Lili Chen, PhD

Lili Chen, PhD

Professor

Clinical Physicist

Research Program

Lab Overview

The lab uses cancer animal models, in particular prostate, head and neck, breast, lung, pancreatic, ovarian and other diseases for understanding pathogenesis and developing novel therapeutic approaches. Staff performs cancer treatment studies including radiotherapy, radio-dynamic therapy, gene therapy, chemotherapy, nanotherapy, and MR-guided high intensity focused ultrasound therapy.

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    Comparison of DVHs for PTV, Rectum and Bladder between CT- and MRI-based IMRT plans

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    Comparison of isodose distributions between CT-and MRI-based IMRT plans

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    MR images showing a prostate tumor in vivo study

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    Clinical Locations

    • Fox Chase Cancer Center
      333 Cottman Avenue
      Philadelphia, PA 19111
      Phone: 888-369-2427

    Educational Background

    • PhD, Medical Physics and Biophysics Physics Dept, Royal Marsden Hosp/Institute of Cancer Research, University of London, London, U.K., 1994
    • MD, Medical University of Shanghai, Shanghai, China, 1982

    Honors & Awards

    • Fellowship Award AAPM, 2013;
    • Who’s Who in America, 2013;
    • Best paper in Physics (Therapy), Medical Physics, 2012;
    • Best paper in Physics (Imaging), Medical Physics, 2012;
    • AAPM/IPEM Medical Physics Travel Grant, 2009;
    • LAP Award of Excellence for best radiation oncology article, ACMP, 2005

    People

    Research Interests

    • Linac based SBRT
    • Radiodynamic therapy and PET MR implementation
    • Non-thermal HIFU for breast cancer
    • Implementation of MRI-based treatment planning for 3DCRT and IMRT (project leader)
    • MRS applications for radiotherapy (team member)
    • MR-guided HIFU for cancer surgery/therapy (project leader)
    • MR-guided HIFU to enhance drug delivery (project leader)

    Misc

    • Jian-Hua Ren, Visiting Physicist
    • Peng Zhang, Visiting Radiation Oncologist
    • Chunting Wang, Visiting Scientist
    • Binh Nguyen, Visiting Student
    • Jennifer Zhu, Visiting Research Assistant
    • Elan Jones, Visiting Student
    • Xiu Xu, Visiting Research Assistant

    Selected Publications

    Xu Q., Tong X., Lin M., Chen X., ElDib A., Lin T., Chen L., Ma C.C., Time and frequency to observe fiducial markers in mlc-modulated fields during prostate imrt/vmat beam delivery. Phys Med. 76: 142-149, 2020. PMC7528608. https://www.ncbi.nlm.nih.gov/pubmed/32679409.

    Shan G., Hu W., Chen L., Price R.A., Ma C.C., Dosimetric evaluation of image-guided radiation therapy for prostate cancer. Med Dosim. 46(2): 117-126, 2021. https://www.ncbi.nlm.nih.gov/pubmed/33020024.

    Panetta J.V., Cvetkovic D., Chen X., Chen L., Ma C.C., Radiodynamic therapy using 15-mv radiation combined with 5-aminolevulinic acid and carbamide peroxide for prostate cancer in vivo. Phys Med Biol. 65(16): 165008, 2020. PMC8409498. https://www.ncbi.nlm.nih.gov/pubmed/32464613.

    Ma C-M, Chen X, Cvetkovic D, Chen L, An In-Vivo Investigation of the Therapeutic Effect of Pulsed Focused Ultrasound on Tumor Growth, Med. Phys. (2014) 41, 122901; doi: 10.1118/1.4901352. PubMed

    Gupta R, Cvetkovic D, Ma CM, Chen L (2014) Targeted Approach for Prostate Cancer Treatment: Synthesis and Characterization of Docetaxel-Loaded Perfluorocarbon Nanodroplets. J Cancer Sci Clin Oncol 1(1): 102. doi: 10.15744/2394-6520.1.102. 

    Chen X, Cvetkovic D, Ma C-M, Chen L Quantitative Study of Focused Ultrasound Enhanced Doxorubicin Delivery to Prostate Tumor In Vivo with MRI guidance Med. Phys. 39 2780-2786 (2012). PubMed

    Mu Z, Ma C-M, Chen X, Pollack A and Chen L. MR Guided Pulsed High Intensity Focused Ultrasound Enhancement of Docetaxel Combined with Radiotherapy for Prostate Cancer Treatment Phys. Med. Biol. 57 535–545 (2012). PubMed

    Chen L, Mu Z, Hachem P, Ma C-M and Pollack A. MR-guided focused ultrasound: enhancement of intratumoral uptake of [3H]-docetaxel in vivo Phys. Med. Biol., 55: 7399-7410 (2010). PubMed

    Chen L, Paskalev K, Xu X, Zhu J, Feigenberg S, Pollack A, Hu W, Ma C-M. Prostate Cancer IMRT: Rectal Dose Variation During the Course of the Treatment in Image Guided Radiation Therapy. Radiotherapy and Oncology, 95: 198-202 (2010). PubMed

    Chen L, Nguyen T-B, Jones E, Chen Z, Luo W, Wang L, Price RA, Pollack A and Ma C-M. MRI-Based Treatment Planning for Prostate IMRT: Creation of Digitally Reconstructed Radiographs (DRR). International Journal of Radiation Oncology Biology Physics 68:(3): 903-11 (2007). PubMed... Expand

    Additional Publications

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