Gene Environment Risk Assessment and Colorectal Cancer Screening in an Average Risk Population:  A Randomized, Controlled Trial.  Annals of Internal Medicine 2014; 161(8):537-45  PubMed

Horwitz E and Weinberg DS: Medicare Physician Payment Data: Is this Transparency? Ann Intern Med. 2014;161:291-292   PubMed

Weinberg DS and Schoen RE: New Advances in Colorectal Cancer Screening. Ann Intern Med. 2014;160(9):ITC5-1

Weinberg DS, Keenan E, Ruth K, Devarajan K, Rodoletz M, Bieber EJ. A randomized trial comparing a web-based versus print-based intervention to increase CRC screening. JAMA Intern Med. 2013;173:122-9.

Shaheen N, Denberg T, Chou R, Qaseem A, Shekelle P, Weinberg DS: Overuse of upper gastrointestinal endoscopy in acid reflux disease. Ann Intern Med. 2012;157:808-816

Additional Publications




Our Patient Satisfaction Rating is an average of all responses to care provider related questions from our nationally-recognized Press Ganey Patient Satisfaction Survey. Learn more.


4.9 / 5.0


  • 4.8
  • 4.9
  • 5.0
  • 5.0
  • 5.0


  • 5.0
    April 27, 2020
    I spoke to Dr. Weinberg on the phone. He was very helpful in answering my questions.
  • 5.0
    March 02, 2020
    I would only go to Dr. Weinberg for this particular medical problem.
  • 5.0
    January 30, 2020
    [...] The doctor was very thorough and spent a lot of time with me. very professional and caring. The post procedure was excellent as well.
  • 5.0
    January 23, 2020
    Always very happy with the care received. Never have had a problem or issue. Trust and admire Dr Wineburg and his dedication to his patience.
  • 5.0
    January 23, 2020
    great Dr and nurses very pleasant visit
  • 5.0
    January 02, 2020
    Dr. Weinberg continues to be a most caring, knowledgeable and personable care provider - He treats patients with genuine concern & patience. So fortunate to have Dr. Weinberg for our care. Thank you! [...]
  • 5.0
    December 10, 2019
    The best on all my NEEDS.
  • 5.0
    December 06, 2019
    I always have confidence in what Dr. Weinberg suggests.
  • 5.0
    December 04, 2019
    Dr. Weinberg is a great doctor!
  • 5.0
    August 13, 2019
    Dr. Weinberg was easy to talk to. He explained things in a simplified, understandable way. His nurse was friendly and very thorough.
  • 5.0
    August 06, 2019
    Doctor was understanding, excellent and concerned.
  • 5.0
    July 23, 2019
  • 5.0
    May 01, 2019
    It is always a pleasure to see Dr. Weinberg & his nurse. They are both kind & caring as well as excellent at their profession.
  • 5.0
    April 30, 2019
    Excellent expertise. I was recommend to see Dr. Weinberg by another dr. This was a second opinion. His advice [...] put me on a path to healing and my issue was improved.
  • 5.0
    April 25, 2019
    Dr. Weinberg was able to identify what he believed me to be suffering from gastrointestinally (for the past 2 years) by looking at fecal study results conducte by another provider. Subsequent to my consultation with him and being prescribed digestive enzymes and eliminating alcohol my condition has improved significantly. I wish that I had made an appointment with him a year ago!
  • 5.0
    April 12, 2019
    Thank you Dr Weinberg and Staff for your most caring and professional care. It is truly appreciated.
  • 5.0
    March 28, 2019
    I always enjoy seeing Dr. Weinberg, as he is quite competent and easy to talk to.

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