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I am a medical oncologist specializing in genitourinary cancers. I became a physician and an oncologist for many reasons including the ability to sometimes cure life-threatening illness, having the opportunity to care for ill patients, and being a part of a rapidly evolving and improving field. But perhaps the most important reason for entering oncology for me was the chance to build deep relationships with patients and their families at a time when they are the most vulnerable and in need, to be their advocate and resource, to guide them through a grueling time and hope with them for the best.
I believe that every cancer patient deserves the utmost compassionate, individualized, expert and prompt care. I came to Fox Chase after completing my fellowship at the University of Chicago because here I can offer just that. By working together with each patient, their family and a team of my expert colleagues, we can harness the most recent advances in oncology for each patient.
In my clinical practice I focus on the care of patients with prostate, kidney, bladder, penile, adrenal and testicular cancer and I am proud to be part of a large multidisciplinary team of distinguished clinicians and researchers at Fox Chase. Over the last decade, the number of treatment options for patients with advanced cancers has greatly expanded and at Fox Chase we can offer both the latest standard-of-care as well as new experimental approaches. My particular research interest is in health outcomes as well as clinical trials development for genitourinary cancers.
A cancer diagnosis is one of the most difficult times in a person’s life; my primary goal is to bring together all the resources of a cutting-edge cancer center to the patient in a compassionate and individualized manner.
Fellow, Maclean Center for Clinical Medical Ethics, University of Chicago, Chicago, IL
Fellow and Chief Fellow, Hematology and Medical Oncology, University of Chicago Medical Center, Chicago, IL
Intern, Resident and Chief Resident, University of Pittsburgh Medical Center, Pittsburgh, PA
MD, University of Pittsburgh, Pittsburgh, PA, 2006
American Board of Internal Medicine, Medical Oncology, 2013
American Board of Internal Medicine, 2009
American Society of Clinical Oncology
Honors & Awards
ASCO/AACR Methods in Clinical Research Workshop Selected Participant, Vail, CO, 2014
Illinois Medical Oncology Society Fellows Award, Chicago, Illinois, 2012
Senior Presentation Award, University of Pittsburgh School of Medicine Department of Medicine, 2009
Lucien J. Rubenstein Memorial Award, American Brain Tumor Association, 2003
Morris H. and Gertrude M. Harris Foundation Scholarship, University of Pittsburgh School of Medicine, Pittsburgh, PA, 2002–2006
Drug development for genitourinary malignancies
Health outcomes/services research
Geynisman D.M., Du E.X., Yang X., Sendhil S.R., Tejo V.D., Betts K.A.,Huo S., Temporal trends of adverse events and costs of nivolumab plus ipilimumab versus sunitinib in advanced renal cell carcinoma. Future Oncol. 18(10): 1219-1234, 2022. https://www.ncbi.nlm.nih.gov/pubmed/34939424.
Geynisman D.M., Kadow B.T., Shuch B.M., Boorjian S.A., Matin S.F., Rampersaud E., Milestone B.N., Plimack E.R., Zibelman M.R., Kutikov A., Smaldone M.C., Chen D.Y., Viterbo R., Joshi S., Greenberg R.E., Malizzia L., McGowan T., Ross E.A.,Uzzo R.G., Sporadic angiomyolipomas (amls) growth kinetics while on everolimus (sage): Results of a phase ii trial. J Urol. 204(3): 531-537, 2020. PMC7695484. https://www.ncbi.nlm.nih.gov/pubmed/32250730.
Strother M.C., Kutikov A., Epstein M., Bochner E., Deng M., Handorf E., Lewis B., Ghatalia P., Greenberg R.E., Chen D., Viterbo R., Anari F., Smaldone M.C., Zibelman M.R., Uzzo R.G., Plimack E.R., Geynisman D.M., Safety of neoadjuvant chemotherapy in patients with muscle-invasive bladder cancer and malignant ureteric obstruction. BJU Int. 129(3): 364-372, 2022. https://www.ncbi.nlm.nih.gov/pubmed/33780097.
Changa NM, Xie WL, Bilen MA, Dzimitrowicz H, Burkart J, Geynisman DM, Balakrishnan A, Bowman IA, Jain R, Stadler W, Zakharia Y, Narayan V, Beuselinck B, McKay RR, Tripathi A, Pachynski R, Hahn AW, Hsu J, Shah SA, Lam ET, Rose TL, Mega AE, Vogelzang N, Harrison MR, Mortazavi A, Plimack ER, Vaishampayan U, Hammers H, George S, Haas N, Agarwal N, Pal SK, Srinivas S, Carneiro BA, Heng DYC, Bosse D, Choueiri TK, Harshman LC. Cabozantinib in advanced non-clear-cell renal cell carcinoma: a multicentre, retrospective, cohort study. Lancet Oncology, 20(4):581-90, 2019.
