David S. Weinberg, MD, MSc

David Weinberg, MD, MSc

Clinical Locations

Primary Location

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111


Chair, Department of Medicine

Chief, Section of Gastroenterology

Audrey Weg Schaus and Geoffrey Alan Weg Chair in Medical Science

Treatment Focus

Molecular Epidemiology of Gastrointestinal Disease; Risk Assessment

Research Program

Key Awards

Philadelphia Magazine Top Docs 2021

Treatment Philosophy

I joined the staff at Fox Chase Cancer Center in 2001 as director of gastroenterology. While my gastroenterology colleagues and I see many patients with cancers of all types, we are very happy to care for the gastrointestinal needs of patients without cancer as well.

I have a special interest in cancer prevention, especially for patients who are at average risk for gastrointestinal cancers. The current methods of gastrointestinal cancer prevention tools, like colonoscopy, are very effective. However, it is very likely that the next generation of screening techniques will be substantially better. Finding new ways to increase participation in screening programs and to use molecular or genetic markers to provide more accurate estimates of risk are particular interests of mine. Hopefully, finding such markers will allow for better targeting of screening and other risk reduction strategies now and in the future.

Colorectal cancer (CRC) is the second leading cause of cancer death in the U.S. Periodic screening can reduce the incidence and mortality from this disease. Unfortunately, screening is underutilized. Less than 50% of the U.S. population has been appropriately screened according to standard guidelines. The poor acceptance rate is particularly disappointing since no other common human malignancy represents such an appropriate target for cancer prevention. Effective strategies to increase screening rates, targeted towards patients or providers, have proven elusive. The major goals of our research program are the development of novel CRC risk stratification tools in average risk populations to facilitate more appropriate use of screening tests as well as investigating new methods to increase screening utilization. Several ongoing, large multi-center trials are underway that investigate new clinical platforms for CRC screening, the impact of gene-environment interaction on CRC risk stratification and the utility of patient specific information tailoring to increase CRC screening use.


Chair, Department of Medicine

David S. Weinberg, MD, MSc, has served as the Chair of the Department of Medicine and the Director of Gastroenterology since his appointment in 2008.

Dr. Weinberg’s research centers on the prevention and control of gastrointestinal malignancies with a particular interest in biomarkers, chemoprevention, the cost effectiveness of clinical care and in novel methods to promote cancer screening utilization. He currently holds research support from the National Institutes of Health, the pharmaceutical industry, and philanthropic organizations. He is the author of more than 150 peer reviewed manuscripts and sits on the editorial boards of several biomedical journals including Gastroenterology.

In addition to research, Dr Weinberg continues an active clinical practice in Gastroenterology, winning multiple “top doctor” awards. In addition, he serves as the Chief Medical Officer of the Temple University Health System’s Office of International Health. Beyond activities at Fox Chase he has been appointed to leadership roles on national committees for a range of groups including the American Board of Internal Medicine, the National Cancer Institute, the American College of Physicians (ACP) and the American Gastroenterological Association (AGA).

Dr. Weinberg received his undergraduate degree magna cum laude from Yale University and his MD from Cornell University Medical College, where he earned the Research Thesis Award and was a member of the Alpha Omega Alpha honorary society. He served his internship and residency in internal medicine at Beth Israel Hospital in Boston and then his Gastroenterology fellowship training at the University of Pennsylvania. Concurrently, he was a National Research Service Award fellow in cancer epidemiology earning a masters’ degree in epidemiology from the University of Pennsylvania.

Education and Training

Educational Background

  • Fellow, Gastroenterology, University of Pennsylvania, Philadelphia, PA
  • Fellow, Clinical Epidemiology, University of Pennsylvania, Philadelphia, PA
  • Resident, Internal Medicine, Beth Israel Hospital, Boston, MA 
  • MSc, Cancer Epidemiology, University of Pennsylvania, Philadelphia, PA
  • MD, Cornell University Medical College, New York, NY
  • BA, Yale University, New Haven, CT


  • Gastroenterology, American Board of Internal Medicine


  • National Comprehensive Cancer Network (NCCN)
    • Genetic: Colorectal/Colorectal Cancer Screening Panel
  • American Association for Cancer Research
  • American College of Gastroenterology
  • American Gastroenterological Association, Fellow
  • National Institutes of Health

Honors & Awards

  • Philadelphia Magazine Top Doctors, 2009-20
  • Best Doctors in America® , 2019-2020, Gastroenterology
  • America’s Top Doctors®, 2015-17
Patient Stories

