Lili Chen, PhD

Professor

Clinical Physicist

Research Program

Cancer Signaling and Microenvironment

Lab Overview

The lab uses cancer animal models, in particular prostate, head and neck, breast, lung, pancreatic, ovarian and other diseases for understanding pathogenesis and developing novel therapeutic approaches. Staff performs cancer treatment studies including radiotherapy, radio-dynamic therapy, gene therapy, chemotherapy, nanotherapy, and MR-guided high intensity focused ultrasound therapy.

Comparison of DVHs for PTV, Rectum and Bladder between CT- and MRI-based IMRT plans
Comparison of isodose distributions between CT-and MRI-based IMRT plans
MR images showing a prostate tumor in vivo study

Clinical Locations

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111
Phone: 888-369-2427

Educational Background

PhD, Medical Physics and Biophysics Physics Dept, Royal Marsden Hosp/Institute of Cancer Research, University of London, London, U.K., 1994
MD, Medical University of Shanghai, Shanghai, China, 1982

Honors & Awards

Fellowship Award AAPM, 2013;
Who’s Who in America, 2013;
Best paper in Physics (Therapy), Medical Physics, 2012;
Best paper in Physics (Imaging), Medical Physics, 2012;
AAPM/IPEM Medical Physics Travel Grant, 2009;
LAP Award of Excellence for best radiation oncology article, ACMP, 2005

People

Dusica Cvetkovic, MD, MS

Research Associate

W230

215-728-3661

[email protected]
Theresa Richardson, RT, (CT), (MR)

Simulation Therapist

P0143

215-728-2581

[email protected]
Lorraine Medoro

Administrative Assistant

P1096

215-728-3043

[email protected]
Roohi Gupta, PhD

Medical Physics Resident

P0103

215-728-1426

[email protected]
Bin Wang, PhD

Medical Physics Resident

P0103

215-728-1426

[email protected]
Wei He

Visiting Scientist

P0103

[email protected]

Research Interests

Linac based SBRT
Radiodynamic therapy and PET MR implementation
Non-thermal HIFU for breast cancer
Implementation of MRI-based treatment planning for 3DCRT and IMRT (project leader)
MRS applications for radiotherapy (team member)
MR-guided HIFU for cancer surgery/therapy (project leader)
MR-guided HIFU to enhance drug delivery (project leader)

Misc

Jian-Hua Ren, Visiting Physicist
Peng Zhang, Visiting Radiation Oncologist
Chunting Wang, Visiting Scientist
Binh Nguyen, Visiting Student
Jennifer Zhu, Visiting Research Assistant
Elan Jones, Visiting Student
Xiu Xu, Visiting Research Assistant

Selected Publications

Xu Q., Tong X., Lin M., Chen X., ElDib A., Lin T., Chen L., Ma C.C., Time and frequency to observe fiducial markers in mlc-modulated fields during prostate imrt/vmat beam delivery. Phys Med. 76: 142-149, 2020. PMC7528608. https://www.ncbi.nlm.nih.gov/pubmed/32679409.

Shan G., Hu W., Chen L., Price R.A., Ma C.C., Dosimetric evaluation of image-guided radiation therapy for prostate cancer. Med Dosim. 46(2): 117-126, 2021. https://www.ncbi.nlm.nih.gov/pubmed/33020024.

Panetta J.V., Cvetkovic D., Chen X., Chen L., Ma C.C., Radiodynamic therapy using 15-mv radiation combined with 5-aminolevulinic acid and carbamide peroxide for prostate cancer in vivo. Phys Med Biol. 65(16): 165008, 2020. PMC8409498. https://www.ncbi.nlm.nih.gov/pubmed/32464613.

Ma C-M, Chen X, Cvetkovic D, Chen L, An In-Vivo Investigation of the Therapeutic Effect of Pulsed Focused Ultrasound on Tumor Growth, Med. Phys. (2014) 41, 122901; doi: 10.1118/1.4901352. PubMed

Gupta R, Cvetkovic D, Ma CM, Chen L (2014) Targeted Approach for Prostate Cancer Treatment: Synthesis and Characterization of Docetaxel-Loaded Perfluorocarbon Nanodroplets. J Cancer Sci Clin Oncol 1(1): 102. doi: 10.15744/2394-6520.1.102.

Chen X, Cvetkovic D, Ma C-M, Chen L Quantitative Study of Focused Ultrasound Enhanced Doxorubicin Delivery to Prostate Tumor In Vivo with MRI guidance Med. Phys. 39 2780-2786 (2012). PubMed

Mu Z, Ma C-M, Chen X, Pollack A and Chen L. MR Guided Pulsed High Intensity Focused Ultrasound Enhancement of Docetaxel Combined with Radiotherapy for Prostate Cancer Treatment Phys. Med. Biol. 57 535–545 (2012). PubMed

Chen L, Mu Z, Hachem P, Ma C-M and Pollack A. MR-guided focused ultrasound: enhancement of intratumoral uptake of [3H]-docetaxel in vivo Phys. Med. Biol., 55: 7399-7410 (2010). PubMed

Chen L, Paskalev K, Xu X, Zhu J, Feigenberg S, Pollack A, Hu W, Ma C-M. Prostate Cancer IMRT: Rectal Dose Variation During the Course of the Treatment in Image Guided Radiation Therapy. Radiotherapy and Oncology, 95: 198-202 (2010). PubMed

Chen L, Nguyen T-B, Jones E, Chen Z, Luo W, Wang L, Price RA, Pollack A and Ma C-M. MRI-Based Treatment Planning for Prostate IMRT: Creation of Digitally Reconstructed Radiographs (DRR). International Journal of Radiation Oncology Biology Physics 68:(3): 903-11 (2007). PubMed... Expand