Renata Gordon from the Zeng-Jie Yang Lab spoke about “Cholesterol biosynthesis represents a therapeutic target for hedgehog pathway associated malignancies”. The presentation focused on the role of Hedgehog in various malignancies including medulloblastoma, discussion of Gorlin Syndrome, a summary of the molecular subtypes of medulloblastoma, and targeting of shh-gli by small molecules. Novel approaches to targeting cholesterol biosynthesis were discussed along with use of preclinical models to advance translational directions.
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