Chang-Ming Charlie Ma, PhD, FASTRO

Charlie Chang-Ming Ma, MD

Professor

Vice Chairman, Department of Radiation Oncology

Director, Radiation Physics

Research Program

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    High-intensity focused ultrasound (HIFU)

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    Electron-specific multileaf collimator

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    Electron-specific multileaf collimator

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    Laser proton accelerator

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    Experimental acceleration for proton acceleration

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    Coulomb mirror effect

     

    Clinical Locations

    • Fox Chase Cancer Center
      333 Cottman Avenue
      Philadelphia, PA 19111
      Phone: 888-369-2427

    Educational Background

    • Postdoctoral Fellow, Medical Physics, Royal Marsden Hospital, Institute of Cancer Research, Sutton, U.K., 1993
    • PhD, Royal Marsden Hospital/Institute of Cancer Research/London University, Sutton, U.K., 1991
    • MS, University of Shanghai for Science & Technology, Shanghai, China, 1986
    • BS, Zhejiang University, Hangzhou, China, 1982

    Certifications

    • Therapeutic Radiologic Physics, American Board of Radiology, 2004

    Memberships

    • Institute of Physics
    • American Association of Physicists in Medicine (AAPM)
    • American College of Medical Physics (ACMP)
    • American Society for Therapeutic Radiology and Oncology (ASTRO)
    • European Society for Therapeutic Radiology and Oncology (ESTRO)
    • Canadian Organization of Medical Physicists (COMP)
    • Cyberknife Society (CS)
    • Society of Directors of Academic Medical Physicists Programs (SDAMPP)
    • AAPM San Francisco Bay Area Chapter (SFBAC)
    • AAPM Delaware Valley Chapter (DVC)
    • North American Chinese Medical Physicists Association (NACMPA)

    Honors & Awards

    • Hall of Fame, NACMPA, 2015
    • Fellow, ASTRO, 2014
    • Fellow, ACMP, 2010
    • Fellow, AAPM, 2005
    • Fellow, Institute of Physics (IOP), 2004
    • "Who’s Who in American Medicine and Healthcare," 2005 -
    • "Who’s Who in American Education," 2005 -
    • "Who’s Who in the World," 2005 -
    • "Who’s Who in America," 2004 -

    People

    Additional Staff

    George Cherian - Dosimetrist
    Kevin Crawford - Dosimetrist
    Robert Gleason - Dosimetrist
    Zheng Dong - Dosimetrist
    Gage Price -Dosimetrist
    Melisa Phung -Dosimetrist 

    Thomas Hofmann - Chief Therapist


    Thomas Sprankle - Systems Implementation Specialist
    Matthew Young - Systems Analyst
    Jon Christman - Radiation Oncology Engineer
    Dave Liounis - Radiation Oncology Engineer
    Chris Davis -  Transport/Mold Room Technician
    Lilia Biehl- Radiation Therapy Scheduler

    Jarrett Brown - Staff Therapist
    Grady Birmelin - Staff Therapist
    Ronald Brown - Staff Therapist
    Sandee Clibanoff  - Staff Therapist
    Kristen Cosgrove - Staff Therapist
    Kristy Esterly - Staff Therapist
    Barbara Farley-McDonnell - Staff Therapist
    Megan Gleason- Staff Therapist
    Rebecca Godown- Staff Therapist
    Alyssa Green​ - Staff Therapist
    Michael Gutierrez - Staff Therapist
    Donna Hazlett - Staff Therapist
    Amanda Hunton - Staff Therapist
    Megan Lutey - Staff Therapist
    Dana McDonald, - Staff Therapist
    Tracey Murphy - Staff Therapist
    Michael Murray - Staff Therapist
    Robert Novak - Staff Therapist
    Dominic Sabato - Staff Therapist
    Noelle Schillinger - Staff Therapist
    Barbara Sims - Staff Therapist
    Brandis Singleton - Staff Therapist
    Stephanie Ryan - Staff Therapist
    William Tynan - Staff Therapist
    Donna Videtto - Staff Therapist
    Alexis Zanetich - Staff Therapist
    Deborah Weitzner - Manager, Rad Onc Coding/Compliance (Therapist)




    Sarah Hill - Pool Therapist
    Kailey Hopkins - Pool Therapist
    Ashley Kerrigan- Pool Therapist
    Kimberly McGlinchey- Pool Therapist
    Michaela Naughton- Pool Therapist
    Sarangi Patel- Pool Therapist
    Gianna Tippy- Pool Therapist
     

    Karen Cummins - Simulation Therapist
    Maureen Ferri - Simulation Therapist
    Susan Gallelli, RTT - Simulation Therapist
    Kelly Hopkins - Simulation Therapist
    Theresa Richardson - Simulation Therapist

    Lab Overview

    The radiation physics and cancer biology laboratory uses cancer animal models, in particular prostate, head and neck, breast, lung, pancreatic, ovarian and other diseases for understanding pathogenesis and developing novel therapeutic approaches. The staff perform cancer treatment studies combining radiation therapy, radio-dynamic therapy, gene therapy, chemotherapy, nanotherapy, and MR-guided high intensity focused ultrasound therapy.

