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Visiting Scientist
The role of nutrition in development and progression of cancer
Pancreatic cancer is the 4th leading cause of cancer deaths in the US with a 5-year survival rate of less than 7% and a median survival of only 3 to 6 months. The majority of pancreatic ductal adenocarcinomas are diagnosed at a late stage, are not surgically resectable, and respond poorly to chemotherapy, so an emphasis on earlier detection methods is critical. Several groups have reported a possible link between diet and the development of pancreatic cancer, but any potential mechanism has yet to be determined. Our lab is interested in elucidating the role of dietary components that affect signaling events that promote the development of pancreatic cancer.
Hartman T.R.*, Ventresca E.M.*, Hopkins A.*, Zinshteyn D., Singh T., O’Brien, J., Neubert B., Hartman M.G., Schofield H.K., Stavrides K.P., Talbot D., Riggs D., O’Reilly A.M. 2015. Novel tools for genetic manipulation of Follicle Stem Cells in the Drosophila ovary reveal an integrin-dependent transition from quiescence to proliferation. Genetics. 199, 935-957. PubMed
Hartman T.R., Strochlic T.I., Ji Y., Zinshteyn D., O'Reilly A.M.. 2013. Diet Controls Drosophila Follicle Stem Cell Proliferation Via Hedgehog Sequestration and Release. Journal of Cell Biology. 201(5):741-57. PubMed
Hartman, T.R., Zinshteyn, D., Schofield, H.K., Nicolas, E., Okada, A., and O’Reilly, A.M. Drosophila Boi Limits Hedgehog Levels to Suppress Follicle Stem Cell Proliferation. Journal of Cell Biology, 191:943-52, 2010. PMICD: PMC2995164. PubMed
Karbowniczek, M. Zitserman, D., Khabibullin, D., Hartman, T., Yu, J., Morrison, T., Nicolas, E., Squillace, R., Roegiers, F., Henske, E.P. The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development. J. Clin. Invest. 120:93-102, 2010. PMCID: PMC2798691. PubMed
Hartman, T.R., Liu, D., Zilfou, J.T., Robb, V., Morrison, T., Watnick, T., Henske, E.P. The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin-I-independent pathway. Hum. Mol. Genet. 18:151-163, 2009. PMCID: PMC2644647. PubMed
Pugacheva, E.N., Jablonski, S.A., Hartman, T.R., Henske, E.P., Golemis, E.A. HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell 129:1351-1363, 2007. PMCID: PMC2504417. PubMed
Cash, T.P., Gruber, J.J., Hartman, T.R., Henske, E.P., and Simon, M.C. Loss of Birt-Hogg-Dubé Tumor Suppressor Results in Apoptotic Resistance Due to Aberrant TGFβ-Mediated Transcription. Oncogene, 3-:2534-46, 2011. PMID: 21258407 PubMed
Hartman, T.R., Nicolas, E., Klein-Szanto, A., Al-Saleem, T., Cash, T.P., Simon, M.C., Henske, E.P. The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis. Oncogene 28:1594-1604, 2009. PubMed
Van Slegtenhorst, M., Khabibullin, D., Hartman, T.R., Nicolas, E., Kruger, W.D., Henske, E.P. The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces Pombe. J. Biol. Chem. 282:24583-24590, 2007. PubMed
Bolinger, C., Yilmaz, A., Hartman, T.R., Kovacic, M.B., Fernandez, S., Ye, J., Forget, M., Green, P.L., Boris-Lawrie, K. RNA helicase A interacts with divergent lymphotropic retroviruses and promotes translation of human T-cell leukemia virus type 1. Nucleic Acids Res. 35:2629-2642, 2007. PubMed
Hartman, T.R., Qian, S., Bolinger, C., Fernandez, S., Schoenberg, D.R., Boris-Lawrie, K. RNA helicase A is necessary for translation of selected messenger RNAs. Nat. Struct. Mol. Biol. 13:509-516, 2006. PubMed
Tiffiney.Hartman@fccc.edu
Office Phone: 215-214-1505
Office: W463
Tiffiney.Hartman@fccc.edu
Office Phone: 215-214-1505
Office: W463
Visiting Scientist
The role of nutrition in development and progression of cancer
Pancreatic cancer is the 4th leading cause of cancer deaths in the US with a 5-year survival rate of less than 7% and a median survival of only 3 to 6 months. The majority of pancreatic ductal adenocarcinomas are diagnosed at a late stage, are not surgically resectable, and respond poorly to chemotherapy, so an emphasis on earlier detection methods is critical. Several groups have reported a possible link between diet and the development of pancreatic cancer, but any potential mechanism has yet to be determined. Our lab is interested in elucidating the role of dietary components that affect signaling events that promote the development of pancreatic cancer.
