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Andrzej Ptasznik, MD, PhD, DSci

Andrzej Ptasznik
About

Associate Research Professor

Collaborating Member, Cancer Biology

Research Program

Education and Training

Educational Background

  • DSci, Habilitated Doctor in Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland, 2000
  • Postdoctoral Fellowship, Department of Immunology, The Scripps Research Institute, La Jolla-San Diego, 1993-95
  • Research Fellowship, Center for Gerontological Research, Medical College of Pennsylvania, Philadelphia, PA, 1990-92
  • Residency Central Clinical Hospital, Warsaw and Clinical Hospital, Szczecin, Poland, 1984-87
  • PhD, Experimental Immuno-Hematology, Postgraduate Medical Center, Warsaw, Poland, 1984
  • MD, Pomeranian University School of Medicine, Szczecin, Poland, 1982

Memberships

  • American Pancreatic Association
  • American Society of Hematology
  • International Society of Experimental Hematology

Honors & Awards

  • Habilitated Doctor Thesis, Poland, 2000
  • NIA Fellowship Award, 1990
Research Profile

Research Program

Research Interests

Ptasznik lab – signal transduction and the linkage between inflammation and cancer

  • Signal transduction by the chemokine receptor CXCR4 in normal and malignant cells. Crosstalk between oncoproteins and chemokine signaling.
  • Mechanisms of cell transformation by BCR-ABL and Src-family kinases – drug resistance.
  • Role of aberrant cell signaling in inflammation and fibrosis. The goal is to identify compounds or procedures that can reduce inflammation and fibrosis, and suppress the linkage between inflammation and tumorigenesis.
Former Staff

Hung Pham, PhD
Mobeen Malik, PhD
Ying-Yu Chen, MSci
Brian Tomkowicz, PhD
Suneetha Chinta, MD

Publications

Selected Publications

Pham H, Birtolo C, Chheda C, Yang W, Rodriguez MD, Liu ST, Gugliotta G, Lewis MS, Cirulli V, Pandol SJ, and Ptasznik A. Essential role of Lyn in fibrosis. Front. Physiol. 7:387 (2016). PMCID: PMC5006658

Liu ST, Pham H, Pandol SJ, and Ptasznik A. Src as the link between inflammation and cancer. Front Physiol. (16) 416 (2014). PMCID: PMC3893689

Malik M, Chen YY, Kienzle MF, Tomkowicz B., Collman RG, Ptasznik A. Migration and LFA-1 mediated attachment of primary human monocytes to activated brain microvascular endothelia is regulated by SDF-1 through Lyn kinase. J Immunol,, 181(7), 4632-7 (2008). PMCID: PMC2721474

Chen YY, Malik M, Tomkowicz BE, Collman RG, Ptasznik A. BCR-ABL1 alters SDF-1-dependent adhesive responses through the ß2 integrin LFA-1 in leukemia cells. Blood,111(10), 5182-6 (2008). PMCID: PMC2384141

Nakata Y, Tomkowicz B, Gewirtz AM and Ptasznik A. Integrin inhibition through Lyn dependent crosstalk from CXCR4 chemokine receptor in normal human CD34+ marrow cells. Blood, 107(11), 4234-9 (2006). PMCID: PMC1895784

Ptasznik A., Nakata Y, Kalota A, Emerson SG. and Gewirtz AM. Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug resistant, BCRABL1(+) leukemia cells. Nature Med 10(11): 1187-9 (2004).  PMID: 15502840

Ptasznik A., Urbanowska E, Chinta S., Costa MA, Katz BA., Stanislaus MA, Demir G., Linnekin D, Pan ZK., Gewirtz AM. Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells. J Exp Med. 196(5):667- 78. (2002). PMICD: PMC2193994

Ptasznik, A., Beattie, G.M., Mally, M.I., Cirulli, V, Lopez, A., and Hayek, A. Phosphatidylinositol 3-kinase is a negative regulator of cellular (islet cell) differentiation. J. Cell Biol. 137: 1127-36. (1997). PMCID: PMC2136228

Ptasznik, A., Prossnitz, E.R., Yoshikawa, D., Smrca, A.,Traynor-Kaplan, A., and Bokoch, G. M.. A tyrosine kinase signaling pathway accounts for the majority of phosphatidylinositol 3,4,5- trisphosphate formation in chemoattractant-stimulated human neutrophils. J. Biol Chem. 271: 25204-7. (1996).  PMID: 8810279

Ptasznik, A., Traynor-Kaplan, A., and Bokoch, G.M. G-protein coupled chemoattractant receptors regulate Lyn tyrosine kinase-Shc adapter protein signaling complexes in human leukocytes. J. Biol. Chem. 270: 19969-73. (1995). PMID: 7650013

Additional Publications

Dr. Ptasznik on PubMed

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