Manipulation of synthetic approaches in the design and synthesis of biologically active agents. Methodologies included: 1, 3-dipolar cycloaddition reactions, Claisen's rearrangement, Diels-Alder reactions, chemistry of ketenes, sulfilimines, synthesis of substituted steroids. Use of receptor homology, bioisoteric replacement strategies, rational and structure-based drug design approaches Utilizing natural products as a unique resource for discovering innovation therapeutics. Applying enabling technology platforms to evaluate drug-like properties of all discovered molecules to ensure clinical effectiveness of drug candidates. Design of chemical probes in support of translation medicine.