Endometrial Cancer Treatment

At Fox Chase Cancer Center, our multidisciplinary team of gynecologic surgeons, medical oncologists, radiation oncologists, pathologists and radiologists work closely to correctly diagnose your endometrial cancer and help you understand your options so that you can make an informed decision about your treatment.

As a regional and national leader in cancer care, the Center has a depth of experience in treating all types of endometrial cancer.

Our skilled, multispecialty gynecologic cancer team meets regularly to review patient cases and map out a personalized treatment plan. We strive to treat your cancer in the least invasive way possible with innovative surgical techniques and combination therapies that give you the best chance of a successful outcome.

Our doctors are also actively involved in developing new therapies for treating endometrial cancer. Through clinical trials, we are able to offer our patients access to promising treatments and experimental therapies that may not be available elsewhere. Ask your Fox Chase doctor if a clinical trial is right for you.

Your Treatment Options

Treatment for endometrial cancer depends on the stage, type and grade of your tumor; your age, health history and personal goals; and whether or not it has invaded the muscle wall of the uterus. Your personalized treatment plan will be determined after consultations with multiple physician specialties within the multidisciplinary team and may include a combination of one or more of the following treatment options:


Fox Chase gynecologic surgeons are highly skilled in both radical surgery and minimally-invasive techniques, such as laparoscopic and robotic surgery. Procedures offered to patients with endometrial cancer include:

  • Complete surgical options for staging and treatment
  • Surgical treatment of pre-invasive lesions
  • Elective removal of the ovaries and uterus to reduce risk of cancer in high-risk women
  • Plastic and reconstructive surgery to improve quality of life, restore anatomy and retain function

Gynecologic surgeons at Fox Chase are regional and national leaders in performing complex surgeries for patients with endometrial cancer. Our physicians perform these procedures via robotic, laparoscopic and traditional abdominal incision approaches, depending on a patient’s individual needs.

Radiation Therapy

The radiation oncologists at Fox Chase specialize in treating endometrial cancer using the latest radiation therapies. Radiation therapy uses high-energy beams to kill cancer cells and may be given in combination with chemotherapy if you are unable to tolerate surgery or in combination with chemotherapy and surgery for patients with invasive cancer.

Systemic Therapy

The medical oncologists at the Center are regional and national leaders in the treatment of endometrial cancer. As part of the multidisciplinary team, your medical oncologist will help to determine your personalized treatment plan, which may include systemic therapies such as targeted therapy, immunotherapy, or chemotherapy either as standard of care or as part of a clinical trial.

Systemic therapy may be given before or after surgery to patients with muscle invasive or locally advanced endometrial cancer. It may also be recommended to patients who are diagnosed after the cancer has spread to other parts of the body (metastatic cancer).

Clinical Trials

Fox Chase actively participates in a number of clinical trials for patients with endometrial cancer. In addition to receiving excellent care, our patients also benefit from the groundbreaking research that we do to expand our understanding of new cancer therapies and treatments. We encourage eligible patients to participate in clinical trials that are available and appropriate for their stage and type of endometrial cancer.

Preserving Fertility

Certain gynecological cancers and their related treatments can lead to a loss of fertility. The gynecologic oncology team at Fox Chase works with younger women to explore fertility sparing treatment options that may preserve their ability to have children, including surgical techniques that may leave reproductive organs intact.