Gene Panels: Genetic Testing for Hereditary Cancer

Posted on Thursday, May 1, 2014

Genetic testing for hereditary cancer risk has been available for about 20 years. A family history with more than one case of the same or related cancers, young cancers, or people who had cancer more than once might be offered genetic testing. This testing could be for many different gene mutations known to increase the risk for certain cancers.

Some of the most common cancer genetic tests are for the BRCA1 or BRCA2 genes related to inherited breast and ovarian cancer, or the Lynch syndrome genes related to inherited colon, stomach, uterine, and ovarian cancers. Genetic testing is often costly and testing for more than one genetic syndrome can be difficult to do.

New technology, called Next Generation Sequencing, has given genetic testing laboratories the ability to look at dozens of cancer risk genes. Several labs now offer multigene panels that look at genes related to specific or related types of cancer, like breast, colon, or kidney cancer.

The benefits of multigene panels include the ability to look at several genes at one time, possibly reduce cost, and test for more recently discovered genes that might have been too expensive to test for in the past.

There are also many challenges to multigene panels. One challenge is the addition of new genes for which we do not yet have good information. There is also the chance to get an unexpected genetic result and a higher possibility of an unclear genetic test result called a genetic variant of uncertain significance. Sometimes, the results are hard to interpret for healthy family members.

Fox Chase Cancer Center began offering multigene panels to all eligible patients in 2013. We created new education tools to help patients understand these panels. Our team is here to provide support and education to make sure every patient is comfortable with the information they receive from multigene testing.

We continue to offer syndrome-specific testing, because this type of testing has the lowest possibility of an unclear result and is sometimes faster, which is important if someone needs genetic testing information to help guide cancer treatment. A genetic counselor can help review your testing options, so you can make a decision that is right for you and your family.

The Fox Chase Risk Assessment Program offers genetic counseling to patients with a personal or family history of cancer. Patients who have had negative genetic testing in the past may want to consider further testing with a multigene panel.

For questions or comments about this post, please contact us.

Andrea Forman, MS, LCGC

About Andrea Forman, MS, LCGC

Andrea Forman, MS, LCGC, is a genetic counselor at Fox Chase Cancer Center. When she meets with patients, Andrea reviews their medical and family history in order to determine the personal and possibly inherited factors that could affect the patient's risk to develop certain cancers. She can help her patients and their families understand the influence of these different risk factors and help to coordinate genetic testing, if appropriate. 

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