CRC-SPORE External Advisory Board Meeting. Dr. El-Deiry presented the Program Schematic and Administrative Structure, Advisory Boards, Funding Base, and an overall Program Overview. There was discussion of candidate projects and Cores including Project 1 Targeting c-MET in BRCA-mutant colorectal cancer: El-Deiry, Olszanski & colleagues, Project 2 Clinical implications of microbiome heterogeneity in colon cancer: Issa, Sigurdson, & colleagues, Project 3 Targeting the kinome in KRAS mutant colon cancer: Chernoff, Cohen, Duncan & colleagues, Project 4 MicroRNA signature for the detection of flat and polypoid colitis-associated colorectal neoplasias: Clapper, Cooper & colleagues, and Project 5 Paracrine hormone hypothesis of colorectal cancer: Waldman, Weinberg & colleagues as well as Project 6 Dependence receptors and colorectal cancer: Grady & colleagues. Dr. El-deiry presented Core A Administration, and Core B Biostatistics and Bioinformatics was presented by Ross & colleagues, and Core C Pathology was presented by Connolly, and Cooper. Several candidate Career Enhancement and Developmental Projects were presented including Career Enhancement Project 1 Immunotherapy of CRC via next generation BiTEs: Robinson, Developmental Project 1 Alteration of DNA demethylation in CRC: Epigenetic biomarkers and implications for therapy: Bellacosa, Developmental Project 2 Role of Rpl22 loss in promoting colorectal cancer development and treatment resistance: Wiest, Career Enhancement Project 2 Tumor microenvironment, tumor elicited inflammation and colon cancer: Grivennikov.