Chang-Ming Charlie Ma, PhD, FASTRO

Charlie Chang-Ming Ma, MD
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Professor

Vice Chairman, Department of Radiation Oncology

Director, Radiation Physics

Research Program

  • High-intensity focused ultrasound (HIFU)

  • Electron-specific multileaf collimator

  • Electron-specific multileaf collimator

  • Laser proton accelerator

  • Experimental acceleration for proton acceleration

  • Coulomb mirror effect

     

    Clinical Locations

    Educational Background

    • Postdoctoral Fellow, Medical Physics, Royal Marsden Hospital, Institute of Cancer Research, Sutton, U.K., 1993
    • PhD, Royal Marsden Hospital/Institute of Cancer Research/London University, Sutton, U.K., 1991
    • MS, University of Shanghai for Science & Technology, Shanghai, China, 1986
    • BS, Zhejiang University, Hangzhou, China, 1982

    Certifications

    • Therapeutic Radiologic Physics, American Board of Radiology, 2004

    Memberships

    • Institute of Physics
    • American Association of Physicists in Medicine (AAPM)
    • American College of Medical Physics (ACMP)
    • American Society for Therapeutic Radiology and Oncology (ASTRO)
    • European Society for Therapeutic Radiology and Oncology (ESTRO)
    • Canadian Organization of Medical Physicists (COMP)
    • Cyberknife Society (CS)
    • Society of Directors of Academic Medical Physicists Programs (SDAMPP)
    • AAPM San Francisco Bay Area Chapter (SFBAC)
    • AAPM Delaware Valley Chapter (DVC)
    • North American Chinese Medical Physicists Association (NACMPA)

    Honors & Awards

    • Hall of Fame, NACMPA, 2015
    • Fellow, ASTRO, 2014
    • Fellow, ACMP, 2010
    • Fellow, AAPM, 2005
    • Fellow, Institute of Physics (IOP), 2004
    • "Who’s Who in American Medicine and Healthcare," 2005 -
    • "Who’s Who in American Education," 2005 -
    • "Who’s Who in the World," 2005 -
    • "Who’s Who in America," 2004 -

    People

    Lab Overview

    The radiation physics and cancer biology laboratory uses cancer animal models, in particular prostate, head and neck, breast, lung, pancreatic, ovarian and other diseases for understanding pathogenesis and developing novel therapeutic approaches. The staff perform cancer treatment studies combining radiation therapy, radio-dynamic therapy, gene therapy, chemotherapy, nanotherapy, and MR-guided high intensity focused ultrasound therapy.

    Lab Description

    The Radiation Physics section consists of radiation physicists, research scientists and fellows, dosimetrists, simulation and therapy technologists and other technical and supporting staff, who are responsible for accurate planning and delivery of radiation dose for radiation therapy. The mission is to provide the best possible technical support for radiation therapy and to advance the efficacy of cancer treatment through the integration of new technical innovations with clinical and basic research. The radiation cancer biology laboratory uses cancer animal models, in particular prostate, head and neck, breast, lung, pancreatic, ovarian and other diseases for understanding pathogenesis and developing novel therapeutic approaches. The staff perform cancer treatment studies combining radiation therapy, radio-dynamic therapy, gene therapy, chemotherapy, nanotherapy, and MR-guided high intensity focused ultrasound therapy.

    Our current research projects include image-guided radiotherapy (IGRT), advanced treatment delivery techniques such as intensity modulated radiation therapy (IMRT) and volumetric modulated radiotherapy (VMAT), stereotactic radiosurgery and stereotactic body radiotherapy (SRS/SBRT), pulsed low-dose-rate radiotherapy (PLDR), radiodynamic therapy (RDT), MRI guided HIFU therapy, laser accelerated proton and light ion beams, target localization, organ motion compensation, MRI/PET based functional imaging and treatment assessment, Monte Carlo dose calculation, and analyses of biological effects of radiation.

    Selected Publications

    Lin T., Wang L.,Charlie Ma C.M., Monte carlo dose calculation - a qa method for srt and sbrt plans in treating multiple and small metastatic lesions. J Med Phys. 47(1): 99-104, 2022. PMC9084579. https://www.ncbi.nlm.nih.gov/pubmed/35548031.

    Liu S., Liu Y., Yang J., Santos T.D., Yang L., Li M., Jiang Q.,Ma C., Survival outcome after stereotactic body radiotherapy for locally advanced and borderline resectable pancreatic cancer: A systematic review and meta-analysis. Transl Oncol. 14(8): 101139, 2021. PMC8188566. https://www.ncbi.nlm.nih.gov/pubmed/34091293.

    Panetta J.V., Cvetkovic D., Chen X., Chen L.,Ma C.C., Radiodynamic therapy using 15-mv radiation combined with 5-aminolevulinic acid and carbamide peroxide for prostate cancer in vivo. Phys Med Biol. 65(16): 165008, 2020. PMC8409498. https://www.ncbi.nlm.nih.gov/pubmed/32464613.

    Eldib A, Fareed M, Weiss S, Hayes S, Nguyen B, Mora G, Li JS, Chibani O, Addelgawad M and Ma CM. Dosimetric evaluation of a rotating gamma-ray system for stereotactic body radiation therapy, Journal of Radiation Oncology (2020) https://doi.org/10.1007/s13566-020-00437-9

    Panetta J, Cvetkovic D, Chen X, Chen L, Ma CM. Radiodynamic therapy using 15-MV radiation combined with 5-aminolevulinic acid and carbamide peroxide for prostate cancer in vivo. Phys Med Biol, 2020 https://doi.org/10.1088/1361-6560/ab9776

    Price RA, Jin LH, Meyer J, Chen L, Lin T, Eldib A, Chen X, Liu J, Veltchev I, Wang L and Ma CM. Practical Clinical Implementation of the Special Physics Consultation Process in the Re-irradiation Environment, Advances in Radiation Oncology (2020) https://doi.org/10.1016/j.adro.2020.09.027

    Xu Q, Tong X, Lin M, Chen X, Eldib A, Lin T, Chen L and Ma CM, Feasibility of Real-Time Target Localization Using EPID for Prostate IMRT/VMAT, Phys Med. (2020) 76:142-9

    Ma CM, Chetty IJ, Deng J, Faddegon B, Jiang SB, Li JS, Seuntjens J, Siebers JV, Traneus E, Beam modeling and beam model commissioning for Monte Carlo dose calculation-based radiation therapy treatment planning: Report of AAPM Task Group 157. Med Phys. 2020. 47:e1-e18; first published PMID: 2019. 31679157. doi: 10.1002/mp.13898

    Paly J, Deng M, Lee CT, Hayes SB, Galloway TJ, Hallman MA, Weiss SE, Horwitz EM, Price RA, Ma CM, Meyer JE. Pelvic Reirradiation Utilizing Pulsed Low-dose Rate Radiation Therapy, American Journal of Clinical Oncology, 2020, doi: 10.1097/COC.0000000000000741

    Lin T and Ma CM. Positioning Errors of Metal Localization Devices with Motion Artifacts on kV and MV Cone Beam CT, British Journal of Radiology/open, 2019 https://doi.org/10.1259/bjro.20190013... Expand

    Additional Publications

    My NCBI

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