    Lab Description

    The Radiation Physics section consists of radiation physicists, research scientists and fellows, dosimetrists, simulation and therapy technologists and other technical and supporting staff, who are responsible for accurate planning and delivery of radiation dose for radiation therapy. The mission is to provide the best possible technical support for radiation therapy and to advance the efficacy of cancer treatment through the integration of new technical innovations with clinical and basic research. The radiation cancer biology laboratory uses cancer animal models, in particular prostate, head and neck, breast, lung, pancreatic, ovarian and other diseases for understanding pathogenesis and developing novel therapeutic approaches. The staff perform cancer treatment studies combining radiation therapy, radio-dynamic therapy, gene therapy, chemotherapy, nanotherapy, and MR-guided high intensity focused ultrasound therapy.

    Our current research projects include image-guided radiotherapy (IGRT), advanced treatment delivery techniques such as intensity modulated radiation therapy (IMRT) and volumetric modulated radiotherapy (VMAT), stereotactic radiosurgery and stereotactic body radiotherapy (SRS/SBRT), pulsed low-dose-rate radiotherapy (PLDR), radiodynamic therapy (RDT), MRI guided HIFU therapy, laser accelerated proton and light ion beams, target localization, organ motion compensation, MRI/PET based functional imaging and treatment assessment, Monte Carlo dose calculation, and analyses of biological effects of radiation.

    Selected Publications

    Lin T., Wang L.,Charlie Ma C.M., Monte carlo dose calculation - a qa method for srt and sbrt plans in treating multiple and small metastatic lesions. J Med Phys. 47(1): 99-104, 2022. PMC9084579. https://www.ncbi.nlm.nih.gov/pubmed/35548031.

    Liu S., Liu Y., Yang J., Santos T.D., Yang L., Li M., Jiang Q.,Ma C., Survival outcome after stereotactic body radiotherapy for locally advanced and borderline resectable pancreatic cancer: A systematic review and meta-analysis. Transl Oncol. 14(8): 101139, 2021. PMC8188566. https://www.ncbi.nlm.nih.gov/pubmed/34091293.

    Panetta J.V., Cvetkovic D., Chen X., Chen L.,Ma C.C., Radiodynamic therapy using 15-mv radiation combined with 5-aminolevulinic acid and carbamide peroxide for prostate cancer in vivo. Phys Med Biol. 65(16): 165008, 2020. PMC8409498. https://www.ncbi.nlm.nih.gov/pubmed/32464613.

    Eldib A, Fareed M, Weiss S, Hayes S, Nguyen B, Mora G, Li JS, Chibani O, Addelgawad M and Ma CM. Dosimetric evaluation of a rotating gamma-ray system for stereotactic body radiation therapy, Journal of Radiation Oncology (2020) https://doi.org/10.1007/s13566-020-00437-9

    Panetta J, Cvetkovic D, Chen X, Chen L, Ma CM. Radiodynamic therapy using 15-MV radiation combined with 5-aminolevulinic acid and carbamide peroxide for prostate cancer in vivo. Phys Med Biol, 2020 https://doi.org/10.1088/1361-6560/ab9776

    Price RA, Jin LH, Meyer J, Chen L, Lin T, Eldib A, Chen X, Liu J, Veltchev I, Wang L and Ma CM. Practical Clinical Implementation of the Special Physics Consultation Process in the Re-irradiation Environment, Advances in Radiation Oncology (2020) https://doi.org/10.1016/j.adro.2020.09.027

    Xu Q, Tong X, Lin M, Chen X, Eldib A, Lin T, Chen L and Ma CM, Feasibility of Real-Time Target Localization Using EPID for Prostate IMRT/VMAT, Phys Med. (2020) 76:142-9

    Ma CM, Chetty IJ, Deng J, Faddegon B, Jiang SB, Li JS, Seuntjens J, Siebers JV, Traneus E, Beam modeling and beam model commissioning for Monte Carlo dose calculation-based radiation therapy treatment planning: Report of AAPM Task Group 157. Med Phys. 2020. 47:e1-e18; first published PMID: 2019. 31679157. doi: 10.1002/mp.13898

    Paly J, Deng M, Lee CT, Hayes SB, Galloway TJ, Hallman MA, Weiss SE, Horwitz EM, Price RA, Ma CM, Meyer JE. Pelvic Reirradiation Utilizing Pulsed Low-dose Rate Radiation Therapy, American Journal of Clinical Oncology, 2020, doi: 10.1097/COC.0000000000000741

    Lin T and Ma CM. Positioning Errors of Metal Localization Devices with Motion Artifacts on kV and MV Cone Beam CT, British Journal of Radiology/open, 2019 https://doi.org/10.1259/bjro.20190013

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