Gina M. Mantia-Smaldone, MD

Gina Mantia-Smaldone, MD

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Clinical Locations

  • Fox Chase Cancer Center
    333 Cottman Avenue
    Philadelphia, PA 19111
    Phone: 888-369-2427
  • Fox Chase - East Norriton
    2701 Dekalb Pike
    East Norriton, PA 19401
    Phone: 888-369-2427

Associate Professor, Department of Surgical Oncology

Gynecologic Oncology Fellowship Program Director

Specialties

  • Gynecologic Oncology

Areas of Expertise

Endometrial (Uterine) Cancer, Vulvar Cancer, Cervical Cancer, Uterine Sarcoma, Ovarian & Primary Peritoneal Cancer

Treatment Focus

Minimally invasive surgery (laparoscopy and robotic surgery); endometrial cancer and hyperplasia; cervical cancer and dysplasia; vulvar cancer and dysplasia; vaginal cancer and dysplasia; gestational trophoblastic disease; surgical management of pelvic masses

Research Program

Distinctions

Treatment Philosophy

I am excited to be a part of the gynecologic cancer patient care team at Fox Chase Cancer Center. I chose to work at Fox Chase to provide comprehensive, cutting-edge oncologic care by translating advances in research directly into my clinical practice.

As a gynecologic oncologist, I specialize in the surgical and medical management of tumors of the uterus, cervix, ovary, fallopian tube, vulva and vagina. I have extensive experience with complex open, laparoscopic and robotic surgery, which allows me to tailor a surgical plan based upon a patient’s needs and preferences. I also have expertise in administering intravenous and intraperitoneal chemotherapy for gynecologic malignancies. As a member of the multidisciplinary gynecologic cancer patient care team, I work closely with my colleagues in medical and radiation oncology to develop a comprehensive treatment plan that offers the best chance of cure for each patient.

I appreciate the challenges and commitment necessary to care for cancer patients. I understand that a cancer diagnosis can be overwhelming for patients and their families, and I always treat patients how I would want my family members to be treated: with honesty and compassion. I devote the time necessary to educate my patients on their options so they are best able to make an informed decision about their treatment.

Professionally, my research interests focus on endometriosis-associated ovarian cancer and hereditary ovarian cancer, including those resulting from BRCA1 or 2 mutations. The abundant resources available at Fox Chase, as well as my research experiences during my postdoctoral fellowship at the Magee-Womens Research Institute and as a clinical fellow at the University of Pennsylvania allow for me to participate in translational research and investigate innovative therapies to improve the quality of life for women with gynecologic malignancies.

Educational Background

  • Clinical Fellow, Gynecologic Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, 2010-2013
  • Fellow, Ovarian Cancer Immunology, Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, 2008-2010
  • Resident, Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, 2004-2008
  • MD, State University of New York at Stony Brook School of Medicine, Stony Brook, NY, 2004
  • BA, Biochemistry and Molecular Biology, Boston University, Boston, MA, 2000

Certifications

  • American Board of Obstetrics and Gynecology
  • American Board of Obstetrics and Gynecology - Gynecologic Oncology

Memberships

  • American Association for Cancer Research
  • American College of Obstetrics and Gynecology
  • NRG Oncology – Ovarian Cancer Core Committee; New Investigator Committee
  • Society of Gynecologic Oncology, Registry Taskforce Committee
  • Teal Tea Foundation, Advisory Board Member
  • Alpha Omega Alpha

Honors & Awards

  • Philadelphia Magazine Top Doctors, 2022-2024
  • Main Line Today Top Doctors, 2018-2019

Research Interests

  • Fertility and gynecologic cancers
  • Endometriosis-related ovarian cancer
  • Hereditary ovarian cancer
  • Immunotherapy and ovarian cancer

Selected Publications

Cronin S., Ahmed N., Craig A.D., King S., Huang M., Chu C.S., Mantia-Smaldone G.M., Non-gestational ovarian choriocarcinoma: A rare ovarian cancer subtype. Diagnostics (Basel). 12(3)2022. PMC8947355. https://www.ncbi.nlm.nih.gov/pubmed/35328112.

