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Publications of Interest

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Molecular profiling of 6,892 colorectal cancer samples suggests different possible treatment options specific to metastatic sites.
El-Deiry WS, Vijayvergia N, Xiu J, Scicchitano A, Lim B, Yee NS, Harvey HA, Gatalica Z, Reddy S.
Cancer Biol Ther. 2015;16(12):1726-37. doi: 10.1080/15384047.2015.1113356.
PMID: 26553611

Phase 1 Dose Escalation Study of MEDI-565, a Bispecific T-Cell Engager that Targets Human Carcinoembryonic Antigen, in Patients With Advanced Gastrointestinal Adenocarcinomas.
Pishvaian M, Morse MA, McDevitt J, Norton JD, Ren S, Robbie GJ, Ryan PC, Soukharev S, Bao H, Denlinger CS.
Clin Colorectal Cancer. 2016 Aug 4. pii: S1533-0028(16)30116-5. doi: 10.1016/j.clcc.2016.07.009. [Epub ahead of print]
PMID: 27591895

Patterns of use and tolerance of anti-epidermal growth factor receptor antibodies in older adults with metastatic colorectal cancer.
Dotan E, Devarajan K, D'Silva AJ, Beck A, Kloth DD, Cohen SJ, Denlinger C.
Clin Colorectal Cancer. 2014 Sep;13(3):192-8. doi: 10.1016/j.clcc.2014.05.003.
PMID: 25074246 
Free PMC Article

Circulating Tumor Cells Versus Circulating Tumor DNA in Colorectal Cancer: Pros and Cons.
Tan CR, Zhou L, El-Deiry WS.
Curr Colorectal Cancer Rep. 2016 Jun;12(3):151-161.
PMID: 27516729

Colorectal Cancer Screening in the United States: What Is the Best FIT?
Weinberg Md DS, Barkun A, Turner BJ.
Ann Intern Med. 2016 Oct 25. doi: 10.7326/M16-2341. [Epub ahead of print] No abstract available.
PMID: 27776358

Chemotherapy use and adoption of new agents is affected by age and comorbidities in patients with metastatic colorectal cancer.
Vijayvergia N, Li T, Wong YN, Hall MJ, Cohen SJ, Dotan E.
Cancer. 2016 Oct 15;122(20):3191-3198. doi: 10.1002/cncr.30077.
PMID: 27379436

Colitis-Associated and Sporadic Colon Cancers: Different Diseases, Different Mutations?
Grivennikov SI, Cominelli F.
Gastroenterology. 2016 Apr;150(4):808-10. doi: 10.1053/j.gastro.2016.02.062. No abstract available.
PMID: 26924087

Genetic testing for hereditary cancer predisposition: BRCA1/2, Lynch syndrome, and beyond.
Hall MJ, Obeid EI, Schwartz SC, Mantia-Smaldone G, Forman AD, Daly MB.
Gynecol Oncol. 2016 Mar;140(3):565-74. doi: 10.1016/j.ygyno.2016.01.019. Review.
PMID: 26812021

Small-Molecule Prodigiosin Restores p53 Tumor Suppressor Activity in Chemoresistant ColorectalCancer Stem Cells via c-Jun-Mediated ΔNp73 Inhibition and p73 Activation.
Prabhu VV, Hong B, Allen JE, Zhang S, Lulla AR, Dicker DT, El-Deiry WS.
Cancer Res. 2016 Apr 1;76(7):1989-99. doi: 10.1158/0008-5472.CAN-14-2430.
PMID: 26759239

Novel and Emerging Targeted Therapies of Colorectal Cancer.
Finnberg N, Gokare P, El-Deiry WS.
Curr Clin Pharmacol. 2015;10(4):279-98. Review.
PMID: 26548905

Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against ColorectalCancer via p73 Activation and Degradation of Mutant p53.
Zhang S, Zhou L, Hong B, van den Heuvel AP, Prabhu VV, Warfel NA, Kline CL, Dicker DT, Kopelovich L, El-Deiry WS.
Cancer Res. 2015 Sep 15;75(18):3842-52. doi: 10.1158/0008-5472.CAN-13-1079.
PMID: 26294215 
Free PMC Article

Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner.
Prabhu VV, Allen JE, Dicker DT, El-Deiry WS.
Cancer Res. 2015 Apr 1;75(7):1423-32. doi: 10.1158/0008-5472.CAN-13-3451.
PMID: 25712124 
Free PMC Article

Optimizing surveillance and balancing evidence with patient expectations.
Denlinger C, Langbaum TS.
J Natl Compr Canc Netw. 2014 May;12(5 Suppl):781-4.
PMID: 24853216

 

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