PHILADELPHIA (November 21, 2018)— For the second time this year, Sergei Grivennikov, PhD, assistant professor in the Cancer Prevention and Control Program at Fox Chase Cancer Center, has received a R01 grant from the National Cancer Institute to support research on the connection between inflammation and colorectal cancer. The grant will provide $2.5 million over five years.
The Grivennikov laboratory studies the molecular and cellular mechanisms underlying how immune and inflammatory pathways promote tumor growth and progression. With this grant, the lab will conduct studies to define the role of microbiota and tumor‑specific microbial stimuli required to control tumor-elicited inflammation in colorectal cancer.
Earlier this year Grivennikov earned a separate five-year R01 grant from the NCI to determine the contribution of IL-17B/RB signaling to colorectal cancer and evaluate its mechanisms of action. The long-term goal of that work is to propose improved colorectal cancer prevention and treatment practices based upon better understanding of molecular predictors of primary and recurrent metastasis.
“We are grateful for this support, and will use this funding to the best of our ability to learn how inflammatory and cancer cells communicate, uncovering new principles and basic mechanisms operating within tumor microenvironment,” Grivennikov said.