Cripe JC, Handorf E, Brown JL, Woodman S, Rubin SC, Jain A and Mantia-Smaldone GM. National Cancer Database Report of Lymphadenectomy Trends in Endometrial Cancer. Accepted for publication to International Journal of Gynecological Cancer, 3/10/17.

Andersen C, Sikora M, Boisen M, Ma T, Christie A, Tseng G, Park YS, Luthra S, Chandran U, Haluska P, Mantia-Smaldone GM, Odunsi K, McLean K, Lee A, Elishaev E, Edwards RP, and Oesterreich S. Active estrogen receptor-alpha signaling in ovarian cancer models and clinical specimens. Clin Cancer Res. 2017 Jan 10. pii: clincanres.1501.2016. doi: 10.1158/1078-0432.CCR-16-1501. [Epub ahead of print]

 Mirza MR, Monk BJ, Herrstedt J, Oza AM, Mahner S, Redondo A, Fabbro M, Ledermann JA, Lorusso D, Vergote I, Ben-Baruch NE, Marth C, Mądry R, Christensen RD, Berek JS, Dørum A, Tinker AV, du Bois A, González-Martín A, Follana P, Benigno B, Rosenberg P, Gilbert L, Rimel BJ, Buscema J, Balser JP, Agarwal S, Matulonis UA; ENGOT-OV16/NOVA Investigators.Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer. N Engl J Med. 2016 Dec 1;375(22):2154-2164.

  Meyer LA, Cronin AM, Sun CC, Bixel K, Bookman MA, Cristea MC, Griggs JJ, Levenback CF, Burger RA, Mantia-Smaldone G, Matulonis UA, Niland JC, O'Malley DM, Wright AA. Use and Effectiveness of Neoadjuvant Chemotherapy for Treatment of Ovarian Cancer. J Clin Oncol. 2016 Sep 6. pii: JCO681239. [Epub ahead of print]

Esselen KM, Cronin A, Bixel K, Bookman M, Burger RA, Cohn D, Cristea M, Griggs J, Levenback CF, Mantia-Smaldone G, Meyer LA, Matulonis U, Niland J, Sun C, O’Malley DM, Wright A. Use of CA-125 Tests and CT Scans for Surveillance in Ovarian Cancer: Value-based Cancer Care? JAMA Oncol. 2016 Nov 1;2(11):1427-1433. doi: 10.1001/jamaoncol.2016.1842.

Shaikh T, Churilla TM, Mantia-Smaldone GM, Chu C, Rubin SC, Anderson PR.  The role of adjuvant radiation in lymph node positive endometrial adenocarcinoma. Gynecol Oncol. 2016 Jun;141(3):434-9. doi: 10.1016/j.ygyno.2016.04.010.

Churilla T, Egleston B, Dong Y, Shaikh T, Murphy C, Mantia-Smaldone G, Chu C, Rubin S, Anderson P. Disparities in the management and outcome of cervical cancer in the United States according to health insurance status. Gynecol Oncol. 2016 Jun;141(3):516-23. doi: 10.1016/j.ygyno.2016.03.025.

Hall MJ, Obeid EI, Schwartz SC, Mantia-Smaldone G, Forman AD, Daly MB.  Genetic testing for hereditary cancer predisposition: BRCA1/2, Lynch syndrome and beyond. Gynecol Oncol. 2016 Mar;140(3):565-74. doi: 10.1016/j.ygyno.2016.01.019

Wright AA, Cronin A, Milne DE, Bookman MA, Burger RA, Cohn DE, Cristea MC, Griggs JJ, Keating NL, Levenback CF, Mantia-Smaldone G, Matulonis UA, Meyer LA, Niland JC, Weeks JC, O'Malley DM.  Use and Effectiveness of Intraperitoneal Chemotherapy for Treatment of Ovarian Cancer. J Clin Oncol. 2015 Sep 10;33(26):2841-7. doi: 10.1200/JCO.2015.61.4776. Epub 2015 Aug 3.

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