Hereditary Breast and Ovarian Syndrome (HBOS) is a rare hereditary cancer syndrome associated with

• Female or male breast cancer (DCIS or invasive)
• Ovarian and fallopian tube cancer
• Prostate cancer
• Other cancers such as primary peritoneal, pancreatic cancer and melanoma 

Cowden Syndrome is a rare hereditary cancer syndrome that involves:

• Breast, uterine cancer and thyroid cancer
• Fibrocystic breasts, uterine fibroids and thyroid diseases
• Multiple noncancerous, tumor-like growths called “hamartomas” commonly found on the skin and mucous membranes, such as the lining of the mouth and nose, but can also occur in the intestinal tract and other parts of the body
• Macrocephaly, or an enlarged head can also be present

Li-Fraumeni Syndrome (LFS) is a rare hereditary cancer syndrome associated with

• Breast cancer
• Sarcomas, or soft tissue cancer
• Leukemia, or blood cancer
• Cancers of the adrenal cortex, which is part of the adrenal gland, brain, pancreas, and colon
• Several other cancers can also be seen in LFS, with some occuring in childhood