Stephen M. Sykes Receives Department of Defense Grant for Pediatric Leukemia Research

November 2, 2018

PHILADELPHIA (November 1, 2018) — Stephen M. Sykes PhD, assistant professor in the Blood Cell Development and Function Program at Fox Chase Cancer Center, has received a grant from the Department of Defense to support research on targeting the unfolded protein response in pediatric leukemia. The grant will provide approximately $732,000 over two years.

The Sykes laboratory studies molecular pathways and how they are differently regulated in leukemia versus normal cell development. With this grant from the Peer Reviewed Cancer Research Program, they will seek to identify molecular pathways that could serve as a foundation for developing effective therapies for the treatment of pediatric acute myeloid leukemia (AML).

The lab will conduct studies to assess the therapeutic utility of targeting downstream transcriptional targets and upstream activators within the unfolded protein response (UPR). The specific goals of this project are to identify transcriptional targets of ATF4 and XBPS1S that support MLL-rearranged AML and assess chemical inhibitors of the UPR in MLL-rearranged AML.

There will be an estimated 19,520 new diagnoses of AML in 2018, which accounts for about one third of all leukemia diagnoses.


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