Michael Autieri, PhD
Professor
Associate Director and Professor, Cardiovascular Research Center, Lewis Katz School of Medicine
Professor, Physiology, Lewis Katz School of Medicine
Professor, Sol Sherry Thrombosis Research Center, Lewis Katz School of Medicine
Professor, Center for Metabolic Disease Research, Lewis Katz School of Medicine
Research Program
Educational Background
- PhD, Hahnemann University, Philadelphia, PA
Research Program
Research Interests
The long-term focus of our research program is the identification and characterization of proteins and pathways which play a role in regulation of vascular inflammation, with a current focus on the role of endogenous anti-inflammatory cytokines in this process. We have two distinct, but related areas of investigation: 1- inhibition of vascular occlusive diseases such as atherosclerosis, restenosis, and allograft vasculopathy, and; 2- promotion of angiogenesis to treat peripheral vascular disease. Currently, we are focusing on an endogenous anti-inflammatory cytokine termed IL-19 which: regulates macrophage polarity, macrophage and smooth muscle cell cholesterol homeostasis, smooth muscle and endothelial cell proliferation, and decreases inflammatory mRNA stability, suggesting that this cytokine may represent a therapeutic modality to treat vascular inflammatory diseases.
Additional Publications
Contact Information
Lewis Katz School of Medicine,
Temple University
Research at Fox Chase Cancer Center includes faculty from throughout Temple Health and Temple University, including the Temple School of Engineering, Temple School of Pharmacy and the Lewis Katz School of Medicine.
Professor
Associate Director and Professor, Cardiovascular Research Center, Lewis Katz School of Medicine
Professor, Physiology, Lewis Katz School of Medicine
Professor, Sol Sherry Thrombosis Research Center, Lewis Katz School of Medicine
Professor, Center for Metabolic Disease Research, Lewis Katz School of Medicine
Research Program
Education
Educational Background
- PhD, Hahnemann University, Philadelphia, PA
Research Profile
Research Interests
The long-term focus of our research program is the identification and characterization of proteins and pathways which play a role in regulation of vascular inflammation, with a current focus on the role of endogenous anti-inflammatory cytokines in this process. We have two distinct, but related areas of investigation: 1- inhibition of vascular occlusive diseases such as atherosclerosis, restenosis, and allograft vasculopathy, and; 2- promotion of angiogenesis to treat peripheral vascular disease. Currently, we are focusing on an endogenous anti-inflammatory cytokine termed IL-19 which: regulates macrophage polarity, macrophage and smooth muscle cell cholesterol homeostasis, smooth muscle and endothelial cell proliferation, and decreases inflammatory mRNA stability, suggesting that this cytokine may represent a therapeutic modality to treat vascular inflammatory diseases.