Marielle Brueck
Undergraduate Research Student
3500 N. Broad St., Philadelphia, PA 19140
Jorge Gómez Deza, MRes, PhD
Assistant Professor
Research Program
Peripheral neuropathy and chronic pain are a common side effect of chemotherapy treatment for which there are no available treatments.
The Gómez-Deza Lab aims to understand how neurons are damaged in response to chemotherapy. However, our research is widely applicable to other neurodegenerative conditions such as glaucoma, traumatic brain injury (TBI) or Amyotrophic Lateral Sclerosis (ALS).
To do this, we employ a wide range of molecular and biochemical techniques, including iPSC differentiation into human neurons, whole genome CRISPR interference screens, RNAseq, CRISPR knock-ins/ knock-outs, and advanced microscopy.
The lab has a strong clinical focus. We are deeply interested in uncovering new molecular mechanisms that drive axon degeneration and neuron death to develop novel therapeutic strategies.
Our mission is also to educate and train the next generation of scientists by fostering a safe, innovative, fun and diverse environment that empowers individuals to reach their full potential. We value mental well-being, maintain a healthy work-life balance, and welcome everyone to our team.
Educational Background
- BSc in Biochemistry - University College London
- MRes in Translational Science - King's College London
- PhD in Basic and Clinical Neuroscience - King's College London
Memberships
- American Society for Cell Biology
- Spanish Researchers in the USA (ECUSA)
Honors & Awards
- NICHD Early Career Award
- NCATS Research Project grant
- Milton-Safenowitz ALSA Postdoctoral Fellowship
- Motor Neurone Disease Association Short term grant
People
Selected Publications
ATF2 phosphorylation is a core transcriptional driver of neuron apoptosis. Gómez-Deza J*, Nebiyou M, El Touny LH, Alkaslasi MR, Zuo Z, Wlaschin JJ, Nadal-Nicolás FM, Stavsky A, Zhang X, Slavutsky AL, Zhang AY, Lloyd EYH, Hayashi PM, Ashby N, Brueck MG, Sohn M, Dale RK, Thomas GM, Li W, Chih-Chien Cheng K, Rocha PP, Le Pichon CE. * Neuron. 2026 May 19:S0896-6273(26)00330-2. doi: 10.1016/j.neuron.2026.04.035. PMID: 42161275 *Co-corresponding authors.
Gomez-Deza J, Slavutsky AL, Nebiyou M, Le Pichon CE. Local production of reactive oxygen species drives vincristine-induced axon degeneration. Cell Death Dis. 2023 Dec 8;14(12):807. doi: 10.1038/s41419-023-06227-8. PubMed PMID: 38065950; PubMed Central PMCID: PMC10709426.
Gomez-Deza J, Lee YB, Troakes C, Nolan M, Al-Sarraj S, Gallo JM, Shaw CE. Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their degeneration. Acta Neuropathol Commun. 2015 Jun 25;3:38. doi: 10.1186/s40478-015-0218-y. PubMed PMID: 26108573; PubMed Central PMCID: PMC4479315.