Alison Kovalchik

Breast Cancer

Alison Kovalchik

Breast Cancer

In 2013, Alison Kovalchik learned she carried the BRCA1 mutation that increases the risk for developing breast cancer. Because she already had a number of other health issues, she was very worried about her options for preventive treatment. Upon the recommendation of her doctor, Alison sought answers from a specialist at Fox Chase Cancer Center, where she later had preventive surgery. She was assigned to a team of physicians from several different departments who all worked together to form an individualized treatment plan to ensure the best outcome. "Even though Fox Chase is a cancer center, its staff considers the patient as a whole person, which is something I hadn’t encountered elsewhere, and, to me, it is a true miracle," Alison said. "Fox Chase Cancer Center’s doctors worked as a team to treat me...I trust my team at Fox Chase. My doctors gave me my life back—in all ways, not only with the BRCA mutation risk. I know I’m in the best hands for my care."

James Slade

Colorectal Cancer;  Prostate Cancer

James Slade

Colorectal Cancer;  Prostate Cancer

I was in my early 60s when my first PSA blood test detected slightly elevated levels, and I was advised to be retested 8 months later. When the levels increased 50% on the second test, my doctor in New Jersey performed a biopsy. The diagnosis was prostate cancer.

Albert Anderson

Colorectal Cancer

Albert Anderson

Colorectal Cancer

"Although the gastroenterologist recommended that I wait 6 months for a follow-up test, my wife and I decided that I should get a second opinion at Fox Chase Cancer Center, where I had been successfully treated for prostate cancer 3 years prior. "

Research Profile

Research Program

Research Interests

  • Gastrointestinal cancer prevention and control 
  • Cancer chemoprevention
  • Cost and clinical effectiveness studies

Selected Publications

Weinberg DS, Carlos R, Gatsonis C, Zeh H and O’Dwyer P: Study design and rationale for a comparative study of two pancreatic cyst surveillance strategies. Contemp Clinical Trials 2020; 97:106144

Kuntz K, Popp J, Beck JB, Zauber A, Weinberg DS: Cost-Effectiveness of Post-Diagnostic Surveillance Strategies After Resection of Colorectal Cancer: Is There a Role for CT Colonography? BMJ Open Gastro 2020: 7:e000450. doi: 10.1136/bmjgast-2020-000450

Kutikov A, Weinberg DS, Edelman MJ, Horwitz EM, Uzzo RG, and Fisher RI: A War on Two Fronts: Cancer Care in the Time of COVID-19. Annals of Internal Medicine 2020 Jun 2;172(11):756-758

Weinberg DS and Schoen RE: Pre-neoplastic Colorectal Polyps: “I Found Them, Now What?” Annals of Internal Medicine 2019; 171:667-6682.

Weinberg DS, Mitnick J, Keenan EM and Ross EA: Post-operative Colorectal Cancer Surveillance: Preference for Optical Colonoscopy Over Computerized Tomographic Colonography. Cancer Causes and Control 2019;30(11):1269-1273


Weinberg DS, Pickhardt PJ, Bruining DH, Edwards K, Fletcher JG, Gollub MJ, Keenan EM, Kupfer SS, Li T, Lubner  SJ, Markowitz AJ, Ross EA. Computed Tomography Colonography vs Colonoscopy for Colorectal Cancer Surveillance After Surgery. Gastroenterology 2018;154(4):927-934

Kupfer S, Lubner S, Ross E, Li T, Keenan E and Weinberg DS: Adherence to Post-Resection Colorectal Cancer Surveillance at National Cancer Institute-Designated Comprehensive Cancer Centers. Cancer Med. 2018;7(11):5351-5358

Additional Publications




Our Patient Satisfaction Rating is an average of all responses to care provider related questions from our nationally-recognized Press Ganey Patient Satisfaction Survey. Learn more.


4.8 / 5.0


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  • 4.7


  • No Star Ratings Available June 17, 2021
    Dr. Weinberg is always thorough and includes me in discussion on future treatment. He is also friendly while still being appropriate. I look forward to our yearly visits.
  • No Star Ratings Available May 15, 2021
    Good experience
  • 5.0
    March 15, 2021
    Fox Chase Hospital and Staff are always very professional and compassionate and always happy to help you with any questions, concerns and comfort.
  • 5.0
    October 21, 2020
    Excellent experience with Dr. Weinberg. His nurse, [...] & entire team.
  • 5.0
    September 21, 2020
    My visit [...] was pleasant, informative and encouraging.
  • 5.0
    September 18, 2020
    Great service!
  • 5.0
    April 27, 2020
    I spoke to Dr. Weinberg on the phone. He was very helpful in answering my questions.

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