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Stephen M. Sykes Receives American Cancer Society Grant for Acute Myeloid Leukemia Research

January 7, 2019

Stephen M. Sykes, PhD. The Sykes laboratory studies how molecular pathways are differently regulated in leukemia versus normal cell development. With this grant, the lab will seek to uncover molecular targets that can serve as a basis for developing novel acute myeloid leukemia (AML) therapies.Stephen M. Sykes, PhD. The Sykes laboratory studies how molecular pathways are differently regulated in leukemia versus normal cell development. With this grant, the lab will seek to uncover molecular targets that can serve as a basis for developing novel acute myeloid leukemia (AML) therapies.PHILADELPHIA (January 7, 2019) – Stephen M. Sykes, PhD, assistant professor in the Blood Cell Development and Function Program at Fox Chase Cancer, has received a Research Scholar Grant from the American Cancer Society to support research on the elucidation and exploitation of molecular pathways that support leukemia. The grant will provide approximately $792,000 over a period of four years.

The Sykes laboratory studies how molecular pathways are differently regulated in leukemia versus normal cell development. With this grant, the lab will seek to uncover molecular targets that can serve as a basis for developing novel acute myeloid leukemia (AML) therapies.

The lab will conduct studies to dissect the roles of the proteins JUN and ATF3 in orchestrating transcriptional programs that support AML, as well as interrogate these JUN/ATF3-regulated leukemia-supportive transcriptional programs to identify potential therapeutic entry points in AML.

AML is an aggressive blood cancer that currently has a survival rate below 25 percent.

“In addition to seeking new therapies for AML, we anticipate that our eventual findings will have far reaching implications, because the proteins we are studying play key roles in several forms of cancer,” Sykes said.

       

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