Hartman T.R.*, Ventresca E.M.*, Hopkins A.*, Zinshteyn D., Singh T., O’Brien, J., Neubert B., Hartman M.G., Schofield H.K., Stavrides K.P., Talbot D., Riggs D., O’Reilly A.M. 2015. Novel tools for genetic manipulation of Follicle Stem Cells in the Drosophila ovary reveal an integrin-dependent transition from quiescence to proliferation. Genetics. 199, 935-957. PubMed
Hartman T.R., Strochlic T.I., Ji Y., Zinshteyn D., O'Reilly A.M.. 2013. Diet Controls Drosophila Follicle Stem Cell Proliferation Via Hedgehog Sequestration and Release. Journal of Cell Biology. 201(5):741-57. PubMed
Hartman, T.R., Zinshteyn, D., Schofield, H.K., Nicolas, E., Okada, A., and O’Reilly, A.M. Drosophila Boi Limits Hedgehog Levels to Suppress Follicle Stem Cell Proliferation. Journal of Cell Biology, 191:943-52, 2010. PMICD: PMC2995164. PubMed
Karbowniczek, M. Zitserman, D., Khabibullin, D., Hartman, T., Yu, J., Morrison, T., Nicolas, E., Squillace, R., Roegiers, F., Henske, E.P. The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development. J. Clin. Invest. 120:93-102, 2010. PMCID: PMC2798691. PubMed
Hartman, T.R., Liu, D., Zilfou, J.T., Robb, V., Morrison, T., Watnick, T., Henske, E.P. The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin-I-independent pathway. Hum. Mol. Genet. 18:151-163, 2009. PMCID: PMC2644647. PubMed
Pugacheva, E.N., Jablonski, S.A., Hartman, T.R., Henske, E.P., Golemis, E.A. HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell 129:1351-1363, 2007. PMCID: PMC2504417. PubMed
Cash, T.P., Gruber, J.J., Hartman, T.R., Henske, E.P., and Simon, M.C. Loss of Birt-Hogg-Dubé Tumor Suppressor Results in Apoptotic Resistance Due to Aberrant TGFβ-Mediated Transcription. Oncogene, 3-:2534-46, 2011. PMID: 21258407 PubMed
Hartman, T.R., Nicolas, E., Klein-Szanto, A., Al-Saleem, T., Cash, T.P., Simon, M.C., Henske, E.P. The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis. Oncogene 28:1594-1604, 2009. PubMed
Van Slegtenhorst, M., Khabibullin, D., Hartman, T.R., Nicolas, E., Kruger, W.D., Henske, E.P. The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces Pombe. J. Biol. Chem. 282:24583-24590, 2007. PubMed
Bolinger, C., Yilmaz, A., Hartman, T.R., Kovacic, M.B., Fernandez, S., Ye, J., Forget, M., Green, P.L., Boris-Lawrie, K. RNA helicase A interacts with divergent lymphotropic retroviruses and promotes translation of human T-cell leukemia virus type 1. Nucleic Acids Res. 35:2629-2642, 2007. PubMed
Hartman, T.R., Qian, S., Bolinger, C., Fernandez, S., Schoenberg, D.R., Boris-Lawrie, K. RNA helicase A is necessary for translation of selected messenger RNAs. Nat. Struct. Mol. Biol. 13:509-516, 2006. PubMed