Fox Chase Cancer Center News

BRCA1 Mutations Influence Therapy Resistance Mechanisms in Breast and Ovarian Cancers

PHILADELPHIA (September 25, 2018)— In addition to impacting cancer risk, mutations in the BRCA1 gene also have a role in determining whether a patient responds to certain types of therapies. In a new publication, Neil Johnson, PhD, found that cancers with different types of BRCA1 mutations have varying susceptibilities to biological pathways that induce resistance to PARP inhibitors, an emerging class of cancer drugs

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