The lab uses cancer animal models, in particular prostate, head and neck, breast, lung, pancreatic, ovarian and other diseases for understanding pathogenesis and developing novel therapeutic approaches. Staff performs cancer treatment studies including radiotherapy, radio-dynamic therapy, gene therapy, chemotherapy, nanotherapy, and MR-guided high intensity focused ultrasound therapy.
Implementation of MRI-based treatment planning for 3DCRT and IMRT (project leader)
MRS applications for radiotherapy (team member)
MR-guided HIFU for cancer surgery/therapy (project leader)
MR-guided HIFU to enhance drug delivery (project leader)
Jian-Hua Ren, Visiting Physicist
Peng Zhang, Visiting Radiation Oncologist
Chunting Wang, Visiting Scientist
Binh Nguyen, Visiting Student
Jennifer Zhu, Visiting Research Assistant
Elan Jones, Visiting Student
Xiu Xu, Visiting Research Assistant
Xu Q., Tong X., Lin M., Chen X., ElDib A., Lin T., Chen L., Ma C.C., Time and frequency to observe fiducial markers in mlc-modulated fields during prostate imrt/vmat beam delivery. Phys Med. 76: 142-149, 2020. PMC7528608. https://www.ncbi.nlm.nih.gov/pubmed/32679409.
Panetta J.V., Cvetkovic D., Chen X., Chen L., Ma C.C., Radiodynamic therapy using 15-mv radiation combined with 5-aminolevulinic acid and carbamide peroxide for prostate cancer in vivo. Phys Med Biol. 65(16): 165008, 2020. PMC8409498. https://www.ncbi.nlm.nih.gov/pubmed/32464613.
Ma C-M, Chen X, Cvetkovic D, Chen L, An In-Vivo Investigation of the Therapeutic Effect of Pulsed Focused Ultrasound on Tumor Growth, Med. Phys. (2014) 41, 122901; doi: 10.1118/1.4901352. PubMed
Gupta R, Cvetkovic D, Ma CM, Chen L (2014) Targeted Approach for Prostate Cancer Treatment: Synthesis and Characterization of Docetaxel-Loaded Perfluorocarbon Nanodroplets. J Cancer Sci Clin Oncol 1(1): 102. doi: 10.15744/2394-6520.1.102.
Chen X, Cvetkovic D, Ma C-M, Chen L Quantitative Study of Focused Ultrasound Enhanced Doxorubicin Delivery to Prostate Tumor In Vivo with MRI guidance Med. Phys. 39 2780-2786 (2012). PubMed
Mu Z, Ma C-M, Chen X, Pollack A and Chen L. MR Guided Pulsed High Intensity Focused Ultrasound Enhancement of Docetaxel Combined with Radiotherapy for Prostate Cancer Treatment Phys. Med. Biol. 57 535–545 (2012). PubMed
Chen L, Mu Z, Hachem P, Ma C-M and Pollack A. MR-guided focused ultrasound: enhancement of intratumoral uptake of [3H]-docetaxel in vivo Phys. Med. Biol., 55: 7399-7410 (2010). PubMed
Chen L, Paskalev K, Xu X, Zhu J, Feigenberg S, Pollack A, Hu W, Ma C-M. Prostate Cancer IMRT: Rectal Dose Variation During the Course of the Treatment in Image Guided Radiation Therapy. Radiotherapy and Oncology, 95: 198-202 (2010). PubMed
Chen L, Nguyen T-B, Jones E, Chen Z, Luo W, Wang L, Price RA, Pollack A and Ma C-M. MRI-Based Treatment Planning for Prostate IMRT: Creation of Digitally Reconstructed Radiographs (DRR). International Journal of Radiation Oncology Biology Physics 68:(3): 903-11 (2007). PubMed...Expand
Chen Z, Ma C-M, Paskalev K, Li J, Yang J, Richardson T, Palacio L, Xu X and Chen L. Investigation of MR Image Distortion for Radiotherapy Treatment Planning of Prostate Cancer. Phys. Med. Biol 51 1393-1403 (2006).
Chen L, Price RA Jr., Wang L, Li JS, Qin L, Shawn M, Ma C-M, Freedman GM and Pollack A. MRI-Based Treatment Planning for Radiotherapy: Dosimetric Verification for Prostate IMRT. International Journal of Radiation Oncology Biology Physics 60(2): 636-47 (2004). PubMed
Chen L, Price RA Jr., Wang L, Li JS, Qin L, Ding M, Palacio E, T-B Nguyen, Ma C-M, Pollack A. Dosimetric evaluation of MRI-based treatment planning for prostate cancer. Phys. Med. Biol. 49: 5157-5170 (2004).
Chen L, Bouley D, Harris B, Butts K. MRI study of immediate cell viability in focused ultrasound lesions in the rabbit brain. Journal of Magnetic Resonance Imaging. 13:23-30, 2001.
Chen L, Bouley D, Yuh E, D’Arceuil H, Butts K. Study of focused ultrasound tissue damage using MRI and histology. Journal of Magnetic Resonance Imaging. 10:146-153, 1999.
Chen L, ter Haar G, Bensted J P M and Hill C R. Histological study of normal liver and tumour bearing treated with focused ultrasound Ultrasound Med. Biol. 25: 847-856, 1999.
Chen L, ter Haar G, Hill C R, Eccles S A, Box G and ensted J P M. Treatment of implanted rat liver tumors with high-intensity focused ultrasound. Ultrasound Med. Biol. 24: 1475-88, 1998.
Chen L, ter Haar G and Hill C R. Influence of ablated tissue on the formation of high-intensity focused ultrasound lesions. Ultrasound Med. Biol. 23:921-931, 1997. Collapse
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