Samuel Litwin, PhD

Sam Litwin, PhD

Associate Professor

Doubly dichotomized data
A median cut-point, m1
Establishing an optimal cutpoint after group sizes are determined


Educational Background

  • PhD, Electrical Engineering, University of Pennsylvania, Philadelphia, PA
  • MS, Electrical Engineering, University of Pennsylvania, Philadelphia, PA
  • BS, Electrical Engineering, University of Pennsylvania, Philadelphia, PA

Research Interests

  • Design of efficient clinical trials
  • Analysis of clinical data
  • Modeling of cellular and viral behavior

Lab Overview

  • Design of one-sample, two-stage clinical trials that allow early stopping in time, as well as in terms of patients' numbers
  • Design of two-sample, two-stage clinical trials that miminize sample number by exchanging global for only local robustness
  • Mathematical models for the behavior of hepatitus B viral clearance

Selected Publications

Xu J, Kadariya Y, Cheung M, Pei J, Talarchek J, Sementino E, Tan Y, Menges CW, Cai KQ, Litwin S, Peng H, Karar J, Rauscher FJ, Testa JR. Germline mutation of Bap1 accelerates development of asbestos-induced malignant mesothelioma. Cancer Res. 2014 Aug 15;74(16):4388-97. PubMed PMID: 24928783; PubMed Central PMCID: PMC4165574. PubMed

Haas NB, Quirt I, Hotte S, McWhirter E, Polintan R, Litwin S, Adams PD, McBryan T, Wang L, Martin LP, vonMehren M, Alpaugh RK, Zweibel J, Oza A. Phase II trial of vorinostat in advanced melanoma. Invest New Drugs. 2014 Jun;32(3):526-34. PubMed PMID: 24464266. PubMed

Do TV, Xiao F, Bickel LE, Klein-Szanto AJ, Pathak HB, Hua X, Howe C, O'Brien SW, Maglaty M, Ecsedy JA, Litwin S, Golemis EA, Schilder RJ, Godwin AK, Connolly DC. Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion. Oncogene. 2014 Jan 30;33(5):539-49. PubMed PMID: 23334327; PubMed Central PMCID: PMC3640671. PubMed

D'Souza JW, Reddy S, Goldsmith LE, Shchaveleva I, Marks JD, Litwin S, Robinson MK. Combining anti-ERBB3 antibodies specific for domain I and domain III enhances the anti-tumor activity over the individual monoclonal antibodies. PLoS One. 2014;9(11):e112376. PubMed PMID: 25386657; PubMed Central PMCID: PMC4227695. PubMed

Hensley HH, Roder NA, O'Brien SW, Bickel LE, Xiao F, Litwin S, Connolly DC. Combined in vivo molecular and anatomic imaging for detection of ovarian carcinoma-associated protease activity and integrin expression in mice. Neoplasia. 2012 PubMed

Doss M, Egleston BL, Litwin S. Comments on "Studies of the Mortality of Atomic Bomb Survivors Report 14 1950-2003: An Overview of Cancer and Noncancer Diseases" (Radiat Res 2012; 177:229-43) Radiat Res. Forthcoming 2012. PubMed

Hensley HH, Roder NA, O'Brien SW, Bickel LE, Xiao F, Litwin S, Connolly DC. Combined in vivo molecular and anatomic imaging for detection of ovarian carcinoma-associated protease activity and integrin expression in mice. Neoplasia 2012; 14(6):451-62. PubMed

Ratushny V, Pathak HB, Beeharry N, Tikhmyanova N, Xiao F, Li T, Litwin S, Connolly DC, Yen TJ, Weiner LM, Godwin AK, Golemis EA. Dual inhibition of SRC and Aurora kinases induces postmitotic attachment defects and cell death. Oncogene 2012; 31(10):1217-27. PubMed

Sill M, Rubinstein L, Litwin S, Yothers G. A method for utilizing bivariate efficacy outcome measures to screen regimens for activity in 2-stage phase II clinical trials. Clin Trials. 2012; 9(4):385-95.

Wong YN, Litwin S, Vaughn D, Cohen S, Plimack ER, Lee J, Song W, Dabrow M, Brody M, Tuttle H, Hudes G. Phase II trial of cetuximab with or without paclitaxel in patients with advanced urothelial tract carcinoma. J Clin Oncol. 2012 Oct 1;30(28):3545-51. PubMed PMID: 22927525; PubMed Central PMCID: PMC3454772. PubMed

Cauchi C, Somaiah N, Engstrom PF, Litwin S, Lopez M, Lee J, Davey M, Bove B, von Mehren M. Evaluation of nilotinib in advanced GIST previously treated with imatinib and sunitinib. Cancer Chemother Pharmacol. 2011; 69(4):977-82. PubMed

Silvers RM, Smith JA, Schowalter M, Litwin S, Liang Z, Geary K, Daniel R. Modification of integration site preferences of an HIV-1-based vector by expression of a novel synthetic protein. Hum Gene Ther. 2010; 3:337-49. PubMed

Cohen RJ, Paskalev K, Litwin S, Price Jr RA, Feigenberg SJ, Konski AA. Esophageal motion during radiotherapy: quantification and margin implications. Dis Esophagus, 2010; 3:33-42. PubMed

Mason WS, Liu C, Aldrich CE, Litwin S, Yeh MM. Clonal expansion of normal-appearing human hepatocytes during chronic hepatitis B virus infection. J Virol. 2010; 84:8308-15. PubMed

Mason WS, Litwin S, Jilbert AR. Immune selection during chronic hepadnavirus infection. Hepatol Int. 2008 Mar;2(1):3-16. PubMed PMID: 19669275; PubMed Central PMCID: PMC2716866. PubMed