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Lymphoma Treatment

Lymphoma Treatment at Fox Chase

Where you go for lymphoma care—and how quickly you are seen—can make a big difference. At Fox Chase Cancer Center, our multidisciplinary medical teams work closely to expedite your care and provide an accurate diagnosis. Most importantly, your Fox Chase team will be with you every step of the way.

As a regional and national leader in cancer care, we have a wealth of experience treating all types of lymphoma and offer the most advanced treatments. Our skilled hematology/oncology team meets regularly to review patient cases and map out a personalized treatment plan. We strive to treat your cancer in the best possible way using immunotherapy, combination therapy, and stem cell transplant, and innovative cellular therapy (e.g., CAR T) that give you the best chance of a successful outcome with minimal toxicity.

After your diagnosis, your medical team will work closely with you to help you understand your condition and develop a customized treatment program.

Treatment is based on multiple factors:

  • The type of Hodgkin or non-Hodgkin lymphoma
  • The disease stage and whether it is fast- or slow-growing
  • The molecular, genetic and clinical features of the disease
  • Your age, health, and personal goals

At Fox Chase, you can be connected with a nurse navigator. The nurse navigator’s goal is to make sure you see as many members of your treatment team as possible in one day. Together, these specialists all weigh in on your case and even meet once a week to discuss it. The specialists create a tailored plan for you, and we set it in motion right away.

Your plan might include one or more of the following treatment options.

Hodgkin Lymphoma Treatment Options

Hodgkin lymphoma can often be cured. The type and stage of Hodgkin lymphoma are considered when developing a personalized treatment plan. Immunotherapy, chemotherapy, chemotherapy with radiation, stem cell transplantation, or other approaches may be used.

Immunotherapy drugs like the checkpoint inhibitors are one of many innovative treatment options. Checkpoint inhibitors use the patient’s own immune cells to recognize and attack tumors. The body’s immune system uses T cells to help fight disease, while keeping immune T cells from attacking normal healthy cells. Cancer cells can take advantage of this by disguising themselves as normal cells. Checkpoint inhibitors disrupt this disguise, releasing the brakes on the immune system and allowing the T cells to attack cancer.

Antibody drug conjugates are potent drugs that can be added to a chemotherapy regimen.

Chemotherapy alone or in combination with radiation is highly effective for patients with newly diagnosed Hodgkin lymphoma.

Stem cell transplant, also called bone marrow transplant, involves replacing the patient’s stem cells with new ones. Stem cell transplant is sometimes used if Hodgkin lymphoma comes back after initial therapy. An autologous stem cell transplant using a patient’s own stem cells or an allogeneic stem cell transplant using a donor’s cells may be recommended.

Non-Hodgkin Lymphoma Treatment Options

Immunotherapy is one of the innovative new treatments for lymphoma.  

  • Antibody drug conjugates are potent drugs that can be added to a chemotherapy regimen.
  • Checkpoint inhibitors use the body’s own immune cells to recognize and destroy cancer cells. The body’s immune system uses T cells to help fight diseases like cancer, while keeping immune T cells from attacking normal cells. Cancer cells take advantage of this by sending out normal immune checkpoint molecules to disguise themselves. Checkpoint inhibitors disrupt this disguise, freeing T cells to recognize and attack the cancer cells.
  • Chimeric antigen receptor (CAR) T-cell therapy is a powerful new treatment used for some patients with lymphoma. CAR T-cell therapy uses a patient’s own T cells to destroy cancer cells. Scientists take T cells from a patient’s blood, modify the T cells so that they recognize cancer, and then infuse these cancer-fighting T cells back into the patient.

Chemotherapy is an effective approach for treating and potentially curing patients with non-Hodgkin lymphoma. Chemotherapy can kill cancer cells throughout the body.

Targeted therapy with small molecules such as ibrutinib, acalabrutinib, and lenolidamide.

Radiation therapy may be used for forms of lymphoma that are particularly sensitive to radiation. It is now possible to use lower doses of radiation therapy over smaller areas than ever before. Fox Chase has one of the country’s largest and most dynamic programs in radiation oncology. Each radiation oncologist is a cancer specialist with extensive experience in radiation therapy as it is used in the management of cancer. They continue to develop the image-guided radiation therapies of the future.

Stem cell transplant, also called bone marrow transplant, involves replacing the patient’s stem cells with new ones. Stem cell transplant may be used if lymphoma has returned after initial treatment, or as a life-extending therapy. Depending on the case, autologous transplant, using the patient’s own stem cells, or allogeneic transplant, using donor stem cells, may be used.

Active Surveillance may be recommended for slow-growing (indolent) lymphoma if you are not experiencing symptoms. Your medical team will conduct regular physical exams, blood tests, and imaging studies. Patients with this type of disease may not need treatment for years.

Clinical trials give Fox Chase patients access to promising treatments and experimental therapies. Fox Chase is committed to finding new drugs and new treatment approaches to improve survival, decrease toxicity, and maintain patient quality of life. In addition to immunotherapy and chemotherapy clinical trials, we also have trials using highly specific monoclonal antibodies (manmade proteins that can be used alone or to carry drugs or other agents directly to a tumor), small molecules and cellular therapy.

Why choose Fox Chase for lymphoma treatment?

Getting rapid care for lymphoma at a National Cancer Institute-designated center can make a big difference. At Fox Chase Cancer Center, we work with you to choose a treatment approach that offers the best chance of controlling your cancer, preserving function and reducing the risk of recurrence.

Our nationally-recognized multidisciplinary medical teams help make individualized decisions based on your type and stage of lymphoma. The hematologic oncology team meets regularly to review new or challenging cases in depth and reach a consensus on treatment strategies. This coordinated approach lets us offer the most thorough, supportive and personalized care as well as access to innovative therapies and state-of-the-art technologies for diagnosing and treating your lymphoma.

What To Do Next

Request an appointment online, or call 888-FOX-CHASE. For general information or to ask us a question, please visit our Contact Us page.

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