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Tiffiney Roberts Hartman, PhD

Tiffiney Hartman, PhD
About

Visiting Scientist

Education and Training

Educational Background

  • PhD, Molecular, Cellular & Developmental Biology, Ohio State University, Columbus, OH, 2003
  • BS, Biology, University of Akron, Akron, OH, 1996

Honors & Awards

  • Edward David Lustbader Award, Third-Place Poster Presentation, 17th Annual Postdoctoral Research  Conference, Fox Chase Cancer Center, Philadelphia, PA, 2012 
  • Jean and Baruch Blumberg Award for Best Postdoctoral Seminar of the Year 2010-2011, Fox Chase Cancer Center, Philadelphia, PA, 2011
  • Board of Associates 1 year Fellowship, Fox Chase Cancer Center, Philadelphia, PA, 2010
  • Myrovlytis Trust 1 year Research Grant to study Birt-Hogg-Dubé Syndrome (declined), 2008
  • Ruth L. Kirschstein National Research Service Award for Individual, Postdoctoral Fellows (NIH F32), 2006
  • NIH T32 Internal Training Grant, Fox Chase Cancer Center, Philadelphia, PA, 2005
  • Second-Place, Roche Molecular Biochemicals Distinguished Seminar Award, The Ohio State University, Columbus, OH, 2001
  • First-Place Poster Presentation, Molecular and Cellular Biology Division, College of Veterinary Research Day, The Ohio State University, Columbus, OH, 2000
  • Runner-up, Poster Presentation, College of Veterinary Medicine Research Day, The Ohio State University, Columbus, OH.1996   Elected Member of Phi Sigma Alpha honorary society, Buchtel College of Arts and Sciences, The University of Akron, Akron, OH, 1999
  • First-Place Poster Presentation, Biological Sciences Division, 13th Annual Edward H. Hayes Graduate Research Forum, The Ohio State University, Columbus, OH, 1999
  • Distinguished Teaching Assistant Award, 1997–1998 Academic Year, Introductory Biology Teaching Assistant Program, The Ohio State University, Columbus, OH, 1998
Research Profile

Research Interests

The role of nutrition in development and progression of cancer

  • The effects of dietary components on signaling in premalignant pancreatic lesions
  • Mechanisms leading to progression from PanINs to pancreatic ductal adenocarcinoma

Lab Overview

Pancreatic cancer is the 4th leading cause of cancer deaths in the US with a 5-year survival rate of less than 7% and a median survival of only 3 to 6 months. The majority of pancreatic ductal adenocarcinomas are diagnosed at a late stage, are not surgically resectable, and respond poorly to chemotherapy, so an emphasis on earlier detection methods is critical. Several groups have reported a possible link between diet and the development of pancreatic cancer, but any potential mechanism has yet to be determined. Our lab is interested in elucidating the role of dietary components that affect signaling events that promote the development of pancreatic cancer.

Lab Staff

Benjamin Blake Pressly, BS

Scientific Technician I

Room: R354
215-214-3219

Theresa Konnovitch

Cure Fellow

Room: R354
215-214-3219
Publications

Selected Publications

Hartman T.R.*, Ventresca E.M.*, Hopkins A.*, Zinshteyn D., Singh T., O’Brien, J., Neubert B., Hartman M.G., Schofield H.K., Stavrides K.P., Talbot D., Riggs D., O’Reilly A.M. 2015. Novel tools for genetic manipulation of Follicle Stem Cells in the Drosophila ovary reveal an integrin-dependent transition from quiescence to proliferation. Genetics. 199, 935-957. PubMed

Hartman T.R., Strochlic T.I., Ji Y., Zinshteyn D., O'Reilly A.M.. 2013. Diet Controls Drosophila Follicle Stem Cell Proliferation Via Hedgehog Sequestration and Release. Journal of Cell Biology. 201(5):741-57. PubMed

Hartman, T.R., Zinshteyn, D., Schofield, H.K., Nicolas, E., Okada, A., and O’Reilly, A.M. Drosophila Boi Limits Hedgehog Levels to Suppress Follicle Stem Cell Proliferation. Journal of Cell Biology, 191:943-52, 2010. PMICD: PMC2995164. PubMed

Karbowniczek, M. Zitserman, D., Khabibullin, D., Hartman, T., Yu, J., Morrison, T., Nicolas, E., Squillace, R., Roegiers, F., Henske, E.P. The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development. J. Clin. Invest. 120:93-102, 2010. PMCID: PMC2798691. PubMed

Hartman, T.R., Liu, D., Zilfou, J.T., Robb, V., Morrison, T., Watnick, T., Henske, E.P. The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin-I-independent pathway. Hum. Mol. Genet. 18:151-163, 2009. PMCID: PMC2644647. PubMed

Pugacheva, E.N., Jablonski, S.A., Hartman, T.R., Henske, E.P., Golemis, E.A. HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell 129:1351-1363, 2007. PMCID: PMC2504417. PubMed

Cash, T.P., Gruber, J.J., Hartman, T.R., Henske, E.P., and Simon, M.C. Loss of Birt-Hogg-Dubé Tumor Suppressor Results in Apoptotic Resistance Due to Aberrant TGFβ-Mediated Transcription. Oncogene, 3-:2534-46, 2011. PMID: 21258407   PubMed

Hartman, T.R., Nicolas, E., Klein-Szanto, A., Al-Saleem, T., Cash, T.P., Simon, M.C., Henske, E.P. The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis. Oncogene 28:1594-1604, 2009.  PubMed

Van Slegtenhorst, M., Khabibullin, D., Hartman, T.R., Nicolas, E., Kruger, W.D., Henske, E.P. The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces Pombe. J. Biol. Chem. 282:24583-24590, 2007.  PubMed

Bolinger, C., Yilmaz, A., Hartman, T.R., Kovacic, M.B., Fernandez, S., Ye, J., Forget, M., Green, P.L., Boris-Lawrie, K. RNA helicase A interacts with divergent lymphotropic retroviruses and promotes translation of human T-cell leukemia virus type 1. Nucleic Acids Res. 35:2629-2642, 2007.  PubMed

Hartman, T.R., Qian, S., Bolinger, C., Fernandez, S., Schoenberg, D.R., Boris-Lawrie, K. RNA helicase A is necessary for translation of selected messenger RNAs. Nat. Struct. Mol. Biol. 13:509-516, 2006.  PubMed

Additional Publications

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