Zhang T, Yin C, Boyd DF, Quarato G, Ingram JP, Shubina M, Ragan KB, Ishizuka T, Crawford JC, Tummers B, Rodriguez DA, Xue J, Peri S, Kaiser WJ, López CB, Xu Y, Upton JW, Thomas PG, Green DR, Balachandran S. Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis. Cell. 2020 Mar 19;180(6):1115-1129.e13. doi: 10.1016/j.cell.2020.02.050. PubMed PMID: 32200799; PubMed Central PMCID: PMC7153753. PubMed
Shubina, M., Tummers, B., Boyd, D.F., Zhang, T., Guo, X.Z., Yin, C., Kaiser, W.J., Vogel, P., Green, D.R., Thomas, P.G., Balachandran, S. Necroptosis restricts influenza A virus as a standalone cell death mechanism. J. Exp. Med. 217 (11): e20191259, 2020. PubMed PMID: 32797196; PubMed Central PMCID: PMC7596817 PubMed
Tan, Y., Sementino, S., Cheung, S., Peri, S., Menges, C.W., Kukuyan, A.M., Ross, E., Fox, L.A., Zhang, T., Khazak, V., Ramanathan, S., Jhanwar, S.C., Flores, R.M., Balachandran, S., Testa, J.R. Somatic Epigenetic Silencing of RIPK3 Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma. Clin. Cancer Res 2020 Nov 17: clincanres.3683.2018. doi: 10.1158/1078-0432.CCR-18-3683. Online ahead of print. PMID: 33203643 PMCID in process.
Thomas P.G., Shubina M., Balachandran S. ZBP1/DAI-Dependent Cell Death Pathways in Influenza A Virus Immunity and Pathogenesis. Curr Top Microbiol Immunol, 2020. 3.153. PubMed
Ingram J.P., Thapa R.J., Fisher A., Tummers B., Zhang T., Yin C., Rodriguez D.A., Guo H., Lane R., Williams R., Slifker M.J., Basagoudanavar S.H., Rall G.F., Dillon C.P., Green D.R., Kaiser W.J., Balachandran S. ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1. J Immunol. 203(5): 1348-1355, 2019.PMC6702065. 4.718. PubMed
Zhang T., Balachandran S. Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis. J Cell Biol. 218(6): 1773-1775, 2019.Commentary. 8.891. PubMed
Ingram JP, Tursi S, Zhang T, Guo W, Yin C, M AW-D, van der Heijden J, Cai KQ, Yamamoto M, Finlay BB, Brodsky IE, Grivennikov SI, Tukel C, Balachandran S. A Nonpyroptotic IFN-gamma-Triggered Cell Death Mechanism in Nonphagocytic Cells Promotes Salmonella Clearance In Vivo. Journal of immunology (Baltimore, Md : 1950), 200(10):3626-34, 2018. PubMed
Thapa, R.J., Ingram, J.P., Ragan, K., Nogusa, S., Sridharan, H., Boyd, D., Kosoff, R., Shubina, M., Andrake, M., Sigal, L.J., tenOever, B.R., Thomas, P.G., Upton, J. W., Balachandran, S. DAI senses influenza A virus genomic RNA and activates RIPK3-dependent cell death. Cell Host & Microbe20(5):674-681, 2016. PubMed
Najjar M, Saleh D, Zelic M, Nogusa S, Shah S, Tai A, Finger JN, Polykratis A, Gough PJ, Bertin J, Whalen M, Pasparakis M, Balachandran S, Kelliher M, Poltorak A, Degterev A. RIPK1 and RIPK3 kinases promote cell-death independent inflammation by toll-like receptor 4. Immunity. 2016;45:46-59. PubMed
Nogusa S, Slifker MJ, Ingram JP, Thapa RJ, Balachandran S. RIPK3 is largely dispensable for RIG-I-like receptor- and type I interferon-driven transcriptional responses to influenza A virus in murine fibroblasts. PLoS One. 2016;11:e0158774. PubMed
Nogusa S, Thapa RJ, Dillon CP, Liedmann S, Oguin TH III, Ingram JP, Rodrigues DA, Kosoff R, Sharma S, Sturm O, Verbist K, Gough PJ, Bertin J, Hartmann BM, Sealfon SC, Kaiser WJ, Mocarski ES, Lopez C, Thomas PG, Oberst A, Green DR, Balachandran S. RIPK3 activates parallel pathways of MLKL-driven necroptosis and FADD-mediated apoptosis to protect against influenza A virus. Cell Host Microbe. 2016;20:13-24. PubMed
Najjar M, Suebsuwong C, Ray SR, Thapa R J, Maki JL, Nogusa S, Shah S, Saleh D, Gough PJ, Bertin J, Yuan J, Balachandran S, Cuny GD, Degterev A. Structure guided design of potent and selective ponatinib-based inhibitors for RIPK1. Cell Rep. 2015;10:1850-60. PubMed
Wang X, Wang J, Zheng H, Xie M, Hopewell EL, Albrecht RA, Nogusa S, Garcia-Sastre A, Balachandran S, Beg AA. Differential requirement for the IKKb/NF-kB signaling module in regulating TLR-versus RLR-induced type 1 IFN expression in dendritic cells. J Immunol. 2014;193:2538-45. PubMed
Haugh KA, Shalginskikh N, Nogusa S, Skalka AM, Katz RA, Balachandran S. The interferon-inducible antiviral protein Daxx is not essential for interferon-mediated protection against avian sarcoma virus. Virology J. 2014;11:100. PubMed
Kaiser WJ, Daley-Bauer LP, Thapa RJ, Mandal P, Berger SB, Huang C, Sundararajan A, Guo H, Roback L, Speck SH, Bertin J, Gough PJ, Balachandran S, Mocarski ES. RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition. Proc Natl Acad Sci USA. 2014;111:7753-8. PubMed
Peri S, Devarajan K, Wang DH, Knudson AG, Balachandran S. Meta-analysis identifies NF-κB as a therapeutic target in renal cancer. PLoS One. 2013;8:e76746. PubMed... Expand