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Warren D. Kruger, PhD

Professor Kruger
Education, Training & Credentials

Educational Background

  • BA, Biology, Cornell University, Ithaca, NY, 1985
  • PhD, Genetics, University of California at San Francisco, San Francisco, CA, 1991

Memberships

  • American Society of Human Genetics, 1990
  • American Association for the Advancement of Science, 1995
  • American Association for Cancer Research, 1997
  • Elected President of Fox Chase Cancer Center Faculty Senate, 2010
  • Society for Inherited Metabolic Disorders, 2011
Research Profile

Research Program

Research Interests

Amino Acid Genetics and Human Disease

  • Mouse models with altered sulfur amino acid homeostasis
  • Proteostasis modulators and mutant CBS
  • Targeting MTAP deletion in human cancer
  • Alterations in blood amino acids in human cancer patients.

Lab Overview

Amino acids are the building blocks of proteins and other important biological molecules. The sulfur containing amino acid methionine is especially interesting as alterations in methionine metabolism and methionine-related pathways are found in many human diseases, including rare inborn errors of metabolism to common diseases such as cardiovascular disease and cancer. Currently there are three major projects in the lab. Two concern particular methionine metabolic genes, cystathionine beta-synthase (CBS) and methylthioadenosine phosphorylase (MTAP). A third project is related to understanding how alterations in amino acid metabolism contributes to renal cell carcinoma.

People

Sapna Gupta, PhD

Senior Research Associate

Baiqing Tang, PhD

Senior Research Associate

Hyung-Ok Lee, PhD

Senior Research Associate

Liqun Wang, MD

Senior Technical Specialist

Publications

Selected Publications

Gupta S, Wang L, Kruger WD. Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice. J Inherit Metab Dis. 2015 Aug 1. [Epub ahead of print] (2015) PubMed

Lee HO, Mustafa A, Hudes GR, Kruger WD. Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells. PLoS One. 2015 10:e0131464. doi: 10.1371/journal.pone.0131464 (2015). PubMed

Tang B.Kadariya Y, Chen Y, Slifker M, Kruger WD Expression of MTAP inhibits tumor-related phenotypes in HT1080 cells via a mechanism unrelated to its enzymatic function.G3 5:35-44. doi: 10.1534/g3.114.014555. (2015). PubMed

Shlomi T, Fan J, Tang B, Kruger WD, Rabinowitz JD. Quantitation of cellular metabolic fluxes of methionine. Anal Chem. 86:1583-91. (2014) PubMed

Gupta S, Melnyk SB, Kruger WD. Cystathionine β-synthase-deficient mice thrive on a low methionine diet. FASEB J. 28:781-90 (2014). PubMed

Kadariya Y, Tang B, Al-Saleem T, Hayakawa K, Slifker M, Kruger WD Germline Mutations in Mtap Cooperate with Myc and Pten to Accelerate tumorigenesis in MicePloS One 8: e67635. (2013) PubMed

Gupta S, Wang L, Anderl J, Slifker M, Kirk C, Kruger WD Correction of an inborn error of metabolism using proteasome inhibitors.  Hum. Mutat. 34: 1085-93 (2013) PubMed

Tang B, Testa JR, Kruger WD. Increasing the therapeutic index of 5-flourouracil and 6-thioguanine by targeting loss of MTAP in tumor cells. Cancer Biol Ther.  13:1082-1090 (2012). PubMed

Gupta S. and Kruger, WD., Cystathionine Beta-synthase deficiency causes fat loss in mice.  PLOS ONE 6: e27598 (2011). PubMed

Mustafa  A., Gupta  S., Hudes G.R., Egleston B.L., Uzzo RG, Kruger WD.  Serum amino acid levels as a biomarker for renal cell carcinoma.  J. Urology 186:1206-12 (2011). PubMed (Selected by Faculty of 1000)

This Fox Chase professor participates in the Undergraduate Summer Research Fellowship
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