Rouvinov K, Plimack ER, Zibelman M, Ghatalia P, Geynisman DM. Update on perioperative systemic therapy for urothelial carcinoma. Clinical advances in hematology & oncology : H&O, 17(3):176-83, 2019.
Martinez Chanza N, Xie W, Asim Bilen M, Dzimitrowicz H, Burkart J, Geynisman DM, Balakrishnan A, Bowman IA, Jain R, Stadler W, Zakharia Y, Narayan V, Beuselinck B, McKay RR, Tripathi A, Pachynski R, Hahn AW, Hsu J, Shah SA, Lam ET, Rose TL, Mega AE, Vogelzang N, Harrison MR, Mortazavi A, Plimack ER, Vaishampayan U, Hammers H, George S, Haas N, Agarwal N, Pal SK, Srinivas S, Carneiro BA, Heng DYC, Bosse D, Choueiri TK, Harshman LC. Cabozantinib in advanced non-clear-cell renal cell carcinoma: a multicentre, retrospective, cohort study. The Lancet Oncology, 2019.
Correa AF, Handorf E, Joshi SS, Geynisman DM, Kutikov A, Chen DY, Uzzo RG, Viterbo R, Greenberg RE, Smaldone MC. Differences in Survival Associated with Performance of Lymph Node Dissection in Patients with Invasive Penile Cancer: Results from the National Cancer Database. J Urol, 199(5):1238-44, 2018. PubMed
Geynisman DM, Abbosh PH, Plimack ER, Zibelman M. Chemoimmunotherapy in Metastatic Urothelial Carcinoma. Eur Urol, 2018.
Joshi SS, Handorf E, Strauss D, Correa AF, Kutikov A, Chen DYT, Viterbo R, Greenberg RE, Uzzo RG, Smaldone MC, Geynisman DM. Treatment Trends and Outcomes for Patients With Lymph Node-Positive Cancer of the Penis. JAMA Oncol, 2018.
Geynisman DM, Ross EA, Plimack ER. Osteoclast Inhibitors in Advanced Prostate Cancer: Does the Benefit Extend Beyond Skeletal-Related Events? Eur Urol. 2015 Oct;68(4):578-80. doi: 10.1016/j.eururo.2015.06.009. Epub 2015 Jun 23. PubMed...Expand
Seeger-Nukpezah T, Geynisman DM, Nikonova AS, Benzing T, Golemis EA. The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease. Nat Rev Nephrol. 2015 Sep;11(9):515-34. doi: 10.1038/nrneph.2015.46. Epub 2015 Apr 14. Review. PubMed
Geynisman DM. Anti-programmed Cell Death Protein 1 (PD-1) Antibody Nivolumab Leads to a Dramatic and Rapid Response in Papillary Renal Cell Carcinoma with Sarcomatoid and Rhabdoid Features. Eur Urol. 2015 Jul 17. pii: S0302-2838(15)00612-0. doi: 10.1016/j.eururo.2015.07.008. [Epub ahead of print] PubMed
Shih YC, Smieliauskas F, Geynisman DM, Kelly RJ, Smith TJ. Trends in the Cost and Use of Targeted Cancer Therapies for the Privately Insured Nonelderly: 2001 to 2011. J Clin Oncol. 2015 Jul 1;33(19):2190-6. doi: 10.1200/JCO.2014.58.2320. Epub 2015 May 18. PubMed PMID: 25987701; PubMed Central PMCID: PMC4477789. PubMed
Geynisman DM, Szmulewitz RZ, Plimack ER. Corticosteroids and prostate cancer: friend or foe? Eur Urol. 2015 May;67(5):874-5. doi: 10.1016/j.eururo.2014.08.008. Epub 2014 Aug 20. PubMed
Geynisman DM, Hu JC, Liu L, Tina Shih YC. Treatment patterns and costs for metastatic renal cell carcinoma patients with private insurance in the United States. Clin Genitourin Cancer. 2015 Apr;13(2):e93-100. doi: 10.1016/j.clgc.2014.08.013. Epub 2014 Sep 28. PubMed
Barth P, Dulaimi Al-Saleem E, Edwards KW, Millis SZ, Wong YN, Geynisman DM. Metastatic Extramammary Paget's Disease of Scrotum Responds Completely to Single Agent Trastuzumab in a Hemodialysis Patient: Case Report, Molecular Profiling and Brief Review of the Literature. Case Rep Oncol Med. 2015;2015:895151. doi: 10.1155/2015/895151. Epub 2015 Jan 27. PubMed PMID: 25692060; PubMed Central PMCID: PMC4322830. PubMed
Godwin JL, Zibelman M, Plimack ER, Geynisman DM. Immune checkpoint blockade as a novel immunotherapeutic strategy for renal cell carcinoma: a review of clinical trials. Discov Med. 2014 Dec;18(101):341-50. PubMed
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