Lili Chen, PhD

Lili Chen, PhD

Clinical Locations

Primary Location

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111


Associate Professor

Research Program

Comparison of DVHs for PTV, Rectum and Bladder between CT- and MRI-based IMRT plans
Comparison of isodose distributions between CT-and MRI-based IMRT plans
MR images showing a prostate tumor in vivo study


Education, Training & Credentials

Educational Background

  • PhD, Medical Physics and Biophysics Physics Dept, Royal Marsden Hosp/Institute of Cancer Research, University of London, London, U.K., 1994
  • MD, Medical University of Shanghai, Shanghai, China, 1982

Honors & Awards

  • Fellowship Award AAPM, 2013;
  • Who’s Who in America, 2013;
  • Best paper in Physics (Therapy), Medical Physics, 2012;
  • Best paper in Physics (Imaging), Medical Physics, 2012;
  • AAPM/IPEM Medical Physics Travel Grant, 2009;
  • LAP Award of Excellence for best radiation oncology article, ACMP, 2005
Research Profile

Research Program

Research Interests

  • Linac based SBRT
  • Radiodynamic therapy and PET MR implementation
  • Non-thermal HIFU for breast cancer
  • Implementation of MRI-based treatment planning for 3DCRT and IMRT (project leader)
  • MRS applications for radiotherapy (team member)
  • MR-guided HIFU for cancer surgery/therapy (project leader)
  • MR-guided HIFU to enhance drug delivery (project leader)

Lab Overview

The lab uses cancer animal models, in particular prostate, head and neck, breast, lung, pancreatic, ovarian and other diseases for understanding pathogenesis and developing novel therapeutic approaches. Staff performs cancer treatment studies including radiotherapy, radio-dynamic therapy, gene therapy, chemotherapy, nanotherapy, and MR-guided high intensity focused ultrasound therapy.


Dusica Cvetkovic, MD, MS

Research Associate

Room: W230

Theresa Richardson, RT, (CT), (MR)

Simulation Therapist

Room: P0143

Lorraine Medoro

Administrative Assistant

Room: P1096

Roohi Gupta, PhD

Medical Physics Resident

Room: P0103

Bin Wang, PhD

Medical Physics Resident

Room: P0103

Wei He

Visiting Scientist

Room: P0103
  • Jian-Hua Ren, Visiting Physicist
  • Peng Zhang, Visiting Radiation Oncologist
  • Chunting Wang, Visiting Scientist
  • Binh Nguyen, Visiting Student
  • Jennifer Zhu, Visiting Research Assistant
  • Elan Jones, Visiting Student
  • Xiu Xu, Visiting Research Assistant

Selected Publications

Ma C-M, Chen X, Cvetkovic D, Chen L, An In-Vivo Investigation of the Therapeutic Effect of Pulsed Focused Ultrasound on Tumor Growth, Med. Phys. (2014) 41, 122901; doi: 10.1118/1.4901352. PubMed


Gupta R, Cvetkovic D, Ma CM, Chen L (2014) Targeted Approach for Prostate Cancer Treatment: Synthesis and Characterization of Docetaxel-Loaded Perfluorocarbon Nanodroplets. J Cancer Sci Clin Oncol 1(1): 102. doi: 10.15744/2394-6520.1.102. 


Chen X, Cvetkovic D, Ma C-M, Chen L Quantitative Study of Focused Ultrasound Enhanced Doxorubicin Delivery to Prostate Tumor In Vivo with MRI guidance Med. Phys. 39 2780-2786 (2012). PubMed


Mu Z, Ma C-M, Chen X, Pollack A and Chen L. MR Guided Pulsed High Intensity Focused Ultrasound Enhancement of Docetaxel Combined with Radiotherapy for Prostate Cancer Treatment Phys. Med. Biol. 57 535–545 (2012). PubMed


Chen L, Mu Z, Hachem P, Ma C-M and Pollack A. MR-guided focused ultrasound: enhancement of intratumoral uptake of [3H]-docetaxel in vivo Phys. Med. Biol., 55: 7399-7410 (2010). PubMed


Chen L, Paskalev K, Xu X, Zhu J, Feigenberg S, Pollack A, Hu W, Ma C-M. Prostate Cancer IMRT: Rectal Dose Variation During the Course of the Treatment in Image Guided Radiation Therapy. Radiotherapy and Oncology, 95: 198-202 (2010). PubMed


Chen L, Nguyen T-B, Jones E, Chen Z, Luo W, Wang L, Price RA, Pollack A and Ma C-M. MRI-Based Treatment Planning for Prostate IMRT: Creation of Digitally Reconstructed Radiographs (DRR). International Journal of Radiation Oncology Biology Physics 68:(3): 903-11 (2007). PubMed


Chen Z, Ma C-M, Paskalev K, Li J, Yang J, Richardson T, Palacio L, Xu X and Chen L. Investigation of MR Image Distortion for Radiotherapy Treatment Planning of Prostate Cancer. Phys. Med. Biol 51 1393-1403 (2006).


Chen L, Price RA Jr., Wang L, Li JS, Qin L, Shawn M, Ma C-M, Freedman GM and Pollack A. MRI-Based Treatment Planning for Radiotherapy: Dosimetric Verification for Prostate IMRT. International Journal of Radiation Oncology Biology Physics 60(2): 636-47 (2004). PubMed


Chen L, Price RA Jr., Wang L, Li JS, Qin L, Ding M, Palacio E, T-B Nguyen, Ma C-M, Pollack A. Dosimetric evaluation of MRI-based treatment planning for prostate cancer. Phys. Med. Biol. 49: 5157-5170 (2004). 


Chen L, Bouley D, Harris B, Butts K. MRI study of immediate cell viability in focused ultrasound lesions in the rabbit brain. Journal of Magnetic Resonance Imaging. 13:23-30, 2001.


Chen L, Bouley D, Yuh E, D’Arceuil H, Butts K. Study of focused ultrasound tissue damage using MRI and histology. Journal of Magnetic Resonance Imaging. 10:146-153, 1999.


Chen L, ter Haar G, Bensted J P M and Hill C R. Histological study of normal liver and tumour bearing treated with focused ultrasound Ultrasound Med. Biol. 25: 847-856, 1999.


Chen L, ter Haar G, Hill C R, Eccles S A, Box G and ensted J P M. Treatment of implanted rat liver tumors with high-intensity focused ultrasound. Ultrasound Med. Biol. 24: 1475-88, 1998.


Chen L, ter Haar G and Hill C R. Influence of ablated tissue on the formation of high-intensity focused ultrasound lesions. Ultrasound Med. Biol. 23:921-931, 1997.

Additional Publications